HCY

(11alpha,14beta)-11,17,21-trihydroxypregn-4-ene-3,20-dione

Created:	2007-10-13
Last modified:	2021-03-01

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13 entries where HCY is found as a standalone ligand

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Chemical Details
Formal Charge	0
Atom Count	56
Chiral Atom Count	7
Bond Count	59
Aromatic Bond Count	0

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Chemical Component Summary
Name	(11alpha,14beta)-11,17,21-trihydroxypregn-4-ene-3,20-dione
Synonyms	CORTISOL
Systematic Name (OpenEye OEToolkits)	(8S,9S,10R,11S,13S,14S,17R)-11,17-dihydroxy-17-(2-hydroxyethanoyl)-10,13-dimethyl-2,6,7,8,9,11,12,14,15,16-decahydro-1H-cyclopenta[a]phenanthren-3-one
Formula	C₂₁ H₃₀ O₅
Molecular Weight	362.46
Type	NON-POLYMER

Chemical Descriptors
Type	Program	Version	Descriptor
SMILES	ACDLabs	10.04	O=C(CO)C3(O)C2(CC(O)C4C1(C(=CC(=O)CC1)CCC4C2CC3)C)C
SMILES	CACTVS	3.341	C[C]12CCC(=O)C=C1CC[CH]3[CH]4CC[C](O)(C(=O)CO)[C]4(C)C[CH](O)[CH]23
SMILES	OpenEye OEToolkits	1.5.0	CC12CCC(=O)C=C1CCC3C2C(CC4(C3CCC4(C(=O)CO)O)C)O
Canonical SMILES	CACTVS	3.341	C[C@]12CCC(=O)C=C1CC[C@H]3[C@@H]4CC[C@](O)(C(=O)CO)[C@@]4(C)C[C@H](O)[C@H]23
Canonical SMILES	OpenEye OEToolkits	1.5.0	C[C@]12CCC(=O)C=C1CC[C@@H]3[C@@H]2[C@H](C[C@]4([C@H]3CC[C@@]4(C(=O)CO)O)C)O
InChI	InChI	1.03	InChI=1S/C21H30O5/c1-19-7-5-13(23)9-12(19)3-4-14-15-6-8-21(26,17(25)11-22)20(15,2)10-16(24)18(14)19/h9,14-16,18,22,24,26H,3-8,10-11H2,1-2H3/t14-,15-,16-,18+,19-,20-,21-/m0/s1
InChIKey	InChI	1.03	JYGXADMDTFJGBT-VWUMJDOOSA-N

Drug Info: DrugBank

DrugBank ID	DB00741
Name	Hydrocortisone
Groups	approved vet_approved
Description	Hydrocortisone, or cortisol, is a glucocorticoid secreted by the adrenal cortex.[A188387] Hydrocortisone is used to treat immune, inflammatory, and neoplastic conditions.[L10529,L10532,L10535,L10538,L7772,L7321] It was discovered in the 1930s by Edward Kendall and named Compound F, or 17-hydroxycorticosterone.[A188420] Hydrocortisone was granted FDA approval on 5 August 1952.[L10574]
Synonyms	(11β)-11,17,21-trihydroxypregn-4-ene-3,20-dione 11beta-hydrocortisone 11beta,17alpha,21-Trihydroxy-4-pregnene-3,20-dione Hydrocortisone Reichstein's substance M Hydrocortisonum 17-Hydroxycorticosterone Hidrocortisona Kendall's compound F 4-pregnen-11β,17α,21-triol-3,20-dione Cortisol 11β-hydrocortisone
Brand Names	Preparation H Hydrocortisone Cortizone 10 Hydratensive Healing Anti Itch Hydrocortisone Cream 0.5% USP Cipro HC Equate Hydrocortisone Topical Proctosedyl Sup Gelmicin Hydrocortisone with Aloe H-Releve Anti-Itch Cho-A Care Lot 1% Ana Cool Rapid Soothing Cooling Formula Hydrocortisone Plus Alumier MD Post Procedure Kit with Hydrocortisone Auro-hydrocortisone SeaCalm Skin Itch Relief Instant Cooling Hydrocortisone Maximum Strength with Aloe Basic Care Hydrocortisone meijer Hydrocortisone Plus 