CL6

1-[(2-CHLOROPHENYL)(DIPHENYL)METHYL]-1H-IMIDAZOLE

Created:	2006-10-26
Last modified:	2021-03-01

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9 entries where CL6 is found as a standalone ligand

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Chemical Details
Formal Charge	0
Atom Count	42
Chiral Atom Count	0
Bond Count	45
Aromatic Bond Count	23

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Chemical Component Summary
Name	1-[(2-CHLOROPHENYL)(DIPHENYL)METHYL]-1H-IMIDAZOLE
Synonyms	CLOTRIMAZOLE
Systematic Name (OpenEye OEToolkits)	1-[(2-chlorophenyl)-diphenyl-methyl]imidazole
Formula	C₂₂ H₁₇ Cl N₂
Molecular Weight	344.837
Type	NON-POLYMER

Chemical Descriptors
Type	Program	Version	Descriptor
SMILES	ACDLabs	10.04	Clc1ccccc1C(c2ccccc2)(c3ccccc3)n4ccnc4
SMILES	CACTVS	3.341	Clc1ccccc1C(n2ccnc2)(c3ccccc3)c4ccccc4
SMILES	OpenEye OEToolkits	1.5.0	c1ccc(cc1)C(c2ccccc2)(c3ccccc3Cl)n4ccnc4
Canonical SMILES	CACTVS	3.341	Clc1ccccc1C(n2ccnc2)(c3ccccc3)c4ccccc4
Canonical SMILES	OpenEye OEToolkits	1.5.0	c1ccc(cc1)C(c2ccccc2)(c3ccccc3Cl)n4ccnc4
InChI	InChI	1.03	InChI=1S/C22H17ClN2/c23-21-14-8-7-13-20(21)22(25-16-15-24-17-25,18-9-3-1-4-10-18)19-11-5-2-6-12-19/h1-17H
InChIKey	InChI	1.03	VNFPBHJOKIVQEB-UHFFFAOYSA-N

