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234,440 Structures from the PDB

1,068,577 Computed Structure Models (CSM)

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QUERY: Structure Author = "Knox, J.E."

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Search Summary

This query matches 31 Structures.

Refinements

Structure Determination Methodology

experimental (31)

Scientific Name of Source Organism

Homo sapiens (31)

Taxonomy

Eukaryota (31)

Experimental Method

X-RAY DIFFRACTION (31)

Polymer Entity Type

Protein (31)

Refinement Resolution (Å)

	1.0 - 1.5 (13)
	1.5 - 2.0 (18)

Release Date

	2020 - 2024 (14)
	2025 - 2029 (17)

Enzyme Classification Name

	Hydrolases (31)
	Isomerases (31)

Symmetry Type

	Asymmetric (30)
	Cyclic (1)

AllSelected

1 to 25 of 31 Structures

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Explore in 3D

8G9P \| pdb_00008g9p	Download File View File

Tricomplex of RMC-4998, KRAS G12C, and CypA

Tomlinson, A.C.A., Saldajeno-Concar, M., Knox, J.E., Yano, J.K.

(2023) Science 381: 794-799

Released	2023-08-16
Method	X-RAY DIFFRACTION 1.5 Å
Organisms	Homo sapiens
Macromolecule	GTPase KRas (protein) Peptidyl-prolyl cis-trans isomerase A (protein)
Unique Ligands	CL, GNP, MG, YV2

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8G9Q \| pdb_00008g9q	Download File View File

Tricomplex of Compound-1, KRAS G12C, and CypA

Tomlinson, A.C.A., Chen, A., Knox, J.E., Yano, J.K.

(2023) Science 381: 794-799

Released	2023-08-16
Method	X-RAY DIFFRACTION 1.4 Å
Organisms	Homo sapiens
Macromolecule	GTPase KRas (protein) Peptidyl-prolyl cis-trans isomerase A (protein)
Unique Ligands	GNP, MG, YV6

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8TBF \| pdb_00008tbf	Download File View File

Tricomplex of RMC-7977, KRAS WT, and CypA

Tomlinson, A.C.A., Chen, A., Knox, J.E., Yano, J.K.

(2024) Nature 629: 919-926

Released	2024-02-07
Method	X-RAY DIFFRACTION 1.5 Å
Organisms	Homo sapiens
Macromolecule	GTPase KRas (protein) Peptidyl-prolyl cis-trans isomerase A (protein)
Unique Ligands	EDO, GNP, MG, ZNI

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8TBG \| pdb_00008tbg	Download File View File

Tricomplex of RMC-7977, HRAS WT, and CypA

Chen, A., Tomlinson, A.C.A., Knox, J.E., Yano, J.K.

(2024) Nature 629: 919-926

Released	2024-02-07
Method	X-RAY DIFFRACTION 1.2 Å
Organisms	Homo sapiens
Macromolecule	GTPase HRas (protein) Peptidyl-prolyl cis-trans isomerase A (protein)
Unique Ligands	GNP, GOL, MG, ZNI

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8TBH \| pdb_00008tbh	Download File View File

Tricomplex of RMC-7977, KRAS G12R, and CypA

Bar Ziv, T., Zhang, D., Tomlinson, A.C.A., Knox, J.E., Yano, J.K.

(2024) Nature 629: 919-926

Released	2024-02-07
Method	X-RAY DIFFRACTION 1.5 Å
Organisms	Homo sapiens
Macromolecule	GTPase KRas (protein) Peptidyl-prolyl cis-trans isomerase A (protein)
Unique Ligands	GNP, MG, ZNI

Explore in 3D

8TBI \| pdb_00008tbi	Download File View File

Tricomplex of RMC-7977, NRAS WT, and CypA

Tomlinson, A.C.A., Chen, A., Knox, J.E., Yano, J.K.

(2024) Nature 629: 919-926

Released	2024-02-07
Method	X-RAY DIFFRACTION 1.59 Å
Organisms	Homo sapiens
Macromolecule	GTPase NRas (protein) Peptidyl-prolyl cis-trans isomerase A (protein)
Unique Ligands	GNP, MG, ZNI

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8TBJ \| pdb_00008tbj	Download File View File

Tricomplex of RMC-7977, KRAS G12A, and CypA

Tomlinson, A.C.A., Chen, A., Knox, J.E., Yano, J.K.

