NMY

NEOMYCIN

Created:	2007-07-25
Last modified:	2020-06-05

Find Related PDB Entry
27 entries where NMY is found as a standalone ligand3 entries where NMY is covalently linked to polymer or other heterogen groups

Help Find related ligands:
Similar Ligands (Stereospecific) Similar Ligands (including Stereoisomers) Similar Ligands (Quick Screen) Similar Ligands (Substructure Stereospecific) Similar Ligands (Substructure including Stereoisomers)

Help

Find related ligands:

Similar Ligands (Stereospecific) Similar Ligands (including Stereoisomers) Similar Ligands (Quick Screen) Similar Ligands (Substructure Stereospecific) Similar Ligands (Substructure including Stereoisomers)

Chemical Details
Formal Charge	0
Atom Count	88
Chiral Atom Count	19
Bond Count	91
Aromatic Bond Count	0

Toggle Hydrogen Toggle Labels

Chemical Component Summary
Name	NEOMYCIN
Synonyms	MYCIFRADIN; NEOMAS; PIMAVECORT; VONAMYCIN
Systematic Name (OpenEye OEToolkits)	(2R,3S,4R,5R,6R)-5-amino-2-(aminomethyl)-6-[(1R,2R,3S,4R,6S)-4,6-diamino-2-[(2S,3R,4S,5R)-4-[(2R,3R,4R,5S,6S)-3-amino-6-(aminomethyl)-4,5-dihydroxy-oxan-2-yl]oxy-3-hydroxy-5-(hydroxymethyl)oxolan-2-yl]oxy-3-hydroxy-cyclohexyl]oxy-oxane-3,4-diol
Formula	C₂₃ H₄₆ N₆ O₁₃
Molecular Weight	614.644
Type	NON-POLYMER

Chemical Descriptors
Type	Program	Version	Descriptor
SMILES	ACDLabs	10.04	O(C2C(OC1OC(CN)C(O)C(O)C1N)C(N)CC(N)C2O)C4OC(C(OC3OC(CN)C(O)C(O)C3N)C4O)CO
SMILES	CACTVS	3.341	NC[CH]1O[CH](O[CH]2[CH](N)C[CH](N)[CH](O)[CH]2O[CH]3O[CH](CO)[CH](O[CH]4O[CH](CN)[CH](O)[CH](O)[CH]4N)[CH]3O)[CH](N)[CH](O)[CH]1O
SMILES	OpenEye OEToolkits	1.5.0	C1C(C(C(C(C1N)OC2C(C(C(C(O2)CN)O)O)N)OC3C(C(C(O3)CO)OC4C(C(C(C(O4)CN)O)O)N)O)O)N
Canonical SMILES	CACTVS	3.341	NC[C@H]1O[C@H](O[C@@H]2[C@@H](N)C[C@@H](N)[C@H](O)[C@H]2O[C@@H]3O[C@H](CO)[C@@H](O[C@H]4O[C@@H](CN)[C@@H](O)[C@H](O)[C@H]4N)[C@H]3O)[C@H](N)[C@@H](O)[C@@H]1O
Canonical SMILES	OpenEye OEToolkits	1.5.0	C1[C@H]([C@@H]([C@H]([C@@H]([C@H]1N)O[C@@H]2[C@@H]([C@H]([C@@H]([C@H](O2)CN)O)O)N)O[C@H]3[C@@H]([C@@H]([C@H](O3)CO)O[C@@H]4[C@@H]([C@H]([C@@H]([C@@H](O4)CN)O)O)N)O)O)N
InChI	InChI	1.03	InChI=1S/C23H46N6O13/c24-2-7-13(32)15(34)10(28)21(37-7)40-18-6(27)1-5(26)12(31)20(18)42-23-17(36)19(9(4-30)39-23)41-22-11(29)16(35)14(33)8(3-25)38-22/h5-23,30-36H,1-4,24-29H2/t5-,6+,7-,8+,9-,10-,11-,12+,13-,14-,15-,16-,17-,18-,19-,20-,21-,22-,23+/m1/s1
InChIKey	InChI	1.03	PGBHMTALBVVCIT-VCIWKGPPSA-N

Drug Info: DrugBank

DrugBank ID	DB00452
Name	Framycetin
Groups	approved
Description	A component of neomycin that is produced by Streptomyces fradiae. On hydrolysis it yields neamine and neobiosamine B. (From Merck Index, 11th ed)
Synonyms	Fradiomycin B Framicetina Framycetin sulfate Framycetinum Framycétine Neomycin B Framycetin
Brand Names	Sandoz Opticort Sofra Tulle 10 X 10cm Teva-proctosone Odan Proctomyxin HC Soframycin Sterile Eye Ointment Proctosedyl Sup Soframycin Nasal Spray Sofracort Sterile Ear/eye Drops Proctosedyl Ointment Odan Proctomyxin HC Suppositories Soframycin Eye Ont 0.5% Soframycin Ointment Soframycin Eye Drops Proctol Suppositories Soframycin Eye Drops 0.5% Soframycin Eye Drops 5mg/ml Sofracort Sterile Ear/eye Ointment Sofracort Ear/eye Ointment Soframycin Skin Ointment Sofracort Proctosedyl Sofracort Eye/ear Drops Sofra Tulle Strip (10 X 30cm) Proctol Ointment Proctosedyl Suppositories Soframycin Sterile Eye Ointment 0.5% Sofra-tulle
Indication	For the treatment of bacterial blepharitis, bacterial bonjunctivitis, corneal injuries, corneal ulcers and meibomianitis. For the prophylaxis of ocular infections following foreign body removal
Categories	Agents that produce neuromuscular block (indirect) Aminoglycoside Antibacterials Anti-Bacterial Agents Anti-Infective Agents Carbohydrates Dermatologicals Glycosides Medicated Dressings Medicated Dressings With Antiinfectives Nasal Preparations Nephrotoxic agents Ophthalmologicals Sensory Organs
ATC-Code	D09AA01 R01AX08 S01AA07
CAS number	119-04-0

Drug Targets

Name	Target Sequence	Pharmacological Action	Actions
16S ribosomal RNA	-	unknown	inhibitor
30S ribosomal protein S12	MATVNQLVRKPRARKVAKSNVPALEACPQKRGVCTRVYTTTPKKPNSALR...	unknown	inhibitor
C-X-C chemokine receptor type 4	MEGISIYTSDNYTEEMGSGDYDSMKEPCFREENANFNKIFLPTIYSIIFL...	unknown	antagonist

Drug Info/Drug Targets: DrugBank 3.0: a comprehensive resource for 'omics' research on drugs. Knox C, Law V, Jewison T, Liu P, Ly S, Frolkis A, Pon A, Banco K, Mak C, Neveu V, Djoumbou Y, Eisner R, Guo AC, Wishart DS. Nucleic Acids Res. 2011 Jan; 39 (Database issue):D1035-41. | PMID:21059682