SRO

SEROTONIN

Created:	2007-07-11
Last modified:	2024-09-27

Find Related PDB Entry
44 entries where SRO is found as a standalone ligand3 entries where SRO is covalently linked to polymer or other heterogen groups

Help Find related ligands:
Similar Ligands (Stereospecific) Similar Ligands (including Stereoisomers) Similar Ligands (Quick Screen) Similar Ligands (Substructure Stereospecific) Similar Ligands (Substructure including Stereoisomers)

Help

Find related ligands:

Similar Ligands (Stereospecific) Similar Ligands (including Stereoisomers) Similar Ligands (Quick Screen) Similar Ligands (Substructure Stereospecific) Similar Ligands (Substructure including Stereoisomers)

Chemical Details
Formal Charge	0
Atom Count	25
Chiral Atom Count	0
Bond Count	26
Aromatic Bond Count	10

Toggle Hydrogen Toggle Labels

Chemical Component Summary
Name	SEROTONIN
Synonyms	3-(2-AMINOETHYL)-1H-INDOL-5-OL
Systematic Name (OpenEye OEToolkits)	3-(2-aminoethyl)-1H-indol-5-ol
Formula	C₁₀ H₁₂ N₂ O
Molecular Weight	176.215
Type	NON-POLYMER

Chemical Descriptors
Type	Program	Version	Descriptor
SMILES	ACDLabs	10.04	Oc1cc2c(cc1)ncc2CCN
SMILES	CACTVS	3.341	NCCc1c[nH]c2ccc(O)cc12
SMILES	OpenEye OEToolkits	1.5.0	c1cc2c(cc1O)c(c[nH]2)CCN
Canonical SMILES	CACTVS	3.341	NCCc1c[nH]c2ccc(O)cc12
Canonical SMILES	OpenEye OEToolkits	1.5.0	c1cc2c(cc1O)c(c[nH]2)CCN
InChI	InChI	1.03	InChI=1S/C10H12N2O/c11-4-3-7-6-12-10-2-1-8(13)5-9(7)10/h1-2,5-6,12-13H,3-4,11H2
InChIKey	InChI	1.03	QZAYGJVTTNCVMB-UHFFFAOYSA-N

Drug Info: DrugBank

DrugBank ID	DB08839
Name	Serotonin
Groups	investigational nutraceutical
Description	For temporary relief of nervousness, anxiety, mood swings, joint pains, weakness, drowsiness, itching and lethargy. Not evaluated by the FDA, homeopathic product.
Synonyms	3-(2-Aminoethyl)-1H-indol-5-ol thrombotonin Serotonin hydrochloride Serotonin sérotonine 5-Hydroxytryptamine Enteramine thrombocytin 5-HT
Categories	Amines Antidepressive Agents Autacoids Biogenic Amines Biogenic Monoamines Biological Factors Central Nervous System Depressants Complex Mixtures Endopeptidases Heterocyclic Compounds, Fused-Ring Indoles Inflammation Mediators Neurotransmitter Agents Serine Proteases Serotonergic Drugs Shown to Increase Risk of Serotonin Syndrome Serotonin Agents Serotonin Receptor Agonists Snake Venoms Toxins, Biological Tryptamines Venoms Viper Venoms
CAS number	50-67-9

Drug Targets

Name	Target Sequence	Pharmacological Action
Sodium-dependent serotonin transporter	METTPLNSQKQLSACEDGEDCQENGVLQKVVPTPGDKVESGQISNGYSAV...	unknown
5-hydroxytryptamine receptor 2A	MDILCEENTSLSSTTNSLMQLNDDTRLYSNDFNSGEANTSDAFNWTVDSE...	unknown
5-hydroxytryptamine receptor 3A	MLLWVQQALLALLLPTLLAQGEARRSRNTTRPALLRLSDYLLTNYRKGVR...	unknown
5-hydroxytryptamine receptor 3B	MLSSVMAPLWACILVAAGILATDTHHPQDSALYHLSKQLLQKYHKEVRPV...	unknown
Synaptic vesicular amine transporter	MALSELALVRWLQESRRSRKLILFIVFLALLLDNMLLTVVVPIIPSYLYS...	unknown
Solute carrier family 22 member 2	MPTTVDDVLEHGGEFHFFQKQMFFLLALLSATFAPIYVGIVFLGFTPDHR...	unknown
View More

Drug Info/Drug Targets: DrugBank 3.0: a comprehensive resource for 'omics' research on drugs. Knox C, Law V, Jewison T, Liu P, Ly S, Frolkis A, Pon A, Banco K, Mak C, Neveu V, Djoumbou Y, Eisner R, Guo AC, Wishart DS. Nucleic Acids Res. 2011 Jan; 39 (Database issue):D1035-41. | PMID:21059682