RCSB PDB: Search

2JII \| pdb_00002jii	Download File View File

Structure of vaccinia related kinase 3

Bunkoczi, G., Eswaran, J., Pike, A.C.W., Uppenberg, J., Ugochukwu, E., von Delft, F., Cooper, C., Salah, E., Savitsky, P., Burgess-Brown, N., Keates, T., Fedorov, O., Sobott, F., Arrowsmith, C.H., Edwards, A., Sundstrom, M., Weigelt, J., Knapp, S.

(2009) Structure 17: 128-138

Released	2007-07-10
Method	X-RAY DIFFRACTION 2 Å
Organisms	Homo sapiens
Macromolecule	SERINE/THREONINE-PROTEIN KINASE VRK3 MOLECULE: VACCINIA RELATED KINASE 3 (protein)
Unique Ligands	EDO

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2OV2 \| pdb_00002ov2	Download File View File

The crystal structure of the human RAC3 in complex with the CRIB domain of human p21-activated kinase 4 (PAK4)

Ugochukwu, E., Yang, X., Elkins, J.M., Burgess-Brown, N., Bunkoczi, G., Debreczeni, J.E.D., Sundstrom, M., Arrowsmith, C.H., Weigelt, J., Edwards, A., von Delft, F., Knapp, S., Doyle, D.A., Structural Genomics Consortium (SGC)

To be published

Released	2007-03-13
Method	X-RAY DIFFRACTION 2.1 Å
Organisms	Homo sapiens
Macromolecule	Ras-related C3 botulinum toxin substrate 3 (protein) Serine/threonine-protein kinase PAK 4 (protein)
Unique Ligands	CL, EDO, GCP, MG

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2P6X \| pdb_00002p6x	Download File View File

Crystal structure of human tyrosine phosphatase PTPN22

Ugochukwu, E., Salah, E., Barr, A., Shrestha, L., Alfano, I., Burgess-Brown, N., King, O., Umeano, C., Papagrigoriou, E., Pike, A.C.W., Bunkoczi, G., Turnbull, A., Uppenberg, J., Sundstrom, M., Arrowsmith, C.H., Weigelt, J., Edwards, A., von Delft, F., Knapp, S., Structural Genomics Consortium (SGC)

(2009) Cell 136: 352-363

Released	2007-04-03
Method	X-RAY DIFFRACTION 1.9 Å
Organisms	Homo sapiens
Macromolecule	Tyrosine-protein phosphatase non-receptor type 22 (protein)
Unique Ligands	CL, EDO

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2PA1 \| pdb_00002pa1	Download File View File

Structure of the PDZ domain of human PDLIM2 bound to a C-terminal extension from human beta-tropomyosin

Uppenberg, J., Shrestha, L., Elkins, J., Burgess-Brown, N., Salah, E., Bunkoczi, G., Papagrigoriou, E., Pike, A.C.W., Turnbull, A.P., Ugochukwu, E., Umeano, C., von Delft, F., Weigelt, J., Arrowsmith, C.H., Edwards, A., Sundstrom, M., Doyle, D.A., Structural Genomics Consortium (SGC)

(2010) Protein Sci 19: 731-741

Released	2007-05-01
Method	X-RAY DIFFRACTION 1.7 Å
Organisms	Homo sapiens
Macromolecule	PDZ and LIM domain protein 2 (protein)
Unique Ligands	CL

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2PKT \| pdb_00002pkt	Download File View File

Crystal structure of the human CLP-36 (PDLIM1) bound to the C-terminal peptide of human alpha-actinin-1

Uppenberg, J., Gileadi, C., Elkins, J., Bray, J., Burgess-Brown, N., Salah, E., Gileadi, O., Bunkoczi, G., Ugochukwu, E., Umeano, C., von Delft, F., Weigelt, J., Arrowsmith, C.H., Edwards, A., Sundstrom, M., Doyle, D.A., Structural Genomics Consortium (SGC)

(2010) Protein Sci 19: 731-741

Released	2007-05-08
Method	X-RAY DIFFRACTION 1.5 Å
Organisms	Homo sapiens
Macromolecule	PDZ and LIM domain protein 1 (protein)
Unique Ligands	ACT, CA, CL, PEG, PG4

