LYS

LYSINE

Created:	1999-07-08
Last modified:	2024-09-27

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187 entries where LYS is found as a standalone ligand67 entries where LYS is covalently linked to polymer or other heterogen groups 227,291 entries where LYS is found in a polymer sequence

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Chemical Details
Formal Charge	1
Atom Count	25
Chiral Atom Count	1
Bond Count	24
Aromatic Bond Count	0

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Chemical Component Summary
Name	LYSINE
Systematic Name (OpenEye OEToolkits)	[(5S)-5-amino-6-hydroxy-6-oxo-hexyl]azanium
Formula	C₆ H₁₅ N₂ O₂
Molecular Weight	147.195
Type	L-PEPTIDE LINKING

Chemical Descriptors
Type	Program	Version	Descriptor
SMILES	ACDLabs	10.04	O=C(O)C(N)CCCC[NH3+]
SMILES	CACTVS	3.341	N[CH](CCCC[NH3+])C(O)=O
SMILES	OpenEye OEToolkits	1.5.0	C(CC[NH3+])CC(C(=O)O)N
Canonical SMILES	CACTVS	3.341	N[C@@H](CCCC[NH3+])C(O)=O
Canonical SMILES	OpenEye OEToolkits	1.5.0	C(CC[NH3+])C[C@@H](C(=O)O)N
InChI	InChI	1.03	InChI=1S/C6H14N2O2/c7-4-2-1-3-5(8)6(9)10/h5H,1-4,7-8H2,(H,9,10)/p+1/t5-/m0/s1
InChIKey	InChI	1.03	KDXKERNSBIXSRK-YFKPBYRVSA-O

Drug Info: DrugBank

DrugBank data are sourced from datasets licensed under a Creative Common's Attribution-NonCommercial 4.0 International License

DrugBank ID	DB00123
Name	Lysine
Groups	approved nutraceutical
Description	Lysine (abbreviated as Lys or K) is an α-amino acid with the chemical formula HO2CCH(NH2)(CH2)4NH2. This amino acid is an essential amino acid, which means that humans cannot synthesize it. Its codons are AAA and AAG. Lysine is a base, as are arginine and histidine. The ε-amino group acts as a site for hydrogen binding and a general base in catalysis. Common posttranslational modifications include methylation of the ε-amino group, giving methyl-, dimethyl-, and trimethyllysine. The latter occurs in calmodulin. Other posttranslational modifications include acetylation. Collagen contains hydroxylysine which is derived from lysine by lysyl hydroxylase. O-Glycosylation of lysine residues in the endoplasmic reticulum or Golgi apparatus is used to mark certain proteins for secretion from the cell.
Synonyms	Lysine monohydrate L-Lysin Lysine Lysinum Lysine acid (S)-lysine (S)-α,ε-diaminocaproic acid L-2,6-Diaminocaproic acid Lysina (S)-2,6-diaminohexanoic acid L-lys 6-ammonio-L-norleucine LYS Lysine acetate Lysine dihydrate Lysine hydrochloride L-Lysine
Brand Names	Nephramine Liq IV Periolimel 2.5% E Aminosyn II in Dextrose Smofkabiven Extra Nitrogen Electrolyte Free Olimel 5.7% Aminosyn 3.5% M Travasol E Aminosyn II with Electrolytes Primene 10% Aminosyn II 8.5% Injection Effervescent Potassium Chloride Aminosyn II with Electrolytes in Dextrose with Calcium Travasol Amino Acid Inj 5.5% Premasol - sulfite-free (Amino Acid) Quick Mix 2.5% Travasol Aa With Electrolytes With 25% Dextrose Injec 2.75% Travasol Amino Acid Injection With Electrolytes In 5% Dextrose Quickmix Clinisol RenAmin Aminosyn II In Dextrose Injection TrophAmine 4.25% Travasol Amino Acid Injection With Electrolytes In 20% Dextrose Quickmix Olimel 5.7% E Aminosyn 5% Aminosyn RF Injection Renamin (amino Acids) Injection Aminosyn 7% Aminosyn-PF 7% 4.25% Travasol Amino Acid Without Electrolytes In 5% Dextrose Quickmix Aminosyn HF Olimel 4.4% E Xyzmune Olimel 4.4% Travasol Inj Without Electrolytes 8.5% Synthamin Aminosyn RF 5% Travasol Amino Acid Injection With Electrolytes In 20% Dextrose Aminosyn 10% W Electrolytes FreAmine III Travasol 4.25% Travasol Amino Acid Injection With Electrolytes In 20% Dextrose 2.5% Travasol Amino Acid Injection With Electrolytes In 10% Dextrose Aminosyn II 7% With 50% Dextrose ProcalAmine Aminosyn II and Dextrose Primene 10%-liq IV Aminosyn 8.5% Injection With Electrolytes 2.5% Travasol Amino Acid Injection With Electrolytes In 10% Dextrose Clinimix Hepatasol Vamin N FreAmine HBC 8.5% Freamine III Aminosyn II 7% M In 10% Dextrose(dual Chamber) 2.75%travasol Amino Acid InJ.W.eleC.W.5%dex. Travasol Inj Without Electrolytes 5.5% 4.25% Travasol Amino Acid Injection Without Electrolytes In 20% Dextrose Lysakare Aminosyn II 5% Inj NephrAmine 4.25% Amino Acid Injection Without Electrolytes In 20% Dextrose Quickmix Novamine 4.25% Travasol Amino Acid Injection Without Electrolytes In 25% Dextrose 4.25%trav. Amino Acid InJ.W.O.elect.5%dext. Olimel 7.6% E 2.5% Travasol Amino Acid Injection Without Electrolytes In 10% Dextrose Quickmix 2.75% Travasol Amino Acid Injection With Electrolytes In 25% Dextrose Quickmix Clinimix 2.5% Travasol Aa Without Electrolytes In 10% Dextrose Injec Olimel 3.3% E Smofkabiven Electrolyte Free 4.25% Travasol Amino Acid Injection With Electrolytes In 10% Dextrose Perikabiven Clinimix E Aminosyn II 7% With 10% Dextrose Smofkabiven Extra Nitrogen ProSol 5% Travasol Amino Acid Injection Without Electrolytes In 25% Dextrose 4.25% Travasol Amino Acid Injection Without Electrlytes In 10% Dextrose Aminosyn-PF 4.25% Travasol Amino Acid Injection With Electrolytes In 25% Dextrose Smofkabiven Peripheral Olimel 7.6% Aminosyn II 8.5% M In 20% Dextrose (dual Chamber) Imubolic Aminosyn Smofkabiven Aminosyn II 10% With Electrolytes Essepna Plenamine Primene 2.5%travasol Amino Acid InJ.W.eleC.W.25%dex 4.25%travasol Amino Acid InJ.W.elecw.5%dex. Aminosyn II 7% Injection Clinimix 5% Travasol Amino Acid Injection Without Electrolytes In 20% Dextrose 4.25% Travasol Amino Acid Injection With Electrolytes In 5% Dextrose Quickmix Vamin 18 Electrolyte-free 20% Prosol Nutrineal Pd4 Aminosyn II Aminosyn II 8.5% With 50% Dextrose Kabiven 2.75% Travas. Amino Acid InJ.W.elecw.25%dex Aminosyn Sulfite Free Travasol Amino Acid Inj 8.5% Aminosyn 8.5% HepatAmine Aminosyn-PF 10%
Indication	Supplemental lysine has putative anti-herpes simplex virus activity. There is preliminary research suggesting that it may have some anti-osteoporotic activity.
Categories	Amino Acids Amino Acids, Basic Amino Acids, Diamino Amino Acids, Essential Amino Acids, Peptides, and Proteins Blood and Blood Forming Organs Blood Substitutes and Perfusion Solutions Detoxifying Agents for Antineoplastic Treatment Dietary Supplements I.V. Solution Additives Lysine Proteinogenic Amino Acids Supplements
ATC-Code	V03AF11 B05XB03
CAS number	56-87-1