Drug Info: DrugBank

DrugBank ID	DB00257
Name	Clotrimazole
Groups	approved vet_approved
Description	This drug is a broad spectrum antimycotic or antifungal agent. Clotrimazole's antimycotic properties were discovered in the late 1960s [A174094]. Clotrimazole falls under the _imidazole_ category of _azole_ antifungals, possessing broad-spectrum antimycotic activity [A174094]. It is available in various preparations, including creams, pessaries, and troche formulations (slowly dissolving tablets). As well as its antifungal activity, clotrimazole has become a drug of interest in treating several other diseases such as sickle cell disease, malaria and some cancers [A174094]. The minimal side effect profile of this drug and its uncomplicated metabolic profile have led it to gain widespread acceptance for the treatment of mycotic outbreaks such as vaginal yeast infections as well as athlete's foot [A174097].
Synonyms	1-((2-Chlorophenyl)diphenylmethyl)-1H-imidazole 1-(o-Chlorotrityl)imidazole 1-(o-Chloro-α,α-diphenylbenzyl)imidazole Clotrimazol Clotrimazole 1-(α-(2-Chlorophenyl)benzhydryl)imidazole Clotrimazolum
Brand Names	Canesten External Cream MakeSense TopCare Clotrimazole 3 Akin Anti-fungal Canesten 1 Day Internal Cream Canesten 100mg Vaginal Inserts Terrasil Rapid-Clear Anti-Fungal Canesten Combi-pak 1 Day Therapy Clotrimaderm Vaginal 3 Clotrimazole Antifungal Clotrimazole and Betamethasone Dipropionate Up and Up Jock Itch Relief Fungicure Intensive WinCo Antifungal Gerlasan Hand meijer Clotrimazole 3 Pedesil Canesten 1 Vaginal Tablet Combi-pak First Aid Research Antifungal Cream 1oz TM-Clotrimazole PRO-EX Anti Fungal Clotrimazole Vaginal 6 Oheal Ringworm Cream Thera plus Antifungal Clotrimazole sunmark Clotrimazole 3 Fungistat Max Signature Care Antifungal Clotrimazol Canesoral Combi Dr Sheffield Athletes Foot Walgreens Clotrimazole CAREONE Clotrimazole Canesten 3 Vaginal Tablet Combi-pak Jock Itch Antifungal Rexall Jock Itch S-Cream CLOTRIMAZOLE Cream 1% PMS-clotrimazole-betamethasone Ringworm Au Kah Chuen Antifungal Major Clotrimazole Athlete Foot Cream with Clotrimazole Athlete s Foot Afac Pedesil Maximum Strength Canesten Extra Strength External Antifungal Cream Good Neighbor Pharmacy Clotrimazole Protective Nail and skin Terrasil Anti-Fungal Treatment MAX Protective and Moisturizing Skin Kroger ATHLETES FOOT Goodsense Athletes Foot Forticept Antifungal Foot Cream Jock Itch Clotrimazole Antifungal Lucky SuperSoft Athletes Foot PerfectHeal Antifungal Canesten 200 Mg Vaginal Inserts Neo-zol Cream 1% Terrasil Jock Itch Treatment Maximum Strength Jock Itch Olp Clotrimazole Clotrimazol Dual 1MED Clotrimazole 1% Antifungal Cream Skin Repair Fungicure Manicure Pedicure Liquid Gel Astonea Clotrimazole 1% Athletes Foot meijer Athletes Foot Terrasil Anti-Fungal Treatment Anti-Fungal Terrasil Tinea Treatment Maximum Strength Forticept Antifungal Cooling TerrasilMed ANTIFUNGAL Canesten 1% Topical Solution Clotrimazole Topical Solution 1% Fungicure Pumpspray Rugby Clotrimazole Antifungal Cream Clotrimazole Topical Solution USP, 1% Family Wellness Clotrimazole 1 Anti Fungal Cream Canesten Crm 1% Top Lotrimin Quality Choice Athletes Foot Sunmark Clotrimazole Signature Care Jock Itch Walgreens Jock Itch Shield and Protect Anti-Fungal Taro-clotrimazole/betamethasone Dipropionate CVS Pharmacy ITCH RELIEF ANTIFUNGAL Signature Care Athletes Foot Budpak Antifungal Clotrimazole Clotrimazole-fluconazole Combi ShopRite antifungal CVS Clotrimazole Maximum Strength Clotrimazole 1% Topical Antifungal Cream