SPM

SPERMINE

Created:	1999-07-08
Last modified:	2024-09-27

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248 entries where SPM is found as a standalone ligand5 entries where SPM is covalently linked to polymer or other heterogen groups

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Chemical Details
Formal Charge	0
Atom Count	40
Chiral Atom Count	0
Bond Count	39
Aromatic Bond Count	0

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Chemical Component Summary
Name	SPERMINE
Systematic Name (OpenEye OEToolkits)	N,N'-bis(3-aminopropyl)butane-1,4-diamine
Formula	C₁₀ H₂₆ N₄
Molecular Weight	202.34
Type	NON-POLYMER

Chemical Descriptors
Type	Program	Version	Descriptor
SMILES	ACDLabs	10.04	NCCCNCCCCNCCCN
SMILES	CACTVS	3.341	NCCCNCCCCNCCCN
SMILES	OpenEye OEToolkits	1.5.0	C(CCNCCCN)CNCCCN
Canonical SMILES	CACTVS	3.341	NCCCNCCCCNCCCN
Canonical SMILES	OpenEye OEToolkits	1.5.0	C(CCNCCCN)CNCCCN
InChI	InChI	1.03	InChI=1S/C10H26N4/c11-5-3-9-13-7-1-2-8-14-10-4-6-12/h13-14H,1-12H2
InChIKey	InChI	1.03	PFNFFQXMRSDOHW-UHFFFAOYSA-N

Drug Info: DrugBank

DrugBank ID	DB00127
Name	Spermine
Groups	experimental nutraceutical
Description	Spermine is a spermidine-derived biogenic polyamine found as a polycation at all pH values. Found in various tissues and organisms, it often acts as an essential growth factor in some bacterial species. Spermine is associated with nucleic acids, particularly in viruses, and is thought to stabilize the helical structure.
Synonyms	Spermina 4,9-diaza-1,12-dodecanediamine 4,9-diazadodecane-1,12-diamine N,N'-Bis(3-aminopropyl)-1,4-butanediamine Musculamine Spermine dihydrate Spermine
Indication	For nutritional supplementation, also for treating dietary shortage or imbalance
Categories	Amines Biogenic Amines Biogenic Polyamines Dietary Supplements OCT1 substrates Polyamines Supplements
CAS number	71-44-3

Drug Targets

Name	Target Sequence	Pharmacological Action	Actions
Spermine synthase	MAAARHSTLDFMLGAKADGETILKGLQSIFQEQGMAESVHTWQDHGYLAT...	unknown	ligand
Spermine oxidase	MQSCESSGDSADDPLSRGLRRRGQPRVVVIGAGLAGLAAAKALLEQGFTD...	unknown	ligand
DNA	-	unknown	binder
Ornithine decarboxylase	MNNFGNEEFDCHFLDEGFTAKDILDQKINEVSSSDDKDAFYVADLGDILK...	unknown	product of
Extracellular calcium-sensing receptor	MAFYSCCWVLLALTWHTSAYGPDQRAQKKGDIILGGLFPIHFGVAAKDQD...	unknown
Beta-1 adrenergic receptor	MGAGVLVLGASEPGNLSSAAPLPDGAATAARLLVPASPPASLLPPASESP...	unknown
Beta-2 adrenergic receptor	MGQPGNGSAFLLAPNGSHAPDHDVTQERDEVWVVGMGIVMSLIVLAIVFG...	unknown
Diamine acetyltransferase 1	MAKFVIRPATAADCSDILRLIKELAKYEYMEEQVILTEKDLLEDGFGEHP...	unknown	substrate
Diamine acetyltransferase 2	MASVRIREAKEGDCGDILRLIRELAEFEKLSDQVKISEEALRADGFGDNP...	unknown	substrate
Xanthine dehydrogenase/oxidase	MTADKLVFFVNGRKVVEKNADPETTLLAYLRRKLGLSGTKLGCGEGGCGA...	unknown	inhibitor
Solute carrier family 22 member 4	MRDYDEVIAFLGEWGPFQRLIFFLLSASIIPNGFNGMSVVFLAGTPEHRC...	unknown	inhibitor
Solute carrier family 22 member 1	MPTVDDILEQVGESGWFQKQAFLILCLLSAAFAPICVGIVFLGFTPDHHC...	unknown	substrate
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Drug Info/Drug Targets: DrugBank 3.0: a comprehensive resource for 'omics' research on drugs. Knox C, Law V, Jewison T, Liu P, Ly S, Frolkis A, Pon A, Banco K, Mak C, Neveu V, Djoumbou Y, Eisner R, Guo AC, Wishart DS. Nucleic Acids Res. 2011 Jan; 39 (Database issue):D1035-41. | PMID:21059682