MGT

7N-METHYL-8-HYDROGUANOSINE-5'-TRIPHOSPHATE

Created:	1999-07-08
Last modified:	2011-06-04

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30 entries where MGT is found as a standalone ligand4 entries where MGT is covalently linked to polymer or other heterogen groups 1 entries where MGT is found in a polymer sequence

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Chemical Details
Formal Charge	0
Atom Count	53
Chiral Atom Count	6
Bond Count	55
Aromatic Bond Count	0

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Chemical Component Summary
Name	7N-METHYL-8-HYDROGUANOSINE-5'-TRIPHOSPHATE
Systematic Name (OpenEye OEToolkits)	[[(2R,3S,4R,5R)-5-(2-amino-7-methyl-6-oxo-1,8-dihydropurin-9-yl)-3,4-dihydroxy-oxolan-2-yl]methoxy-hydroxy-phosphoryl] phosphono hydrogen phosphate
Formula	C₁₁ H₂₀ N₅ O₁₄ P₃
Molecular Weight	539.223
Type	NON-POLYMER

Chemical Descriptors
Type	Program	Version	Descriptor
SMILES	ACDLabs	10.04	O=P(O)(O)OP(=O)(O)OP(=O)(O)OCC3OC(N1C=2N=C(N)NC(=O)C=2N(C1)C)C(O)C3O
SMILES	CACTVS	3.341	CN1CN([CH]2O[CH](CO[P](O)(=O)O[P](O)(=O)O[P](O)(O)=O)[CH](O)[CH]2O)C3=C1C(=O)NC(=N3)N
SMILES	OpenEye OEToolkits	1.5.0	CN1CN(C2=C1C(=O)NC(=N2)N)C3C(C(C(O3)COP(=O)(O)OP(=O)(O)OP(=O)(O)O)O)O
Canonical SMILES	CACTVS	3.341	CN1CN([C@@H]2O[C@H](CO[P@@](O)(=O)O[P@@](O)(=O)O[P](O)(O)=O)[C@@H](O)[C@H]2O)C3=C1C(=O)NC(=N3)N
Canonical SMILES	OpenEye OEToolkits	1.5.0	CN1CN(C2=C1C(=O)NC(=N2)N)[C@H]3[C@@H]([C@@H]([C@H](O3)CO[P@](=O)(O)O[P@](=O)(O)OP(=O)(O)O)O)O
InChI	InChI	1.03	InChI=1S/C11H20N5O14P3/c1-15-3-16(8-5(15)9(19)14-11(12)13-8)10-7(18)6(17)4(28-10)2-27-32(23,24)30-33(25,26)29-31(20,21)22/h4,6-7,10,17-18H,2-3H2,1H3,(H,23,24)(H,25,26)(H2,20,21,22)(H3,12,13,14,19)/t4-,6-,7-,10-/m1/s1
InChIKey	InChI	1.03	BUJQMJUTTBGELS-KQYNXXCUSA-N

Drug Info: DrugBank

DrugBank ID	DB03358
Name	7-Methyl-7,8-dihydroguanosine 5'-(tetrahydrogen triphosphate)
Groups	experimental
Synonyms	7-Methyl-7,8-dihydroguanosine 5'-(tetrahydrogen triphosphate)

Drug Targets

Name	Target Sequence	Pharmacological Action	Actions
Cap-specific mRNA (nucleoside-2'-O-)-methyltransferase	MDVVSLDKPFMYFEEIDNELDYEPESANEVAKKLPYQGQLKLLLGELFFL...	unknown

Drug Info/Drug Targets: DrugBank 3.0: a comprehensive resource for 'omics' research on drugs. Knox C, Law V, Jewison T, Liu P, Ly S, Frolkis A, Pon A, Banco K, Mak C, Neveu V, Djoumbou Y, Eisner R, Guo AC, Wishart DS. Nucleic Acids Res. 2011 Jan; 39 (Database issue):D1035-41. | PMID:21059682