AIN

2-(ACETYLOXY)BENZOIC ACID

Created:	2004-04-08
Last modified:	2020-05-26

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Chemical Details
Formal Charge	0
Atom Count	21
Chiral Atom Count	0
Bond Count	21
Aromatic Bond Count	6

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Chemical Component Summary
Name	2-(ACETYLOXY)BENZOIC ACID
Synonyms	ACETYLSALICYLIC ACID; ASPIRIN
Systematic Name (OpenEye OEToolkits)	2-acetyloxybenzoic acid
Formula	C₉ H₈ O₄
Molecular Weight	180.157
Type	NON-POLYMER

Chemical Descriptors
Type	Program	Version	Descriptor
SMILES	ACDLabs	10.04	O=C(Oc1ccccc1C(=O)O)C
SMILES	CACTVS	3.341	CC(=O)Oc1ccccc1C(O)=O
SMILES	OpenEye OEToolkits	1.5.0	CC(=O)Oc1ccccc1C(=O)O
Canonical SMILES	CACTVS	3.341	CC(=O)Oc1ccccc1C(O)=O
Canonical SMILES	OpenEye OEToolkits	1.5.0	CC(=O)Oc1ccccc1C(=O)O
InChI	InChI	1.03	InChI=1S/C9H8O4/c1-6(10)13-8-5-3-2-4-7(8)9(11)12/h2-5H,1H3,(H,11,12)
InChIKey	InChI	1.03	BSYNRYMUTXBXSQ-UHFFFAOYSA-N

Drug Info: DrugBank

DrugBank ID	DB00945
Name	Acetylsalicylic acid
Groups	approved vet_approved
Description	Also known as _Aspirin_, acetylsalicylic acid (ASA) is a commonly used drug for the treatment of pain and fever due to various causes. Acetylsalicylic acid has both anti-inflammatory and antipyretic effects. This drug also inhibits platelet aggregation and is used in the prevention of blood clots stroke, and myocardial infarction (MI) [FDA label]. Interestingly, the results of various studies have demonstrated that long-term use of acetylsalicylic acid may decrease the risk of various cancers, including colorectal, esophageal, breast, lung, prostate, liver and skin cancer [A177325]. Aspirin is classified as a _non-selective cyclooxygenase (COX) inhibitor_ [A32682, A177268] and is available in many doses and forms, including chewable tablets, suppositories, extended release formulations, and others [L5968]. Acetylsalicylic acid is a very common cause of accidental poisoning in young children. It should be kept out of reach from young children, toddlers, and infants [FDA label].
Synonyms	Lysine acetylsalicylate 2-Acetoxybenzoic acid o-acetoxybenzoic acid acide 2-(acétyloxy)benzoïque Acetylsalicylate ASA Salicylic acid acetate Acetylsalicylsäure O-acetylsalicylic acid Aspirina 2-Acetoxybenzenecarboxylic acid Polopiryna ácido acetilsalicílico Acide acétylsalicylique Acidum acetylsalicylicum Azetylsalizylsäure o-carboxyphenyl acetate Acetylsalicylic acid Aspirin
Brand Names	Alka-Seltzer Plus Cold and Cough Acetylsalicylic Acid, Caffeine and 8 Mg Codeine Phosphate Aspirin 325mg Bayer Low Dose Physicians Care Extra Strength Pain Reliever Bayer Plus Extra Strength Asa 325 Mg Tablets Regular Strength Acido Acetilsalicilico With enteric coat Coricidin Nd Tab Acetaminophen, Aspirin, Caffeine Asa 975 Tab Acetaminophen Aspirin and Caffeine Calmine Tab Genuine First Aid Industrial First Aid Handy Solutions GENUINE ASPIRIN BAYER HyVee Health Effervescent Cold Relief Aspirin Low Dose Safety Coated MEDI-FIRST Aspirin Asa-650 Comprimes Retard Asaphen EC Medique Pain Off ASPIRIN Regular Strength Aspirin Regular Strength Regular Strength 4211 First Aid Kit Acetylsalicylic Acid A.S.A. Tablets 325mg Right Remedies Aspirin Low Dose 81 mg Bromo Seltzer Sunmark Adult Aspirin Acetylsalicylic Acid Tab 300mg Adventure Medical Kits 1-2 Person First Aid Alka Seltzer Plus 2s Blister Pack 4246 First Aid Kit Natural Aspirin plus Lemon and Honey Dietary Supplement Dg Health Headache Relief Added Strength Sunmark Aspirin Adult Low Strength FIRST AID Contains 101 PIECES Alka-Seltzer Plus Multi-Symptom Cold Day and Night Chewable Adult Low Dose Aspirin Family Wellness Migraine Relief Extra Strength Aspirin Alka-seltzer Flavoured Aspirin Stomach Guard Regular Strength Headache Relief PM Regular Strength Asa Headache Tab 300mg Aspirin Granules Lil Drug Store Headache Relief Extra Strength Publix Super Markets Inc Super Extra Strength Aspirin Backache Up and Up Chewable Aspirin Walgreens Antacid Pain Relief Extra Strength Novo Ac and C 8mg Tab Value PharmaPain Reliever Extra Strength CVS Health Medication and Topical Refill Pouch 4221 First Aid Kit Health Mart Aspirin Novasen Drug Mart Effervescent Pain Relief Duoplavin Alka-Seltzer Plus Cold Day and Night Extra Strength Headach Relief Lowprin Aspirin Low Dose Sugar Free Excedrin PM Triple Action Caplets Equate Migraine Relief Meijer Effervescent Antacid and Pain Relief 4388 First Aid Kit Enteric Coated Aspirin Regular Strength 4228 First Aid Kit Publix Fast Relief Effervescent Madelon Acetylsalicylic Acid Tab 325mg BP Walmart Pain Relief Powder Ag-asa Chew Aspirin Leader Low Dose Aspirin K-Mart SmartSense First Aid Contains 101 Pieces Aspirin Low Strength Adult Alka Seltzer Flavoured Jamp-asa Chew Family Wellness