PX9

Pramocaine

Created:	2015-02-06
Last modified:	2015-07-01

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6 entries where PX9 is found as a standalone ligand

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Chemical Details
Formal Charge	0
Atom Count	48
Chiral Atom Count	0
Bond Count	49
Aromatic Bond Count	6

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Chemical Component Summary
Name	Pramocaine
Systematic Name (OpenEye OEToolkits)	4-[3-(4-butoxyphenoxy)propyl]morpholine
Formula	C₁₇ H₂₇ N O₃
Molecular Weight	293.401
Type	NON-POLYMER

Chemical Descriptors
Type	Program	Version	Descriptor
SMILES	ACDLabs	12.01	O(c2ccc(OCCCN1CCOCC1)cc2)CCCC
SMILES	CACTVS	3.385	CCCCOc1ccc(OCCCN2CCOCC2)cc1
SMILES	OpenEye OEToolkits	1.9.2	CCCCOc1ccc(cc1)OCCCN2CCOCC2
Canonical SMILES	CACTVS	3.385	CCCCOc1ccc(OCCCN2CCOCC2)cc1
Canonical SMILES	OpenEye OEToolkits	1.9.2	CCCCOc1ccc(cc1)OCCCN2CCOCC2
InChI	InChI	1.03	InChI=1S/C17H27NO3/c1-2-3-12-20-16-5-7-17(8-6-16)21-13-4-9-18-10-14-19-15-11-18/h5-8H,2-4,9-15H2,1H3
InChIKey	InChI	1.03	DQKXQSGTHWVTAD-UHFFFAOYSA-N