12 Moisturizers Emo Cort Sol 2.5% USP Herb Street Anti-Itch Stick Family Wellness Maximum Strength Hydrocortisone Proctozone HC FixMySkin Healing Balm Vanilla Fragrance Instant Cooling Itch Relief Berkley and Jensen Hydrocortisone Makesense Maximum Strength Dermarest Eczema Medicated Aquanil HC Anti-itch 1% Hydrocortisone Smart Sense Anti Itch Maximum Strength Hydrocortisone with Aloe Maximum Strength signature care Hydrocortisone Bencort Cortisporin Ophthalmic Hydrocortisone 1 Plus 10 Tecnu Corticool Barriere HC 1% Selsun Blue Scalp Itch Treatment Loesch Anti-Itch Therapy Hydrocortisone Cream 1% with Aloe Vera Quality Choice Hydrocortisone Maximum Strength AFASSCO 1% Hydrocortisone Live Better Hydrocortisone with Aloe Assured Welly Itch Fix Cicatricure Ultra Moisturizing Cortaine -B Aqueous Dermasorb AF Complete Kit S-Cream HYDROCORTISONE 1% Itch Relief Cortisone Cream Intensive Healing Ketocon Shopko Maximum Strength Soothe Rodan Fields Natureplex Hydrocortisone Hydro CVS Health Maxium Strentgh Cortisone Cortisone 10 Sensitive Skin Creme Shopko Hydrocortisone Plus 12 Moisturizers Maximum Strength Healthy Accents Cortisone Maximum Strength Maximum Strength Gold Bond Medicated Anti-itch Cream Intensive Formula Hydrocortisone Ointment 0.5% Good Neighbor Pharmacy Hydrocortisone With Aloe for Sensitive Skin Hydro Skin Quatriderm Anti-itch Sunmark Hydrocortisone with Aloe Maximum Strength Pharmaskincare Brightening Dermarelief Cream Cortizone 10 Hydratensive Soothing Anti Itch Harris Teeter Maximum Strength Anti-Itch Hydrocortisone Plus 12 Moisturizers Meijer Anti Itch Proctosedyl Hydrocortisone Cream 0.5% Dermazene Dermarest Dricort 0.5% Hydrocortisone Anti-itch Careone Anti Itch Medi-First Hydrocortisone Welly First Aid Kit Family Care Hydrocortisone CVS Cools Itch Fast Neomycin and Polymyxin B Sulfates, Bacitracin Zinc and Hydrocortisone Cortizone 10 for Psoriasis Sterex Lot Plus Thera Plus Our Family Hydrocortisone with Aloe Rodan and Fields Soothe Proctocort Hydrocortisone 0.5% / Hydroquinone 6% / Tretinoin 0.025% Family Wellness Hydrocortisone CVS Health Hydrocortisone Anti Itch Dermaquest Skin Therapy Post-Skin Resurfacing Balm Hytone Pharmaskincare Multi-Gly Skin Relief Cream Maximum Strength Hydrocortisone Cream with Aloe CeraVe Anti-Itch ProCure Hydrocortisone Plus Calendula Barmicil Plus Neomycin and Polymyxin B Sulfates and Hydrocortisone Otic Suspension Duane Reade hydrocortisone CliniCalm Up and Up Anti Itch FixMySkin Healing Balm Fragrance-Free Weeks and Leo Anti-itch Aveeno Hydrocortisone Anti-itch Cream Quality Choice Itch Relief Poison Oak and Ivy Maximum Strength Hydrocortisone Plus Moisturizing Aloe Cortaid 12-Hour Advanced Anti-Itch Itch Stuff Cortisone Plus Aloe Maximum Strength First Aid Only Hydrocortisone 1% Anti-Itch Glytone soothe calming Cortate Ont 1% Anti-Itch with Aloe Cvs