VOG

(1S,2S,3R,4S,5S)-5-[(1,3-dihydroxypropan-2-yl)amino]-1-(hydroxymethyl)cyclohexane-1,2,3,4-tetrol

Created:	2018-01-30
Last modified:	2021-03-01

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2 entries where VOG is found as a standalone ligand

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Chemical Details
Formal Charge	0
Atom Count	39
Chiral Atom Count	5
Bond Count	39
Aromatic Bond Count	0

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Chemical Component Summary
Name	(1S,2S,3R,4S,5S)-5-[(1,3-dihydroxypropan-2-yl)amino]-1-(hydroxymethyl)cyclohexane-1,2,3,4-tetrol
Synonyms	voglibose
Systematic Name (OpenEye OEToolkits)	(1~{S},2~{S},3~{R},4~{S},5~{S})-5-[1,3-bis(oxidanyl)propan-2-ylamino]-1-(hydroxymethyl)cyclohexane-1,2,3,4-tetrol
Formula	C₁₀ H₂₁ N O₇
Molecular Weight	267.276
Type	NON-POLYMER

Chemical Descriptors
Type	Program	Version	Descriptor
SMILES	ACDLabs	12.01	C1(CC(C(C(C1O)O)O)NC(CO)CO)(O)CO
SMILES	CACTVS	3.385	OCC(CO)N[CH]1C[C](O)(CO)[CH](O)[CH](O)[CH]1O
SMILES	OpenEye OEToolkits	2.0.6	C1C(C(C(C(C1(CO)O)O)O)O)NC(CO)CO
Canonical SMILES	CACTVS	3.385	OCC(CO)N[C@H]1C[C@](O)(CO)[C@@H](O)[C@H](O)[C@H]1O
Canonical SMILES	OpenEye OEToolkits	2.0.6	C1[C@@H]([C@@H]([C@H]([C@@H]([C@]1(CO)O)O)O)O)NC(CO)CO
InChI	InChI	1.03	InChI=1S/C10H21NO7/c12-2-5(3-13)11-6-1-10(18,4-14)9(17)8(16)7(6)15/h5-9,11-18H,1-4H2/t6-,7-,8+,9-,10-/m0/s1
InChIKey	InChI	1.03	FZNCGRZWXLXZSZ-CIQUZCHMSA-N

Drug Info: DrugBank

DrugBank ID	DB04878
Name	Voglibose
Groups	investigational
Description	Voglibose is an alpha-glucosidase inhibitor used for lowering post-prandial blood glucose levels in people with diabetes mellitus. It is made in India by Ranbaxy Labs and sold under the trade name Volix.
Synonyms	Voglibosum Voglibose Voglibosa
Indication	For the treatment of diabetes. It is specifically used for lowering post-prandial blood glucose levels thereby reducing the risk of macrovascular complications.
Categories	Alcohols Alimentary Tract and Metabolism Blood Glucose Lowering Agents Carbohydrates Cyclohexanes Cycloparaffins Drugs Used in Diabetes Enzyme Inhibitors Fatty Alcohols Glycoside Hydrolase Inhibitors Hexanols Lipids Oral Hypoglycemics Sugar Alcohols
ATC-Code	A10BF03
CAS number	83480-29-9

Drug Targets

Name	Target Sequence	Pharmacological Action	Actions
Maltase-glucoamylase	MARKKLKKFTTLEIVLSVLLLVLFIISIVLIVLLAKESLKSTAPDPGTTG...	unknown	inhibitor

Drug Info/Drug Targets: DrugBank 3.0: a comprehensive resource for 'omics' research on drugs. Knox C, Law V, Jewison T, Liu P, Ly S, Frolkis A, Pon A, Banco K, Mak C, Neveu V, Djoumbou Y, Eisner R, Guo AC, Wishart DS. Nucleic Acids Res. 2011 Jan; 39 (Database issue):D1035-41. | PMID:21059682