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2PPI \| pdb_00002ppi	Download File View File

Structure of the BTB (Tramtrack and Bric a brac) domain of human Gigaxonin

Amos, A., Turnbull, A.P., Tickle, J., Keates, T., Bullock, A., Savitsky, P., Burgess-Brown, N., Debreczeni, J.E., Ugochukwu, E., Umeano, C., Pike, A.C.W., Papagrigoriou, E., Sundstrom, M., Arrowsmith, C.H., Weigelt, J., Edwards, A., von Delft, F., Knapp, S., Structural Genomics Consortium (SGC)

To be published

Released	2007-05-08
Method	X-RAY DIFFRACTION 2.4 Å
Organisms	Homo sapiens
Macromolecule	Gigaxonin (protein)

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2PQ5 \| pdb_00002pq5	Download File View File

Crystal structure of Dual specificity protein phosphatase 13 (DUSP13)

Ugochukwu, E., Salah, E., Savitsky, P., Barr, A., Pantic, N., Niesen, F., Burgess-Brown, N., Berridge, G., Bunkoczi, G., Uppenberg, J., Pike, A.C.W., Sundstrom, M., Arrowsmith, C.H., Weigelt, J., Edwards, A., von Delft, F., Knapp, S., Structural Genomics Consortium (SGC)

To be published

Released	2007-05-22
Method	X-RAY DIFFRACTION 2.3 Å
Organisms	Homo sapiens
Macromolecule	Dual specificity protein phosphatase 13 (protein)

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2Q3G \| pdb_00002q3g	Download File View File

Structure of the PDZ domain of human PDLIM7 bound to a C-terminal extension from human beta-tropomyosin

Gileadi, C., Papagrigoriou, E., Elkins, J., Burgess-Brown, N., Salah, E., Gileadi, O., Umeano, C., Bunkoczi, G., von Delft, F., Uppenberg, J., Pike, A.C.W., Arrowsmith, C.H., Edwards, A., Weigelt, J., Sundstrom, M., Doyle, D.A., Structural Genomics Consortium (SGC)

(2010) Protein Sci 19: 731-741

Released	2007-06-19
Method	X-RAY DIFFRACTION 1.11 Å
Organisms	Homo sapiens
Macromolecule	PDZ and LIM domain protein 7 (protein)
Unique Ligands	CL, EDO

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2QEP \| pdb_00002qep	Download File View File

Crystal structure of the D1 domain of PTPRN2 (IA2beta)

Ugochukwu, E., Barr, A., Alfano, I., Berridge, G., Burgess-Brown, N., Das, S., Fedorov, O., King, O., Niesen, F., Watt, S., Savitsky, P., Salah, E., Pike, A.C.W., Bunkoczi, G., von Delft, F., Sundstrom, M., Edwards, A., Arrowsmith, C.H., Weigelt, J., Knapp, S., Structural Genomics Consortium (SGC)

(2009) Cell 136: 352-363

Released	2007-07-24
Method	X-RAY DIFFRACTION 2.5 Å
Organisms	Homo sapiens
Macromolecule	Receptor-type tyrosine-protein phosphatase N2 (protein)
Unique Ligands	CL

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2QME \| pdb_00002qme	Download File View File

Crystal structure of human RAC3 in complex with CRIB domain of human p21-activated kinase 1 (PAK1)

Ugochukwu, E., Yang, X., Elkins, J.M., Burgess-Brown, N., Bunkoczi, G., Sundstrom, M., Arrowsmith, C.H., Weigelt, J., Edwards, A., von Delft, F., Knapp, S., Doyle, D., Structural Genomics Consortium (SGC)

To be published

Released	2007-08-28
Method	X-RAY DIFFRACTION 1.75 Å
Organisms	Homo sapiens
Macromolecule	CRIB domain of the Serine/threonine-protein kinase PAK 1 (protein) Ras-related C3 botulinum toxin substrate 3 (protein)
Unique Ligands	GCP, GOL, MG

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2UZC \| pdb_00002uzc	Download File View File

Structure of human PDLIM5 in complex with the C-terminal peptide of human alpha-actinin-1

Bunkoczi, G., Elkins, J., Salah, E., Burgess-Brown, N., Papagrigoriou, E., Pike, A.C.W., Turnbull, A., Gileadi, O., von Delft, F., Arrowsmith, C.H., Edwards, A., Sundstrom, M., Weigelt, J., Doyle, D.

