HGA

GLUTAMINE HYDROXAMATE

Created:	1999-07-08
Last modified:	2024-09-27

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2 entries where HGA is found as a standalone ligand

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Chemical Details
Formal Charge	0
Atom Count	21
Chiral Atom Count	1
Bond Count	20
Aromatic Bond Count	0

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Chemical Component Summary
Name	GLUTAMINE HYDROXAMATE
Systematic Name (OpenEye OEToolkits)	(2S)-2-amino-5-(hydroxyamino)-5-oxo-pentanoic acid
Formula	C₅ H₁₀ N₂ O₄
Molecular Weight	162.144
Type	NON-POLYMER

Chemical Descriptors
Type	Program	Version	Descriptor
SMILES	ACDLabs	10.04	O=C(NO)CCC(C(=O)O)N
SMILES	CACTVS	3.341	N[CH](CCC(=O)NO)C(O)=O
SMILES	OpenEye OEToolkits	1.5.0	C(CC(=O)NO)C(C(=O)O)N
Canonical SMILES	CACTVS	3.341	N[C@@H](CCC(=O)NO)C(O)=O
Canonical SMILES	OpenEye OEToolkits	1.5.0	C(CC(=O)NO)[C@@H](C(=O)O)N
InChI	InChI	1.03	InChI=1S/C5H10N2O4/c6-3(5(9)10)1-2-4(8)7-11/h3,11H,1-2,6H2,(H,7,8)(H,9,10)/t3-/m0/s1
InChIKey	InChI	1.03	YVGZXTQJQNXIAU-VKHMYHEASA-N

Drug Info: DrugBank

DrugBank ID	DB02446
Name	Glutamine hydroxamate
Groups	experimental
Synonyms	L-gamma-Glutamyl hydroxamate Glutamine hydroxamate Glutamic acid gamma-monohydroxamate gamma-Glutamyl hydroxamate L-glutamic acid γ-hydroxamic acid Glutamate-gamma-hydroxamate Glutamyl-gamma-hydroxamate Glutamate-gamma-hydroxamic acid
Categories	Amines Amino Acids Amino Acids, Acidic Amino Acids, Dicarboxylic Amino Acids, Peptides, and Proteins Aspartate Aminotransferases, antagonists & inhibitors Hydroxy Acids Hydroxylamines
CAS number	1955-67-5

Drug Targets

Name	Target Sequence	Pharmacological Action	Actions
Glutamine--fructose-6-phosphate aminotransferase [isomerizing]	MCGIVGAIAQRDVAEILLEGLRRLEYRGYDSAGLAVVDAEGHMTRLRRLG...	unknown

Drug Info/Drug Targets: DrugBank 3.0: a comprehensive resource for 'omics' research on drugs. Knox C, Law V, Jewison T, Liu P, Ly S, Frolkis A, Pon A, Banco K, Mak C, Neveu V, Djoumbou Y, Eisner R, Guo AC, Wishart DS. Nucleic Acids Res. 2011 Jan; 39 (Database issue):D1035-41. | PMID:21059682