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234,785 Structures from the PDB

1,068,577 Computed Structure Models (CSM)

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QUERY: Structure Author = "Ofek, G."

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Search Summary

This query matches 31 Structures.

Refinements

Structure Determination Methodology

experimental (31)

Scientific Name of Source Organism

	Homo sapiens (26)
	Human immunodeficiency virus 1 (19)
	Human immunodeficiency virus type 1 group M subtype D (isolate Z6) (2)
	Mus musculus (2)
	Thermus aquaticus (2)
	Ebola virus - Mayinga, Zaire, 1976 (1)
	Gallus gallus (1)
	Hepacivirus hominis (1)
	Human immunodeficiency virus type 1 (1)
	Macaca fascicularis (1)

More...

Taxonomy

	Eukaryota (30)
	Riboviria (21)
	Riboviria (RNA viruses and viroids) (3)
	Bacteria (2)
	other sequences (1)

Experimental Method

	X-RAY DIFFRACTION (30)
	ELECTRON MICROSCOPY (1)

Polymer Entity Type

Protein (31)

Refinement Resolution (Å)

	1.5 - 2.0 (5)
	2.0 - 2.5 (16)
	2.5 - 3.0 (4)
	3.0 - 3.5 (3)
	3.5 - 4.0 (2)
	4.0 - 4.5 (1)

Release Date

	2000 - 2004 (4)
	2010 - 2014 (9)
	2015 - 2019 (11)
	2020 - 2024 (7)

Enzyme Classification Name

Hydrolases (1)

Symmetry Type

Asymmetric (31)

SCOP Classification

	All beta proteins (8)
	Alpha and beta proteins (a+b) (1)

AllSelected

1 to 25 of 31 Structures

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1PS5 \| pdb_00001ps5	Download File View File

STRUCTURE OF THE MONOCLINIC C2 FORM OF HEN EGG-WHITE LYSOZYME AT 2.0 ANGSTROMS RESOLUTION

Majeed, S., Ofek, G., Belachew, A., Huang, C., Zhou, T., Kwong, P.D.

(2003) Structure 11: 1061-1070

Released	2003-09-09
Method	X-RAY DIFFRACTION 2 Å
Organisms	Gallus gallus
Macromolecule	Lysozyme C (protein)
Unique Ligands	SO4

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1TJG \| pdb_00001tjg	Download File View File

Crystal Structure of the broadly neutralizing anti-HIV-1 antibody 2F5 in complex with a gp41 7mer epitope

Ofek, G., Tang, M., Sambor, A., Katinger, H., Mascola, J.R., Wyatt, R., Kwong, P.D.

(2004) J Virol 78: 10724-10737

Released	2004-10-05
Method	X-RAY DIFFRACTION 2 Å
Organisms	Homo sapiens Human immunodeficiency virus type 1
Macromolecule	Envelope glycoprotein GP41 (protein) FAB 2F5 Heavy Chain (protein) FAB 2F5 Light Chain (protein)
Unique Ligands	EDO, IPA

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1TJH \| pdb_00001tjh	Download File View File

Crystal Structure of the broadly neutralizing anti-HIV-1 antibody 2F5 in complex with a gp41 11mer epitope

Ofek, G., Tang, M., Sambor, A., Katinger, H., Mascola, J.R., Wyatt, R., Kwong, P.D.

(2004) J Virol 78: 10724-10737

Released	2004-10-05
Method	X-RAY DIFFRACTION 2.1 Å
Organisms	Homo sapiens Human immunodeficiency virus type 1 group M subtype D (isolate Z6)
Macromolecule	Envelope glycoprotein GP41 (protein) anti-HIV-1 antibody 2F5 Heavy Chain (protein) anti-HIV-1 antibody 2F5 Light Chain (protein)
Unique Ligands	EDO, IPA

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1TJI \| pdb_00001tji	Download File View File

Crystal Structure of the broadly neutralizing anti-HIV-1 antibody 2F5 in complex with a gp41 17mer epitope

Ofek, G., Tang, M., Sambor, A., Katinger, H., Mascola, J.R., Wyatt, R., Kwong, P.D.

(2004) J Virol 78: 10724-10737

Released	2004-10-05
Method	X-RAY DIFFRACTION 2.2 Å
Organisms	Homo sapiens Human immunodeficiency virus type 1 group M subtype D (isolate Z6)
Macromolecule	Envelope Glycoprotein GP41 (protein) anti-HIV-1 antibody 2F5 Heavy Chain (protein) anti-HIV-1 antibody 2F5 Light Chain (protein)
Unique Ligands	EDO, IPA

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3LES \| pdb_00003les	Download File View File

2F5 Epitope scaffold ES2

Ofek, G., Guenaga, F.J., Schief, W.R., Skinner, J., Wyatt, R., Baker, D., Kwong, P.D.