Migraine Pain Stoppers EX Neutra-seltzer 4340 First Aid Kit Sunmark Aspirin Asa Tab 325mg Relief Asa Extra Strength Goodys PM Pain Reliever Asa Suppositories 150mg 4356 First Aid Kit A.S.A. 80mg Acetylsalicylic Acid Tablets Ecotrin 4376 First Aid Kit Asa EC 80 Aspirin 81mg Enteric coated Delayed Release Enteric Coated Aspirin Dg Health Aspirin Halfprin Low Dose Aspirin Adult Low Dose Enteric Coated Aspirin Pain Relief Added Strength PMS-pharnal-C1/2 Capsules Family Wellness Effervescent Cold Relief Original Xpect Pain Away Extra Strength Aspirin With Stomach Guard Extra Strength - Tab ACME FIRST AID Contains 404 PIECES Acetylsalicylic Acid Tab 325mg Aspirin E-C Low Dose Safety Coated Acetaminophen 250mg Aspirin 250mg Caffeine 65mg 4154 First Aid Kit Pain Relief Aspirin 10 Person ANSI Aspirin Backache Genuine Aspirin Adult Low strength Aspirin Medi-First Plus Aspirin Neo Tigol Tab Extra Pain Reliever 4303 First Aid Kit Aspirin Adult Low Strength Aspirin Kirkland Signature Migraine Relief Bayer Womens Uline Aspirin Leader Headache Formula Added Strength Dr Pausins Low Dose Aspirin A.C. & C 8mg Tab Aspirin Enteric Coated, Regular Strength Effervescent Pain Relief Muscle Relaxant and Back Pain Relief Extra Strength Tablets Robaxisal C-1/8 Tablets Bufferin Regular Strength Pain Relief Durlaza Travel Savvy Aspirin Up and Up Aspirin Bc Cherry Aramark Pain Free Percodan Alka-Seltzer Plus Cold Night Sns-asa EC ASPIRIN Low Strength GOOD NEIGHBOR PHARMACY FIRST AID Contains 202 PIECES PMS-asa EC Aspirin Pain reliver Pain Stoppers Regular WinCo Foods Effervescent Cold Relief Pal-pravastatin-asa Headache Formula Added Strength Adult Low Dose 692 Tablet A.C.& C Tablets Antidol Tablets CVS All Purpose First Aid Kit Thrulife Extra Strength Headache Relief Aspirin Safety Coated Sunmark migraine relief Muscle and Back Pain Relief With Asa Extra Strength Alka-Seltzer Plus Cold Medicine Sparkling Original Enteric Coated A.S.a (caplet) Pain Reliever 4240 First Aid Kit Effervescent Cold Relief Lowprin 80mg Alka-seltzer Morning Relief Rexall Coated Daily Low Dose Asa Aspirin - Children's Size - Tablets Sunmark aspirin adult low strength Aspirin Rapid Relief Ascriptin Maximum Strength Buffered Aspirin Health Mart Migraine Formula BackAid Inflammatory Pain Formula Formu Care pain reliever added strength Walgreens Pain Relief Powder Good Neighbor Pharmacy Migraine Relief Aspirin Adult low dose Only For FIRST AID MEDICINE Rapidol Aspirin Yosprala Phenaphen No.3 Cap Seedalmerk Walgreens Effervescent Pain Relief Excedrin Menstrual Complete Flanax Aspirin Pain Reliever Buffered Aspirin Regular Strength C T Acetylsalicylic Acid Codeine and Caf Tab Bayer Aspirin Regimen Chewable Low Dose Aspirin Orange Low Dose Aspirin Low Dose Asa 80mg Ascomp with Codeine 4332 First Aid Kit FIRST AID Contains 1000 PIECES Medi First Pain Relief Fiorinal Aspirin Tablets 325mg Headache Relief Added Strength Orphenadrine Citrate Aspirin Caffeine Soma Muscle and Back Pain Relief With Asa Pronal C1/4 Capsules Coated Aspirin Low-dose Topcare Migraine Relief Asa Tablets USP 325 mg Leader Migraine Relief Entrophen 80mg Health Sense Aspirin 81 C2 Tab With Codeine Dolex Forte Asadol 325mg Excedrin Migraine, CVP HEALTH Genuine Bayer Aspirin Muscle Relaxant and Back Pain Relief Regular Strength Tablets Pamprin Max Menstrual Pain Relief Trianal C½ Extra Strength Muscle & Back Pain Asa 500 Mg Methocarbamol 400 Mg & Acetylsalicylic Acid 500 mg M-asa 80 Mg Croquable Splizz Pain Reliever - Grapefruit-flavored ALKA SELTZER PLUS Cold Day and Night Effervescent Aspirin and Dipyridamole Aspirin With Stomach Guard Kroger Value Aspirin Quality Choice Pain Relief Powder Bi Electro Extra Strength Biovanta Trip Action Tart Cherry and Honey Aspirin NSAID Circle K Headache Relief Alka-Seltzer XTRA STRENGTH Muscle & Back Pain Relief Extra Strength Equate Aspirin Chewable Robaxisal C 1/4 Vanquish Excedrin Extra Strength Extra Pain Relief Basic Care Aspirin Rugby Adult Aspirin Robaxisal Extra Strength Bufferin Top Value Effervescent Cold Relief Alka Seltzer Plus Cold Ru-21 Hangover Relief Medpurine 4249 First Aid Kit enteric coated aspirin Regular Strength Aspirin Enteric Safety-Coated Excinol Migraine (Acetaminophen) Pronal Capsules Robaxisal Caplets Meijer Effervescent Cold Relief Low Dose Chewable Aspirin Crane Safety Aspirin Goodys Extra Strength Alka-Seltzer Plus Cold Sparkling Original PowerFast Fizz Aspirin and Extended-release Dipyridamole Stanback Anacin ES Family Care Effervescent Antacid and Pain Relief 4032 First Aid Kit A.C. & C. 8mg Aspirin Enteric Coated Caplet 325mg Aspirin Regular Strength Safety Coated Aspirin 81 mg Low Dose Ready America First Aid Pocket - 33 Pieces Aspirin 5 grain CAREALL Aspirin PMS-asa Walgreens