GLO

D-glucose

Created:	1999-07-08
Last modified:	2024-09-27

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9 entries where GLO is found as a standalone ligand1 entries where GLO is covalently linked to polymer or other heterogen groups 6 entries where GLO is found in a branched oligosaccharide

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Chemical Details
Formal Charge	0
Atom Count	24
Chiral Atom Count	4
Bond Count	23
Aromatic Bond Count	0

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Chemical Component Summary
Name	D-glucose
Synonyms	D-GLUCOSE IN LINEAR FORM
Systematic Name (OpenEye OEToolkits)	(2R,3S,4R,5R)-2,3,4,5,6-pentahydroxyhexanal
Formula	C₆ H₁₂ O₆
Molecular Weight	180.156
Type	D-SACCHARIDE

Chemical Descriptors
Type	Program	Version	Descriptor
SMILES	ACDLabs	10.04	O=CC(O)C(O)C(O)C(O)CO
SMILES	CACTVS	3.341	OC[CH](O)[CH](O)[CH](O)[CH](O)C=O
SMILES	OpenEye OEToolkits	1.5.0	C(C(C(C(C(C=O)O)O)O)O)O
Canonical SMILES	CACTVS	3.341	OC[C@@H](O)[C@@H](O)[C@H](O)[C@@H](O)C=O
Canonical SMILES	OpenEye OEToolkits	1.5.0	C([C@H]([C@H]([C@@H]([C@H](C=O)O)O)O)O)O
InChI	InChI	1.03	InChI=1S/C6H12O6/c7-1-3(9)5(11)6(12)4(10)2-8/h1,3-6,8-12H,2H2/t3-,4+,5+,6+/m0/s1
InChIKey	InChI	1.03	GZCGUPFRVQAUEE-SLPGGIOYSA-N