Hydrocortisone With Aloe Piyanping antiitch PS-2896 Hydrocortisone Cream 1%, 0.9g Welly Adventure First Aid Kit TheraCare Hydrocortisone Cream TrueLipids 1% Hydrocortisone Barrier Cream Quatriderm Creme Nf Avedana Hydrocortisone Maximum Strength Nizoral Scalp Itch Relief Clindamycin 1% / Hydrocortisone 2.5% / Niacinamide 4% TheraCare Maximum Strength 1% Hydrocortisone TopCare Hydrocortisone Cortizone 10 Poison Ivy Relief Pads Neo-poly-bac Hydro WinCo Foods Hydrocortisone Cream Intensive Healing Publix hydro plus Hydrocortisone 0.5% / Hydroquinone 8% / Tretinoin 0.05% CVS Maximum Strength Feminine Anti-Itch Cream Aquaphor Itch Relief Quality Choice Maximum Strength Anti Itch Maximum Strength Cortizone 10 Quick Shot 360 Continuous CVS Anti-Itch Hydrocortisone meijer Hydrocortisone HydrocortisoneLotion Hydrocortisone 2.5% / Iodoquinol 1% / Ketoconazole 2% Corti-Sav Mycozyl HC Blue-Emu Anti-Itch Cream Signature Care Hydrocortisone Scarguard MD Care One hydrocortisone maximum strength Equate Hydrocortisone Smart Sense Hydrocortisone Xerese Pramoxine-HC Regular Strength Hydrocortisone Cream Quality Choice Anti Itch Ti-U-lac HC Lotion Oto End 10 Proctosol-HC Alkindi Sprinkle Intensive Healing Anti Itch Good Neighbor Pharmacy Hydrocortisone Alkindi Colocort Dr. Throwers Hydrotet SAFEWAY Hydrocortisone Plus 12 Moisturizers WinCo Maximum Strength Hydrocortisone Hydrocortisone 0.5% / Hydroquinone 4% / Tretinoin 0.025% Maximum Strength Anti-Itch Apres Peel Soothing Balm Hydrocortisone Plus 10 Moisturizers Welly Superhero Supplies Kit Maximum-H Meijer Anti-itch with Aloe Welly Excursion First Aid Kit Welly Human Repair Kit Cortisone maximum strength Dr Lift Soothing Cream Equaline Anti Itch Yes To Coconut Eczema Relief Anti-Itch Regular Strength Post-Treatment Repair Cream Premier Value Hydrocortisone Up and Up Hydrocortisone Anti Itch Meijer Max. Strength Anti-Itch Cream Intensive Healing Formula Good Sense Anti Itch Hydrocortisone D Maximum Strength Hydrocortisone Hydrocortisone Butyrate Hydrocortisone Ultra Strength Hydrocortisone Crm 1% Dr H Stabilizer Harris Teeter Anti-Itch Intensive Healing Family Wellness NeilMed Anti-Itch Preparation H Soothing Relief Anti-itch Vioform + Hydrocortisone Cooling Itch Relief Well at Walgreens Smart Sense Anti Itch Cortizone 10 Anti-itch for Diabetics Skin Cooling Itch Relief Rite Aid Good Neighbor Pharmacy Hydrocortisone with Aloe Xpect Hydrocortisone Hydrocortisone Cream Intensive Healing Cortizone 10 Market Basket Anti-Itch Cream Plus OLIVIA QUIDO FIRM and FADE II Hydrocortisone Anti-Itch FixMySkin Healing Balm Unflavored Hydrocortisone Continuous Alumier MD Intensive Recovery Hydrocortisone 2.5% / Ketoconazole 2% NEOMYCIN and POLYMYXIN B SULFATES and HYDROCORTISONE Neosporin Eczema Essentials Anti Itch Itch Fixer Cortaid Intensive Therapy Cooling Medi-First Plus Hydrocortisone