Effervescent Cold Relief Plus Alka-Seltzer Plus Severe Cold PowerFast Fizz Day and Night Fiorinal-C 1/4 Signature Care Aspirin Extra Strength Asa 500mg Novo-propoxyn Compound Cap Effervescent Antacid and Pain Relief Chronic Pain/Fever Relief BUTALBITAL, ASPIRIN, CAFFEINE and CODEINE PHOSPHATE Vida Mia Pain Relief Bayer Aspirin Regimen enteric coated Pro-aas - 80 (croquable) Sound Body Migraine Relief Euro Asa Splizz Pain Reliever - Orange-flavored Phenaphen No 3 Cap Valumeds Aspirin Extra Strength Headache Aspirin Pain Relief Alka-Seltzer Plus Night Cold Medicine Instantine - Tablets Biovanta Trip Action Green Apple and Honey A.S.A. 325 Mg Tablet Alka Seltzer Low Dose Miniprin Enteric Safety Coated 4389 First Aid Kit Blowfish Sunmark Aspirin Regular Strength Enteric Coated Asprin Low Dose Aspirin Low Dose Chewable Orange Bayer Back and Body Extra Strength Excedrin Extra Strength and Excedrin Tension Headache 4251 First Aid Kit Trianal Capsules 4313 First Aid Kit Alka Seltzer Originial 1s Blister Pack ARC FIRST AID Contains 101 PIECES Hardcase Enteric Safety Coated Aspirin Nervine Tab Rexall Aspirin Aspirin 81 MG Asa Ect 650mg Asa-caffeine-codeine BC Cherry Excedrin Extra Strength Geltabs PHL-asa E.C. GenCare Headache Relief ULINE Aspirin Safety Coated Aspirin 325 mg Regular Strength Buffered Aspirin Kirkland Signature Migraine Headache Relief Asa Acetylsalicylic Acid Anacin AF Low Dose Aspirin Chewable Medique Products Aspirin Methoxisal-C 1/2 HEALTH SENSE Adult Chewable Low Strength Aspirin Muscle and Back Pain Relief Aspirin 325 mg FIRST AID Contains 101 PIECES HARDCASE Axisal-C1/8 FIRST AID Contains 303 PIECES Good Sense Effervescent Cold Relief Solves - aspirin Cherry Low dose aspirin 81mg Alka-Seltzer Plus Severe Cold Night PowerFast Fizz A.S.A. Enteric Coated Tab 650mg Critical Care Aspirin to Go Asa 325mg Up and Up Migraine Relief Alka-Seltzer Plus Cold and Cough Formula Anacin Caplets Aspirin 81mg Quick Chews Aspirin Adult low strength Bayer Chewable - Aspirin Regimen Low Dose Aspirin Cherry Flavored SohMed Pain Reliever pain relief back and body EXTRA STRENGTH Bayer Fast Release Entrophen Ect 975mg Butalbital, Aspirin and Caffeine Low Strength Chewable Aspirin Acetylsalicylic Acid Extra Strength Stomach Protection 500mg Caplets 292 Tab Enteric Coated Asa Daily Low Dose Bayer Rapid Relief Regular Strength Aspirin EC Orphengesic Forte Medi First Plus Aspirin Aspirin Express Pack Aspergum 325 Mg (cherry) Excedrin Migraine 4230 First Aid Kit Leader Effervescent Antacid and Pain Relief Entrophen Chewable dihydrocodeine bitartrate and aspirin and caffeine DC Health Mart Adult Aspirin Rugby Aspirin Aspirin and Omeprazole Delayed-release Tab Alka-Seltzer Plus Cold Formula (Cherry Burst) Green Guard Pain and Ache Relief London Drugs Coated Daily Low-dose Asa Natural Aspirin plus Immune Supporting Dietary Supplement Methoxisal Extra Strength Muscle & Back Pain Asa 325 Mg Methocarbamol 400 Mg & Acetylsalicylic Acid 325 mg Quality Choice Effervescent Antacid and Pain Relief Value Pharma Aspirin Pain Reliever Teva-tecnal Bufferin Low Dose Buffered Aspirin Signature Care Migraine Relief Coryphen 325 Tab Low Dose Aspirin 81 mg Safety Coated Aspirin 325 Mg EC Asasantine Cap Headache Formula Extra Strength Phenaphen No.2 Cap Fasprin Alka Seltzer Evt Health Mart Migraine Relief Migraine Relief Rx Act headache formula added strength CVS Health Extra Strength Antacid and Pain Reliever Good Sense Headache Relief Basic Care Migraine Relief Pain Reliever Plus 4342 First Aid Kit 81 mg Low Dose Aspirin Top Value Effervescent Pain Relief Norgesic Forte Tab Asatab 80 Mg Chewable Tablets Dollar General Effervescent Cold Relief Acetylsalicylic Acid 325mg Tablets USP 4250 First Aid Kit St. Joseph Safety Coated Aspirin ENTERIC COATED ASPIRIN Regular Strength Alka-Seltzer Hangover Relief Aspirin 325 Dr. Juans Santo Remedio PARA LA ACIDEZ MEDIQUE Aspirin Asadol 650mg ASPIRIN Low Dose Aspirin Safety Coated Enteric, Regular Strength Synalgos Aspirin Thin coated Arthriten Max Midol Regular MYGRIN Nighttime Bufferin Extra -strength Rivacodan Norgesic Forte Butalbital, Aspirin, Caffeine and Codeine Phosphate Rapidol Aspirin Display 2x25 Kroger Effervescent Antacid and Pain Relief Ache and Pain Relief to Go Aspirin Enteric Safety Coated Aspirin Plus Stomach Guard Tab Natural Aspirin plus Tart Cherry Dietary Supplement Good Sense Migraine Formula Aspirin 81mg Family Wellness Pain Relief Powder Good Neighbor Pharmacy Aspirin Aspirin chewable low dose Pain Relief Maximum Strength Aspirin Safety Coated Adult Low Dose 7 Select Aspirin Trianal C¼ Up and Up Antacid and Pain Relief MooreBrand Aspirin Entrophen Chewable Aspirin Adult low dose Alka-Seltzer Plus Multi-Symptom Cold and Cough Circle K Headache