Clotrimazole Jock Itch Occulus SKIN HYDRATING TOPICAL FOAM CLO-1 ANTIFUNGAL FOAM Our Family Athletes Foot Jock-eze Canesten Combi 1 Day Votriza-AL Walgreens Clotrimazole 3 Terrasil Ringworm Treatment MAX Myclo-gyne Inserts Mycozyl AC Myclo Tab 100mg Terrasil Jock-Itch Treatment MAX Scheinpharm Clotrimazole 1% Gyne-Lotrimin 7 Clotrimaderm Topical Solution 1% USP Clotrimazole External Cream Healthy Accents Antifungal Smart Sense Athletes Foot Antifungal Walgreens Clotrimazole Antifungal UpandUp Clotrimazole Canesten Combi 1 Day Internal + External Creams Clotrimazole Athletes Foot Leader Clotrimazole Anti-Fungal Terbinafine HCl Chlortimazole and Tolnaftate Clotrimazole Cream 1% Good Neighbor Pharmacy Clotrimazole 3 Foot Care Clotrimazole Rexall Athletes Foot Good Sense Athletes Foot antifungal Best Choice Clotrimazole Gehwol Fusskraft Nail and Skin Protection Clotrimazole External Antifungal Cream Quality Choice Clotrimazole Equaline Antifungal Cream Gyne-Lotrimin 3 Lotrimin Antifungal Aspiera Anti-Fungal Athletes Foot Kroger Jock Itch Antifungal Foot Clotrimazole Vaginal 3 Family Care Clotrimazole Anti-Fungal Cream 1% TheraPlus Plus Clotrimaderm Vaginal 6 Terrasil Tinea Treatment MAX Fortinia Publix athletic foot Fungicure Manicure Pedicure Anti Fungal Zapotol Clotrimazole Occulus Skin Hydrating Topical Foam CLO-1 Soothing Antifungal Cream Clotrimaderm External Cream CVSHealth Antifungal DermacinRx Therazole Pak Gehwol Nail Protection Pen Anti Fungal Atopalm Clotrimazole Antifungal Meijer Clotrimazole Antifungal WinCo Foods Antifungal Mycelex CAREALL Clotrimazole CVS Antifungal Ringworm First Aid Research Antifungal .5oz Fungicure Liquid Gel Jock Itch Cream with Clotrimazole Myclo-derm Solution 1% Cura Hongo Antifungal TopCare Antifungal Neo-zol Vaginal Cream 2% Extra Strength Clotrimazole Extra Fort -fluconazole Combi Fastrin Anti - Fungal Skin Care Kleer-Plex Fungistat Athlete Foot Cure Clotrimazole 1% Athletes Foot Canesten Combi 1 Day Comfortab + Extra Strength External Cream Forticept Antifungal Foot Gel Oheal Manuka Honey Eczema Cream Family Wellness Antifungal Myclo Crm 50mg Fortinia OF Family Care Antifungal Gehwol med Foot Canesten Comfortab 3 Kerasal foot and toe Athletes Foot Antifungal Antifungal Dynarex Antifungal Clotrimazole Topical Myclo Crm 10mg Terrasil Antifungal Cream Maximum Strength Antifungal Cream Myclo Solution Rite Aid antifungal ringworm Terrasil Foot and Nail Anti-Fungal Maximum Strength Clotrimazole Extra Strength External Antifungal Cream Family Care Clotrimazole Antifungal Clotrimaderm Topical Canesten Comfortab 1 Desenex SoundBody Clotrimazole Antifungal Up and Up Athletes Foot Canesten 6 Day Internal Cream Footlogix Intensive Care Diabetic Formula Botanimedix TineaRX Antifungal Drying Emulsion Blossom Pharmaceuticals Antifungal ClotrimazOil Antifungal Smooth Gator Fungus Eliminator Micotrin AC SIMPLY VITAL Antifungal Cream Canesten Crm 1% Vag Lakesia Terrasil JockItch Treatment Maximum Strength Equate Jock Itch Hua Tuo Xian Gao Antifungal Western Family Athletes Foot Clotrimazole JiDeSheng Clotrimazole/Betameth Equaline Clotrimazole Antifungal Meijer Athletes Foot Cream AF CVS Pharmacy Clotrimazole 3 Dermatin Antifungal Myclo-derm Cream 1% Myclo-gyne Cream 1% Kleer-Plex Fungistat Fungus Cure Terrasil Foot and Nail Anti-Fungal Canesten 3 Day Internal Cream Canesten 1% Topical Cream Neo-zol Vaginal Cream 1% Silka Ringworm Canesten V Leader Athletes Foot Clotrimazole Footlogix Canesten Liq 1% Hua Tuo Xian Gao Lotriderm Terrasil Anti-fungal Treatment Antifungal Topcare