Drug Info: DrugBank

DrugBank ID	DB01914
Name	D-glucose
Groups	approved vet_approved investigational
Description	Glucose is a simple sugar (monosaccharide) generated during phosynthesis involving water, carbon and sunlight in plants. It is produced in humans via hepatic gluconeogenesis and breakdown of polymeric glucose forms (glycogenolysis). It circulates in human circulation as blood glucose and acts as an essential energy source for many organisms through aerobic or anaerobic respiration and fermentation.[A19399] It is primarily stored as starch in plants and glycogen in animals to be used in various metabolic processes in the cellular level. Its aldohexose stereoisomer, dextrose or D-glucose, is the most commonly occurring isomer of glucose in nature. L-glucose is a synthesized enantiomer that is used as a low-calorie sweetener and laxative.[T28] The unspecified form of glucose is commonly supplied as an injection for nutritional supplementation or metabolic disorders where glucose levels are improperly regulated.[L786] Glucose is listed on the World Health Organization's List of Essential Medicines, the most important medications needed in a basic health system.
Synonyms	D-glucose monohydrate D-Glucose in linear form D-glucose, anhydrous Dextrose, anhydrous Dextrose anhydrous Glucose, anhydrous Anhydrous dextrose D-glucose Glucose anhydrous D(+)-Glucose aldehydo-D-glucose
Brand Names	5% Dextrose Aminosyn II with Electrolytes in Dextrose with Calcium Haemonetics Anticoagulant Citrate Dextrose Solution Clinimix Milrinone Lactate in Dextrose Normosol-M and Dextrose SUEROLYTE Oral Electrolyte Solution Peach Flavor Additive Formula 3 Isolyte S in Dextrose Lidocaine Hydrochloride and Dextrose SUEROLYTE Oral Electrolyte Solution Cherry Flavor Anti Nausea Ringers and Dextrose Dextrose monohydrate Nauzene Grape Hemosol Lg4 Sterile Cord Blood Collection Unit Lactated Ringers and Dextrose Prismasol Bgk4/2.5 SUEROLYTE Oral Electrolyte Solution Grape Flavor Dialysis Solution 35 K4 Haemonetics Anticoagulant Citrate Phosphate Double Dextrose Solution (CP2D) IMUFLEX WB-SP Blood Bag System with Integral Whole Blood Leukocyte Reduction Filter (Saving Platelets) with Diversion Blood Sampling Arm Anticoagulant Citrate Phosphate Dextrose (CPD) and OPTISOL (AS-5) Red Cell Preservative Aminosyn II and Dextrose Prismasol B22gk4/0 SUEROLYTE Oral Electrolyte Solution Apple Flavor Potassium Chloride and Dextrose Prismasol Bgk4/0/1.2 Anticoagulant Citrate Dextrose A Perikabiven Alcohol and Dextrose SUEROLYTE Oral Electrolyte Solution Coconut Flavor Dianeal for Peritoneal Dialysis Plasma-Lyte M and Dextrose Sterile Cord Blood Collection Unit (MSC127D) Lingtea Prismasol Bgk2/3.5 Lidocaine Hci and Dextrose Prismasol Bgk4/3.5 Anticoagulant Citrate Phosphate Dextrose (CPD) Blood-Pack Units in PL 146 Plastic Selutrio 10 ACD Blood-Pack Units (PL 146 Plastic) Sterile Cord Blood Collection Unit (msc123d) Dextrose Monohydrate CPD Solution CPDA-1 Blood Collection System Selutrio 40 Haemonetics Additive Solution Formula 3 (AS-3) Dextrose Imuflex Wb-SP Blood Bag System With Integral Whole Blood Leukocyte Reduction Filter (saving Platelets) With Diversion Blood Sampling Arm Prismasol 2 Acd A AGF Mesenchymal Capillary Individual Acd-A Basic Dental Emergency Kit Dialysis Solution 35 K2 Pall Sterile Cord Blood Collection Unit Isolyte M in Dextrose Myocard-DX Dextrose and Electrolyte No. 75 As 3 Heparin Sodium in Dextrose TERUFLEX Blood Bag System Anticoagulant Citrate Phosphate Dextrose (CPD) AND OPTISOL Red Cell Preservative Reveos Select CPD/AS-5 Red Cell Preservative For Collection Of Blood Sag-mannitol Solution Alcohol in Dextrose Potassium Chloride Deluxe Dental Emergency Kit Sterile Cord Blood Collection Unit (MSC128D) Infant Dextrose PrismaSol Adsol Red Cell Preservation SUEROLYTE Oral Electrolyte Solution Unflavored Flavor Mld Leukotrap WB System Ionosol MB and Dextrose Potassium Chloride in Lactated Ringers and Dextrose SUEROLYTE Oral Electrolyte Solution Pineapple Flavor Aminosyn II in Dextrose Isolyte H in Dextrose Leucoflex CGP Ionosol and Dextrose DIANEAL PD-2 with Dextrose TERUFLEX Blood Bag System Anticoagulant Citrate Phosphate Dextrose Adenine (CPDA-1) Elliotts B SUEROLYTE Oral Electrolyte Solution Strawberry Banana Flavor Dextrose and Electrolyte No. 48 Jilgyungyi AGF Mesenchymal Capillary 5 pcs IMUFLEX WB-RP Blood Bag System with Integral Whole Blood Leukocyte Reduction Filter (Removing Platelets) with Diversion Blood Sampling Arm Anticoagulant Citrate Phosphate Dextrose (CPD) AND OPTISOL (AS-5) Red Cell Preservative SUEROLYTE Oral Electrolyte Solution Orange Flavor Ionosol B and Dextrose Cpd/adsol Cpda-1 MTL1 Leucoflex TERUFLEX Blood Bag System with Blood Sampling Arm Anticoagulant Citrate Phosphate Dextrose (CPD) AND OPTISOL (AS-5) Red Cell Preservative Theophylline in Dextrose TERUFLEX Blood Bag System with Diversion Blood Sampling Arm Anticoagulant Citrate Phosphate Dextrose (CPD) AND OPTISOL (AS-5) Red Cell Preservative Prismasol Bgk2/0 25% Dextrose Infant Cpd Plasma-lyte 56 and Dextrose SUEROLYTE Oral Electrolyte Solution Tropical Fruits Flavor Hemosol Lg2 50% Dextrose Nutricel Additive System - CP2D Dextrose in Lactated Ringers Anticoagulant Citrate Dextrose (ACD-A) SUEROLYTE Oral Electrolyte Solution Mango Flavor SUEROLYTE Oral Electrolyte Solution Bubbe Gum Flavor Dextrose in Ringers Dopamine Hydrochloride in Dextrose Isolyte P in Dextrose Potassium Chloride in Dextrose Plasma-Lyte 148 and dextrose Anticoagulant Citrate Dextrose A ACD-A Prismasol 4 Delflex Prismasol Bgk0/2.5 Glucose 5% Dextrose Injection Dextrose and Sodium Chloride Potassium Chloride in Dextrose and Sodium Chloride SUEROLYTE Oral Electrolyte Solution Horchate Flavor CPD/ADSOL Red Cell Preservation Solution System (PL 2209) SUEROLYTE Oral Electrolyte Solution Lemon-Lime Flavor ADSOL Red Cell Preservation Solution System in Plastic Container (PL 146 Plastic) Dobutamine Hydrochloride in Dextrose DIANEAL Low Calcium with Dextrose Kabiven
Indication	Glucose pharmaceutical formulations (oral tablets, injections) are indicated for caloric supply and carbohydrate supplementation in case of nutrient deprivation. It is also used for metabolic disorders such as hypoglycemia.[L787]
Categories	Carbohydrates Compounds used in a research, industrial, or household setting Diet, Food, and Nutrition Flavoring Agents Food Food Additives Food Ingredients Glucose Hexoses Monosaccharides Pharmaceutic Aids Pharmaceutical Preparations Physiological Phenomena Sweetening Agents
CAS number	50-99-7

