7TWU

Crystal structure of human phenylethanolamine N-methyltransferase (PNMT) in complex with (2S)-2-amino-4-(((5-(6-amino-9H-purin-9-yl)-3,4-dihydroxytetrahydrofuran-2-yl)methyl)(4-(7,8-dichloro-1,2,3,4-tetrahydroisoquinolin-4-yl)butyl)amino)butanoic acid and AdoHcy (SAH)

External Resource: Annotation

Domain Annotation: SCOP2 Classification
Domain Annotation: ECOD Classification
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification
Pharos: Disease Associations

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
B	SCOP2B Superfamily	S-adenosyl-L-methionine-dependent methyltransferases	8041718	3000118	SCOP2B (2022-06-29)
A	SCOP2B Superfamily	S-adenosyl-L-methionine-dependent methyltransferases	8041718	3000118	SCOP2B (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
B	NNMT_PNMT_TEMT	e7twuB1	A: a/b three-layered sandwiches	X: Rossmann-like	H: Rossmann-related	T: S-adenosyl-L-methionine-dependent methyltransferases	F: NNMT_PNMT_TEMT	ECOD (1.6)
A	NNMT_PNMT_TEMT	e7twuA1	A: a/b three-layered sandwiches	X: Rossmann-like	H: Rossmann-related	T: S-adenosyl-L-methionine-dependent methyltransferases	F: NNMT_PNMT_TEMT	ECOD (1.6)

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A, B	Phenylethanolamine N-methyltransferase	phenylethanolamine N-methyltransferase activity transferase activity, transferring one-carbon groups N-methyltransferase activity transferase activity methyltransferase activity catalytic activity S-adenosylmethionine-dependent methyltransferase activity	organic hydroxy compound metabolic process catechol-containing compound metabolic process amine metabolic process biogenic amine biosynthetic process biosynthetic process catecholamine metabolic process amine biosynthetic process phenol-containing compound metabolic process organic hydroxy compound biosynthetic process catecholamine biosynthetic process phenol-containing compound biosynthetic process metabolic process cellular process catechol-containing compound biosynthetic process organic hydroxy compound metabolic process catechol-containing compound metabolic process amine metabolic process biogenic amine biosynthetic process biosynthetic process catecholamine metabolic process amine biosynthetic process phenol-containing compound metabolic process organic hydroxy compound biosynthetic process catecholamine biosynthetic process phenol-containing compound biosynthetic process metabolic process cellular process catechol-containing compound biosynthetic process biogenic amine metabolic process methylation epinephrine biosynthetic process epinephrine metabolic process	cellular anatomical structure intracellular anatomical structure cytoplasm cytosol

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A, B	IPR025820	Methyltransferase NNMT/PNMT/TEMT, conserved site	Conserved Site
A, B	IPR000940	Methyltransferase, NNMT/PNMT/TEMT	Family
A, B	IPR053384	SAM-dependent methyltransferase	Family
A, B	IPR029063	S-adenosyl-L-methionine-dependent methyltransferase superfamily	Homologous Superfamily

Pharos: Disease Associations Pharos Homepage Annotation

Chains	Drug Target	Associated Disease
A, B	Pharos: P11086	adenoma inflammatory bowel disease malignant glioma primary biliary cholangitis systemic lupus erythematosus bipolar disorder lung adenocarcinoma malignant mesothelioma psoriasis ulcerative colitis Crohn disease lung cancer marginal zone lymphoma rheumatoid arthritis

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM157729.