ProCure Hydrocortisone Cream Plus TopCare Hydrocortisone 1% with Aloe Dg Health Hydrocortisone Cortizone 10 Intensive Healing Odan Proctomyxin HC Up and Up anti itch maximum strength Barmicil Anti-itch Shoprite Hydrocortisone Exchange Select Hydrocortisone Hydrocortisone and Acetic Acid FIRST Dukes Mouthwash Compounding Caring Mills Hydrocortisone Winco Maximum Strength Hydrocortisone Hydrocortisone Plus 12 Moisturizers Maximum Strength Loesch HC-10 ANTI-ITCH THERAPY hydrocortisone Iodoquinol Proctozone-HC Hydrocortisone 1 Procto-Med HC CVS Maximum Strength Anti-Itch Cream Walgreens Hydrocortisone Plus 12 Moisturizers 141060 Hydrocortisone 0.5% / Hydroquinone 4% / Tretinoin 0.025% HydroCortisone Intensive Healing Formula Meijer Maximum Strength Anti-itch Cream wiith Aloe Hydrocortisone Cream USP 0.5% meijer Itch and Rash Relief Cipro HC Otic Suspension DG Health Hydrocortisone Maximum Strength Anti itch Premier Value Hydrocortisone Plus 12 Moisturizers Hydrocortisone HC Home PapKit Hydrocortisone Rectal Suspension (Retention) Smart sense Hydrocortisone CVS Anti itch Hydrocortisone 1% Freds Hydrocortisone Plus 12 Moisturizers Harris Teeter Anti-Itch Cooling Relief Leader Hydrocortisone Post Treatment Balm Proactiv Solution Anti-Itch Scalp FIRST Marys Mouthwash Compounding H Plus Holdings Nourishing Thera plus Anti-itch with aloe Hydrocortisone Cortane-B Rugby Hydroskin Scalpicin Anti-Itch Maximum Strength Bioelements Immediate Comfort Hydrocortisone DermaCort Anti-itch Leader Hydrocortisone With Aloe Rephresh Cooling Pharmaskincare Acnecare Cream Anti-itch Feminine Care Scalpicin Maximum Strength Caldecort Cortef OREAD GOLD Anti-Itch Foam Oticin HC Ear Drops Health Mart Pharmacy Hydrocortisone Maximum Strength with Aloe Theracort Total Relief Atopalm Maximum Strength Anti-Itch glo SKIN BEAUTY Remedy Gel DG Health Hydrocortisone Hydrocortisone Hydrocortisone Intensive Healing Formula Family Wellness Max Strength 1 Hydrocortisone Cream Vioform Hydrocortisone Mild Ala-Scalp Acetasol HC Insect Bite Relief Hydrocortisone maximum strength Green Guard Maximum Strength Hydrocortisone Cortizone 10 Itch Relief Massaging Rollerball Kirkland Signature Hydrocortisone Plus Maximum Strength Aveeno Hydrocortisone ANTI-ITCH TopCare Hydrocortisone Plus 12 Moisturizers Fulton Street Market Anti itch Casporyn HC Quality Choice Anti Itch with Aloe DG health hydrocortisone Hydrocortisone 2.5% / Levocetirizine Dihydrochloride 2% Hydrocortisone Cream 1% Anti-Itch Scherer Labs Instant Cooling Itch Relief CVS Anti-Itch Medi-First Neomycin and Polymyxin B Sulfates and Hydrocortisone Hycort Retention Enema 100mg/60ml Hydrocortisone Maximum Strength sunmark Hydrocortisone Maximum Strength Cortisone Cream with Aloe Itch and Bite Relief First Aid Kit Pediaderm HC Hydrocortisone with aloe Petrocort Antipruritic Lip 21 Aloe Cort Dr. Sheffield