Drug Targets

Name	Target Sequence	Pharmacological Action	Actions
Hexokinase-1	MIAAQLLAYYFTELKDDQVKKIDKYLYAMRLSDETLIDIMTRFRKEMKNG...	unknown	substrate
Glucokinase	MLDDRARMEAAKKEKVEQILAEFQLQEEDLKKVMRRMQKEMDRGLRLETH...	unknown	substrate
Serum albumin	MKWVTFISLLFLFSSAYSRGVFRRDAHKSEVAHRFKDLGEENFKALVLIA...	unknown	binder
Solute carrier family 2, facilitated glucose transporter member 1	MEPSSKKLTGRLMLAVGGAVLGSLQFGYNTGVINAPQKVIEEFYNQTWVH...	unknown	substrate
Solute carrier family 2, facilitated glucose transporter member 2	MTEDKVTGTLVFTVITAVLGSFQFGYDIGVINAPQQVIISHYRHVLGVPL...	unknown	substrate
Solute carrier family 2, facilitated glucose transporter member 3	MGTQKVTPALIFAITVATIGSFQFGYNTGVINAPEKIIKEFINKTLTDKG...	unknown	substrate
Solute carrier family 2, facilitated glucose transporter member 4	MPSGFQQIGSEDGEPPQQRVTGTLVLAVFSAVLGSLQFGYNIGVINAPQK...	unknown	substrate
Solute carrier family 2, facilitated glucose transporter member 5	MEQQDQSMKEGRLTLVLALATLIAAFGSSFQYGYNVAAVNSPALLMQQFY...	unknown	substrate
Solute carrier family 2, facilitated glucose transporter member 6	MQEPLLGAEGPDYDTFPEKPPPSPGDRARVGTLQNKRVFLATFAAVLGNF...	unknown	substrate
Solute carrier family 2, facilitated glucose transporter member 7	MENKEAGTPPPIPSREGRLQPTLLLATLSAAFGSAFQYGYNLSVVNTPHK...	unknown	substrate
Solute carrier family 2, facilitated glucose transporter member 8	MTPEDPEETQPLLGPPGGSAPRGRRVFLAAFAAALGPLSFGFALGYSSPA...	unknown	substrate
Solute carrier family 2, facilitated glucose transporter member 9	MARKQNRNSKELGLVPLTDDTSHAGPPGPGRALLECDHLRSGVPGGRRRK...	unknown	substrate
Solute carrier family 2, facilitated glucose transporter member 10	MGHSPPVLPLCASVSLLGGLTFGYELAVISGALLPLQLDFGLSCLEQEFL...	unknown	substrate
Solute carrier family 2, facilitated glucose transporter member 11	MRALRRLIQGRILLLTICAAGIGGTFQFGYNLSIINAPTLHIQEFTNETW...	unknown	substrate
Solute carrier family 2, facilitated glucose transporter member 12	MVPVENTEGPSLLNQKGTAVETEGSGSRHPPWARGCGMFTFLSSVTAAVS...	unknown	substrate
Sodium/glucose cotransporter 1	MDSSTWSPKTTAVTRPVETHELIRNAADISIIVIYFVVVMAVGLWAMFST...	unknown	substrate
Sodium/glucose cotransporter 2	MEEHTEAGSAPEMGAQKALIDNPADILVIAAYFLLVIGVGLWSMCRTNRG...	unknown	substrate
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Drug Info/Drug Targets: DrugBank 3.0: a comprehensive resource for 'omics' research on drugs. Knox C, Law V, Jewison T, Liu P, Ly S, Frolkis A, Pon A, Banco K, Mak C, Neveu V, Djoumbou Y, Eisner R, Guo AC, Wishart DS. Nucleic Acids Res. 2011 Jan; 39 (Database issue):D1035-41. | PMID:21059682