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234,440 Structures from the PDB

1,068,577 Computed Structure Models (CSM)

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QUERY: Structure Author = "Asano, Y."

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Search Summary

This query matches 333 Structures.

Refinements

Structure Determination Methodology

experimental (333)

Scientific Name of Source Organism

	Homo sapiens (246)
	Rattus norvegicus (83)
	Mus musculus (5)

Taxonomy

Eukaryota (333)

Experimental Method

X-RAY DIFFRACTION (333)

Polymer Entity Type

Protein (333)

Refinement Resolution (Å)

	0.5 - 1.0 (18)
	1.0 - 1.5 (236)
	1.5 - 2.0 (52)
	2.0 - 2.5 (20)
	2.5 - 3.0 (7)

Release Date

	2005 - 2009 (4)
	2010 - 2014 (23)
	2015 - 2019 (73)
	2020 - 2024 (233)

Enzyme Classification Name

	Transferases (93)
	Hydrolases (6)

Symmetry Type

	Asymmetric (329)
	Cyclic (13)

SCOP Classification

	Alpha and beta proteins (a/b) (88)
	All beta proteins (12)
	Artifacts (7)

AllSelected

1 to 25 of 333 Structures

Page 1 of 14

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Explore in 3D

3HVH \| pdb_00003hvh	Download File View File

Rat catechol O-methyltransferase in complex with a catechol-type, N6-methyladenine-containing bisubstrate inhibitor

Ehler, A., Schlatter, D., Stihle, M., Benz, J., Rudolph, M.G.

(2009) Angew Chem Int Ed Engl 48: 9092-9096

Released	2009-10-13
Method	X-RAY DIFFRACTION 1.3 Å
Organisms	Rattus norvegicus
Macromolecule	Catechol O-methyltransferase (protein)
Unique Ligands	542, CL, CXS, MG, SO4

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3HVI \| pdb_00003hvi	Download File View File

Rat catechol O-methyltransferase in complex with a catechol-type, N6-ethyladenine-containing bisubstrate inhibitor

Ehler, A., Schlatter, D., Stihle, M., Benz, J., Rudolph, M.G.

(2009) Angew Chem Int Ed Engl 48: 9092-9096

Released	2009-10-13
Method	X-RAY DIFFRACTION 1.2 Å
Organisms	Rattus norvegicus
Macromolecule	Catechol O-methyltransferase (protein)
Unique Ligands	619, CL, D1D, MG, NA

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3HVJ \| pdb_00003hvj	Download File View File

Rat catechol O-methyltransferase in complex with a catechol-type, N6-propyladenine-containing bisubstrate inhibitor

Ehler, A., Schlatter, D., Stihle, M., Benz, J., Rudolph, M.G.

(2009) Angew Chem Int Ed Engl 48: 9092-9096

Released	2009-10-13
Method	X-RAY DIFFRACTION 1.79 Å
Organisms	Rattus norvegicus
Macromolecule	Catechol O-methyltransferase (protein)
Unique Ligands	705, BTB, CL, MG

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3HVK \| pdb_00003hvk	Download File View File

Rat catechol O-methyltransferase in complex with a catechol-type, purine-containing bisubstrate inhibitor - humanized form

Ehler, A., Schlatter, D., Stihle, M., Benz, J., Rudolph, M.G.

(2009) Angew Chem Int Ed Engl 48: 9092-9096

Released	2009-10-13
Method	X-RAY DIFFRACTION 1.3 Å
Organisms	Rattus norvegicus
Macromolecule	Catechol O-methyltransferase (protein)
Unique Ligands	719, CL, MG, NHE

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3NW9 \| pdb_00003nw9	Download File View File

Rat COMT in complex with a methylpurin-containing bisubstrate inhibitor

Ehler, A., Schlatter, D., Stihle, M., Benz, J., Rudolph, M.G.

(2011) Chemistry 17: 6369-6381

Released	2011-03-16
Method	X-RAY DIFFRACTION 1.65 Å
Organisms	Rattus norvegicus
Macromolecule	Catechol O-methyltransferase (protein)
Unique Ligands	637, CL, MG, NHE

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3NWB \| pdb_00003nwb	Download File View File

Rat COMT in complex with a fluorinated desoxyribose-containing bisubstrate inhibitor avoids hydroxyl group

Ehler, A., Schlatter, D., Stihle, M., Benz, J., Rudolph, M.G.