(2010) Protein Sci 19: 731-741

Released	2007-05-08
Method	X-RAY DIFFRACTION 1.5 Å
Organisms	Homo sapiens
Macromolecule	PDZ AND LIM DOMAIN 5 (protein)
Unique Ligands	CL, EDO

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2V1W \| pdb_00002v1w	Download File View File

Crystal structure of human LIM protein RIL (PDLIM4) PDZ domain bound to the C-terminal peptide of human alpha-actinin-1

Soundararajan, M., Shrestha, L., Pike, A.C.W., Salah, E., Burgess-Brown, N., Elkins, J., Umeano, C., Ugochukwu, E., von Delft, F., Arrowsmith, C.H., Edwards, A., Weigelt, J., Sundstrom, M., Doyle, D.

(2010) Protein Sci 19: 731

Released	2007-06-12
Method	X-RAY DIFFRACTION 1.9 Å
Organisms	Homo sapiens
Macromolecule	PDZ AND LIM DOMAIN PROTEIN 4 (protein)
Unique Ligands	1PE, EDO, MG

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2V1X \| pdb_00002v1x	Download File View File

Crystal structure of human RECQ-like DNA helicase

Pike, A.C.W., Shrestha, B., Burgess-Brown, N., King, O., Ugochukwu, E., Watt, S., Edwards, A., Arrowsmith, C.H., Weigelt, J., Sundstrom, M., Gileadi, O.

(2009) Proc Natl Acad Sci U S A 106: 1039

Released	2007-07-03
Method	X-RAY DIFFRACTION 2 Å
Organisms	Homo sapiens
Macromolecule	ATP-DEPENDENT DNA HELICASE Q1 (protein)
Unique Ligands	ADP, CL, EDO, MG, ZN

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2V7O \| pdb_00002v7o	Download File View File

Crystal structure of human calcium-calmodulin-dependent protein kinase II gamma

Pike, A.C.W., Rellos, P., Fedorov, O., Burgess-Brown, N., Shrestha, L., Ugochukwu, E., Pilka, E.S., von Delft, F., Edwards, A., Weigelt, J., Arrowsmith, C.H., Sundstrom, M., Knapp, S.

(2010) PLoS Biol 8: 426

Released	2007-09-11
Method	X-RAY DIFFRACTION 2.25 Å
Organisms	Homo sapiens
Macromolecule	CALCIUM/CALMODULIN-DEPENDENT PROTEIN KINASE TYPE II GAMMA CHAIN (protein)
Unique Ligands	DRN, EDO

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2VPH \| pdb_00002vph	Download File View File

Crystal structure of the human protein tyrosine phosphatase, non- receptor type 4, PDZ domain

Roos, A.K., Wang, J., Burgess-Brown, N., Elkins, J.M., Kavanagh, K., Pike, A.C.W., Filippakopoulos, P., Arrowsmith, C.H., Weigelt, J., Edwards, A., von Delft, F., Bountra, C., Knapp, S.

To be published

Released	2008-03-18
Method	X-RAY DIFFRACTION 1.9 Å
Organisms	Homo sapiens
Macromolecule	TYROSINE-PROTEIN PHOSPHATASE NON-RECEPTOR TYPE 4 (protein)

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2VSV \| pdb_00002vsv	Download File View File

Crystal structure of the PDZ domain of human rhophilin-2

Pike, A.C.W., Kochan, G., Sun, Z., Shafqat, N., Pilka, E.S., Roos, A., Elkins, J., Burgess-Brown, N., Murray, J.W., von Delft, F., Wikstrom, M., Edwards, A., Arrowsmith, C.H., Bountra, C., Oppermann, U.