Athletes Foot Canesoral Combi 1 Day Clotrimaderm-fluconazole Combi-pack Shopko Athletes Foot Ciclomazole Clotrimazole 1% Anti-Fungal Cream Fungicure Manicure Pedicure Terrasil Athletes Foot AntiFungal Treatment Max FungaZoil Advanced Rugby Antifungal Clotrimazole Betamethasone Clotrimazole HEB Antifungal Live Better Antifungal Femmesil Alevazol Canesten 2% Vaginal Cream Canesten Combi 3 Day Canesten External Antifungal Cream Lotrisone Canesten Vaginal Inserts 100mg Aptrimazole 1.0% Antifungal Cream Exchange Select Atheletes foot
Indication	Topical preparations Clotrimazole topical cream is indicated for the topical treatment of the following dermal infections [F3088], [F3121]: Tinea pedis, tinea cruris, and tinea corporis due to _Trichophyton rubrum_, _Trichophyton mentagrophytes_, _Epidermophyton floccosum_ Candidiasis due to _Candida albicans_ Tinea versicolor due to _Malassezia furfur_ Diaper rash infected by _Candida albicans_ In some preparations, clotrimazole may be combined with betamethasone dipropionate, a corticosteroid [F3121]. Oral preparations The oral troche preparation is indicated for the local treatment of oropharyngeal candidiasis [FDA label]. It is also indicated as a prophylactic drug to reduce the incidence of oropharyngeal candidiasis in patients immunocompromised by conditions such as chemotherapy, radiotherapy, or steroid therapy utilized in the treatment of leukemia, solid tumors, or renal transplantation [FDA label]. Troche preparations are not indicated for the treatment of any systemic mycoses [FDA label].
Categories	Anti-Infective Agents Anti-Infective Agents, Local Antifungal Agents Antifungal Agents (Vaginal) Antifungals for Dermatological Use Antifungals for Topical Use Antiinfectives and Antiseptics for Local Oral Treatment Azole Antifungals BSEP/ABCB11 Inhibitors BSEP/ABCB11 Substrates Cytochrome P-450 CYP2A6 Inhibitors Cytochrome P-450 CYP2A6 Inhibitors (strong) Cytochrome P-450 CYP2B6 Inducers Cytochrome P-450 CYP2B6 Inducers (strength unknown) Cytochrome P-450 CYP2B6 Inhibitors Cytochrome P-450 CYP2B6 Inhibitors (strong) Cytochrome P-450 CYP2C8 Inhibitors Cytochrome P-450 CYP2C8 Inhibitors (moderate) Cytochrome P-450 CYP2C8 Inhibitors (strong) Cytochrome P-450 CYP2C9 Inhibitors Cytochrome P-450 CYP2C9 Inhibitors (moderate) Cytochrome P-450 CYP2C9 Inhibitors (strong) Cytochrome P-450 CYP2D6 Inhibitors Cytochrome P-450 CYP2D6 Inhibitors (moderate) Cytochrome P-450 CYP2E1 Inhibitors Cytochrome P-450 CYP2E1 Inhibitors (moderate) Cytochrome P-450 CYP3A Inducers Cytochrome P-450 CYP3A Inducers (strong) Cytochrome P-450 CYP3A Inhibitors Cytochrome P-450 CYP3A Substrates Cytochrome P-450 CYP3A4 Inducers Cytochrome P-450 CYP3A4 Inducers (strength unknown) Cytochrome P-450 CYP3A4 Inhibitors Cytochrome P-450 CYP3A4 Inhibitors (strength unknown) Cytochrome P-450 CYP3A4 Substrates Cytochrome P-450 CYP3A7 Inducers Cytochrome P-450 CYP3A7 Inducers (strong) Cytochrome P-450 CYP3A7 Inducers (weak) Cytochrome P-450 Enzyme Inducers Cytochrome P-450 Enzyme Inhibitors Cytochrome P-450 Substrates Dermatologicals Enzyme Inhibitors Gynecological Antiinfectives and Antiseptics Hormone Antagonists Hormones, Hormone Substitutes, and Hormone Antagonists Imidazole and Triazole Derivatives Imidazole Derivatives Imidazoles OATP1B1/SLCO1B1 Inhibitors OATP1B1/SLCO1B1 Substrates OATP1B3 inducers P-glycoprotein inducers P-glycoprotein inhibitors P-glycoprotein substrates Steroid Synthesis Inhibitors Stomatological Preparations
ATC-Code	D01AC01 A01AB18 G01AF02 G01AF20
CAS number	23593-75-1