(2012) Acta Crystallogr D Biol Crystallogr 68: 253-260

Released	2011-08-03
Method	X-RAY DIFFRACTION 1.3 Å
Organisms	Rattus norvegicus
Macromolecule	Catechol O-methyltransferase (protein)
Unique Ligands	659, CL, MG, NHE, SO4

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3NWE \| pdb_00003nwe	Download File View File

Rat COMT in complex with a methylated desoxyribose bisubstrate-containing inhibitor avoids hydroxyl group

Ehler, A., Schlatter, D., Stihle, M., Benz, J., Rudolph, M.G.

(2012) Acta Crystallogr D Biol Crystallogr 68: 253-260

Released	2011-08-03
Method	X-RAY DIFFRACTION 1.5 Å
Organisms	Rattus norvegicus
Macromolecule	Catechol O-methyltransferase (protein)
Unique Ligands	662, CL, MG, NHE, SO4

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3OE4 \| pdb_00003oe4	Download File View File

Rat catechol O-methyltransferase in complex with a catechol-type, purine-containing bisubstrate inhibitor - humanized form

Ehler, A., Schlatter, D., Stihle, M., Benz, J., Rudolph, M.G.

(2011) Chemistry 17: 6369-6381

Released	2011-03-16
Method	X-RAY DIFFRACTION 1.49 Å
Organisms	Rattus norvegicus
Macromolecule	Catechol O-methyltransferase (protein)
Unique Ligands	610, MG

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3OE5 \| pdb_00003oe5	Download File View File

Rat catechol O-methyltransferase in complex with a catechol-type, pyridylsulfanyl-containing inhibitor - humanized form

Ehler, A., Schlatter, D., Stihle, M., Benz, J., Rudolph, M.G.

(2011) Chemistry 17: 6369-6381

Released	2011-03-16
Method	X-RAY DIFFRACTION 1.52 Å
Organisms	Rattus norvegicus
Macromolecule	Catechol O-methyltransferase (protein)
Unique Ligands	611, MG

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3OZR \| pdb_00003ozr	Download File View File

Rat catechol O-methyltransferase in complex with a catechol-type, bisubstrate inhibitor, no substituent in the adenine site - humanized form

Ehler, A., Schlatter, D., Stihle, M., Benz, J., Rudolph, M.G.

(2011) Chemistry 17: 6369-6381

Released	2011-03-16
Method	X-RAY DIFFRACTION 1.73 Å
Organisms	Rattus norvegicus
Macromolecule	Catechol O-methyltransferase (protein)
Unique Ligands	CL, MG, OZR

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3OZS \| pdb_00003ozs	Download File View File

Rat catechol O-methyltransferase in complex with a catechol-type, trifluoromethyl-imidazolyl-containing inhibitor - humanized form

Ehler, A., Schlatter, D., Stihle, M., Benz, J., Rudolph, M.G.

(2011) Chemistry 17: 6369-6381

Released	2011-03-16
Method	X-RAY DIFFRACTION 1.44 Å
Organisms	Rattus norvegicus
Macromolecule	Catechol O-methyltransferase (protein)
Unique Ligands	MG, OZS

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3OZT \| pdb_00003ozt	Download File View File

Rat catechol O-methyltransferase in complex with a catechol-type, 4-oxo-pyridinyl-containing inhibitor - humanized form

Ehler, A., Schlatter, D., Stihle, M., Benz, J., Rudolph, M.G.

(2011) Chemistry 17: 6369-6381

Released	2011-03-16
Method	X-RAY DIFFRACTION 1.48 Å
Organisms	Rattus norvegicus
Macromolecule	Catechol O-methyltransferase (protein)
Unique Ligands	MG, OZZ

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3R6T \| pdb_00003r6t	Download File View File

Rat catechol o-methyltransferase in complex with the bisubstrate inhibitor 4'-fluoro-4,5-dihydroxy-biphenyl-3-carboxylic acid {(E)-3-[(2S,4R,5R)-4-hydroxy-5-(6-methyl-purin-9-yl)-tetrahydro-furan-2-yl]-allyl}-amide

Ehler, A., Schlatter, D., Stihle, M., Benz, J., Rudolph, M.G.

(2012) Acta Crystallogr D Biol Crystallogr 68: 253-260

Released	2012-02-01
Method	X-RAY DIFFRACTION 1.2 Å
Organisms	Rattus norvegicus
Macromolecule	Catechol O-methyltransferase (protein)
Unique Ligands	CL, DTD, LU1, MG, NHE, SO4

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3S68 \| pdb_00003s68	Download File View File

Rat COMT in complex with SAM and Tolcapone at 1.85A, P3221, Rfree=22.0

Ehler, A., Schlatter, D., Stihle, M., Benz, J., Rudolph, M.G.

