7RW5
Crystal structure of human methionine adenosyltransferase 2A (MAT2A) in complex with SAM and allosteric inhibitor Compound 1
Domain Annotation: SCOP2 Classification SCOP2 Database Homepage
Chains | Type | Family Name | Domain Identifier | Family Identifier | Provenance Source (Version) |
---|---|---|---|---|---|
A | SCOP2B Superfamily | S-adenosylmethionine synthetase | 8035289 | 3000766 | SCOP2B (2022-06-29) |
A | SCOP2B Superfamily | S-adenosylmethionine synthetase | 8035292 | 3000766 | SCOP2B (2022-06-29) |
A | SCOP2B Superfamily | S-adenosylmethionine synthetase | 8035293 | 3000766 | SCOP2B (2022-06-29) |
D | SCOP2B Superfamily | S-adenosylmethionine synthetase | 8035292 | 3000766 | SCOP2B (2022-06-29) |
D | SCOP2B Superfamily | S-adenosylmethionine synthetase | 8035293 | 3000766 | SCOP2B (2022-06-29) |
D | SCOP2B Superfamily | S-adenosylmethionine synthetase | 8035289 | 3000766 | SCOP2B (2022-06-29) |
B | SCOP2B Superfamily | S-adenosylmethionine synthetase | 8035292 | 3000766 | SCOP2B (2022-06-29) |
B | SCOP2B Superfamily | S-adenosylmethionine synthetase | 8035289 | 3000766 | SCOP2B (2022-06-29) |
B | SCOP2B Superfamily | S-adenosylmethionine synthetase | 8035293 | 3000766 | SCOP2B (2022-06-29) |
C | SCOP2B Superfamily | S-adenosylmethionine synthetase | 8035292 | 3000766 | SCOP2B (2022-06-29) |
C | SCOP2B Superfamily | S-adenosylmethionine synthetase | 8035289 | 3000766 | SCOP2B (2022-06-29) |
C | SCOP2B Superfamily | S-adenosylmethionine synthetase | 8035293 | 3000766 | SCOP2B (2022-06-29) |
Domain Annotation: ECOD Classification ECOD Database Homepage
Chains | Family Name | Domain Identifier | Architecture | Possible Homology | Homology | Topology | Family | Provenance Source (Version) |
---|---|---|---|---|---|---|---|---|
A | S-AdoMet_synt_C | e7rw5A1 | A: a+b two layers | X: Alpha-lytic protease prodomain-like | H: S-adenosylmethionine synthetase (From Topology) | T: S-adenosylmethionine synthetase | F: S-AdoMet_synt_C | ECOD (1.6) |
A | S-AdoMet_synt_M | e7rw5A3 | A: a+b two layers | X: Alpha-lytic protease prodomain-like | H: S-adenosylmethionine synthetase (From Topology) | T: S-adenosylmethionine synthetase | F: S-AdoMet_synt_M | ECOD (1.6) |
A | S-AdoMet_synt_N | e7rw5A2 | A: a+b two layers | X: Alpha-lytic protease prodomain-like | H: S-adenosylmethionine synthetase (From Topology) | T: S-adenosylmethionine synthetase | F: S-AdoMet_synt_N | ECOD (1.6) |
D | S-AdoMet_synt_C | e7rw5D3 | A: a+b two layers | X: Alpha-lytic protease prodomain-like | H: S-adenosylmethionine synthetase (From Topology) | T: S-adenosylmethionine synthetase | F: S-AdoMet_synt_C | ECOD (1.6) |
D | S-AdoMet_synt_M | e7rw5D1 | A: a+b two layers | X: Alpha-lytic protease prodomain-like | H: S-adenosylmethionine synthetase (From Topology) | T: S-adenosylmethionine synthetase | F: S-AdoMet_synt_M | ECOD (1.6) |
D | S-AdoMet_synt_N | e7rw5D2 | A: a+b two layers | X: Alpha-lytic protease prodomain-like | H: S-adenosylmethionine synthetase (From Topology) | T: S-adenosylmethionine synthetase | F: S-AdoMet_synt_N | ECOD (1.6) |
B | S-AdoMet_synt_C | e7rw5B2 | A: a+b two layers | X: Alpha-lytic protease prodomain-like | H: S-adenosylmethionine synthetase (From Topology) | T: S-adenosylmethionine synthetase | F: S-AdoMet_synt_C | ECOD (1.6) |
B | S-AdoMet_synt_M | e7rw5B3 | A: a+b two layers | X: Alpha-lytic protease prodomain-like | H: S-adenosylmethionine synthetase (From Topology) | T: S-adenosylmethionine synthetase | F: S-AdoMet_synt_M | ECOD (1.6) |
B | S-AdoMet_synt_N | e7rw5B1 | A: a+b two layers | X: Alpha-lytic protease prodomain-like | H: S-adenosylmethionine synthetase (From Topology) | T: S-adenosylmethionine synthetase | F: S-AdoMet_synt_N | ECOD (1.6) |
C | S-AdoMet_synt_C | e7rw5C3 | A: a+b two layers | X: Alpha-lytic protease prodomain-like | H: S-adenosylmethionine synthetase (From Topology) | T: S-adenosylmethionine synthetase | F: S-AdoMet_synt_C | ECOD (1.6) |
C | S-AdoMet_synt_M | e7rw5C2 | A: a+b two layers | X: Alpha-lytic protease prodomain-like | H: S-adenosylmethionine synthetase (From Topology) | T: S-adenosylmethionine synthetase | F: S-AdoMet_synt_M | ECOD (1.6) |
C | S-AdoMet_synt_N | e7rw5C1 | A: a+b two layers | X: Alpha-lytic protease prodomain-like | H: S-adenosylmethionine synthetase (From Topology) | T: S-adenosylmethionine synthetase | F: S-AdoMet_synt_N | ECOD (1.6) |
Protein Family Annotation Pfam Database Homepage
Chains | Accession | Name | Description | Comments | Source |
---|---|---|---|---|---|
PF00438 | S-adenosylmethionine synthetase, N-terminal domain (S-AdoMet_synt_N) | S-adenosylmethionine synthetase, N-terminal domain | The three domains of S-adenosylmethionine synthetase have the same alpha+beta fold. | Domain | |
PF02773 | S-adenosylmethionine synthetase, C-terminal domain (S-AdoMet_synt_C) | S-adenosylmethionine synthetase, C-terminal domain | The three domains of S-adenosylmethionine synthetase have the same alpha+beta fold. | Domain | |
PF02772 | S-adenosylmethionine synthetase, central domain (S-AdoMet_synt_M) | S-adenosylmethionine synthetase, central domain | The three domains of S-adenosylmethionine synthetase have the same alpha+beta fold. | Domain |
Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage
InterPro: Protein Family Classification InterPro Database Homepage
Chains | Accession | Name | Type |
---|---|---|---|
IPR022636 | S-adenosylmethionine synthetase superfamily | Homologous Superfamily | |
IPR022629 | S-adenosylmethionine synthetase, central domain | Domain | |
IPR022628 | S-adenosylmethionine synthetase, N-terminal | Domain | |
IPR022631 | S-adenosylmethionine synthetase, conserved site | Conserved Site | |
IPR022630 | S-adenosylmethionine synthetase, C-terminal | Domain | |
IPR002133 | S-adenosylmethionine synthetase | Family |