Relief Extra Strength Crane Safety XS Pain Relief Alka-Seltzer Plus Cold Orange Zest Endodan Pain Aid ESF Acetylsalicylic Acid Extra Strength 500mg Tablets USP 4142 First Aid Kit Foster and Thrive Migraine Relief Smart Sense migraine relief Rivasa 80 Mg EC Reese Headache Powders Quality Choice Effervescent Cold Relief Plus Bayer Aspirin Coachs First Aid Contains 102 Pieces Oxycodone and Aspirin Pain Aid Equagesic Taro-dipyridamole/ Asa Teva-tecnal C 1/4 Pain Away Plus Enteric Coated Asa 325 mg Effervescent Cold Relief - Orange Cove Migraine Relief Handy Solutions Headache Pain Relief Muscle Relaxant and Analgesic Aramark Pain-Free Extra Strength Clopidogrel Kit Asa 500 Mg Tablets Extra Strength Quality Choice Effervescent Cold Relief - Orange Alka-seltzer Original 4395 First Aid Kit McKesson Aspirin Pain Relief Fast Relief Bayer Migraine Formula Regular Strength Aspirin ShopRite Aspirin Aspirin regular strength Chewable Daily Low Dose Asa Citramon Asa 80 Signature Care Effervescent Antacid and Pain Relief Teva-oxycodan Xpect Pain Away Chewable Aspirin pain relief aspirin Low Dose Excedrin Back and Body HyVee Health Effervescent Antacid and Pain Relief Biovanta Trip Action Lemon and Honey Headache Relief Extra Strength Ac and C Tab 1/8gr Aspirin Coated for Delayed Release Extra Strength Low dose Aspirin Aspirin Extra Strength Aspirin Chewable Tablets 325mg Pain Stoppers Euro Asa 325mg Chewable Tablet 7 Select Migraine Formula Dr. Waynes Aspirin Low Dose A.S.A. Tablets 5gr BP Adult Chewable Aspirin Only for Headache Picot Plus Effervescent Alka-seltzer Flavoured - Evt Alka-Seltzer Plus Severe Cold and Flu Biovanta Double Action Ag-asa EC 4209 First Aid Kit Alka-Seltzer Extra Strength ConRx pain Reliever GOODYS Hangover PMS-pharnal-C 1/4 Capsules Anacin Extra Strength Bayer PM Aspirin-dipyridamole Aspirin Plus Stomach Guard Ext.stgth.caplet Low Dose Aspirin Enteric Safety-Coated Back and Body Extra Strength Alka-Seltzer Plus Cold Sparkling Original Dye-Free Aspirin 81 Bc Acetylsalicylic Acid Stomach Protection 325mg Tablets Good Sense headache formula added strength HEB Extra Strength Effervescent Antacid and Pain Relief Good Neighbor Pharmacy aspirin orange flavor chewable Aspirin Tab 325mg USP Euro-asa EC 7 Select Adult Chewable Aspirin Alka-Seltzer Lemon Lime Medi-First Aspirin Aspirin Chewable, Low Dose Clopidogrel/acetylsalicylic Acid Zentiva Aspirin Delayed Release Asa, Caffeine & 8mg Codeine Phosphate Extra Strength Pain Relief Pain Reliever Extra Strength Pronal Tablets Enteric Coated Asa 650 mg Dg Health Migraine Relief Asa Ect 325mg Aspica (Aspirin) A & C Tablets With Codeine 15mg Health Mart Regular Strength Enteric Coated Aspirin DG Health migraine relief Asa-325 Comprimes Retard Coricidin D Tab Pharbest Regular Strength Aspirin Careone Aspirin Equate Aspirin Headache relief Extra Strength Excedrin PM Triple Action Caplets and Excedrin Extra Strength Pain Reliever ARC FIRST AID Contains 303 PIECES HARDCASE Extra Strength Muscle & Back Pain Relief With Asa Aspirin and Dipyridamole Extended Release Alka-Seltzer Plus Ready America First Aid Outdoor- 107 Pieces Aspirin 50 CT Aspirin 81 mg 4248 First Aid Kit 4229 First Aid Kit Care One migraine relief Anacin Extra Strength Tablet Aspirin Arthritis Pain Relief 650 mg Market Basket Effervescent Antacid and Pain Relief Bayer Headache Coraspirina 81 mg Tabletas con cubierta enterica Aspirin enteric coated low dose FIRST AID Contains 303 PIECES HARDCASE Leader Cardinal Health Aspirin Lil Drug Store Aspirin 325 Bayer Basic Care Headache Relief Pain Stopper Extra Smart Sense Aspirin First Aid Direct Aspirin FIRST AID Contains 202 PIECES Aspirin Regimen Painex Tab 0.5gr aspirin Regular strength Entrophen 650mg Caplet Ect Dolodol 4333 First Aid Kit Unishield Aspirin Aspirin Coated Caplets 325 mg Assured Aspirin Vanquish Digital Headache Apo Asa Tab 325mg Effervescent Orange Cold Relief 222 Tablets Bayer Genuine Aspirin A.S.A. With Methocarbamol Night-time Extra Strength Aspirin Chewable Tablets Equate Effervescent Cold Relief Equaline Effervescent Antacid and Pain Relief Medique Medi Seltzer Acetylsalicylic Acid 325mg Tab Effervescent Pain Relief Fast Relief 4232 First Aid Kit Coryphen 650 Codeine 30 Tab Methoxisal-C 1/8 217 Strong Tab Aspirin Safety coated First Aid Only Aspirin Advanced Aspirin Artrifin 24 Caplets 4139 First Aid Kit Easy Care First Aid Kit - Comprehensive Medi First Plus Pain Zapper Viva Asa 325 mg St. Joseph Chewable Aspirin Muscle and Back Pain Relief Extra Strength Topcare Headache Relief Adventure Medical Kits 1-2 Person National Ski Patrol First Aid Asaphen Plus 325 Aspirin Enteric Coated Low Dose Enteric Coated Asa Tablets 650mg Dry Socket Paste 4305 First Aid Kit Asprin and Extended-release