8CV

N-(2-phenylethyl)imidodicarbonimidic diamide

Created:	2017-01-19
Last modified:	2017-11-22

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1 entries where 8CV is found as a standalone ligand

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Chemical Details
Formal Charge	0
Atom Count	30
Chiral Atom Count	0
Bond Count	30
Aromatic Bond Count	6

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Chemical Component Summary
Name	N-(2-phenylethyl)imidodicarbonimidic diamide
Systematic Name (OpenEye OEToolkits)	1-carbamimidoyl-3-(2-phenylethyl)guanidine
Formula	C₁₀ H₁₅ N₅
Molecular Weight	205.26
Type	NON-POLYMER

Chemical Descriptors
Type	Program	Version	Descriptor
SMILES	ACDLabs	12.01	c1(CCN\C(=N)N/C(N)=N)ccccc1
SMILES	CACTVS	3.385	NC(=N)NC(=N)NCCc1ccccc1
SMILES	OpenEye OEToolkits	2.0.6	c1ccc(cc1)CCNC(=N)NC(=N)N
Canonical SMILES	CACTVS	3.385	NC(=N)NC(=N)NCCc1ccccc1
Canonical SMILES	OpenEye OEToolkits	2.0.6	[H]/N=C(/N)\N/C(=N/[H])/NCCc1ccccc1
InChI	InChI	1.03	InChI=1S/C10H15N5/c11-9(12)15-10(13)14-7-6-8-4-2-1-3-5-8/h1-5H,6-7H2,(H6,11,12,13,14,15)
InChIKey	InChI	1.03	ICFJFFQQTFMIBG-UHFFFAOYSA-N

Drug Info: DrugBank

DrugBank ID	DB00914
Name	Phenformin
Groups	approved withdrawn investigational
Description	A biguanide hypoglycemic agent with actions and uses similar to those of metformin. Although it is generally considered to be associated with an unacceptably high incidence of lactic acidosis, often fatal, it is still available in some countries. (From Martindale, The Extra Pharmacopoeia, 30th ed, p290)
Synonyms	Phenforminum Fenformin Phenformine Phenformin hydrochloride Phenformin Fenformina β-Phenethybiguanide
Indication	For the reatment of type II diabetes mellitus.
Categories	Alimentary Tract and Metabolism Amidines Biguanides Blood Glucose Lowering Agents Cytochrome P-450 CYP2D6 Substrates Cytochrome P-450 Substrates Drugs Used in Diabetes Guanidines OCT1 inhibitors OCT1 substrates OCT2 Inhibitors Oral Hypoglycemics
ATC-Code	A10BA01 A10BD01
CAS number	114-86-3

Drug Targets

Name	Target Sequence	Pharmacological Action	Actions
5'-AMP-activated protein kinase catalytic subunit alpha-1	MRRLSSWRKMATAEKQKHDGRVKIGHYILGDTLGVGTFGKVKVGKHELTG...	unknown	activator
ATP-sensitive inward rectifier potassium channel 8	MLARKSIIPEEYVLARIAAENLRKPRIRDRLPKARFIAKSGACNLAHKNI...	unknown	inhibitor
Cytochrome P450 2D6	MGLEALVPLAVIVAIFLLLVDLMHRRQRWAARYPPGPLPLPGLGNLLHVD...	unknown	substrate
Solute carrier family 22 member 2	MPTTVDDVLEHGGEFHFFQKQMFFLLALLSATFAPIYVGIVFLGFTPDHR...	unknown	inhibitor
Solute carrier family 22 member 1	MPTVDDILEQVGESGWFQKQAFLILCLLSAAFAPICVGIVFLGFTPDHHC...	unknown	substrate

Drug Info/Drug Targets: DrugBank 3.0: a comprehensive resource for 'omics' research on drugs. Knox C, Law V, Jewison T, Liu P, Ly S, Frolkis A, Pon A, Banco K, Mak C, Neveu V, Djoumbou Y, Eisner R, Guo AC, Wishart DS. Nucleic Acids Res. 2011 Jan; 39 (Database issue):D1035-41. | PMID:21059682