Hydrocortisone Anti itch Pediotic Family Care Anti-Itch Care One Hydrocortisone Maximum Strength TopCare Hydrocortisone Intensive Healing Formula Cortizone 10 Sensitive Skin Anti-itch Creme Cortisone 10 Intensive Moisture Creme FixMySkin HEALING BODY BALM Fragrance-Free Meijer Anti Itch Cream Plus Hydrocortisone 1% / Hydroquinone 8% / Tretinoin 0.05% Texacort Procto-Pak Publix Hydro Cortenema Sus 100mg/60ml 141017 Hydrocortisone 0.5% / Hydroquinone 6% / Tretinoin 0.025% Itch and Rash Cream HydroSKIN Rugby Hydrocortisone With Aloe CeraVe Developed with Dermatologists Anti Itch Lucky SuperSoft MAXIMUM STRENGTH Proctol Suppositories Medi-Cortisone with Aloe Cortizone 10 Intensive Healing for Eczema TrueLipids Anti-Itch Barrier HEM-EASY RELIEF Herbal Anti-Itch MAXIMUM ITCH RELIEF Psoriasin Itch Control Vioform Hydrocortisone Healing Tree Calming Anti-itch Cortenema FixMySkin HEALING LIP BALM unflavoured Ala Quin NU-DERM Tolereen Anti-pruritic Hydrocortisone With Aloe Discount Drug Mart Anti-itch Audiologist Anti-itch Poison Oak Viniferamine Hydrocortisone Cream Meijer Intense Healing Calmurid HC Crm Rite Aid Cortisone Neomycin, Polymyxin B Sulfates and Hydrocortisone 999 Itch Relieving Emo Cort Cream 2.5% Refuge HC Shopko Hydrocortisone Maximum Strength Intensive Healing Eczema Meijer Maximum Strength Anti-itch Cream Ultra Moisturizing Formula 1oz Theraplex AIM Anti-Itch Moisturizing Cream Harris Teeter Anti-Itch with Aloe AVON HeXashield Anti Itch Cream with Healing Aloe WINCO Hydrocortisone Harris Teeter Anti-Itch Hydrocortisone 1% in Absorbase Odan Proctomyxin HC Suppositories Hemorrodil Unguento Plus Quality Choice Anti-Itch Zims Advanced Hydrocortisone Continuous With Organic Arnica and Aloe Meijer Maximum Strength Anti-itch Cream with Aloe UEC Medical Anti-Itch Hydroxym Monistat Soothing Care Itch Relief Hydrocortisone Anti Itch Hydrocortisone 2.5% / Hydroquinone 4% / Tretinoin 0.025%, Monistat Complete Care Instant Itch Relief Hydrocortisone Ointment 1% Aveeno Hydrocortisone Anti Itch Triple Antibiotic HC KAISER PERMANENTE Hydrocortisone Proctosedyl Suppositories Hydrocortisone Micro Anti Itch Maximum Strength Plus Rexall Hydrocortisone 1 Up and Up Hydrocortisone Zims Advanced Crack Creme With Hydrocortisone Hydrocortisone anti-itch plus Cortate Crm 1% Alcortin Cortisone Maximum Strength Cortizone 10 Cooling Cream Anti-Itch Healerz for Itches Proctocream HC Proctosedyl Ointment Cortisporin Quadrydern Shopko Hydrocortisone Intensive Healing Formula Scalpicin Scalp Itch Medication Maximum Strength Duane Reade Sunmark Hydrocortisone Plus Cortizone 10 Feminine Itch Relief Texacort Solution 1% Maximum Strength Hydrocortisone Cream Advanced Hydrocortisone Shopko Hydrocortisone With Aloe Plenadren Itch relief Cream Emo Cort Lotion 2.5% Meijer Maximum Strength Anti-itch Members Mark Hydrocortisone Sandoz