MET

METHIONINE



Chemical Component Summary

NameMETHIONINE
Identifiers(2S)-2-amino-4-methylsulfanyl-butanoic acid
FormulaC5 H11 N O2 S
Molecular Weight149.211
TypeL-PEPTIDE LINKING
Isomeric SMILESCSCC[C@@H](C(=O)O)N
InChIInChI=1S/C5H11NO2S/c1-9-3-2-4(6)5(7)8/h4H,2-3,6H2,1H3,(H,7,8)/t4-/m0/s1
InChIKeyFFEARJCKVFRZRR-BYPYZUCNSA-N

Chemical Details

Formal Charge0
Atom Count20
Chiral Atom Count1
Bond Count19
Aromatic Bond Count0

Drug Info: DrugBank

DrugBank IDDB00134 
NameMethionine
Groups
  • nutraceutical
  • approved
DescriptionA sulfur containing essential amino acid that is important in many body functions. It is a chelating agent for heavy metals.
Synonyms
  • L-a-Amino-g-methylthiobutyric acid
  • L-(−)-methionine
  • M
  • L-α-amino-γ-methylmercaptobutyric acid
  • Met
Brand Names
  • 2.75% Travasol Amino Acid Injection With Electrolytes In 25% Dextrose Quickmix
  • Aminosyn II with Electrolytes
  • 2.5% Travasol Amino Acid Injection Without Electrolytes In 10% Dextrose Quickmix
  • 2.5%travasol Amino Acid InJ.W.eleC.W.25%dex
  • 4.25% Travasol Amino Acid Injection With Electrolytes In 20% Dextrose
IndicationUsed for protein synthesis including the formation of SAMe, L-homocysteine, L-cysteine, taurine, and sulfate.
Categories
  • Amino Acids
  • Amino Acids, Essential
  • Amino Acids, Neutral
  • Amino Acids, Peptides, and Proteins
  • Amino Acids, Sulfur
ATC-CodeV03AB26
CAS number63-68-3

Drug Targets

NameTarget SequencePharmacological ActionActions
Methionine synthase reductaseMGAASVRAGARLVEVALCSFTVTCLEVMRRFLLLYATQQGQAKAIAEEIC...unknownproduct of
Methionine synthaseMSPALQDLSQPEGLKKTLRDEINAILQKRIMVLDGGMGTMIQREKLNEEH...unknownproduct of
Methionine aminopeptidase 2MAGVEEVAASGSHLNGDLDPDDREEGAASTAEEAAKKKRRKKKKSKGPSA...unknownproduct of
Betaine--homocysteine S-methyltransferase 1MPPVGGKKAKKGILERLNAGEIVIGDGGFVFALEKRGYVKAGPWTPEAAV...unknownproduct of
S-methylmethionine--homocysteine S-methyltransferase BHMT2MAPAGRPGAKKGILERLESGEVVIGDGSFLITLEKRGYVKAGLWTPEAVI...unknownproduct of
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Drug Info/Drug Targets: DrugBank 3.0: a comprehensive resource for 'omics' research on drugs. Knox C, Law V, Jewison T, Liu P, Ly S, Frolkis A, Pon A, Banco K, Mak C, Neveu V, Djoumbou Y, Eisner R, Guo AC, Wishart DS. Nucleic Acids Res. 2011 Jan; 39 (Database issue):D1035-41. | PMID:21059682

Related Resource References

Resource NameReference
PubChem 6137, 6992087
ChEMBL CHEMBL42336
ChEBI CHEBI:57844, CHEBI:16643
CCDC/CSD METHCL01, BANPUC, WOYVIP, URODIP03, URODIP02, CONZIO01, VUQNAY, POVYOP, DLMETA08, DLMETA05, URODIP, FITLID, MOCXUX, METHCL, YUDDIM, LUDHEX, BERQIY, YIGMEI, FAPMAL, FAPMEP, VUQNAY01, BERNIV, FONJAU, ZATNUH, ZATJUD, ZATNOB, ZATJOX, DLMETA12, ZATMOA, ZATLUF
COD 2240074, 2205625, 7212710, 2008948