HSM

HISTAMINE

Created:	1999-07-08
Last modified:	2011-06-04

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42 entries where HSM is found as a standalone ligand

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Chemical Details
Formal Charge	0
Atom Count	17
Chiral Atom Count	0
Bond Count	17
Aromatic Bond Count	5

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Chemical Component Summary
Name	HISTAMINE
Systematic Name (OpenEye OEToolkits)	2-(1H-imidazol-4-yl)ethanamine
Formula	C₅ H₉ N₃
Molecular Weight	111.145
Type	NON-POLYMER

Chemical Descriptors
Type	Program	Version	Descriptor
SMILES	ACDLabs	10.04	n1c(cnc1)CCN
SMILES	CACTVS	3.341	NCCc1c[nH]cn1
SMILES	OpenEye OEToolkits	1.5.0	c1c(nc[nH]1)CCN
Canonical SMILES	CACTVS	3.341	NCCc1c[nH]cn1
Canonical SMILES	OpenEye OEToolkits	1.5.0	c1c(nc[nH]1)CCN
InChI	InChI	1.03	InChI=1S/C5H9N3/c6-2-1-5-3-7-4-8-5/h3-4H,1-2,6H2,(H,7,8)
InChIKey	InChI	1.03	NTYJJOPFIAHURM-UHFFFAOYSA-N

Drug Info: DrugBank

DrugBank ID	DB05381
Name	Histamine
Groups	approved investigational
Description	A depressor amine derived by enzymatic decarboxylation of histidine. It is a powerful stimulant of gastric secretion, a constrictor of bronchial smooth muscle, a vasodilator, and also a centrally acting neurotransmitter.
Synonyms	Histamine phosphate beta-aminoethylimidazole Histamine 4-imidazoleethylamine beta-aminoethylglyoxaline Histamine dihydrochloride 1H-Imidazole-4-ethanamine 5-imidazoleethylamine 2-(4-imidazolyl)ethylamine
Brand Names	Histamine Positive Skin Test Control Camphomex Ceplene Positive Skin Test Control - Histamine Mancore Muscle Mend Roll-ON Pain Reliever Alo Therapeutic Massage Arthrocare Lotion Australian Dream Hand and Wrist Pain Histamine DHCl 0.10 Percent and Menthol 2 Percent PainMD Max REVIVE SCIENCE Natural Hemp Pain Relief Rub Dr. Freds MIRACLE RUB Histatrol BAKERS BEST Arthritis Pain Relief Cream with Hemp and Lavender HAVASU HEMP Soothing Pain Relief Rub Md Science Cannabigerol Pain Relieving Arthritis CVS Arthritis Pain Relief Australian Dream Pain Relieving Arthritis Midalgan ROPANA Pain Relief Cream Alo Therapeutic Massage Pain Relieving Hand and Wrist Pain Cream Positive Skin Test Control-histamine Rematex MINTED LEAF Odorless Histamine DHCl Pain Relief and Hemp Extract Simanix Australian Dream Carpal Tunnel Pain Raging Kakapo Pain Relieve Histamine Phosphate Injection USP, 1mg/ml Arthritis Pain Relief Bakers Best Arthritis Pain Relief with Hemp Seed Md Science Cannabidiol Australian Dream Back Pain AMINO ACTIVE Topical Analgesic Cream Ponos Natural Pain Relief Histamine Phosphate Injection USP Liq Sc DR. MIKES Ponos Pain Relief Cream Roll-On Histamine DHCl 0.10 Percent Royal Labs Hemp Recover Arthritis Relief MUSCLESHOK Back Pain Bakers Best Arthritis Pain Relief ActivOn Ultra Strength Arthritis Arthritis Pain Relief Cream Abee Med MUSCLESHOK Sport Glucosamine Cream EXTRA STRENGTH TerraFreeze Pain Relief Minted Leaf Odorless Pain Relief Walgreens Arthritis Pain Relief Cream
Indication	Histamine phosphate is indicated as a diagnostic aid for the evaluation of gastric acid secretory function.
Categories	Adjuvants, Immunologic Amines Antineoplastic and Immunomodulating Agents Autacoids Biogenic Amines Biogenic Monoamines Biological Factors Cytochrome P-450 CYP3A Inhibitors Cytochrome P-450 Enzyme Inhibitors Diagnostic Agents Ethylamines Gastric Function Histamine Agents Histamine Agonists Imidazoles Inflammation Mediators Neurotransmitter Agents OCT1 substrates OCT2 Inhibitors OCT2 Substrates Other Diagnostics Tests for Gastric Secretion
ATC-Code	L03AX14 V04CG03
CAS number	51-45-6

Drug Targets

Name	Target Sequence	Pharmacological Action	Actions
Histamine H1 receptor	MSLPNSSCLLEDKMCEGNKTTMASPQLMPLVVVLSTICLVTVGLNLLVLY...	unknown	agonist
Histamine H2 receptor	MAPNGTASSFCLDSTACKITITVVLAVLILITVAGNVVVCLAVGLNRRLR...	unknown	agonist
Histamine H3 receptor	MERAPPDGPLNASGALAGEAAAAGGARGFSAAWTAVLAALMALLIVATVL...	unknown	agonist
Histamine H4 receptor	MPDTNSTINLSLSTRVTLAFFMSLVAFAIMLGNALVILAFVVDKNLRHRS...	unknown	agonist
Synaptic vesicular amine transporter	MALSELALVRWLQESRRSRKLILFIVFLALLLDNMLLTVVVPIIPSYLYS...	unknown
Histamine N-methyltransferase	MASSMRSLFSDHGKYVESFRRFLNHSTEHQCMQEFMDKKLPGIIGRIGDT...	unknown	substrate
Solute carrier family 22 member 2	MPTTVDDVLEHGGEFHFFQKQMFFLLALLSATFAPIYVGIVFLGFTPDHR...	unknown	substrate,inhibitor
Solute carrier family 22 member 1	MPTVDDILEQVGESGWFQKQAFLILCLLSAAFAPICVGIVFLGFTPDHHC...	unknown
Solute carrier family 22 member 3	MPSFDEALQRVGEFGRFQRRVFLLLCLTGVTFAFLFVGVVFLGTQPDHYW...	unknown	inhibitor
Solute carrier family 22 member 5	MRDYDEVTAFLGEWGPFQRLIFFLLSASIIPNGFTGLSSVFLIATPEHRC...	unknown	inhibitor
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Drug Info/Drug Targets: DrugBank 3.0: a comprehensive resource for 'omics' research on drugs. Knox C, Law V, Jewison T, Liu P, Ly S, Frolkis A, Pon A, Banco K, Mak C, Neveu V, Djoumbou Y, Eisner R, Guo AC, Wishart DS. Nucleic Acids Res. 2011 Jan; 39 (Database issue):D1035-41. | PMID:21059682