Dipyridamole Dr Pausins Low Dose Chewable Aspirin Orange Flavor Geritrex Aspirin Medi First Pain Ache St. Joseph Chewable Low Dose Aspirin Childrens Low Dose Aspirin Asa Tab 325mg Enteric Coated Rapid Comfort Aspirin Pharbest Aspirin 325mg Enteric Coated A.S.A. EXTRA STRENGTH Headache Relief geltabs Phenaphen No.4 Cap 4225 First Aid Kit Good Neighbor Pharmacy Emergency Preparedness and First Aid Contains 167 Pieces Asatab EC 325mg Enteric Aspirin Regular Strength Goodys Lowprin 325 NobleAid PAIN RELIEVER Extra Strenght Headache Relief EXCEDRIN MIGRAINE acetaminophen, aspirin (nsaid) and caffeine Enteric Aspirin Enteric coated aspirin Regular strength Extra Strength Back and Body Bubbles R Better Effervescent Cold Relief Tri-buffered Asa Tab Asa Extra Strength Caplet 500mg Healthy Accents migraine formula Adult Aspirin Regimen Low Dose Acetaminophen Aspirin Caffeine Equate Effervescent Antacid and Pain Relief Berkley and Jensen Migraine Formula ARC FIRST AID Emergency Preparedness Contains 167 PIECES Bio-asa BAYER 500 mg 282 Tablets Unishield Pain Ache Excedrin Extra Strength Pain Reliever Vazalore TopCare Effervescent Antacid and Pain Relief Acetylsalicylic Acid, Caffeine & 8 Mg Codeine Phosphate Tablets Aspirin Adult Low Dose Aspirin Enteric Equaline aspirin adult low dose Asa 80 mg Alka-Seltzer Plus Severe Cold Powerfast Fizz Night Aspirin Chewable Tablets - 325mg Good Neighbor Pharmacy Headache Relief Butalbital, Aspirin, Caffeine, and Codeine Phosphate Medi First Plus Pain Ache Lab Safety and Supply Tri Buffered Aspirin Direct Safety Aspirin Equagesic Tablets Bayer AM extra stength Signature Care Aspririn 4244 First Aid Kit Pain Reliever Added Strength Aggrenox Protection Excedrin Migraine Geltabs PMS-pharnal Capsules Pravigard Pac Sunmark aspirin low dose Cardiaspirin Protect Dr Pausins Low Dose Chewable Aspirin Cherry Flavor Up and Up aspirin Headache Pain Reliever Enteric Coated A.S.a Premier Value Antacid and Pain Relief Medicine BAYER Aspirin Extra Strength Caplets Chewable Aspirin Low Dose Enteric Coated Low Dose Aspirin Astrin 5gr C2 Buffered Tab Trianal Tablet 282 Tab 4196 First Aid Kit Asa Daily Low Dose PMS-pharnal Tablets Adult Low Dose Aspirin Enteric Safety Coated Safety Coated Low Dose Aspirin Enteric Coated Aspirin regular strength Ana-dent Norgesic Aspirin Enteric Coated Best Choice Effervescent Cold Relief Coricidin Tab Health Sense Ecpirin Pain Relief Extra Strength Good Sense Aspirin Enteric Safety Coated Extra Strength Pain Aid Alka-Seltzer Plus Day and Night Cold Alka-Seltzer Advanced Pain Reliever 4214 First Aid Kit Adult Aspirin Regimen ARC FIRST AID Contains 1000 PIECES Medi First Plus Tri Buffered Aspirin Migralex Dr. Mauskop Headache Relief A.S.A. Clopidogrel/acetylsalicylic Acid Mylan Regular Strength Tri-Buffered Aspirin Miniprin Coryphen 650 Tab Migraine Formula Extra Strength Pain Reliever Alka-Seltzer Plus Severe Cold PowerFast Fizz Non Drowsy Dristan Capsules Entrophen 325mg Caplets ShopRite Migraine Formula Low dose Chewable Aspirin Rivasa 80mg Croquable - Tab Aspirin Low Strength, Enteric 4387 First Aid Kit CVS Health Antacid and Pain Reliever Acetaminophen, Aspirin and Caffeine Aspirin 81 mg Enteric Coated Adalat XL Plus Aspirin 81 Asprin Pain Free Enteric coated aspirin Tri-Buffered Aspirin Regular Strength Aspirin and Extended-Release Dipyridamole Excedrin PM Triple Action Caplets and Excedrin Tension Headache Fiorinal-C 1/2 Extra Strength Headache, Caseys 4good Asa Ect 600mg Leader Aspirin Smart Sense Migraine Formula 365 Everyday Value Aspirin Butalbital Compound Aspirin Coated Caplets 500mg Anacin Phenaphen No 4 Cap Regular strength aspirin Pain Relief Aspirin Low Dose Micro-Coated Aspirin Pain Reliever 2 Aspirin 81 mg Low Dose Alka-Seltzer Original Pronal - C1/2 Capsules Lowprin 325 Chewable Tablet Berkley and Jensen Migraine Relief 50 Person ANSI Extraprin Equate Extra Strength Effervescent Antacid and Pain Relief Equate Daily Low-dose Alka-Seltzer Plus Severe Cold PowerFast Fizz 4346 First Aid Kit Exaprin Rivasa 81 Mg EC Dolomine 37 A.S.A. (acetylsalicylic Acid) Tab 325mg USP Nra-asa 80 Mg Croquable Top Value Effervescent Cold Relief - Orange Henry Schein Aspirin Zee-Seltzer Antacid and Pain Reliever Alka Seltzer Original BioElectro Extra Strength Daytime Pain Relief Good Sense aspirin Regular Strength Enteric coated aspirin Aspirin Migraine Aspir-81 Asaphen Circle K Aspirin 325 Coated Daily Low-dose Asa Extra Strength Aspirin Backache Aspi-Cor Topcare Headache Formula Dr Pausins Aspirin Uricalm Intensive Care One Aspirin Smart Sense Effervescent Antacid and Pain Relief A.S.A. Enteric Coated Tab 325mg Asa Suppositories 650mg Entrophen Ect 500mg Smart Health Aspirin Regular Strength Aspirin - Children's Size 80mg Aspirin