(2024) Nature 629: 919-926

Released	2024-02-07
Method	X-RAY DIFFRACTION 1.45 Å
Organisms	Homo sapiens
Macromolecule	GTPase KRas (protein) Peptidyl-prolyl cis-trans isomerase A (protein)
Unique Ligands	EDO, GNP, GOL, MG, ZNI

Explore in 3D

8TBK \| pdb_00008tbk	Download File View File

Tricomplex of RMC-7977, KRAS G12C, and CypA

Tomlinson, A.C.A., Chen, A., Knox, J.E., Yano, J.K.

(2024) Nature 629: 919-926

Released	2024-02-07
Method	X-RAY DIFFRACTION 1.26 Å
Organisms	Homo sapiens
Macromolecule	GTPase KRas (protein) Peptidyl-prolyl cis-trans isomerase A (protein)
Unique Ligands	GNP, MG, ZNI

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8TBL \| pdb_00008tbl	Download File View File

Tricomplex of RMC-7977, KRAS G12D, and CypA

Tomlinson, A.C.A., Chen, A., Knox, J.E., Yano, J.K.

(2024) Nature 629: 919-926

Released	2024-02-07
Method	X-RAY DIFFRACTION 1.88 Å
Organisms	Homo sapiens
Macromolecule	GTPase KRas (protein) Peptidyl-prolyl cis-trans isomerase A (protein)
Unique Ligands	GNP, MG, ZNI

Explore in 3D

8TBM \| pdb_00008tbm	Download File View File

Tricomplex of RMC-7977, KRAS G12V, and CypA

Tomlinson, A.C.A., Chen, A., Knox, J.E., Yano, J.K.

(2024) Nature 629: 919-926

Released	2024-02-07
Method	X-RAY DIFFRACTION 1.57 Å
Organisms	Homo sapiens
Macromolecule	GTPase KRas (protein) Peptidyl-prolyl cis-trans isomerase A (protein)
Unique Ligands	GNP, GOL, MG, ZNI

Explore in 3D

8TBN \| pdb_00008tbn	Download File View File

Tricomplex of RMC-7977, KRAS G12S, and CypA

Tomlinson, A.C.A., Chen, A., Knox, J.E., Yano, J.K.

(2024) Nature 629: 919-926

Released	2024-02-07
Method	X-RAY DIFFRACTION 1.46 Å
Organisms	Homo sapiens
Macromolecule	GTPase KRas (protein) Peptidyl-prolyl cis-trans isomerase A (protein)
Unique Ligands	GNP, MG, ZNI

Explore in 3D

9AX6 \| pdb_00009ax6	Download File View File

Tricomplex of RMC-6236, KRAS G12D, and CypA

Tomlinson, A.C.A., Saldajeno-Concar, M., Knox, J.E., Yano, J.K.

(2024) Cancer Discov 14: 994-1017

Released	2024-04-17
Method	X-RAY DIFFRACTION 1.65 Å
Organisms	Homo sapiens
Macromolecule	GTPase KRas (protein) Peptidyl-prolyl cis-trans isomerase A (protein)
Unique Ligands	A1AHB, GNP, MG

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9BFV \| pdb_00009bfv	Download File View File

Tri-complex of Compound-23, KRAS G12C, and CypA

Tomlinson, A.C.A., Knox, J.E., Yano, J.K.

(2025) J Med Chem 68: 6041-6063

Released	2025-03-05
Method	X-RAY DIFFRACTION 1.2 Å
Organisms	Homo sapiens
Macromolecule	GTPase KRas (protein) Peptidyl-prolyl cis-trans isomerase A (protein)
Unique Ligands	A1AOV, GNP, MG

Explore in 3D

9BFW \| pdb_00009bfw	Download File View File

Tri-complex of Compound-4, KRAS G12C, and CypA

Tomlinson, A.C.A., Knox, J.E., Yano, J.K.