Drug Info: DrugBank

DrugBank ID	DB09345
Name	Pramocaine
Groups	approved
Description	Pramocaine (also known as pramoxine or pramoxine HCI) is a topical anesthetic and antipruritic. It is used for many dermatological and anorectal/anogenital conditions including minor cuts/burns, insect bites, hives/rashes due to poison ivy exposure, hemorrhoids and other anorectal/anogenital disorders. Pramocaine is available by itself and in combination with other medications in various topical preparations. It works by preventing ionic fluctuations needed for neuron membrane depolarization and action potential propagation.
Synonyms	Pramocaine Pramoxine Pramoxine hydrochloride Pramocaína
Brand Names	Bikini Zone MEDICATED After Shave Fresh Scent Sunmark Caldyphen Clear Leader Triple antibiotic and pain relief Soothing Care Itch Relief Spray Good Sense Triple Antibiotic Hemorrhoidal Cream with Aloe Antibiotic and Pain Relief Maximum Strength Preferred Plus Hemorrhoid Western Family Antibiotic Plus Pain Relief Curad Maximum Strength Triple Antibiotic Equaline Antibiotic Plus Pain Relief for Kids Blistex Ivarest Poison Ivy Itch TopCare Antibiotic Plus Pain Relief Hemorrhoidal Relief Natureplex Antibiotic Plus Pain, Itch, Scar Relief Avedana Hemorrhoidal Maximum Strength Freds Medicated anti itch Sunmark Triple Antibiotic Plus Pain Relief Anti-Itch Wipes MAXIMUM STRENGTH MEDICATED ANTI-ITCH Rite Aid Hydrocortisone Acetate Pramoxine Hcl Select Brand Hemorrhoid Equaline Antibiotic Plus Pain Relief Dr Bells Pomade Vagisil Medicated Wipes Aveeno Restorative Skin Therapy Itch Relief Balm Proctodan-HC Ointment Equate Antibiotic Plus Pain Relief Proctodan-HC Suppositories TopCare Calaclear Cortaine -B Aqueous Leader Triple Antibiotic and Pain Relief Johnson and Johnson First Aid All Purpose 160 CT Welly Bravery Triple Antibiotic with Pain Relief Welly Bravery First Aid Kit GoodSense Antibiotic plus Pain Relief Basic Care First Aid Antibiotic Curasore Honey Pot Gold Bond Intensive Healing Anti Itch Skin Protectant Polysporin Lip Treatment Tronolane Band Aid Antiseptic Cleansing To Go HC Pram H E Buddy Antibiotic Maximum Strength Plus Pain Relief Equate First Aid Antibiotic Plus Pain Relief Smart Sense Triple Antibiotic Pramox HC Cream LiveBetter Antibiotic Plus Pain Relief First Aid Sensitive Anti-Itch Neosporin Plus Pain Relief First Aid Antibiotic/Pain Relieving Itch X Gel Aveeno Calm Plus Restore Itch Relief Balm Clear Anti-itch Lotion Anuzinc Plus Suppositories Hemorrhoidal GNP Caldyphen CeraVe Developed with Dermatologists Itch Relief Moisturizing Triple Antibiotic and Burn Relief Hydrocortisone Acetate Pramoxine Hydrochloride Eczemin Anti Itch Maximum Relief OLP Triple Antibiotic Plus Good Sense Triple Antibiotic and Pain Relief Meijer Antibiotic Plus Pain Relief Live Better Triple Antibiotic plus Pain Relief ATOPALM Hemorrhoidal Pain Relieving Triple Antibiotic and Pain Relief Maximum Strength Gold Bond Medicated Anti-itch Cream Clear Anti-Itch Neosporin Plus Pain Relief Neo To Go First Aid Antiseptic Pain Relieving Humco Calagesic Quality Choice Anti-Itch Clear CareALL Triple Antibiotic plus Pain Relief Rexall Hemorrhoidal TopCare Triple Antibiotic Plus Pain Relief LOLA Vaginal Itch Relief Wipes Dr. Sheffield Hemorrhoid DG Health Antibiotic Sally Hansen Zero bump bikini Equaline First Aid Antibiotic Family Wellness Triple Antibiotic Plus Pain Relief Calamine Clear Rite Aid Soothing Medicated Anit-Itch Atopalm First Aid Triple Antibiotic Protection Moisturizing and Pain Relief Sunmark Hemorrhoidal Calamine Plus CVS Pharmacy Maximum Strength Feminine Wipes Safeway Antibiotic Plus Pain Relief Neosporin Pain Itch Scar Premier Value Calaclear Aveeno Anti Itch Concentrated Antibiotic Plus Pain Relief Maximum Strength Anuzinc HC Plus Pro-relief AVON HeXashield Triple Antibiotic with Pain Relief Itch Relief Moisturizing Cream Quality Choice Anti-itch Medicated DerMend Moisturizing Anti-Itch Luvena Feminine Wipes Anti Itch Soothing 1 Pramoxine Hydrochloride Triple Antibiotic with Pain Relief Smart Sense antibiotic plus pain relief NATUREPLEX ANTIBIOTIC plus PAIN RELIEF Gold Bond Anti-itch Lotion ZyPram SIMPLE PROMISE Simple H Hemorrhoid Relief Cream Pramoxine-HC Topcare Antibiotic Triple Antibiotic Plus Pain Relief Maximum Strength Oto End 10 Aveeno Calamine and Pramoxine Hydrochloride Anti Itch Pramosone Dg Health Triple Antibiotic Bacitraycin Plus Leader Triple Antibiotic Plus Pramox HC Lotion Antibiotic and pain relief maximum strength Clear Itch Relief Healthy Accents Triple Antibiotic First Aid Triple Antibiotic and Pain Relief Maximum Strength Mineral Oil, Pramoxine Hydrochloride