(2012) Acta Crystallogr D Biol Crystallogr 68: 253-260

Released	2012-02-01
Method	X-RAY DIFFRACTION 1.85 Å
Organisms	Rattus norvegicus
Macromolecule	Catechol O-methyltransferase (protein)
Unique Ligands	CL, MG, SAM, SO4, TCW

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3U81 \| pdb_00003u81	Download File View File

Crystal structure of a SAH-bound semi-holo form of rat Catechol-O-methyltransferase

Ehler, A., Schlatter, D., Stihle, M., Benz, J., Rudolph, M.G.

(2012) Acta Crystallogr D Biol Crystallogr 68: 253-260

Released	2012-02-01
Method	X-RAY DIFFRACTION 1.13 Å
Organisms	Rattus norvegicus
Macromolecule	Catechol O-methyltransferase (protein)
Unique Ligands	K, SAH

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4P7F \| pdb_00004p7f	Download File View File

Mouse apo-COMT

Ehler, A., Benz, J., Schlatter, D., Rudolph, M.G.

(2014) Acta Crystallogr D Biol Crystallogr 70: 2163-2174

Released	2014-06-11
Method	X-RAY DIFFRACTION 1.37 Å
Organisms	Mus musculus
Macromolecule	Catechol O-methyltransferase (protein)
Unique Ligands	NA, PI, PO4

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4P7G \| pdb_00004p7g	Download File View File

Rat apo-COMT, phosphate bound

Ehler, A., Benz, J., Schlatter, D., Rudolph, M.G.

(2014) Acta Crystallogr D Biol Crystallogr 70: 2163-2174

Released	2014-06-18
Method	X-RAY DIFFRACTION 2.58 Å
Organisms	Rattus norvegicus
Macromolecule	Catechol O-methyltransferase (protein)
Unique Ligands	K, PO4

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4P7J \| pdb_00004p7j	Download File View File

Rat apo-COMT sulfate bound

Ehler, A., Benz, J., Schlatter, D., Rudolph, M.G.

(2014) Acta Crystallogr D Biol Crystallogr 70: 2163-2174

Released	2014-06-18
Method	X-RAY DIFFRACTION 1.45 Å
Organisms	Rattus norvegicus
Macromolecule	Catechol O-methyltransferase (protein)
Unique Ligands	K, SO4

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4P7K \| pdb_00004p7k	Download File View File

Rat COMT in complex with sinefungin

Ehler, A., Benz, J., Schlatter, D., Rudolph, M.G.

(2014) Acta Crystallogr D Biol Crystallogr 70: 2163-2174

Released	2014-06-18
Method	X-RAY DIFFRACTION 1.22 Å
Organisms	Rattus norvegicus
Macromolecule	Catechol O-methyltransferase (protein)
Unique Ligands	ACT, K, SFG, TLA

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4PYI \| pdb_00004pyi	Download File View File

human apo COMT

Ehler, A., Benz, J., Schlatter, D., Rudolph, M.G.

(2014) Acta Crystallogr D Biol Crystallogr 70: 2163-2174

Released	2014-06-11
Method	X-RAY DIFFRACTION 1.35 Å
Organisms	Homo sapiens
Macromolecule	Catechol O-methyltransferase (protein)
Unique Ligands	NA

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4PYJ \| pdb_00004pyj	Download File View File

human apo-COMT, single domain swap

Ehler, A., Benz, J., Schlatter, D., Rudolph, M.G.

(2014) Acta Crystallogr D Biol Crystallogr 70: 2163-2174

Released	2014-06-11
Method	X-RAY DIFFRACTION 1.9 Å
Organisms	Homo sapiens
Macromolecule	Catechol O-methyltransferase (protein)
Unique Ligands	CL, MG, NA

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4PYK \| pdb_00004pyk	Download File View File

human COMT, double domain swap

Ehler, A., Benz, J., Schlatter, D., Rudolph, M.G.

(2014) Acta Crystallogr D Biol Crystallogr 70: 2163-2174

Released	2014-06-11
Method	X-RAY DIFFRACTION 2.22 Å
Organisms	Homo sapiens
Macromolecule	Catechol O-methyltransferase (protein)
Unique Ligands	CL, MG, NA

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4PYL \| pdb_00004pyl	Download File View File

Humanized rat COMT in complex with sinefungin, Mg2+, and tolcapone

Ehler, A., Benz, J., Schlatter, D., Rudolph, M.G.

(2014) Acta Crystallogr D Biol Crystallogr 70: 2163-2174

Released	2014-06-18
Method	X-RAY DIFFRACTION 2.2 Å
Organisms	Rattus norvegicus
Macromolecule	Catechol O-methyltransferase (protein)
Unique Ligands	MG, SFG, TCW