LYS

LYSINE

Find entries where: LYS

is present as a standalone ligand in 179 entries

as a non-polymer is covalently linked to polymer or other heterogen groups 68 entries

is present in a polymer sequence 221,225 entries

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Chemical Component Summary
Name	LYSINE
Identifiers	[(5S)-5-amino-6-hydroxy-6-oxo-hexyl]azanium
Formula	C₆ H₁₅ N₂ O₂
Molecular Weight	147.195
Type	L-PEPTIDE LINKING
Isomeric SMILES	C(CC[NH3+])C[C@@H](C(=O)O)N
InChI	InChI=1S/C6H14N2O2/c7-4-2-1-3-5(8)6(9)10/h5H,1-4,7-8H2,(H,9,10)/p+1/t5-/m0/s1
InChIKey	KDXKERNSBIXSRK-YFKPBYRVSA-O

Chemical Details
Formal Charge	1
Atom Count	25
Chiral Atom Count	1
Bond Count	24
Aromatic Bond Count	0

Drug Info: DrugBank

DrugBank ID	DB00123
Name	Lysine
Groups	nutraceutical approved
Description	Lysine (abbreviated as Lys or K) is an α-amino acid with the chemical formula HO2CCH(NH2)(CH2)4NH2. This amino acid is an essential amino acid, which means that humans cannot synthesize it. Its codons are AAA and AAG. Lysine is a base, as are arginine and histidine. The ε-amino group acts as a site for hydrogen binding and a general base in catalysis. Common posttranslational modifications include methylation of the ε-amino group, giving methyl-, dimethyl-, and trimethyllysine. The latter occurs in calmodulin. Other posttranslational modifications include acetylation. Collagen contains hydroxylysine which is derived from lysine by lysyl hydroxylase. O-Glycosylation of lysine residues in the endoplasmic reticulum or Golgi apparatus is used to mark certain proteins for secretion from the cell.
Synonyms	Lysine dihydrate L-Lysine L-Lysin Lysine Lysinum L-lys Lysina Lysine monohydrate Lysine hydrochloride (S)-lysine L-2,6-Diaminocaproic acid (S)-2,6-diaminohexanoic acid (S)-α,ε-diaminocaproic acid Lysine acetate LYS 6-ammonio-L-norleucine Lysine acid
Brand Names	2.75% Travasol Amino Acid Injection With Electrolytes In 25% Dextrose Quickmix Aminosyn II with Electrolytes 2.5% Travasol Amino Acid Injection Without Electrolytes In 10% Dextrose Quickmix 2.5%travasol Amino Acid InJ.W.eleC.W.25%dex 4.25% Travasol Amino Acid Injection With Electrolytes In 20% Dextrose Kabiven 5% Travasol Amino Acid Injection Without Electrolytes In 20% Dextrose 4.25% Travasol Amino Acid Injection With Electrolytes In 20% Dextrose Quickmix Smofkabiven Extra Nitrogen Electrolyte Free 4.25% Travasol Amino Acid Injection Without Electrolytes In 20% Dextrose 2.5% Travasol Amino Acid Injection With Electrolytes In 10% Dextrose Clinimix 4.25% Amino Acid Injection Without Electrolytes In 20% Dextrose Quickmix Clinimix Aminosyn II in Dextrose Olimel 7.6% Xyzmune RenAmin 4.25% Travasol Amino Acid Injection With Electrolytes In 5% Dextrose Quickmix Clinisol Novamine Lysakare 5% Travasol Amino Acid Injection With Electrolytes In 20% Dextrose Aminosyn 10% W Electrolytes Aminosyn-PF 7% Aminosyn II 8.5% Injection Aminosyn II 7% With 10% Dextrose Travasol Amino Acid Inj 5.5% Aminosyn II Aminosyn Effervescent Potassium Chloride 20% Prosol Aminosyn RF Injection Nephramine Liq IV Smofkabiven Extra Nitrogen 4.25% Travasol Amino Acid Injection Without Electrolytes In 25% Dextrose Aminosyn 5% Olimel 4.4% E TrophAmine 4.25% Travasol Amino Acid Injection With Electrolytes In 25% Dextrose NephrAmine Smofkabiven 2.75% Travas. Amino Acid InJ.W.elecw.25%dex 5% Travasol Amino Acid Injection Without Electrolytes In 25% Dextrose Aminosyn II In Dextrose Injection Aminosyn II 8.5% With 50% Dextrose Aminosyn 8.5% Injection With Electrolytes Olimel 7.6% E ProcalAmine Aminosyn II 7% With 50% Dextrose Travasol Inj Without Electrolytes 8.5% Premasol - sulfite-free (Amino Acid) 2.75% Travasol Amino Acid Injection With Electrolytes In 5% Dextrose Quickmix Aminosyn 3.5% M Primene 10%-liq IV Aminosyn II and Dextrose 8.5% Freamine III Plenamine 4.25% Travasol Amino Acid Without Electrolytes In 5% Dextrose Quickmix 4.25%trav. Amino Acid InJ.W.O.elect.5%dext. 4.25% Travasol Amino Acid Injection Without Electrlytes In 10% Dextrose Vamin N Aminosyn-PF Olimel 5.7% Smofkabiven Peripheral Aminosyn II with Electrolytes in Dextrose with Calcium Travasol Inj Without Electrolytes 5.5% 2.75%travasol Amino Acid InJ.W.eleC.W.5%dex. Smofkabiven Electrolyte Free Aminosyn II 7% Injection Aminosyn II 8.5% M In 20% Dextrose (dual Chamber) Perikabiven Essepna Periolimel 2.5% E Aminosyn II 7% M In 10% Dextrose(dual Chamber) Aminosyn 8.5% Primene 10% Synthamin Travasol Vamin 18 Electrolyte-free 2.5% Travasol Amino Acid Injection With Electrolytes In 10% Dextrose Olimel 4.4% Primene Clinimix E Aminosyn HF Quick Mix 2.5% Travasol Aa With Electrolytes With 25% Dextrose Injec Aminosyn II 10% With Electrolytes 4.25% Travasol Amino Acid Injection With Electrolytes In 10% Dextrose Aminosyn Sulfite Free Renamin (amino Acids) Injection Aminosyn 7% Hepatasol Aminosyn II 5% Inj Imubolic Clinimix 2.5% Travasol Aa Without Electrolytes In 10% Dextrose Injec FreAmine III Travasol E 4.25%travasol Amino Acid InJ.W.elecw.5%dex. Aminosyn RF Travasol Amino Acid Inj 8.5% HepatAmine Aminosyn-PF 10% Olimel 5.7% E Olimel 3.3% E FreAmine HBC Nutrineal Pd4 ProSol
Indication	Supplemental lysine has putative anti-herpes simplex virus activity. There is preliminary research suggesting that it may have some anti-osteoporotic activity.
Categories	Amino Acids Amino Acids, Basic Amino Acids, Diamino Amino Acids, Essential Amino Acids, Peptides, and Proteins Blood and Blood Forming Organs Blood Substitutes and Perfusion Solutions Detoxifying Agents for Antineoplastic Treatment Dietary Supplements I.V. Solution Additives Lysine Proteinogenic Amino Acids Supplements
ATC-Code	V03AF11 B05XB03
CAS number	56-87-1