Drug Targets

DrugBank data are sourced from datasets licensed under a Creative Common's Attribution-NonCommercial 4.0 International License

Name	Target Sequence	Pharmacological Action	Actions
High affinity cationic amino acid transporter 1	MGCKVLLNIGQQMLRRKVVDCSREETRLSRCLNTFDLVALGVGSTLGAGV...	unknown
Cationic amino acid transporter 4	MARGLPTIASLARLCQKLNRLKPLEDSTMETSLRRCLSTLDLTLLGVGGM...	unknown
Cationic amino acid transporter 3	MPWQAFRRFGQKLVRRRTLESGMAETRLARCLSTLDLVALGVGSTLGAGV...	unknown
Cationic amino acid transporter 2	MIPCRAALTFARCLIRRKIVTLDSLEDTKLCRCLSTMDLIALGVGSTLGA...	unknown
Lysine--tRNA ligase	MAAVQAAEVKVDGSEPKLSKNELKRRLKAEKKVAEKEAKQKELSEKQLSQ...	unknown
Monocarboxylate transporter 10	MVLSQEEPDSARGTSEAQPLGPAPTGAAPPPGPGPSDSPEAAVEKVEVEL...	unknown	substrate,inhibitor
Solute carrier family 22 member 4	MRDYDEVIAFLGEWGPFQRLIFFLLSASIIPNGFNGMSVVFLAGTPEHRC...	unknown	inhibitor
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Drug Info/Drug Targets: DrugBank 3.0: a comprehensive resource for 'omics' research on drugs. Knox C, Law V, Jewison T, Liu P, Ly S, Frolkis A, Pon A, Banco K, Mak C, Neveu V, Djoumbou Y, Eisner R, Guo AC, Wishart DS. Nucleic Acids Res. 2011 Jan; 39 (Database issue):D1035-41. | PMID:21059682