GSH

GLUTATHIONE

Created: 1999-07-08
Last modified:  2024-09-27

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Chemical Details

Formal Charge0
Atom Count37
Chiral Atom Count2
Bond Count36
Aromatic Bond Count0
2D diagram of GSH
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Chemical Component Summary

NameGLUTATHIONE
Systematic Name (OpenEye OEToolkits)(2S)-2-azanyl-5-[[(2R)-1-(2-hydroxy-2-oxoethylamino)-1-oxidanylidene-3-sulfanyl-propan-2-yl]amino]-5-oxidanylidene-pentanoic acid
FormulaC10 H17 N3 O6 S
Molecular Weight307.323
TypeNON-POLYMER

Chemical Descriptors

TypeProgram Version Descriptor
SMILESACDLabs12.01O=C(NCC(=O)O)C(NC(=O)CCC(C(=O)O)N)CS
SMILESCACTVS3.370N[CH](CCC(=O)N[CH](CS)C(=O)NCC(O)=O)C(O)=O
SMILESOpenEye OEToolkits1.7.6C(CC(=O)NC(CS)C(=O)NCC(=O)O)C(C(=O)O)N
Canonical SMILESCACTVS3.370 N[C@@H](CCC(=O)N[C@@H](CS)C(=O)NCC(O)=O)C(O)=O
Canonical SMILESOpenEye OEToolkits1.7.6 C(CC(=O)N[C@@H](CS)C(=O)NCC(=O)O)[C@@H](C(=O)O)N
InChIInChI1.03 InChI=1S/C10H17N3O6S/c11-5(10(18)19)1-2-7(14)13-6(4-20)9(17)12-3-8(15)16/h5-6,20H,1-4,11H2,(H,12,17)(H,13,14)(H,15,16)(H,18,19)/t5-,6-/m0/s1
InChIKeyInChI1.03 RWSXRVCMGQZWBV-WDSKDSINSA-N

Drug Info: DrugBank

DrugBank IDDB00143 
NameGlutathione
Groups
  • approved
  • investigational
  • nutraceutical
DescriptionA tripeptide with many roles in cells. It conjugates to drugs to make them more soluble for excretion, is a cofactor for some enzymes, is involved in protein disulfide bond rearrangement and reduces peroxides.
Synonyms
  • Glutathione-SH
  • 5-L-Glutamyl-L-cysteinylglycine
  • AEC GLUTATHIONE
  • Reduced glutathione
  • GLYCINE, L-.GAMMA.-GLUTAMYL-L-CYSTEINYL-
Brand Names
  • Gluta Whitening Lazy Cream
  • Vista Advanced AREDS2 Formula
  • Tobakient
  • Deyanling(Cranberry Flavored Collagen Peptide)
  • Haruto Hangover Defencepatch
IndicationFor nutritional supplementation, also for treating dietary shortage or imbalance
Categories
  • Amino Acids, Peptides, and Proteins
  • Antidotes
  • Dietary Supplements
  • Glutathione, antagonists & inhibitors
  • Oligopeptides
ATC-CodeV03AB32
CAS number70-18-8

Drug Targets

NameTarget SequencePharmacological ActionActions
Aldose reductaseMASRLLLNNGAKMPILGLGTWKSPPGQVTEAVKVAIDVGYRHIDCAHVYQ...unknown
Matrix metalloproteinase-9MSLWQPLVLVLLVLGCCFAAPRQRQSTLVLFPGDLRTNLTDRQLAEEYLY...unknown
Cytochrome P450 3A4MALIPDLAMETWLLLAVSLVLLYLYGTHSHGLFKKLGIPGPTPLPFLGNI...unknown
Glutathione peroxidaseMTTQLRVVHLLPLLLACFVQTSPKQEKMKMDCHKDEKGTIYDYEAIALNK...unknown
Glutathione reductase, mitochondrialMALLPRALSAGAGPSWRRAARAFRGFLLLLPEPAALTRALSRAMACRQEP...unknown
View More
Drug Info/Drug Targets: DrugBank 3.0: a comprehensive resource for 'omics' research on drugs. Knox C, Law V, Jewison T, Liu P, Ly S, Frolkis A, Pon A, Banco K, Mak C, Neveu V, Djoumbou Y, Eisner R, Guo AC, Wishart DS. Nucleic Acids Res. 2011 Jan; 39 (Database issue):D1035-41. | PMID:21059682

Related Resource References

Resource NameReference
Pharos CHEMBL1543
PubChem 124886, 25246407
ChEMBL CHEMBL1543
ChEBI CHEBI:60836, CHEBI:16856