To be published

Released	2008-07-15
Method	X-RAY DIFFRACTION 1.82 Å
Organisms	Homo sapiens
Macromolecule	RHOPHILIN-2 (protein)

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2VSW \| pdb_00002vsw	Download File View File

The structure of the rhodanese domain of the human dual specificity phosphatase 16

Murray, J.W., Barr, A., Pike, A.C.W., Elkins, J., Phillips, C., Wang, J., Savitsky, P., Roos, A., Bishop, S., Wickstroem, M., Bountra, C., Edwards, A.M., Arrowsmith, C.H., Burgess-Brown, N., Pantic, N., Bray, J., von Delft, F., Gileadi, O., Knapp, S.

To be published

Released	2008-07-15
Method	X-RAY DIFFRACTION 2.2 Å
Organisms	Homo sapiens
Macromolecule	DUAL SPECIFICITY PROTEIN PHOSPHATASE 16 (protein)

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2VUW \| pdb_00002vuw	Download File View File

Structure of human haspin kinase domain

Eswaran, J., Murray, J.W., Filippakopoulos, P., Soundararajan, M., Pike, A.C.W., von Delft, F., Picaud, S., Keates, T., King, O., Wickstroem, M., Bountra, C., Edwards, A.M., Arrowsmith, C.H., Fedorov, O., Burgess-Brown, N., Bray, J., Knapp, S.

(2009) Proc Natl Acad Sci U S A 106: 20198

Released	2008-09-16
Method	X-RAY DIFFRACTION 1.8 Å
Organisms	Homo sapiens
Macromolecule	SERINE/THREONINE-PROTEIN KINASE HASPIN (protein)
Unique Ligands	5ID, DMS, IOD, MPD, NI

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2VWR \| pdb_00002vwr	Download File View File

Crystal structure of the second pdz domain of numb-binding protein 2

Roos, A.K., Guo, K., Burgess-Brown, N., Yue, W.W., Elkins, J.M., Pike, A.C.W., Filippakopoulos, P., Arrowsmith, C.H., Wikstom, M., Edwards, A., von Delft, F., Bountra, C., Doyle, D., Oppermann, U.

To be published

Released	2008-09-16
Method	X-RAY DIFFRACTION 1.3 Å
Organisms	Homo sapiens
Macromolecule	LIGAND OF NUMB PROTEIN X 2 (protein)

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2VX3 \| pdb_00002vx3	Download File View File

Crystal structure of the human dual specificity tyrosine- phosphorylation-regulated kinase 1A

Roos, A.K., Soundararajan, M., Pike, A.C.W., Federov, O., King, O., Burgess-Brown, N., Philips, C., Filippakopoulos, P., Arrowsmith, C.H., Wikstrom, M., Edwards, A., von Delft, F., Bountra, C., Knapp, S.

(2013) Structure 21: 986

Released	2008-09-16
Method	X-RAY DIFFRACTION 2.4 Å
Organisms	Homo sapiens
Macromolecule	DUAL SPECIFICITY TYROSINE-PHOSPHORYLATION- REGULATED KINASE 1A (protein)
Unique Ligands	CL, D15, P6G, SO4

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2VZ6 \| pdb_00002vz6	Download File View File

Structure of human calcium calmodulin dependent protein kinase type II alpha (CAMK2A) in complex with Indirubin E804

Pike, A.C.W., Rellos, P., King, O., Salah, E., Parizotto, E., Fedorov, O., Shrestha, L., Burgess-Brown, N., Roos, A., Murray, J.W., von Delft, F., Edwards, A., Arrowsmith, C.H., Wikstroem, M., Bountra, C., Knapp, S.

(2010) PLoS Biol 8: 426

Released	2008-08-26
Method	X-RAY DIFFRACTION 2.3 Å
Organisms	Homo sapiens
Macromolecule	CALCIUM CALMODULIN DEPENDENT PROTEIN KINASE TYPE II ALPHA CHAIN (protein)
Unique Ligands	FEF, PGO

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2W2C \| pdb_00002w2c	Download File View File

STRUCTURE OF THE TETRADECAMERIC OLIGOMERISATION DOMAIN OF CALCIUM- CALMODULIN DEPENDENT PROTEIN KINASE II DELTA

Pike, A.C.W., Rellos, P., Sethi, R., Salah, E., Burgess-Brown, N., Shrestha, L., Roos, A., Murray, J.W., von Delft, F., Edwards, A., Arrowsmith, C.H., Weigelt, J., Bountra, C., Knapp, S.