Extra Strength Plus Uncoated Aspirin Tri-Buffered Aspirin Aspirin EC Physicians Care Aspirin TopCare Aspirin Oxycodone Hydrochloride and Aspirin C-2 Buffered With Codeine Adult Low Dose Aspirin Enteric Coated Zee Aspirin 4216 First Aid Kit Aspirin Low Dose Chewable Ecotrin Regular Strength Asa EC Aspirin Plus Stomach Guard Extra Strength Auto 157 Rivasa Fc Jamp-asa 81mg EC Fiorinal Tab Deluxe Dental Emergency Kit Pain Relief PM BC Arthritis Topcare Aspirin Care One headache relief added strength Caring Mill Aspirin Coryphen 325 Codeine 30 Tab GOODYS Extra Strength Headache Mixed Fruit Blast Sedal3x WinCo Foods Effervescent Antacid and Pain Relief Robaxisal Tablets Good Neighbor Pharmacy Aspirin Enteric Safety Coated Extra Strength Midol Relief Aspirin 81mg Enteric coated Low Strength Aspirin Regimen Pain Stoppers Extra Excedrin Extra Strength Caplets Anacin Tablet Coated Aspirin - Ect 80mg Methocarbamol and Aspirin Best Choice Effervescent Antacid Pain Relief Added Strength Pain Reliever Healthy Accents Aspirin Aspirin Low Dose Enteric Coated Good Sense Aspirin Family Wellness Effervescent Antacid and Pain Relief Entrophen 325mg Tablets Carisoprodol, Aspirin and Codeine Phosphate Smart Sense Effervescent Cold Relief Aspirin Stomach Guard Extra Strength ARC FIRST AID Contains 404 PIECES Bayer Advanced Aspirin Regular Strength Family Wellness Effervescent Cold Relief Orange Aspirin 81mg Adult Low Dose Asa Extra Strength Tab 500mg Equaline Effervescent Cold Relief Halfprin Low Dose Sunmark Headache Relief Topcare Migraine Formula GFA First Aid 75 Person Metal Case ARC Emergency Preparedness FIRST AID Contains 202 PIECES DG Health Effervescent Antacid and Pain Relief Low Dose Aspirin 282 Mep Tab Alka-Seltzer Plus Night Cold Formula (Lemon) Extra Strength Midol First Aid Direct Chewable Aspirin MEDI-FIRST Tri Buffered Aspirin A.C. & C. 8 mg Enteric Coated Daily Low Dose Asa 81 mg Extra Strength Headache, Circle K Lab Safety Supply Aspirin Alka-Seltzer Plus Multi-Symptom Cold Night Painex Tab 0.25gr Aspirin to Go Cardiospirina 81 mg Tabletas con cubierta enterica Regular Strength Pain Relief Anacin With Codeine Tab Methoxisal-C 1/4 Aspirin, Caffeine, and Dihydrocodeine Bitartrate Pro-aas EC Apo-asa Ld Equaline migraine formula 4134 First Aid Kit 292 Tablets Ac&c Tablets Asa 81 mg Aspirin and Extended - Release Dipyridamole Capsules, 25 mg / 200 mg Coated Daily Low Dose Asa 81 mg Alka-Seltzer Plus Day Non Drowsy Cold Medicine Citrus Aspirin Adult Low Strength Fiorinal with Codeine Green Guard Extra Strength Pain Relief Aspirin enteric safety coated Aspirin Chewable Equaline Aspirin Aspirin Low Dose 4227 First Aid Kit GENUINE FIRST AID Emergency Preparedness Contains 167 PIECES HARDCASE St. Joseph Low Dose Aspirin Caring Mill Migraine Relief Pro-aas EC - 80 Aramark Aspirin Asatab EC 650mg Aspergum Orange 325 mg Ascriptin Regular Strength Buffered Aspirin Arco Pain Tab Berkley and Jensen Aspirin Extra Strength Headache Relief Aspirin Night-time North Aspirin Pain Terminator 2 Severe Alka-Seltzer Plus Severe Cold PowerFast Fizz Orange Zest Mountain Series Weekender Medical Moore Medical Aspirin Alka-Seltzer Plus Cold Formula (Orange Zest) Aspirin Extra Strength With Stomach Guard Bayer Advanced Aspirin Extra Strength Exact Coated Daily Low-dose Asa Pain Free Plus Plus Pharma NSAID 325 mg BioElectro Day Goodys Migraine Relief Percodan-demi Sunmark Migraine Relief Best Choice Pain Relief Powder K-Mart SmartSense First Aid Contains 303 Pieces Green Guard Tri Buffered Aspirin relief Low Dose Aspirin Enteric Safety Coated Goodys Cool Orange Headache Adult Low Strength Aspirin Amazon Basic Care Migraine Relief Asa Chewable Tablets EC-81Aspirin Enteric Coated Praxis Asa EC 81 Mg Daily Low Dose Zee Pain Aid 4365 First Aid Kit Lo-asa 80mg Chewable - Tab Fairfield Health Products Extra Strength Norgesic Tab 4217 First Aid Kit Asa and Caffeine Adventure Medical Kits 1-4 Person First Aid Coated Aspirin GFA First Aid Kit Essentials - 33 Pieces Smart Sense Chewable Aspirin 4224 First Aid Kit Asaphen E.C. 80 mg AspirinLow Dose Low Dose Herbopyrine Tab 325mg Alka-Seltzer Plus Severe Cold and Cough PowerFast Fizz Good Sense Effervescent Antacid and Pain Relief Excedrin Extra Strength Headache PhysiciansCare Extra Stregth Pain Reliever 4355 First Aid Kit C2 Buffered With Codeine Tab Aspirin Extra Strength 500mg Tab USP Care One Original Antacid and Pain Relief 4304 First Aid Kit Jamp-asa EC ARC FIRST AID Contains 101 PIECES Alka-Seltzer Original Flavor Pain Relief Aspirin Chewable, Low Dose Acetaminophen, Aspirin and Codeine Phosphate Pain Terminator Medique at Home Aspirin Leader Extra Strength Effervescent Antacid and Pain Reliever Basic Dental Emergency Kit Tylo Migraine (Acetaminophen) Harris