Cortimyxin Pediadermics Eczema 2 Cortizone 10 Easy Relief Signature Care Anti Itch Proctol Ointment Equaline Anti Itch Maximum Strength Health Mart Pharmacy Hydrocortisone Maximum Strength Plus 12 Moisturizers Up and Up Hydrocortisone One Per Cent Hydrocortisone, Iodoquinol ATOPALM Moisturizing Hydrocortisone Dermoscribe Ichybum Oti Rx Hydrocortisone Crm 0.5% Avedana Hydrocortisone Cream with Aloe Shopko Hydrocortisone FixMySkin Healing Balm Vanilla Flavor Alacort Up and Up anti itch Vanoxide HC Cortizone 10 Cooling Relief Hydrocortisone With Aloe Maximum Strength Dermoscribe Seborrheic Dermatitis Neomycin and Polymyxin B Sulfates, Bacitracin Zinc, and Hydrocortisone Cortisone 10 Overnight Creme S-Oint HYDROCORTISONE 1% Western Family HydroCortisone Hydrocortisone Regular Strength Freds Hydrocortisone with Aloe Quality Choice Hydrocortisone 141061 Hydrocortisone 0.5% / Hydroquinone 8% / Tretinoin 0.025% Hydrocortisone Maximum Strength with aloe HeXashield Anti Itch Cream with Healing Aloe Aquacort Lotion 2.5% Berkley and Jensen Anti Itch Beard Medicated Cremo Hydro Ear Cortizone 10 Plus Aloe Cort Calming Cream Sterex Crm Plus Cortibalm Eczema Skin Mushatts N9 Cortizone-10 Soothing Aloe Creme Kera HC Post peel Protectant Vitality Institute Western Family HydroCortisone Plus 12 Moisturizers Formu Care Anti Itch maximum strength Hydrocortisone Cream Cortisone CVS Cortisone Sandoz Hydrocortisone Rite Aid anti-itch Careone Hydrocortisone 1 Maximum Strength Equate Hydrocortisone Intensive Healing Formula OLP Hydrocortisone 1% Hydrocortisone 0.5% / Hydroquinone 8% / Tretinoin 0.025% Rexall Anti Itch Maximum Strength Relief Cortaid Maximum Strength Good Neighbor Pharmacy Anti Itch Corticol-Aloe CVS Pharmacy Anti-itch Cipro Maximum Strength Cortisone Hydrocortisone 0.5% / Hydroquinone 6% / Tretinoin 0.05% Efmody Scarguard MD Physicians Formula Odan-spor-HC Cortizone 10 Ultra Soothing Creme Topcare Hydrocortisone Cortizone 10 Intensive Healing Feminine Itch Relief Anti Itch Maximum Strength Hydrocortisone 0.5% / Hydroquinone 6% 141016 Hydrocortisone 0.5% / Hydroquinone 4% / Tretinoin 0.025% Hydrocortisone Iodoquinol Cortizone 10 Water Resistant Rexall Hydrocortisone Plus Moisturizers Cortizone 10 Cooling Cooling Itch Relief Neosporin Essentials Trial Pack BudPak Anti-Itch Cortizone 10 Overnight Itch Relief Anti-Itch Scalp Relief Maximum Strength Anusol HC Face Values Hydrocortisone With Aloe CareOne Anti Itch Good Neighbor Pharmacy Hydrocortisone Plus 12 Moisturizers Schein Hydrocortisone OLIVIA QUIDO FIRM and FADE I Sarna Whipped Foam ShopRite Hydrocortisone ECOLAB Hydrocortisone Cream Duane Reade hydrocortisone plus 12 moisturizers Sarna HC Crane Safety Hydrocortisone Hydrocortisone 1% with healing aloe SKIN A COOL Hydrocortisone Anti-Itch Hydrocort Hydrocortisone with Aloe Cortomycin Up and Up Intensive Healing Basic Case Hydrocortisone Anti-Itch HydroSkin Antibiotic Ear (Neo/Polym/HC) Anti Itch