(2025) J Med Chem 68: 6041-6063

Released	2025-03-05
Method	X-RAY DIFFRACTION 1.2 Å
Organisms	Homo sapiens
Macromolecule	GTPase KRas (protein) Peptidyl-prolyl cis-trans isomerase A (protein)
Unique Ligands	A1AOM, BTB, GNP, MG

Explore in 3D

9BFX \| pdb_00009bfx	Download File View File

Tri-complex of Elironrasib (RMC-6291), KRAS G12C, and CypA

Tomlinson, A.C.A., Saldajeno-Concar, M., Knox, J.E., Yano, J.K.

(2025) J Med Chem 68: 6041-6063

Released	2025-03-05
Method	X-RAY DIFFRACTION 1.4 Å
Organisms	Homo sapiens
Macromolecule	GTPase KRas (protein) Peptidyl-prolyl cis-trans isomerase A (protein)
Unique Ligands	A1AOD, CL, GNP, MG

Explore in 3D

9BFY \| pdb_00009bfy	Download File View File

Tri-complex of Compound-14, KRAS G12C, and CypA

Tomlinson, A.C.A., Saldajeno-Concar, M., Knox, J.E., Yano, J.K.

(2025) J Med Chem 68: 6041-6063

Released	2024-06-12
Method	X-RAY DIFFRACTION 1.26 Å
Organisms	Homo sapiens
Macromolecule	GTPase KRas (protein) Peptidyl-prolyl cis-trans isomerase A (protein)
Unique Ligands	A1AOL, CL, GNP, MG

Explore in 3D

9BFZ \| pdb_00009bfz	Download File View File

Tri-complex of Compound-5, KRAS G12C, and CypA

Tomlinson, A.C.A., Saldajeno-Concar, M., Knox, J.E., Yano, J.K.

(2025) J Med Chem 68: 6041-6063

Released	2025-03-05
Method	X-RAY DIFFRACTION 1.8 Å
Organisms	Homo sapiens
Macromolecule	GTPase KRas (protein) Peptidyl-prolyl cis-trans isomerase A (protein)
Unique Ligands	A1AOK, GNP, MG

Explore in 3D

9BG0 \| pdb_00009bg0	Download File View File

Tri-complex of Daraxonrasib (RMC-6236), NRAS WT, and CypA

Tomlinson, A.C.A., Bieder, R., Chen, A., Knox, J.E., Yano, J.K.

(2025) J Med Chem 68: 6064-6083

Released	2025-03-19
Method	X-RAY DIFFRACTION 1.64 Å
Organisms	Homo sapiens
Macromolecule	GTPase NRas (protein) Peptidyl-prolyl cis-trans isomerase A (protein)
Unique Ligands	A1AHB, GNP, MG

Explore in 3D

9BG1 \| pdb_00009bg1	Download File View File

Tri-complex of Compound-3, KRAS G12V, and CypA

Tomlinson, A.C.A., Saldajeno-Concar, M., Knox, J.E., Yano, J.K.

(2025) J Med Chem 68: 6064-6083

Released	2024-06-12
Method	X-RAY DIFFRACTION 1.51 Å
Organisms	Homo sapiens
Macromolecule	GTPase KRas (protein) Peptidyl-prolyl cis-trans isomerase A (protein)
Unique Ligands	A1AOH, GNP, MG

Explore in 3D

9BG2 \| pdb_00009bg2	Download File View File

Tri-complex of Compound-10, KRAS G12V, and CypA

Tomlinson, A.C.A., Bieder, R., Chen, A., Knox, J.E., Yano, J.K.

(2025) J Med Chem 68: 6064-6083

Released	2025-03-19
Method	X-RAY DIFFRACTION 1.64 Å
Organisms	Homo sapiens
Macromolecule	GTPase KRas (protein) Peptidyl-prolyl cis-trans isomerase A (protein)
Unique Ligands	A1AOJ, GNP, MG

Explore in 3D

9BG3 \| pdb_00009bg3	Download File View File

Tri-complex of Daraxonrasib (RMC-6236), NRAS Q61K, and CypA

Tomlinson, A.C.A., Bieder, R., Chen, A., Knox, J.E., Yano, J.K.