Teeter Migraine Relief Headache, Circle K Family Wellness Aspirin Bayer Headache Relief 4213 First Aid Kit Plus Pharma NSAID Aspirin Rite Aid Antacid and Pain Relief Aspirin adult low strength MICRO-COATED ASPIRIN 325 mg BLUE ACME SLEEVE FIRST AID Contains 1000 PIECES Entrophen Ect 650mg ARC FIRST AID Contains 303 PIECES FIRST AID Contains 404 PIECES Butalbital, aspirin, and caffeine Freds Effervescent Antacid Pain Relief Effervescent Pain Relief Fast Relief Fast Relief Methoxisal Rx Act Aspirin Hydrocodone Bitartrate and Aspirin MEDIQUE Tri Buffered Aspirin 25 Person ANSI Dollar General Headache Powders Robaxisal C 1/2 Bufferin Arthritis Phenaphen No 2 Cap Alka Seltzer Plus 1s Blister Pack ASPIRIN 81 MG Low Dose A & C Tablets With Codeine 30mg Carisoprodol and Aspirin Nervine Arthriten Inflammatory Pain Formula Bc Max Childrens Aspirin Headache Relief to Go Equaline headache formula added strength 4215 First Aid Kit Adult Low Dose Aspirin 4291 First Aid Kit Kroger Effervescent Cold Relief Goodys Back and Body Pain Orphenadrine Citrate, Aspirin and Caffeine Teva-tecnal C 1/2 Aspirin Chewable Low Dose FormuCare Aspirin Safety Coated Aspirin Darvon N Compound Pulvule 405 Conney Aspirin Thompson XS Pain Ache Unishield Pain Zapper 217 Healthy Accents headache relief added strength Regular Strength Enteric Coated Aspirin Tabcin 500 Chewable Low Dose Aspirin Butalbital, Aspirin, and Caffeine Instantine Tab Nezger Tab Aspirin Coated for Delayed Release Regular Strength PHL-asa Adults Low Strength Aspirin Enteric Coated Asa Tablets 325mg 692 Tab GENUINE FIRST AID Emergency Preparedness Contains 167 Pieces Excedrin Migraine, TRAVEL BASIX Acetylsalicylic Acid Coated Exaprin-AC Goodys Cool Orange Leader migraine formula Spasmhalt-asa-8 Chewable Low Dose Quality Choice Extra Strength Effervescent Antacid and Pain Relief Anacin Extra Strength Caplets Dg Health Headache Relief Aspir Low Asa
Indication	Pain, fever, and inflammation Acetylsalicylic acid (ASA), in the regular tablet form (immediate-release), is indicated to relieve pain, fever, and inflammation associated with many conditions, including the flu, the common cold, neck and back pain, dysmenorrhea, headache, tooth pain, sprains, fractures, myositis, neuralgia, synovitis, arthritis, bursitis, burns, and various injuries. It is also used for symptomatic pain relief after surgical and dental procedures [FDA label]. The _extra strength_ formulation of acetylsalicylic acid is also indicated for the management migraine pain with photophobia (sensitivity to light) and phonophobia (sensitivity to sound)[FDA label]. Other indications ASA is also indicated for various other purposes, due to its ability to inhibit platelet aggregation. These include: Reducing the risk of cardiovascular death in suspected cases of myocardial infarction (MI) [FDA label]. Reducing the risk of a first non-fatal myocardial infarction in patients, and for reducing the risk of morbidity and mortality in cases of unstable angina and in those who have had a prior myocardial infarction [FDA label]. For reducing the risk of transient ischemic attacks (TIA) and to prevent atherothrombotic cerebral infarction (in conjunction with other treatments) [FDA label]. For the prevention of thromboembolism after hip replacement surgery [FDA label]. For decreasing platelet to platelet adhesion following carotid endarterectomy, aiding in the prevention of transient ischemic attacks (TIA) [FDA label]. Used for patients undergoing hemodialysis with a silicone rubber arteriovenous cannula inserted to prevent thrombosis at the insertion site [FDA Label]. Important note regarding use of the extended-release formulation [F4405] In the setting of acute myocardial infarction, or before percutaneous interventions, the extended-release form of acetylsalicylic acid should not be used. Use immediate-release formulations in scenarios requiring rapid onset of action [Label, F4405]. The extended-release form is taken to decrease the incidence of mortality and myocardial infarction (MI) for individuals diagnosed with chronic coronary artery disease (CAD), including patients with previous myocardial infarction (MI) or unstable angina or with chronic stable angina. Additionally, the extended-release form is used to decrease the risk of death and recurrent episodes of stroke in patients with a history of stroke or TIA [F4405].
