8OG

8-OXO-2'-DEOXY-GUANOSINE-5'-MONOPHOSPHATE

Created:	2000-10-03
Last modified:	2021-03-13

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20 entries where 8OG is found as a standalone ligand246 entries where 8OG is found in a polymer sequence

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Chemical Details
Formal Charge	0
Atom Count	38
Chiral Atom Count	3
Bond Count	40
Aromatic Bond Count	0

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Chemical Component Summary
Name	8-OXO-2'-DEOXY-GUANOSINE-5'-MONOPHOSPHATE
Synonyms	8-OXO-7,8-DIHYDRO-2'-DEOXY-GUANOSINE-5'-MONOPHOSPHATE
Systematic Name (OpenEye OEToolkits)	[(2R,3S,5R)-5-(2-amino-6,8-dioxo-1,7-dihydropurin-9-yl)-3-hydroxy-oxolan-2-yl]methyl dihydrogen phosphate
Formula	C₁₀ H₁₄ N₅ O₈ P
Molecular Weight	363.221
Type	DNA LINKING

Chemical Descriptors
Type	Program	Version	Descriptor
SMILES	ACDLabs	10.04	O=C1C=2NC(=O)N(C=2N=C(N)N1)C3OC(C(O)C3)COP(=O)(O)O
SMILES	CACTVS	3.341	NC1=NC2=C(NC(=O)N2[CH]3C[CH](O)[CH](CO[P](O)(O)=O)O3)C(=O)N1
SMILES	OpenEye OEToolkits	1.5.0	C1C(C(OC1N2C3=C(C(=O)NC(=N3)N)NC2=O)COP(=O)(O)O)O
Canonical SMILES	CACTVS	3.341	NC1=NC2=C(NC(=O)N2[C@H]3C[C@H](O)[C@@H](CO[P](O)(O)=O)O3)C(=O)N1
Canonical SMILES	OpenEye OEToolkits	1.5.0	C1[C@@H]([C@H](O[C@H]1N2C3=C(C(=O)NC(=N3)N)NC2=O)COP(=O)(O)O)O
InChI	InChI	1.03	InChI=1S/C10H14N5O8P/c11-9-13-7-6(8(17)14-9)12-10(18)15(7)5-1-3(16)4(23-5)2-22-24(19,20)21/h3-5,16H,1-2H2,(H,12,18)(H2,19,20,21)(H3,11,13,14,17)/t3-,4+,5+/m0/s1
InChIKey	InChI	1.03	AQIVLFLYHYFRKU-VPENINKCSA-N

Drug Info: DrugBank

DrugBank ID	DB02023
Name	8-oxo-dGMP
Groups	experimental
Synonyms	8-oxo-2'-deoxyguanosine-5'-monophosphate 2'-deoxy-7,8-dihydro-8-oxo-5'-guanylic acid 8-OH-Dgmp 8-hydroxydeoxyguanosine 5'-monophosphate 8-oxo-dGMP 2'-deoxy-7,8-dihydro-8-oxoguanosine 5'-monophosphate
Categories	Guanine Nucleotides Heterocyclic Compounds, Fused-Ring Nucleic Acids, Nucleotides, and Nucleosides Nucleotides Purine Nucleotides Purines Ribonucleotides
CAS number	127027-50-3

Drug Targets

Name	Target Sequence	Pharmacological Action	Actions
8-oxo-dGTP diphosphatase	MKKLQIAVGIIRNENNEIFITRRAADAHMANKLEFPGGKIEMGETPEQAV...	unknown

Drug Info/Drug Targets: DrugBank 3.0: a comprehensive resource for 'omics' research on drugs. Knox C, Law V, Jewison T, Liu P, Ly S, Frolkis A, Pon A, Banco K, Mak C, Neveu V, Djoumbou Y, Eisner R, Guo AC, Wishart DS. Nucleic Acids Res. 2011 Jan; 39 (Database issue):D1035-41. | PMID:21059682