and Zinc Oxide Best Choice Medicated Calamine First Degree Maximum Strength Burn Rexall Maximum Strength Hemorrhoidal Multi Action Anodan-plus Ointment Pain Relief Polysporin Itch Relief Private Label Poison Ivy Wash Best Choice Medicated anti itch Dermoplast Poison Ivy Treatment Equaline Triple Antibiotic Plus DDM Calagesic Pentrexcilina Triple Antibiotic Plus Pain Relief Exchange Select First Aid Triple Anitbiotic Pain Relieving Hemorrhoidal Cream Walgreens Maximum Strength Hemorrhoidal First Aid Clear Anti-Itch medicated pads Rite Aid Family Wellness Novacort Neosporin Plus Pain Relief Neo to Go Equate Hemorrhoidal Blistex Cold and Allergy Lip Soother CVS Anti-Itch Triple Antibiotic Plus NEOSPORIN Plus BURN RELIEF L-Topical CALAMINE 8% PRAMOXINE HCL 1% W15883-CS First Aid Triple Antibiotic Pain and Scar Poison Ivy Wash Pramosone Cream Prax Equate First Aid Antibiotic Pain Relieving Smart Sense Antibiotic Maximum Strength Triple Antibiotic Plus Maximum Strength Itch Relief Lotion Neosporin Plus Pain Relief Clubtray Leader DG Health Medicated Anti-Itch Analgesic Equate Antibiotic Plus Pain, Itch, Scar Relief Pramoxine Hydrochloride Anusol Plus Ointment Aveeno Anti-itch Lotion Itch Relief Clear Skin Protectant CVS LEADER Caldyphen Analpram HC Harris Teeter Triple Antibiotic Plus Pain Relief First Aid Antibiotic and Pain Relief Shopko Triple Antibiotic Plus Neosporin Plus Pain Relief Neo To Go First Aid Antiseptic Pain Relieving For Kids Band Aid Antiseptic Cleansing Hydrocortisone Acetate Pramoxine HCl Triple Antibiotic with Pain Relief Maximum Strength Calamine Ear Itch MD Pramcort Cuadriderma Multi Antibiotic with Pain Relief Maximum Strength Clear Itch Relief Evora Labs Harris Teetter Calagesic Pramoxine Itch relief Procort Calamine Plus Pramoxine HCL Natureplex Antibiotic plus Pain Anesthetic Hemorrhoidal With Aloe Publix antibiotic plus pain relief Extra Strength Bacitraycin Plus Gold Bond Intensive Relief Anti-Itch Vida Mia Calaclear Atopalm First Aid Triple Antibiotic plus Pain Relief CVS Medicated anti itch Cortane-B HEB Calaclear Bikini Zone Medicated After-shave Roll-ON Relief Good Sense Hemorrhoidal Maximum Strength Pain Relief First Aid Maximum Strength Bacitraycin Plus Hemorrhoidal Anesthetic HEB Maximum Strength Pain Relief Hemorrhoidal CeraVe Itch Relief Moisturizing Cream Signature Care Hemorrhoidal Oticin HC Ear Drops Preparation H Totables Pain Relief Penimixcina Anti-Itch Soothing Wipes 1 Pramoxine Hydrochloride Hemorrhoid Ointment First Aid Antiseptic Pain Relieving Best Choice Anti-Itch Clear Prax Wipe CVS Pharmacy Anusol Plus Suppositories Oticin Sandoz Anuzinc Plus Shopko Antibiotic Plus Pain Relief Basic Care First Aid Antibiotic Plus Pain Relief Up and Up First Aid Antibiotic Pain Relieving Sheffield Triple Antibiotic Plus Pain Relief Drs. Pharmacy Triple Antibiotic Plus Anti-Itch CVS Fragrance Free Anti-Itch Proctofoam HC First Aid Antibiotic Up and Up multi action antibiotic Anugesic-HC Ointment Signature Care Hemorrhoidal Cream (with applicator) VAGISIL Anti-Itch Medicated Wipes Maximum Strength CeraVe Itch Relief Moisturizing Shoprite Triple Antibiotic MEDICATED ANTI-ITCH Well at Walgreens Triple Antibiotic Plus Pain Relief Basic Care First Aid Antibiotic and Burn Relief Calamine Plus Pramoxine HCl Skin Relief Medicated Anti-itch Treatment Hemorrhoidal Ointment With Anesthetic for Extra Pain Relief Acella Hydrocortisone Acetate - Pramoxine Singles CVS Calamine Plus Dermarest Eczema Medicated Moist for Sensitive Skin Hemorrhoidal Ointment Bikini Zone Medicated After Shave Spray Itch Relief Moisturizing Lotion CVS Maximum Strength Feminine Anti-Itch Wipes Antibiotic, Pain and Scar Premier Value Antibiotic Plus Pain Relief WinCo Maximum Strength Triple Antibiotic Good Neighbor Pharmacy Antibiotic and Pain Relief Publix Clear Anti-Itch Rite Aid Pharmacy Antibiotic With Pain Relief Nikzon Hemorrhoidal Walgreens Multi-Antibiotic with Pain Relief Cream Hydrocortisone Acetate 2.5% Pramoxine HCl 1% Meijer Triple Antibiotic Plus Dual Action Cream Hemorrhoidal Pain Relief Itch Relief Balm Epifoam Smart Sense triple antibitotic plus pain relief Itch-X Triple Antibiotic Family Wellness Antiseptic and Pain Relief Analpram E Cream 2.5% Kit hydrocortisone acetate 2.5% pramoxine hydrochloride 1% Childrens Double Antibiotic with Pain Relief Triple Antibiotic and Pain Relief Johnson and Johnson First Aid Travel Ready 80 CT Reeses Pinworm Itch Relief Itch X Double Antibiotic Plus Pain Relief Maximum Strength meijer Triple Antibiotic plus Pain Relief Quality Choice Maximum Strength Triple Antibiotic Good Neighbor Pharmacy Triple Antibiotic Plus