Categories	Acids, Carbocyclic Agents causing angioedema Agents causing hyperkalemia Agents that produce hypertension Alimentary Tract and Metabolism Analgesics Analgesics, Non-Narcotic Anti-Inflammatory Agents Anti-Inflammatory Agents, Non-Steroidal Anti-Inflammatory Agents, Non-Steroidal (Non-Selective) Antiinflammatory and Antirheumatic Products Antiplatelet agents Antipyretics Benzene Derivatives Blood and Blood Forming Organs Cardiovascular Agents Cyclooxygenase Inhibitors Cytochrome P-450 CYP2C19 Inducers Cytochrome P-450 CYP2C19 Inducers (strength unknown) Cytochrome P-450 CYP2C9 Substrates Cytochrome P-450 Enzyme Inducers Cytochrome P-450 Substrates Decreased Platelet Aggregation Decreased Prostaglandin Production Drugs that are Mainly Renally Excreted Hematologic Agents Hydroxybenzoates Musculo-Skeletal System Nephrotoxic agents Non COX-2 selective NSAIDS OAT1/SLC22A6 inhibitors OAT3/SLC22A8 Inhibitors P-glycoprotein inducers P-glycoprotein substrates Peripheral Nervous System Agents Platelet Aggregation Inhibitors Excl. Heparin Salicylates Salicylic Acid and Derivatives Sensory System Agents Stomatological Preparations UGT1A6 substrate
ATC-Code	B01AC06 C07FX04 C10BX04 M01BA03 C10BX02 N02BA71 B01AC56 N02AJ07 N02AJ02 N02BA01 B01AF51 C10BX05 N02BA51 A01AD05 C10BX01 C07FX03 N02AJ18 C10BX12 C10BX08 C10BX06 C07FX02
CAS number	50-78-2

Drug Targets

Name	Target Sequence	Pharmacological Action	Actions
Prostaglandin G/H synthase 1	MSRSLLLWFLLFLLLLPPLPVLLADPGAPTPVNPCCYYPCQHQGICVRFG...	unknown	inhibitor
3-hydroxy-3-methylglutaryl-coenzyme A reductase	MLSRLFRMHGLFVASHPWEVIVGTVTLTICMMSMNMFTGNNKICGWNYEC...	unknown	inhibitor
Prostaglandin G/H synthase 2	MLARALLLCAVLALSHTANPCCSHPCQNRGVCMSVGFDQYKCDCTRTGFY...	unknown	inhibitor
Aldo-keto reductase family 1 member C1	MDSKYQCVKLNDGHFMPVLGFGTYAPAEVPKSKALEATKLAIEAGFRHID...	unknown	inhibitor
5'-AMP-activated protein kinase	MRRLSSWRKMATAEKQKHDGRVKIGHYILGDTLGVGTFGKVKVGKHELTG...	unknown	activator
Endothelin-1 receptor	METLCLRASFWLALVGCVISDNPERYSTNLSNHVDDFTTFRGTELSFLVT...	unknown	inhibitor
Cellular tumor antigen p53	MEEPQSDPSVEPPLSQETFSDLWKLLPENNVLSPLPSQAMDDLMLSPDDI...	unknown	inducer
Endoplasmic reticulum chaperone BiP	MKLSLVAAMLLLLSAARAEEEDKKEDVGTVVGIDLGTTYSCVGVFKNGRV...	unknown	inhibitor,binder
Ribosomal protein S6 kinase alpha-3	MPLAQLADPWQKMAVESPSDSAENGQQIMDEPMGEEEINPQTEEVSIKEI...	unknown	inhibitor
NF-kappa-B inhibitor alpha	MFQAAERPQEWAMEGPRDGLKKERLLDDRHDSGLDSMKDEEYEQMVKELQ...	unknown	inhibitor
Tumor necrosis factor-inducible gene 6 protein	MIILIYLFLLLWEDTQGWGFKDGIFHNSIWLERAAGVYHREARSGKYKLT...	unknown	inhibitor,downregulator
Caspase-1	MADKVLKEKRKLFIRSMGEGTINGLLDELLQTRVLNKEEMEKVKRENATV...	unknown	inhibitor,downregulator
Caspase-3	MENTENSVDSKSIKNLEPKIIHGSESMDSGISLDNSYKMDYPEMGLCIII...	unknown	inhibitor,downregulator
Inhibitor of nuclear factor kappa-B kinase subunit beta	MSWSPSLTTQTCGAWEMKERLGTGGFGNVIRWHNQETGEQIAIKQCRQEL...	unknown
Extracellular signal-regulated kinase (ERK)	MAAAAAAGAGPEMVRGQVFDVGPRYTNLSYIGEGAYGMVCSAYDNVNKVR...	unknown
G1/S-specific cyclin-D1	MEHQLLCCEVETIRRAYPDANLLNDRVLRAMLKAEETCAPSVSYFKCVQK...	unknown	downregulator
Myc proto-oncogene protein	MDFFRVVENQQPPATMPLNVSFTNRNYDLDYDSVQPYFYCDEEENFYQQQ...	unknown	downregulator
Proliferating cell nuclear antigen	MFEARLVQGSILKKVLEALKDLINEACWDISSSGVNLQSMDSSHVSLVQL...	unknown	downregulator
Cyclin A	-	unknown	downregulator
Sialidase-1	MTGERPSTALPDRRWGPRILGFWGGCRVWVFAAIFLLLSLAASWSKAEND...	unknown	inhibitor
Cytochrome P450 2C19	MDPFVVLVLCLSCLLLLSIWRQSSGRGKLPPGPTPLPVIGNILQIDIKDV...	unknown	inducer
Cytochrome P450 2C9	MDSLVVLVLCLSCLLLLSLWRQSSGRGKLPPGPTPLPVIGNILQIGIKDI...	unknown	substrate
UDP-glucuronosyltransferase 1-6	MACLLRSFQRISAGVFFLALWGMVVGDKLLVVPQDGSHWLSMKDIVEVLS...	unknown	substrate
Arylamine N-acetyltransferase 2	MDIEAYFERIGYKNSRNKLDLETLTDILEHQIRAVPFENLNMHCGQAMEL...	unknown	substrate
Solute carrier family 22 member 6	MAFNDLLQQVGGVGRFQQIQVTLVVLPLLLMASHNTLQNFTAAIPTHHCR...	unknown	inhibitor
ATP-dependent translocase ABCB1	MDLEGDRNGGAKKKNFFKLNNKSEKDKKEKKPTVSVFSMFRYSNWLDKLY...	unknown	substrate,inducer,modulator
Organic anion transporter 3	MTFSEILDRVGSMGHFQFLHVAILGLPILNMANHNLLQIFTAATPVHHCR...	unknown	inhibitor
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Drug Info/Drug Targets: DrugBank 3.0: a comprehensive resource for 'omics' research on drugs. Knox C, Law V, Jewison T, Liu P, Ly S, Frolkis A, Pon A, Banco K, Mak C, Neveu V, Djoumbou Y, Eisner R, Guo AC, Wishart DS. Nucleic Acids Res. 2011 Jan; 39 (Database issue):D1035-41. | PMID:21059682

Related Resource References

Resource Name	Reference
Pharos	CHEMBL25
PubChem	2244
ChEMBL	CHEMBL25
ChEBI	CHEBI:15365
CCDC/CSD	ACSALA21, ACSALA23, ACSALA14, TAZRAO01, DIFQAK, ACSALA20, DIPJAQ, VUGMIT, ACSALA26, ACSALA15, ARIFOX, KEWNOQ, ACSALA17, ACSALA25, ACSALA01, ACSALA19, SIBYUA, ACSALA27, TAZRAO, HUNJEH, ACSALA28, SIBYUA01, ACSALA02, ACSALA08, ACSALA07, ACSALA05, ACSALA03, ACSALA04, ACSALA06, ACSALA11, ACSALA09, SIBYUA02, ACSALA29, GARYEH, HAPCOU
COD	4100978, 1515581, 1515582, 1516479, 1516480, 1516481, 2104857, 7050897, 7050898, 7050899, 7050901, 7050900, 7050902, 7050903