FOK

FORSKOLIN

Created: 1999-07-08
Last modified:  2011-06-04

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Chemical Details

Formal Charge0
Atom Count63
Chiral Atom Count8
Bond Count65
Aromatic Bond Count0
2D diagram of FOK
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Chemical Component Summary

NameFORSKOLIN
Systematic Name (OpenEye OEToolkits)[(3R,4aR,5S,6S,6aS,10S,10aR,10bS)-3-ethenyl-6,10,10b-trihydroxy-3,4a,7,7,10a-pentamethyl-1-oxo-5,6,6a,8,9,10-hexahydro-2H-benzo[f]chromen-5-yl] ethanoate
FormulaC22 H34 O7
Molecular Weight410.501
TypeNON-POLYMER

Chemical Descriptors

TypeProgram Version Descriptor
SMILESACDLabs10.04O=C2CC(OC3(C(OC(=O)C)C(O)C1C(CCC(O)C1(C)C23O)(C)C)C)(\C=C)C
SMILESCACTVS3.341CC(=O)O[CH]1[CH](O)[CH]2C(C)(C)CC[CH](O)[C]2(C)[C]3(O)C(=O)C[C](C)(O[C]13C)C=C
SMILESOpenEye OEToolkits1.5.0CC(=O)OC1C(C2C(CCC(C2(C3(C1(OC(CC3=O)(C)C=C)C)O)C)O)(C)C)O
Canonical SMILESCACTVS3.341 CC(=O)O[C@H]1[C@@H](O)[C@H]2C(C)(C)CC[C@H](O)[C@]2(C)[C@@]3(O)C(=O)C[C@@](C)(O[C@]13C)C=C
Canonical SMILESOpenEye OEToolkits1.5.0 CC(=O)O[C@H]1[C@H]([C@H]2C(CC[C@@H]([C@@]2([C@@]3([C@@]1(O[C@@](CC3=O)(C)C=C)C)O)C)O)(C)C)O
InChIInChI1.03 InChI=1S/C22H34O7/c1-8-19(5)11-14(25)22(27)20(6)13(24)9-10-18(3,4)16(20)15(26)17(28-12(2)23)21(22,7)29-19/h8,13,15-17,24,26-27H,1,9-11H2,2-7H3/t13-,15-,16-,17-,19-,20-,21+,22-/m0/s1
InChIKeyInChI1.03 OHCQJHSOBUTRHG-KGGHGJDLSA-N

Drug Info: DrugBank

DrugBank IDDB02587 
NameColforsin
Groups
  • experimental
  • investigational
DescriptionPotent activator of the adenylate cyclase system and the biosynthesis of cyclic AMP. From the plant Coleus forskohlii. Has antihypertensive, positive inotropic, platelet aggregation inhibitory, and smooth muscle relaxant activities; also lowers intraocular pressure and promotes release of hormones from the pituitary gland.
Synonyms
  • 7β-acetoxy-8,13-epoxy-1α,6β,9α-trihydroxylabd-14-en-11-one
  • Colforsin
  • colforsina
  • Coleonolk
  • Forskolin
Categories
  • Adjuvants, Immunologic
  • Anti-Asthmatic Agents
  • Autonomic Agents
  • Bronchodilator Agents
  • Cardiotonic Agents
CAS number66575-29-9

Drug Targets

NameTarget SequencePharmacological ActionActions
Adenylate cyclase type 2MWQEAMRRRRYLRDRSEEAAGGGDGLPRSRDWLYESYYCMSQQHPLIVFL...unknown
Guanine nucleotide-binding protein G(s) subunit alpha isoforms shortMGCLGNSKTEDQRNEEKAQREANKKIEKQLQKDKQVYRATHRLLLLGAGE...unknown
Adenylate cyclase type 5MSGSKSVSPPGYAAQKTAAPAPRGGPEHRSAWGEADSRANGYPHAPGGSA...unknown
Cystic fibrosis transmembrane conductance regulatorMQRSPLEKASVVSKLFFSWTRPILRKGYRQRLELSDIYQIPSVDSADNLS...unknowninhibitor
Adenylate cyclaseMAGAPRGGGGGGGGAGEPGGAERAAGTSRRRGLRACDEEFACPELEALFR...unknownactivator
View More
Drug Info/Drug Targets: DrugBank 3.0: a comprehensive resource for 'omics' research on drugs. Knox C, Law V, Jewison T, Liu P, Ly S, Frolkis A, Pon A, Banco K, Mak C, Neveu V, Djoumbou Y, Eisner R, Guo AC, Wishart DS. Nucleic Acids Res. 2011 Jan; 39 (Database issue):D1035-41. | PMID:21059682

Related Resource References

Resource NameReference
Pharos CHEMBL52606
PubChem 47936
ChEMBL CHEMBL52606
ChEBI CHEBI:42471
CCDC/CSD FRSKLN02