Pain Relief Scalpicin Medicated Wipes Gold Bond Anti Itch meijer Antibiotic Plus Pain Relief Oncoderm ItchRx Leader Poison Ivy Wash Cocoskin Proctofoam Careone Triple Antibiotic Pomada De La Campana Triple Antibiotic Pain Relief Premier Value Calagesic Itch-X Gel Rite Aid Cala Itch Relief Anugesic-HC Suppositories Antibiotic Glycerin, Phenylephrine Hydrochloride, Pramoxine, White Petrolatum CVS Hemorrhoidal CVS Itch Relief Galentic Triple Antibiotic Plus Pain Relief HEB Calagesic Equaline Hemorrhoidal Select Brand Calaclear hydrocortisone acetate pramoxine HCl Analpram Advanced Neosporin Plus Pain Relief First Aid Antibiotic Pain Relieving For Kids Tronothane Pramoxine HCl Crm 1% USP Pramosone E Fleet Caladryl Premier Value Triple Antibiotic Plus PrameGel Family Care Maximum Strength Medicated Anti Itch Bactine Pain Relieving Cleansing Spray Publix Calamine Medicated LEADER Caldyphen Clear Select Brand Anti-Itch Analpram E Caladryl Clear Oti Rx Sunmark Antibiotic Plus Pain Relief CVS Health Triple Antibiotic with Pain Relief DDM Calaclear QC Medicated anti itch Neosporin Kids Plus Pain Relief Anodan-plus Pramoxine hydrochloride Hemorrhoidal Maximum Strength Pain Relief DCH Calaspray Itch Relief Prosoria Anti-Itch Moisturizer First Aid Antibiotic plus Burn Relief Natureplex Hemorrhoidal Humco Calaclear Family Care Triple Antibiotic Plus Pain Relief Topcare Triple Antibiotic Tucks Fast Relief Triple antibiotic and pain itch scar Publix antibiotic plus Pain Relief Premier Value Max Strength Antibiotic plus pain relief Hydro Ear Sarna P Bite and Itch Equaline Triple Antibiotic Antibiotic plus Pain Relief First Aid Antibiotic Plus Pain Relief Maximum Strength Ivy Wash Signature Care Triple Antibiotic Tripleantibioticointmentandpainrelief Polysporin Poly To Go Bacitraycin MAX Pain Relief Leader Calamine Plus Johnson and Johnson All Purpose First Aid Kit Aveeno Active Naturals Skin Relief Medicated Anti Itch Treatment Signature Care First Aid Antibiotic Caldyphen Clear Shopko Triple Antibiotic plus Pain Relief Triple antibiotic and pain relief Walgreens Maximum Strength Triple Antibiotic With Pain Relief Walgreens Kids Multi-Antibiotic with Pain Relief Cream Topcare Hemorrhoidal Sarna Sandoz Anuzinc HC Plus TopCare Calagesic Calaclear Antibiotic Plus Pain Relief Pramosone E Cream 2.5% hydrocortisone acetate 2.5% pramoxine hydrochloride 1% Aveeno Anti-Itch Concentrated Bi-Mart Triple Antibiotic plus Pain Relief Care One Maximum Strength First Aid Antibiotic proctofoam HC PREPARATION H Maximum Strength CVS Health Hemorrhoidal Cream First On Topical Analgesic Fissurene Proctofoam NS CVS Health Maximum Strength Feminine Tucks Hemorrhoidal First Aid Antibiotic Bacitraycin Plus Maximum Strength Walgreen Anti-Itch Sunmark Caldiphen Hydrocortisone Acetate and Pramoxine Hydrochloride TheraCare Triple Antibiotic Pain Relief Family Wellness Pain Scar Itch Dermagesic Quality Choice Triple Antibiotic Plus Pain Reliever Itch Relief Medicated Pads CVS Tripleantibioticapainscaritch Triple Antibiotic plus Pain Relief Maximum Strength Family Wellness Plus Pain Relief Antibiotic and Pain Relief Western Family Triple Antibiotic plus Pain Relief Up and Up Antibiotic Plus Pain Relief Up and Up Hemorrhoidal Rugby Caldyphen Clear CVS Medicated Anti-Itch Neosporin Plus Pain Relief Neo To Go First Aid Antibiotic Pain Relieving No More Bumps CAREONE Antibiotic Plus Pain Relief Clear Anti Itch Neosporin Plus Pain Relief Triple Antibiotic plus pain relief
Indication	It is indicated for temporary relief of pain and pruritus from minor lip and skin irritations as well as for temporary relief from pain, burning, itching and discomfort associated with hemorrhoids and other anorectal/anogenital disorders.
Categories	Agents for Treatment of Hemorrhoids and Anal Fissures for Topical Use Anesthetics Anesthetics for Topical Use Anesthetics, Local Antipruritics and Local Anesthetics Antipruritics, Incl. Antihistamines, Anesthetics, Etc. Central Nervous System Agents Central Nervous System Depressants Dermatologicals Oxazines Peripheral Nervous System Agents Sensory System Agents Vasoprotectives
ATC-Code	D04AB07 C05AD07
CAS number	140-65-8

Drug Targets

Name	Target Sequence	Pharmacological Action	Actions
Voltage-gated sodium channel alpha subunit	MEQTVLVPPGPDSFNFFTRESLAAIERRIAEEKAKNPKPDKKDDDENGPK...	unknown	blocker

Drug Info/Drug Targets: DrugBank 3.0: a comprehensive resource for 'omics' research on drugs. Knox C, Law V, Jewison T, Liu P, Ly S, Frolkis A, Pon A, Banco K, Mak C, Neveu V, Djoumbou Y, Eisner R, Guo AC, Wishart DS. Nucleic Acids Res. 2011 Jan; 39 (Database issue):D1035-41. | PMID:21059682