(2025) J Med Chem 68: 6064-6083

Released	2025-03-19
Method	X-RAY DIFFRACTION 1.33 Å
Organisms	Homo sapiens
Macromolecule	GTPase NRas (protein) Peptidyl-prolyl cis-trans isomerase A (protein)
Unique Ligands	A1AHB, CL, GNP, MG

Explore in 3D

9BG4 \| pdb_00009bg4	Download File View File

Tri-complex of Compound-2, KRAS G12V, and CypA

Tomlinson, A.C.A., Chen, A., Knox, J.E., Yano, J.K.

(2025) J Med Chem 68: 6064-6083

Released	2025-03-19
Method	X-RAY DIFFRACTION 1.14 Å
Organisms	Homo sapiens
Macromolecule	GTPase KRas (protein) Peptidyl-prolyl cis-trans isomerase A (protein)
Unique Ligands	A1AOG, CL, GNP, MG

Explore in 3D

9BG5 \| pdb_00009bg5	Download File View File

Tri-complex of Daraxonrasib (RMC-6236), KRAS G13D, and CypA

Tomlinson, A.C.A., Bieder, R., Chen, A., Knox, J.E., Yano, J.K.

(2025) J Med Chem 68: 6064-6083

Released	2025-03-19
Method	X-RAY DIFFRACTION 1.67 Å
Organisms	Homo sapiens
Macromolecule	GTPase KRas (protein) Peptidyl-prolyl cis-trans isomerase A (protein)
Unique Ligands	A1AHB, GNP, MG

Explore in 3D

9BG6 \| pdb_00009bg6	Download File View File

Tri-complex of Daraxonrasib (RMC-6236), KRAS G12V, and CypA

Tomlinson, A.C.A., Saldajeno-Concar, M., Chen, A., Knox, J.E., Yano, J.K.

(2025) J Med Chem 68: 6064-6083

Released	2025-03-19
Method	X-RAY DIFFRACTION 1.66 Å
Organisms	Homo sapiens
Macromolecule	GTPase KRas (protein) Peptidyl-prolyl cis-trans isomerase A (protein)
Unique Ligands	A1AHB, GNP, MG

Explore in 3D

9BG7 \| pdb_00009bg7	Download File View File

Tri-complex of Compound-6, KRAS G12V, and CypA

Tomlinson, A.C.A., Saldajeno-Concar, M., Knox, J.E., Yano, J.K.

(2025) J Med Chem 68: 6064-6083

Released	2025-03-19
Method	X-RAY DIFFRACTION 1.6 Å
Organisms	Homo sapiens
Macromolecule	Isoform 2B of GTPase KRas (protein) Peptidyl-prolyl cis-trans isomerase A (protein)
Unique Ligands	A1AOI, GNP, MG

1 to 25 of 31 Structures

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Structure Determination Methodology

Scientific Name of Source Organism

Taxonomy

Experimental Method

Polymer Entity Type

Refinement Resolution (Å)

Release Date

Enzyme Classification Name

Symmetry Type

8G9P | pdb_00008g9p

8G9Q | pdb_00008g9q

8TBF | pdb_00008tbf

8TBG | pdb_00008tbg

8TBH | pdb_00008tbh

8TBI | pdb_00008tbi

8TBJ | pdb_00008tbj

8TBK | pdb_00008tbk

8TBL | pdb_00008tbl

8TBM | pdb_00008tbm

8TBN | pdb_00008tbn

9AX6 | pdb_00009ax6

9BFV | pdb_00009bfv

9BFW | pdb_00009bfw

9BFX | pdb_00009bfx

9BFY | pdb_00009bfy

9BFZ | pdb_00009bfz

9BG0 | pdb_00009bg0

9BG1 | pdb_00009bg1

9BG2 | pdb_00009bg2

9BG3 | pdb_00009bg3

9BG4 | pdb_00009bg4

9BG5 | pdb_00009bg5

9BG6 | pdb_00009bg6

9BG7 | pdb_00009bg7