Indication	Otic solutions are indicated for infections of the external auditory canal caused by susceptible organisms and with inflammation.[L10529,L10532] Hydrocortisone tablets are indicated for certain endocrine, rheumatic, collagen, allergic, ophthalmic, respiratory, hematologic, neoplastic, edematous, gastrointestinal, and other conditions.[L10535] A hydrocortisone enema is indicated for ulcerative colitis,[L10538] a topical ointment with antibiotics is indicated for corticosteroid responsive dermatoses with infections,[L7772] and a topical cream with [acyclovir] is indicated to treat cold sores.[L7321] Oral granules of hydrocortisone are used as a replacement therapy for Adrenocortical Insufficiency (AI) in children under 17 years of age.[L16533]
Categories	11-Hydroxycorticosteroids 17-Hydroxycorticosteroids Adrenal Cortex Hormones Adrenals Agents for Treatment of Hemorrhoids and Anal Fissures for Topical Use Alimentary Tract and Metabolism Anti-Inflammatory Agents Antidiarrheals, Intestinal Antiinflammatory/antiinfective Agents Corticosteroid Hormone Receptor Agonists Corticosteroids Corticosteroids Acting Locally Corticosteroids for Local Oral Treatment Corticosteroids for Systemic Use Corticosteroids for Systemic Use, Plain Corticosteroids, Dermatological Preparations Corticosteroids, Weak (Group I) Cytochrome P-450 CYP2A6 Inducers Cytochrome P-450 CYP2B6 Inducers Cytochrome P-450 CYP2B6 Inducers (strength unknown) Cytochrome P-450 CYP2C19 Inducers Cytochrome P-450 CYP2C19 Inducers (strength unknown) Cytochrome P-450 CYP2C8 Inducers Cytochrome P-450 CYP2C8 Inducers (strength unknown) Cytochrome P-450 CYP2C9 Inducers Cytochrome P-450 CYP2C9 Inducers (strength unknown) Cytochrome P-450 CYP3A Inducers Cytochrome P-450 CYP3A Substrates Cytochrome P-450 CYP3A4 Inducers Cytochrome P-450 CYP3A4 Inducers (strength unknown) Cytochrome P-450 CYP3A4 Substrates Cytochrome P-450 CYP3A5 Substrates Cytochrome P-450 CYP3A7 Substrates Cytochrome P-450 Enzyme Inducers Cytochrome P-450 Substrates Dermatologicals Fused-Ring Compounds Hormones Hormones, Hormone Substitutes, and Hormone Antagonists Hydrocortisone and derivatives Hydroxycorticosteroids Hyperglycemia-Associated Agents Immunosuppressive Agents Intestinal Antiinflammatory Agents Nasal Preparations OAT3/SLC22A8 Substrates Ophthalmological and Otological Preparations Ophthalmologicals Otologicals P-glycoprotein inducers P-glycoprotein substrates Pregnanes Pregnenediones Pregnenes Sensory Organs Steroids Stomatological Preparations Systemic Hormonal Preparations, Excl. Sex Hormones and Insulins Vasoprotectives
ATC-Code	S01CB03 A01AC03 S01BA02 S01CA03 D07AA02 S01BB01 D07XA01 D07BA04 S02CA03 A07EA02 S02BA01 R01AD60 H02AB09 D07CA01 S03CA04 C05AA01
CAS number	50-23-7

Drug Targets