(2010) Proc Natl Acad Sci U S A 107: 17880-17887

Released	2010-09-29
Method	X-RAY DIFFRACTION 2.77 Å
Organisms	Thermus aquaticus
Macromolecule	RNA polymerase sigma factor (protein)
Unique Ligands	SO4

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3LEV \| pdb_00003lev	Download File View File

HIV-1 antibody 2F5 in complex with epitope scaffold ES2

Ofek, G., Guenaga, F.J., Schief, W.R., Skinner, J., Baker, D., Wyatt, R., Kwong, P.D.

(2010) Proc Natl Acad Sci U S A 107: 17880-17887

Released	2010-09-29
Method	X-RAY DIFFRACTION 2.5 Å
Organisms	Homo sapiens Thermus aquaticus
Macromolecule	2F5 ANTIBODY HEAVY CHAIN (protein) 2F5 ANTIBODY LIGHT CHAIN (protein) RNA polymerase sigma factor (protein)
Unique Ligands	1PE, ATP, GOL

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3LEX \| pdb_00003lex	Download File View File

2F5 Epitope scaffold elicited anti-HIV-1 monoclonal antibody 11F10 in complex with HIV-1 GP41

Ofek, G., Guenaga, F.J., Schief, W.R., Skinner, J., Baker, D., Wyatt, R., Kwong, P.D.

(2010) Proc Natl Acad Sci U S A 107: 17880-17887

Released	2010-09-29
Method	X-RAY DIFFRACTION 1.97 Å
Organisms	Human immunodeficiency virus 1 Mus musculus
Macromolecule	11f10 Antibody Heavy Chain (protein) 11f10 Antibody Light Chain (protein) Envelope glycoprotein gp41 (protein)

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3LEY \| pdb_00003ley	Download File View File

2F5 Epitope scaffold elicited anti-HIV-1 monoclonal antibody 6a7 in complex with HIV-1 GP41

Ofek, G., Guenaga, F.J., Schief, W.R., Skinner, J., Baker, D., Wyatt, R., Kwong, P.D.

(2010) Proc Natl Acad Sci U S A 107: 17880-17887

Released	2010-09-29
Method	X-RAY DIFFRACTION 1.99 Å
Organisms	Human immunodeficiency virus 1 Mus musculus
Macromolecule	6a7 Antibody Heavy Chain (protein) 6a7 Antibody Light Chain (protein) Envelope glycoprotein gp41 (protein)
Unique Ligands	ZN

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4G6F \| pdb_00004g6f	Download File View File

Crystal Structure of 10E8 Fab in Complex with an HIV-1 gp41 Peptide

Ofek, G., Huang, J., Connors, M., Kwong, P.D.

(2012) Nature 491: 406-412

Released	2012-09-26
Method	X-RAY DIFFRACTION 2.1 Å
Organisms	Homo sapiens Human immunodeficiency virus 1
Macromolecule	10E8 Heavy Chain (protein) 10E8 Light Chain (protein) gp41 MPER Peptide (protein)

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4NRX \| pdb_00004nrx	Download File View File

Crystal Structure of HIV-1 Neutralizing Antibody m66 in complex with gp41 MPER peptide

Ofek, G., Yang, Y., Kwong, P.D.

(2014) J Virol 88: 2426-2441

Released	2014-02-05
Method	X-RAY DIFFRACTION 2.21 Å
Organisms	Homo sapiens Human immunodeficiency virus 1
Macromolecule	Envelope glycoprotein gp41 (protein) m66 Heavy Chain (protein) m66 Light Chain (protein)

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4NRY \| pdb_00004nry	Download File View File

Crystal Structure of HIV-1 Neutralizing Antibody m66

Ofek, G., Yang, Y., Kwong, P.D.

(2014) J Virol 88: 2426-2441

Released	2014-02-05
Method	X-RAY DIFFRACTION 3.14 Å
Organisms	Homo sapiens
Macromolecule	m66 Heavy Chain (protein) m66 Light Chain (protein)

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4NRZ \| pdb_00004nrz	Download File View File

Crystal Structure of HIV-1 Neutralizing Antibody m66.6

Ofek, G., Yang, Y., Kwong, P.D.

