NNH

NOR-N-OMEGA-HYDROXY-L-ARGININE

Created:	2000-12-19
Last modified:	2011-06-04

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5 entries where NNH is found as a standalone ligand

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Chemical Details
Formal Charge	0
Atom Count	24
Chiral Atom Count	1
Bond Count	23
Aromatic Bond Count	0

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Chemical Component Summary
Name	NOR-N-OMEGA-HYDROXY-L-ARGININE
Systematic Name (OpenEye OEToolkits)	(2S)-2-amino-4-[(N-hydroxycarbamimidoyl)amino]butanoic acid
Formula	C₅ H₁₂ N₄ O₃
Molecular Weight	176.174
Type	L-PEPTIDE LINKING

Chemical Descriptors
Type	Program	Version	Descriptor
SMILES	ACDLabs	10.04	O=C(O)C(N)CCNC(=[N@H])NO
SMILES	CACTVS	3.341	N[CH](CCNC(=N)NO)C(O)=O
SMILES	OpenEye OEToolkits	1.5.0	[H]N=C(NCCC(C(=O)O)N)NO
Canonical SMILES	CACTVS	3.341	N[C@@H](CCNC(=N)NO)C(O)=O
Canonical SMILES	OpenEye OEToolkits	1.5.0	[H]/N=C(/NCC[C@@H](C(=O)O)N)\NO
InChI	InChI	1.03	InChI=1S/C5H12N4O3/c6-3(4(10)11)1-2-8-5(7)9-12/h3,12H,1-2,6H2,(H,10,11)(H3,7,8,9)/t3-/m0/s1
InChIKey	InChI	1.03	KOBHCUDVWOTEKO-VKHMYHEASA-N

Drug Info: DrugBank

DrugBank ID	DB02381
Name	nor-NOHA
Groups	investigational
Description	N-Hydroxy-nor-L-arginine (nor-NOHA) is under investigation in clinical trial NCT02009527 (Arginase Inhibition in Ischemia-reperfusion Injury).
Synonyms	N-hydroxy-nor-L-arginine nor-NOHA Nomega-Hydroxy-nor-L-arginine N-hydroxy-nor-arginine (2S)-2-amino-4-(((hydroxyamino)iminomethyl)amino)butanoic acid
CAS number	189302-40-7

Drug Targets

Name	Target Sequence	Pharmacological Action	Actions
Arginase-1	MSAKSRTIGIIGAPFSKGQPRGGVEEGPTVLRKAGLLEKLKEQECDVKDY...	unknown

Drug Info/Drug Targets: DrugBank 3.0: a comprehensive resource for 'omics' research on drugs. Knox C, Law V, Jewison T, Liu P, Ly S, Frolkis A, Pon A, Banco K, Mak C, Neveu V, Djoumbou Y, Eisner R, Guo AC, Wishart DS. Nucleic Acids Res. 2011 Jan; 39 (Database issue):D1035-41. | PMID:21059682