(2010) PLoS Biol 8: 426

Released	2008-12-23
Method	X-RAY DIFFRACTION 2.7 Å
Organisms	Homo sapiens
Macromolecule	CALCIUM/CALMODULIN-DEPENDENT PROTEIN KINASE TYPE II DELTA CHAIN (protein)
Unique Ligands	ACT, CD

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2W4O \| pdb_00002w4o	Download File View File

Crystal structure of Human CAMK4 in complex with 4-Amino(sulfamoyl- phenylamino)-triazole-carbothioic acid (2,6-difluoro-phenyl)-amide)

Muniz, J.R.C., Rellos, P., Gileadi, O., Fedorov, O., Filippakopoulos, P., Salah, E., Pike, A., Phillips, C., Niesen, F., Shrestha, L., Burgess-Brown, N., Bullock, A., Berridge, G., von Delft, F., Edwards, A.M., Bountra, C., Arrowsmith, C.H., Weigelt, J., Knapp, S.

To be published

Released	2009-01-20
Method	X-RAY DIFFRACTION 2.17 Å
Organisms	Homo sapiens
Macromolecule	CALCIUM/CALMODULIN-DEPENDENT PROTEIN KINASE TYPE IV (protein)
Unique Ligands	DKI

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2WA0 \| pdb_00002wa0	Download File View File

Crystal structure of the human MAGEA4

Roos, A.K., Cooper, C.D.O., Ugochukwu, E., W Yue, W., Berridge, G., Elkins, J.M., Pike, A.C.W., Bray, J., Filippakopoulos, P., Muniz, J., Chaikuad, A., Burgess-Brown, N., Arrowsmith, C.H., Weigelt, J., Edwards, A., Bountra, C., von Delft, F., Gileadi, O., Oppermann, U.

(2016) PLoS One 11: 48762

Released	2009-03-10
Method	X-RAY DIFFRACTION 2.3 Å
Organisms	Homo sapiens
Macromolecule	MELANOMA-ASSOCIATED ANTIGEN 4 (protein)

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2WEL \| pdb_00002wel	Download File View File

Crystal structure of SU6656-bound calcium/calmodulin-dependent protein kinase II delta in complex with calmodulin

Pike, A.C.W., Rellos, P., Salah, E., Burgess-Brown, N., Keates, T., Muniz, J., Sethi, R., Roos, A., Filippakopoulos, P., von Delft, F., Edwards, A., Weigelt, J., Arrowsmith, C.H., Bountra, C., Knapp, S.

(2010) PLoS Biol 8: 426

Released	2009-04-14
Method	X-RAY DIFFRACTION 1.9 Å
Organisms	Homo sapiens
Macromolecule	CALCIUM/CALMODULIN-DEPENDENT PROTEIN KINASE TYPE II DELTA CHAIN (protein) CALMODULIN (protein)
Unique Ligands	CA, EDO, K88, PO4

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Structure Determination Methodology

Scientific Name of Source Organism

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Experimental Method

Polymer Entity Type

Refinement Resolution (Å)

Release Date

Enzyme Classification Name

Membrane Protein Annotation

Symmetry Type

SCOP Classification

2JII | pdb_00002jii

2OV2 | pdb_00002ov2

2P6X | pdb_00002p6x

2PA1 | pdb_00002pa1

2PKT | pdb_00002pkt

2PPI | pdb_00002ppi

2PQ5 | pdb_00002pq5

2Q3G | pdb_00002q3g

2QEP | pdb_00002qep

2QME | pdb_00002qme

2UZC | pdb_00002uzc

2V1W | pdb_00002v1w

2V1X | pdb_00002v1x

2V7O | pdb_00002v7o

2VPH | pdb_00002vph

2VSV | pdb_00002vsv

2VSW | pdb_00002vsw

2VUW | pdb_00002vuw

2VWR | pdb_00002vwr

2VX3 | pdb_00002vx3

2VZ6 | pdb_00002vz6

2W2C | pdb_00002w2c

2W4O | pdb_00002w4o

2WA0 | pdb_00002wa0

2WEL | pdb_00002wel