Annotations: 8PY4

SAbDab Antibody Annotation SAbDab Database Homepage

Chain	Chain Class	Chain Subclass	Chain Type	Antigen Name(s)	Provenance Source
A [auth D], C [auth F]	Heavy Chain	IGHV3	-	broad substrate specificity atp-binding cassettetransporter abcg2	SAbDab (2024-12-06)
B [auth E], F [auth C]	Light Chain	IGKV13	Kappa	broad substrate specificity atp-binding cassettetransporter abcg2	SAbDab (2024-12-06)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
D [auth B], E [auth A]	PF19055	ABC-2 type transporter (ABC2_membrane_7)	ABC-2 type transporter	-	Family
D [auth B], E [auth A]	PF01061	ABC-2 type transporter (ABC2_membrane)	ABC-2 type transporter	-	Family
D [auth B], E [auth A]	PF00005	ABC transporter (ABC_tran)	ABC transporter	ABC transporters for a large family of proteins responsible for translocation of a variety of compounds across biological membranes. ABC transporters are the largest family of proteins in many completely sequenced bacteria. ABC transporters are comp ...	ABC transporters for a large family of proteins responsible for translocation of a variety of compounds across biological membranes. ABC transporters are the largest family of proteins in many completely sequenced bacteria. ABC transporters are composed of two copies of this domain and two copies of a transmembrane domain Pfam:PF00664. These four domains may belong to a single polypeptide as in Swiss:P13569, or belong in different polypeptide chains.	Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A [auth D], C [auth F]	5d3(fab) heavy chain variable domain	-	-	-
B [auth E], F [auth C]	5D3(Fab) light chain variable domain	-	-	-
D [auth B], E [auth A]	Broad substrate specificity ATP-binding cassette transporter ABCG2	lipid transporter activity sphingolipid transporter activity transporter activity urate transmembrane transporter activity salt transmembrane transporter activity transmembrane transporter activity organic anion transmembrane transporter activity vitamin transmembrane transporter activity riboflavin transmembrane transporter activity xenobiotic transmembrane transporter activity ABC-type transporter activity active transmembrane transporter activity primary active transmembrane transporter activity ATPase-coupled transmembrane transporter activity lipid transporter activity sphingolipid transporter activity transporter activity urate transmembrane transporter activity salt transmembrane transporter activity transmembrane transporter activity organic anion transmembrane transporter activity vitamin transmembrane transporter activity riboflavin transmembrane transporter activity xenobiotic transmembrane transporter activity ABC-type transporter activity active transmembrane transporter activity primary active transmembrane transporter activity ATPase-coupled transmembrane transporter activity ABC-type xenobiotic transporter activity ATP-dependent activity binding adenyl ribonucleotide binding nucleotide binding purine ribonucleotide binding purine ribonucleoside triphosphate binding nucleoside phosphate binding ion binding purine nucleotide binding organic cyclic compound binding anion binding adenyl nucleotide binding ATP binding heterocyclic compound binding carbohydrate derivative binding ribonucleotide binding small molecule binding identical protein binding protein binding protein homodimerization activity protein dimerization activity pyrophosphatase activity ATP hydrolysis activity ribonucleoside triphosphate phosphatase activity hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides hydrolase activity hydrolase activity, acting on acid anhydrides catalytic activity sulfur compound transmembrane transporter activity amide transmembrane transporter activity biotin transmembrane transporter activity monocarboxylic acid transmembrane transporter activity carboxylic acid transmembrane transporter activity organic acid transmembrane transporter activity efflux transmembrane transporter activity	transmembrane transport localization transport export from cell cellular process export across plasma membrane establishment of localization organic anion transport membrane lipid metabolic process sphingolipid biosynthetic process biosynthetic process lipid biosynthetic process primary metabolic process metabolic process transmembrane transport localization transport export from cell cellular process export across plasma membrane establishment of localization organic anion transport membrane lipid metabolic process sphingolipid biosynthetic process biosynthetic process lipid biosynthetic process primary metabolic process metabolic process sphingolipid metabolic process membrane lipid biosynthetic process lipid metabolic process transepithelial transport riboflavin transport nitrogen compound transport vitamin transport renal urate salt excretion excretion multicellular organismal process system process renal system process renal tubular secretion xenobiotic transport across blood-brain barrier xenobiotic transport vascular transport circulatory system process vascular process in circulatory system transport across blood-brain barrier cellular response to stimulus cellular detoxification cellular response to chemical stimulus response to stimulus response to chemical detoxification cellular response to toxic substance response to toxic substance small molecule metabolic process urate metabolic process purine-containing compound metabolic process carboxylic acid transport biotin transport organic acid transport monocarboxylic acid transport amide transport sulfur compound transport	cell periphery cellular anatomical structure apical part of cell membrane plasma membrane plasma membrane region apical plasma membrane membrane-bounded organelle mitochondrial membrane intracellular anatomical structure mitochondrion intracellular membrane-bounded organelle intracellular organelle organelle envelope cell periphery cellular anatomical structure apical part of cell membrane plasma membrane plasma membrane region apical plasma membrane membrane-bounded organelle mitochondrial membrane intracellular anatomical structure mitochondrion intracellular membrane-bounded organelle intracellular organelle organelle envelope mitochondrial envelope organelle cytoplasm organelle membrane external side of apical plasma membrane side of membrane cell surface external side of plasma membrane membrane microdomain membrane raft nucleus membrane-enclosed lumen intracellular organelle lumen nucleoplasm organelle lumen nuclear lumen brush border membrane cluster of actin-based cell projections plasma membrane bounded cell projection brush border cell projection cell projection membrane

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
D [auth B], E [auth A]	IPR043926	ABC transporter family G domain	Domain
D [auth B], E [auth A]	IPR003439	ABC transporter-like, ATP-binding domain	Domain
D [auth B], E [auth A]	IPR003593	AAA+ ATPase domain	Domain
D [auth B], E [auth A]	IPR027417	P-loop containing nucleoside triphosphate hydrolase	Homologous Superfamily
D [auth B], E [auth A]	IPR050352	ATP-binding cassette subfamily G transporters	Family
D [auth B], E [auth A]	IPR013525	ABC-2 type transporter, transmembrane domain	Domain

Pharos: Disease Associations Pharos Homepage Annotation

Chains	Drug Target	Associated Disease
D [auth B], E [auth A]	Pharos: Q9UNQ0	gout hyperuricemia primary biliary cholangitis diffuse large B-cell lymphoma rheumatoid arthritis head and neck squamous cell carcinoma adenoma nervous system disorder papillary adenoma breast cancer follicular thyroid adenoma microcystic adenoma breast carcinoma colorectal cancer large cell medulloblastoma gout hyperuricemia primary biliary cholangitis diffuse large B-cell lymphoma rheumatoid arthritis head and neck squamous cell carcinoma adenoma nervous system disorder papillary adenoma breast cancer follicular thyroid adenoma microcystic adenoma breast carcinoma colorectal cancer large cell medulloblastoma malignant mesothelioma acute T cell leukemia nephrolithiasis adrenal cortex carcinoma osteosarcoma breast disease colorectal carcinoma cutaneous lupus erythematosus lung adenocarcinoma cancer transitional cell carcinoma lung cancer adrenal cortex adenoma non-small cell lung carcinoma pilocytic astrocytoma ulcerative colitis Crohn disease

Membrane Protein Annotation: PDBTM PDBTM Database Homepage

Chains	External Link	Comment
D [auth B], E [auth A]	PDBTM	Annotated as membrane protein by PDBTM

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM157729.