LGC

D-glucono-1,5-lactone

Created:	2000-08-25
Last modified:	2020-07-17

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13 entries where LGC is found as a standalone ligand1 entries where LGC is covalently linked to polymer or other heterogen groups

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Chemical Details
Formal Charge	0
Atom Count	22
Chiral Atom Count	4
Bond Count	22
Aromatic Bond Count	0

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Chemical Component Summary
Name	D-glucono-1,5-lactone
Synonyms	(3S,4R,5R,6S)-3,4,5-TRIHYDROXY-6-(HYDROXYMETHYL)TETRAHYDRO-2H-PYRAN-2-ONE; GLUCONOLACTONE
Systematic Name (OpenEye OEToolkits)	(3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-one
Formula	C₆ H₁₀ O₆
Molecular Weight	178.14
Type	D-SACCHARIDE

Chemical Descriptors
Type	Program	Version	Descriptor
SMILES	ACDLabs	10.04	O=C1OC(CO)C(O)C(O)C1O
SMILES	CACTVS	3.341	OC[CH]1OC(=O)[CH](O)[CH](O)[CH]1O
SMILES	OpenEye OEToolkits	1.5.0	C(C1C(C(C(C(=O)O1)O)O)O)O
Canonical SMILES	CACTVS	3.341	OC[C@H]1OC(=O)[C@H](O)[C@@H](O)[C@@H]1O
Canonical SMILES	OpenEye OEToolkits	1.5.0	C([C@@H]1[C@H]([C@@H]([C@H](C(=O)O1)O)O)O)O
InChI	InChI	1.03	InChI=1S/C6H10O6/c7-1-2-3(8)4(9)5(10)6(11)12-2/h2-5,7-10H,1H2/t2-,3-,4+,5-/m1/s1
InChIKey	InChI	1.03	PHOQVHQSTUBQQK-SQOUGZDYSA-N

Drug Info: DrugBank

DrugBank ID	DB04564
Name	Gluconolactone
Groups	approved experimental
Description	Gluconolactone is a naturally-occurring food additive used as a sequestrant, an acidifier, or a curing, pickling, or leavening agent. It is a cyclic ester of D-gluconic acid. Pure gluconolactone is a white odorless crystalline powder.
Synonyms	Gluconolactone Gluconic acid lactone D-glucono-1,5-lactone 1,5-Gluconolactone delta-gluconolactone GDL Glucono-delta-lactone D-gluconic acid delta-lactone Glucono delta-lactone D-threo-Aldono-1,5-lactone 1,5-D-gluconolactone
Brand Names	Renacidin
Categories	Acids, Acyclic Calculi Dissolution Agent Carbohydrates Hydroxy Acids Irrigation Sugar Acids
CAS number	90-80-2

Drug Targets

Name	Target Sequence	Pharmacological Action	Actions
Lactase-phlorizin hydrolase	MELSWHVVFIALLSFSCWGSDWESDRNFISTAGPLTNDLLHNLSGLLGDQ...	unknown

Drug Info/Drug Targets: DrugBank 3.0: a comprehensive resource for 'omics' research on drugs. Knox C, Law V, Jewison T, Liu P, Ly S, Frolkis A, Pon A, Banco K, Mak C, Neveu V, Djoumbou Y, Eisner R, Guo AC, Wishart DS. Nucleic Acids Res. 2011 Jan; 39 (Database issue):D1035-41. | PMID:21059682