Drug Targets

Name	Target Sequence	Pharmacological Action	Actions
Cytochrome P450 51	MAIVETVIDGINYFLSLSVTQQISILLGVPFVYNLVWQYLYSLRKDRAPL...	unknown	antagonist,inhibitor
Intermediate conductance calcium-activated potassium channel protein 4	MGGDLVLGLGALRRRKRLLEQEKSLAGWALVLAGTGIGLMVLHAEMLWFG...	unknown	inhibitor
Ergosterol	-	unknown	inhibitor
Nuclear receptor subfamily 1 group I member 2	MEVRPKESWNHADFVHCEDTESVPGKPSVNADEEVGGPQICRVCGDKATG...	unknown	activator
Hydroxycarboxylic acid receptor 2	MNRHHLQDHFLEIDKKNCCVFRDDFIVKVLPPVLGLEFIFGLLGNGLALW...	unknown	partial agonist
Cytochrome P450 2C8	MEPFVVLVLCLSFMLLFSLWRQSCRRRKLPPGPTPLPIIGNMLQIDVKDI...	unknown	inhibitor
Cytochrome P450 3A4	MALIPDLAMETWLLLAVSLVLLYLYGTHSHGLFKKLGIPGPTPLPFLGNI...	unknown	substrate,inhibitor,inducer
Cytochrome P450 2B6	MELSVLLFLALLTGLLLLLVQRHPNTHDRLPPGPRPLPLLGNLLQMDRRG...	unknown	inhibitor,inducer
Cytochrome P450 2D6	MGLEALVPLAVIVAIFLLLVDLMHRRQRWAARYPPGPLPLPGLGNLLHVD...	unknown	inhibitor
Cytochrome P450 2A6	MLASGMLLVALLVCLTVMVLMSVWQQRKSKGKLPPGPTPLPFIGNYLQLN...	unknown	inhibitor
Cytochrome P450 2C9	MDSLVVLVLCLSCLLLLSLWRQSSGRGKLPPGPTPLPVIGNILQIGIKDI...	unknown	inhibitor
Cytochrome P450 2E1	MSALGVTVALLVWAAFLLLVSMWRQVHSSWNLPPGPFPLPIIGNLFQLEL...	unknown	inhibitor
Cytochrome P450 3A7	MDLIPNLAVETWLLLAVSLILLYLYGTRTHGLFKKLGIPGPTPLPFLGNA...	unknown	inducer
P-glycoprotein 1	MDLEGDRNGGAKKKNFFKLNNKSEKDKKEKKPTVSVFSMFRYSNWLDKLY...	unknown	inhibitor,inducer
Bile salt export pump	MSDSVILRSIKKFGEENDGFESDKSYNNDKKSRLQDEKKGDGVRVGFFQL...	unknown	substrate,inhibitor
Solute carrier organic anion transporter family member 1B1	MDQNQHLNKTAEAQPSENKKTRYCNGLKMFLAALSLSFIAKTLGAIIMKS...	unknown	substrate,inhibitor
Solute carrier organic anion transporter family member 1B3	MDQHQHLNKTAESASSEKKKTRRCNGFKMFLAALSFSYIAKALGGIIMKI...	unknown	inducer
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Drug Info/Drug Targets: DrugBank 3.0: a comprehensive resource for 'omics' research on drugs. Knox C, Law V, Jewison T, Liu P, Ly S, Frolkis A, Pon A, Banco K, Mak C, Neveu V, Djoumbou Y, Eisner R, Guo AC, Wishart DS. Nucleic Acids Res. 2011 Jan; 39 (Database issue):D1035-41. | PMID:21059682