(2014) J Virol 88: 2426-2441

Released	2014-02-05
Method	X-RAY DIFFRACTION 2.42 Å
Organisms	Homo sapiens
Macromolecule	M66.6 HEAVY CHAIN (protein) M66.6 LIGHT CHAIN (protein)
Unique Ligands	ZN

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4U6G \| pdb_00004u6g	Download File View File

Crystal structure of 10E8 Fab in complex with a hydrocarbon-stapled HIV-1 gp41 MPER peptide

Ofek, G., Bird, G.H., Walensky, L.D., Kwong, P.D.

To be published

Released	2014-12-03
Method	X-RAY DIFFRACTION 4.2012 Å
Organisms	Homo sapiens Human immunodeficiency virus 1
Macromolecule	10E8 Fab Heavy Chain (protein) 10E8 Fab Light Chain (protein) SAH-MPER(662-683KKK)(B,q) (protein)

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5IQ7 \| pdb_00005iq7	Download File View File

Crystal structure of 10E8-S74W Fab in complex with an HIV-1 gp41 peptide.

Ofek, G., Kwon, Y.D., Caruso, W., Kwong, P.D.

(2016) J Virol 90: 5899-5914

Released	2016-04-20
Method	X-RAY DIFFRACTION 3.2869 Å
Organisms	Homo sapiens Human immunodeficiency virus 1
Macromolecule	10E8-S74W Heavy Chain (protein) 10E8-S74W Light Chain (protein) gp41 MPER peptide (protein)

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5IQ9 \| pdb_00005iq9	Download File View File

Crystal structure of 10E8v4 Fab in complex with an HIV-1 gp41 peptide.

Ofek, G., Kwon, Y.D., Caruso, W., Kwong, P.D.

(2016) J Virol 90: 5899-5914

Released	2016-04-20
Method	X-RAY DIFFRACTION 2.4 Å
Organisms	Homo sapiens Human immunodeficiency virus 1
Macromolecule	10E8v4 Heavy Chain (protein) 10E8v4 Light Chain (protein) gp41 MPER peptide (protein)

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5JNY \| pdb_00005jny	Download File View File

Crystal Structure of 10E8 Fab

Ofek, G., Kwong, P.

(2016) PLoS One 11: e0157409-e0157409

Released	2016-07-13
Method	X-RAY DIFFRACTION 3.041 Å
Organisms	Homo sapiens
Macromolecule	10E8 Heavy Chain (protein) 10E8 Light Chain (protein)
Unique Ligands	CL, IPA

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5U3J \| pdb_00005u3j	Download File View File

Crystal Structure of DH511.1 Fab in Complex with HIV-1 gp41 MPER Peptide

Ofek, G., Wu, L., Lougheed, C.S., Williams, L.D., Nicely, N.I., Haynes, B.F.

(2017) Sci Immunol 2:

Released	2017-02-15
Method	X-RAY DIFFRACTION 2.74 Å
Organisms	Homo sapiens Human immunodeficiency virus 1
Macromolecule	DH511.1 Heavy Chain (protein) DH511.1 Light Chain (protein) gp41 MPER peptide (protein)

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5U3K \| pdb_00005u3k	Download File View File

Crystal Structure of DH511.2 Fab in Complex with HIV-1 gp41 MPER 662-683 Peptide

Ofek, G., Wu, L., Lougheed, C.S., Williams, L.D., Nicely, N.I., Haynes, B.F.

(2017) Sci Immunol 2:

Released	2017-02-15
Method	X-RAY DIFFRACTION 2.637 Å
Organisms	Homo sapiens Human immunodeficiency virus 1
Macromolecule	DH511.2 Fab Heavy Chain (protein) DH511.2 Fab Light Chain (protein) gp41 MPER peptide (protein)
Unique Ligands	CA, CL

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5U3L \| pdb_00005u3l	Download File View File

Crystal Structure of DH511.2 Fab in Complex with HIV-1 gp41 MPER 670-683 Peptide

Ofek, G., Wu, L., Lougheed, C.S., Williams, L.D., Nicely, N.I., Haynes, B.F.

(2017) Sci Immunol 2:

Released	2017-02-15
Method	X-RAY DIFFRACTION 2.165 Å
Organisms	Homo sapiens Human immunodeficiency virus 1
Macromolecule	DH511.2 Fab Heavy Chain (protein) DH511.2 Fab Light Chain (protein) gp41 MPER peptide (protein)

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5U3M \| pdb_00005u3m	Download File View File

Crystal Structure of DH511.11P Fab in Complex with HIV-1 gp41 MPER Peptide

Ofek, G., Wu, L., Lougheed, C.S., Williams, L.D., Nicely, N.I., Haynes, B.F.