Name	Target Sequence	Pharmacological Action	Actions
Glucocorticoid receptor	MDSKESLTPGREENPSSVLAQERGDVMDFYKTLRGGATVKVSASSPSLAV...	unknown	agonist
Annexin A1	MAMVSEFLKQAWFIENEEQEYVQTVKSSKGGPGSAVSPYPTFNPSSDVAA...	unknown	agonist
Cytochrome P450 3A4	MALIPDLAMETWLLLAVSLVLLYLYGTHSHGLFKKLGIPGPTPLPFLGNI...	unknown	substrate,inducer
Cytochrome P450 3A5	MDLIPNLAVETWLLLAVSLVLLYLYGTRTHGLFKRLGIPGPTPLPLLGNV...	unknown	substrate
Cytochrome P450 3A7	MDLIPNLAVETWLLLAVSLILLYLYGTRTHGLFKKLGIPGPTPLPFLGNA...	unknown	substrate
Cytochrome P450 11B1, mitochondrial	MALRAKAEVCMAVPWLSLQRAQALGTRAARVPRTVLPFEAMPRRPGNRWL...	unknown	substrate
Cytochrome P450 11B2, mitochondrial	MALRAKAEVCVAAPWLSLQRARALGTRAARAPRTVLPFEAMPQHPGNRWL...	unknown	substrate
Cytochrome P450 2C8	MEPFVVLVLCLSFMLLFSLWRQSCRRRKLPPGPTPLPIIGNMLQIDVKDI...	unknown	inducer
3-oxo-5-beta-steroid 4-dehydrogenase	MDLSAASHRIPLSDGNSIPIIGLGTYSEPKSTPKGACATSVKVAIDTGYR...	unknown	substrate
3-oxo-5-alpha-steroid 4-dehydrogenase 2	MQVQCQQSPVLAGSATLVALGALALYVAKPSGYGKHTESLKPAATRLPAR...	unknown	substrate
Corticosteroid 11-beta-dehydrogenase isozyme 2	MERWPWPSGGAWLLVAARALLQLLRSDLRLGRPLLAALALLAALDWLCQR...	unknown	substrate
Corticosteroid 11-beta-dehydrogenase isozyme 1	MAFMKKYLLPILGLFMAYYYYSANEEFRPEMLQGKKVIVTGASKGIGREM...	unknown	substrate
Cytochrome P450 2A6	MLASGMLLVALLVCLTVMVLMSVWQQRKSKGKLPPGPTPLPFIGNYLQLN...	unknown	inducer
Cytochrome P450 1B1	MGTSLSPNDPWPLNPLSIQQTTLLLLLSVLATVHVGQRLLRQRRRQLRSA...	unknown	inducer
Cytochrome P450 2B6	MELSVLLFLALLTGLLLLLVQRHPNTHDRLPPGPRPLPLLGNLLQMDRRG...	unknown	inducer
Cytochrome P450 2C9	MDSLVVLVLCLSCLLLLSLWRQSSGRGKLPPGPTPLPVIGNILQIGIKDI...	unknown	inducer
Cytochrome P450 2C19	MDPFVVLVLCLSCLLLLSIWRQSSGRGKLPPGPTPLPVIGNILQIDIKDV...	unknown	inducer
Sex hormone-binding globulin	MESRGPLATSRLLLLLLLLLLRHTRQGWALRPVLPTQSAHDPPAVHLSNG...	unknown	binder
Corticosteroid-binding globulin	MPLLLYTCLLWLPTSGLWTVQAMDPNAAYVNMSNHHRGLASANVDFAFSL...	unknown	binder
P-glycoprotein 1	MDLEGDRNGGAKKKNFFKLNNKSEKDKKEKKPTVSVFSMFRYSNWLDKLY...	unknown	substrate,inducer
Solute carrier organic anion transporter family member 1A2	MGETEKRIETHRIRCLSKLKMFLLAITCAFVSKTLSGSYMNSMLTQIERQ...	unknown	inhibitor
Solute carrier family 22 member 8	MTFSEILDRVGSMGHFQFLHVAILGLPILNMANHNLLQIFTAATPVHHCR...	unknown	substrate
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Drug Info/Drug Targets: DrugBank 3.0: a comprehensive resource for 'omics' research on drugs. Knox C, Law V, Jewison T, Liu P, Ly S, Frolkis A, Pon A, Banco K, Mak C, Neveu V, Djoumbou Y, Eisner R, Guo AC, Wishart DS. Nucleic Acids Res. 2011 Jan; 39 (Database issue):D1035-41. | PMID:21059682

Related Resource References

Resource Name	Reference
Pharos	CHEMBL389621
PubChem	5754
ChEMBL	CHEMBL389621
ChEBI	CHEBI:17650
CCDC/CSD	ZZZPNG01, ZZZPNG03, GOGQEZ, CORTMS01, COWNEI, CORTMS, ZZZPNG02, CORTPY, SACWAY01, SACWAY, ZZZPNG04
COD	1559402