Drug Targets

Name	Target Sequence	Pharmacological Action	Actions
High affinity cationic amino acid transporter 1	MGCKVLLNIGQQMLRRKVVDCSREETRLSRCLNTFDLVALGVGSTLGAGV...	unknown
Cationic amino acid transporter 4	MARGLPTIASLARLCQKLNRLKPLEDSTMETSLRRCLSTLDLTLLGVGGM...	unknown
Cationic amino acid transporter 3	MPWQAFRRFGQKLVRRRTLESGMAETRLARCLSTLDLVALGVGSTLGAGV...	unknown
Low affinity cationic amino acid transporter 2	MIPCRAALTFARCLIRRKIVTLDSLEDTKLCRCLSTMDLIALGVGSTLGA...	unknown
Lysine--tRNA ligase	MAAVQAAEVKVDGSEPKLSKNELKRRLKAEKKVAEKEAKQKELSEKQLSQ...	unknown
Monocarboxylate transporter 10	MVLSQEEPDSARGTSEAQPLGPAPTGAAPPPGPGPSDSPEAAVEKVEVEL...	unknown	substrate,inhibitor
Solute carrier family 22 member 4	MRDYDEVIAFLGEWGPFQRLIFFLLSASIIPNGFNGMSVVFLAGTPEHRC...	unknown	inhibitor
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Drug Info/Drug Targets: DrugBank 3.0: a comprehensive resource for 'omics' research on drugs. Knox C, Law V, Jewison T, Liu P, Ly S, Frolkis A, Pon A, Banco K, Mak C, Neveu V, Djoumbou Y, Eisner R, Guo AC, Wishart DS. Nucleic Acids Res. 2011 Jan; 39 (Database issue):D1035-41. | PMID:21059682