6ZP

2-(6'-oxo-1'-phenyl[1',6'-dihydro[2,3'-bipyridine]]-5'-yl)benzonitrile

Created: 2016-08-01
Last modified:  2016-10-19

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Chemical Details

Formal Charge0
Atom Count42
Chiral Atom Count0
Bond Count45
Aromatic Bond Count18
2D diagram of 6ZP
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Chemical Component Summary

Name2-(6'-oxo-1'-phenyl[1',6'-dihydro[2,3'-bipyridine]]-5'-yl)benzonitrile
Systematic Name (OpenEye OEToolkits)2-(2-oxidanylidene-1-phenyl-5-pyridin-2-yl-pyridin-3-yl)benzenecarbonitrile
FormulaC23 H15 N3 O
Molecular Weight349.385
TypeNON-POLYMER

Chemical Descriptors

TypeProgram Version Descriptor
SMILESACDLabs12.01N#Cc1ccccc1C3=CC(c2ncccc2)=CN(C3=O)c4ccccc4
SMILESCACTVS3.385O=C1N(C=C(C=C1c2ccccc2C#N)c3ccccn3)c4ccccc4
SMILESOpenEye OEToolkits2.0.5c1ccc(cc1)N2C=C(C=C(C2=O)c3ccccc3C#N)c4ccccn4
Canonical SMILESCACTVS3.385 O=C1N(C=C(C=C1c2ccccc2C#N)c3ccccn3)c4ccccc4
Canonical SMILESOpenEye OEToolkits2.0.5 c1ccc(cc1)N2C=C(C=C(C2=O)c3ccccc3C#N)c4ccccn4
InChIInChI1.03 InChI=1S/C23H15N3O/c24-15-17-8-4-5-11-20(17)21-14-18(22-12-6-7-13-25-22)16-26(23(21)27)19-9-2-1-3-10-19/h1-14,16H
InChIKeyInChI1.03 PRMWGUBFXWROHD-UHFFFAOYSA-N

Drug Info: DrugBank

DrugBank IDDB08883 
NamePerampanel
Groups approved
DescriptionPerampanel is a noncompetitive AMPA glutamate receptor antagonist. It is marketed under the name Fycompa™ and is indicated as an adjunct in patients over 12 years old for the treatment of partial-onset seizures that may or may not occur with generalized seizures. The FDA label includes an important black-boxed warning of serious or life-threatening behavioral and psychiatric reactions in patients taking Fycompa™.
Synonyms
  • Perampanel
  • Perampanelum
  • Perampanel hydrate
  • 3-(2-Cyanophenyl)-5-(2-pyridyl)-1-phenyl-1,2-dihydropyridin-2-one
  • Pérampanel
Brand Names
  • Fycompa
  • Taro-perampanel
IndicationPerampanel is indicated for the treatment of partial-onset seizures with or without secondarily generalized seizures in epileptic patients four years of age and older. It is also indicated as an adjunct in the treatment of primary generalized tonic-clonic seizures in epileptic patients aged 12 years and older.[L40913]
Categories
  • AMPA Receptor Antagonists
  • Anticonvulsants
  • Central Nervous System Depressants
  • Cytochrome P-450 CYP1A2 Substrates
  • Cytochrome P-450 CYP2B6 Inducers
ATC-CodeN03AX22
CAS number380917-97-5

Drug Targets

NameTarget SequencePharmacological ActionActions
Glutamate receptor 1MQHIFAFFCTGFLGAVVGANFPNNIQIGGLFPNQQSQEHAAFRFALSQLT...unknownantagonist
Cytochrome P450 3A4MALIPDLAMETWLLLAVSLVLLYLYGTHSHGLFKKLGIPGPTPLPFLGNI...unknownsubstrate,inducer
Cytochrome P450 3A5MDLIPNLAVETWLLLAVSLVLLYLYGTRTHGLFKRLGIPGPTPLPLLGNV...unknownsubstrate
Cytochrome P450 1A2MALSQSVPFSATELLLASAIFCLVFWVLKGLRPRVPKGLKSPPEPWGWPL...unknownsubstrate
Cytochrome P450 2B6MELSVLLFLALLTGLLLLLVQRHPNTHDRLPPGPRPLPLLGNLLQMDRRG...unknownsubstrate,inducer
Drug Info/Drug Targets: DrugBank 3.0: a comprehensive resource for 'omics' research on drugs. Knox C, Law V, Jewison T, Liu P, Ly S, Frolkis A, Pon A, Banco K, Mak C, Neveu V, Djoumbou Y, Eisner R, Guo AC, Wishart DS. Nucleic Acids Res. 2011 Jan; 39 (Database issue):D1035-41. | PMID:21059682

Related Resource References

Resource NameReference
Pharos CHEMBL1214124
PubChem 9924495
ChEMBL CHEMBL1214124
ChEBI CHEBI:71013