Annotations: 7MQK

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
C	Antibiotic_NAT	e7mqkC1	A: a/b three-layered sandwiches	X: Hypothetical protein TT1679 (From Topology)	H: Hypothetical protein TT1679 (From Topology)	T: Hypothetical protein TT1679	F: Antibiotic_NAT	ECOD (1.6)
A	Antibiotic_NAT	e7mqkA1	A: a/b three-layered sandwiches	X: Hypothetical protein TT1679 (From Topology)	H: Hypothetical protein TT1679 (From Topology)	T: Hypothetical protein TT1679	F: Antibiotic_NAT	ECOD (1.6)
B	Antibiotic_NAT	e7mqkB1	A: a/b three-layered sandwiches	X: Hypothetical protein TT1679 (From Topology)	H: Hypothetical protein TT1679 (From Topology)	T: Hypothetical protein TT1679	F: Antibiotic_NAT	ECOD (1.6)
D	Antibiotic_NAT	e7mqkD1	A: a/b three-layered sandwiches	X: Hypothetical protein TT1679 (From Topology)	H: Hypothetical protein TT1679 (From Topology)	T: Hypothetical protein TT1679	F: Antibiotic_NAT	ECOD (1.6)

AMR Gene: CARD Annotation CARD Database Homepage

Chains	Accession	Short Name	Description	Provenance Source (Version)
A, B, C, D	ARO:3002536	AAC(3)-IIIa	AAC(3)-IIIa is a chromosomal-encoded aminoglycoside acetyltransferase in P. aeruginosa.	CARD (3.3.0)

AMR Gene Family: CARD Annotation CARD Database Homepage

Chains	Accession	Gene Family	Drug Class	Resistance Machanism	Provenance Source (Version)
A, B, C, D	ARO:3000322	AAC(3)	aminoglycoside antibiotic	antibiotic inactivation	CARD (3.3.0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A, B, C, D	PF02522	Aminoglycoside 3-N-acetyltransferase (Antibiotic_NAT)	Aminoglycoside 3-N-acetyltransferase	This family consists of bacterial aminoglycoside 3-N-acetyltransferases EC:2.3.1.81, these catalyse the reaction: Acetyl-Co + a 2-deoxystreptamine antibiotic <=> CoA + N3'-acetyl-2-deoxystreptamine antibiotic. The enzyme can use ...	This family consists of bacterial aminoglycoside 3-N-acetyltransferases EC:2.3.1.81, these catalyse the reaction: Acetyl-Co + a 2-deoxystreptamine antibiotic <=> CoA + N3'-acetyl-2-deoxystreptamine antibiotic. The enzyme can use a range of antibiotics with 2-deoxystreptamine rings as acceptor for its acetyltransferase activity, this inactivates and confers resistance to gentamicin, kanamycin, tobramycin, neomycin and apramycin amongst others.	Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A, B, C, D	Aminoglycoside N(3)-acetyltransferase III	identical protein binding protein binding binding protein homodimerization activity protein dimerization activity coenzyme A binding amide binding nucleoside phosphate binding ion binding organic cyclic compound binding anion binding heterocyclic compound binding small molecule binding sulfur compound binding identical protein binding protein binding binding protein homodimerization activity protein dimerization activity coenzyme A binding amide binding nucleoside phosphate binding ion binding organic cyclic compound binding anion binding heterocyclic compound binding small molecule binding sulfur compound binding acetyltransferase activity N-acetyltransferase activity acyltransferase activity aminoglycoside 3-N-acetyltransferase activity acyltransferase activity, transferring groups other than amino-acyl groups transferase activity catalytic activity N-acyltransferase activity aminoglycoside N-acetyltransferase activity	antibiotic metabolic process metabolic process cellular process catabolic process organophosphate catabolic process nucleoside phosphate catabolic process acetyl-CoA metabolic process nucleobase-containing compound metabolic process cellular catabolic process acyl-CoA metabolic process nucleobase-containing small molecule metabolic process phosphate-containing compound metabolic process small molecule metabolic process sulfur compound metabolic process antibiotic metabolic process metabolic process cellular process catabolic process organophosphate catabolic process nucleoside phosphate catabolic process acetyl-CoA metabolic process nucleobase-containing compound metabolic process cellular catabolic process acyl-CoA metabolic process nucleobase-containing small molecule metabolic process phosphate-containing compound metabolic process small molecule metabolic process sulfur compound metabolic process amide metabolic process thioester metabolic process phosphorus metabolic process acetyl-CoA catabolic process nucleoside phosphate metabolic process primary metabolic process purine-containing compound catabolic process nucleobase-containing compound catabolic process purine-containing compound metabolic process sulfur compound catabolic process organophosphate metabolic process polyol metabolic process organic hydroxy compound metabolic process alcohol metabolic process 2-deoxystreptamine metabolic process cellular response to stimulus cellular response to antibiotic cellular response to chemical stimulus response to stimulus response to chemical response to antibiotic	-

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A, B, C, D	IPR003679	Aminoglycoside N(3)-acetyltransferase-like	Family
A, B, C, D	IPR028345	Aminoglycoside 3-N-acetyltransferase-like	Homologous Superfamily

Protein Modification Annotation

Modified Residue(s)
Chain	Residue(s)	Description
A, B, C, D	CSO	Parent Component: CYS RESID: AA0205 PSI-MOD : L-cysteine sulfenic acid MOD:00210

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM157729.