(2017) Sci Immunol 2:

Released	2017-02-15
Method	X-RAY DIFFRACTION 2.418 Å
Organisms	Homo sapiens Human immunodeficiency virus 1
Macromolecule	DH511.11P Fab Heavy Chain (protein) DH511.11P Fab Light Chain (protein) gp41 MPER peptide (protein)

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5U3N \| pdb_00005u3n	Download File View File

Crystal Structure of DH511.12P Fab in Complex with HIV-1 gp41 MPER Peptide

Ofek, G., Wu, L., Lougheed, C.S., Williams, L.D., Nicely, N.I., Haynes, B.F.

(2017) Sci Immunol 2:

Released	2017-02-15
Method	X-RAY DIFFRACTION 2 Å
Organisms	Homo sapiens Human immunodeficiency virus 1
Macromolecule	DH511.12P Fab Heavy Chain (protein) DH511.12P Fab Light Chain (protein) gp41 MPER peptide (protein)

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5U3O \| pdb_00005u3o	Download File View File

Crystal Structure of DH511.2_K3 Fab in Complex with HIV-1 gp41 MPER Peptide

Ofek, G., Wu, L., Lougheed, C.S., Williams, L.D., Nicely, N.I., Haynes, B.F.

(2017) Sci Immunol 2:

Released	2017-02-15
Method	X-RAY DIFFRACTION 1.761 Å
Organisms	Homo sapiens Human immunodeficiency virus 1
Macromolecule	DH511.2_K3 Fab Heavy Chain (protein) DH511.2_K3 Fab Light Chain (protein) gp41 MPER peptide (protein)

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5U3P \| pdb_00005u3p	Download File View File

Crystal Structure of DH511.4 Fab

Nicely, N.I., Williams, L.D., Ofek, G., Haynes, B.F.

(2017) Sci Immunol 2:

Released	2017-02-15
Method	X-RAY DIFFRACTION 1.5 Å
Organisms	Homo sapiens
Macromolecule	DH511.4 Fab Heavy Chain (protein) DH511.4 Fab Light Chain (protein)

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6EAY \| pdb_00006eay	Download File View File

Structural Basis for Broad Neutralization of Ebolaviruses by an Antibody Targeting the Glycoprotein Fusion Loop

Janus, B.M., Ofek, G.

(2018) Nat Commun 9: 3934-3934

Released	2018-10-10
Method	X-RAY DIFFRACTION 3.72 Å
Organisms	Ebola virus - Mayinga, Zaire, 1976 Macaca fascicularis
Macromolecule	CA45 heavy chain (protein) CA45 light chain (protein) Envelope glycoprotein (protein)
Unique Ligands	NAG
Unique branched monosaccharides	BMA, MAN, NAG

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6VBO \| pdb_00006vbo	Download File View File

Crystal structure of anti-HIV-1 antibody DH813 bound to gp120 V2 peptide

Janus, B.M., Ofek, G.

(2020) JCI Insight 5:

Released	2020-02-12
Method	X-RAY DIFFRACTION 1.683 Å
Organisms	Homo sapiens Human immunodeficiency virus 1
Macromolecule	DH813 heavy chain (protein) DH813 light chain (protein) Envelope glycoprotein gp160 (protein)

1 to 25 of 31 Structures

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Structure Determination Methodology

Scientific Name of Source Organism

Taxonomy

Experimental Method

Polymer Entity Type

Refinement Resolution (Å)

Release Date

Enzyme Classification Name

Symmetry Type

SCOP Classification

1PS5 | pdb_00001ps5

1TJG | pdb_00001tjg

1TJH | pdb_00001tjh

1TJI | pdb_00001tji

3LES | pdb_00003les

3LEV | pdb_00003lev

3LEX | pdb_00003lex

3LEY | pdb_00003ley

4G6F | pdb_00004g6f

4NRX | pdb_00004nrx

4NRY | pdb_00004nry

4NRZ | pdb_00004nrz

4U6G | pdb_00004u6g

5IQ7 | pdb_00005iq7

5IQ9 | pdb_00005iq9

5JNY | pdb_00005jny

5U3J | pdb_00005u3j

5U3K | pdb_00005u3k

5U3L | pdb_00005u3l

5U3M | pdb_00005u3m

5U3N | pdb_00005u3n

5U3O | pdb_00005u3o

5U3P | pdb_00005u3p

6EAY | pdb_00006eay

6VBO | pdb_00006vbo