Annotations: 7DZI

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
B	SCOP2B Superfamily	Lipocalins	8040616	3001332	SCOP2B (2022-06-29)
A	SCOP2B Superfamily	Lipocalins	8040616	3001332	SCOP2B (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
B	Lipocalin_7	e7dziB1	A: beta barrels	X: Lipocalins/Streptavidin	H: Lipocalins (From Topology)	T: Lipocalins	F: Lipocalin_7	ECOD (1.6)
A	Lipocalin_7	e7dziA1	A: beta barrels	X: Lipocalins/Streptavidin	H: Lipocalins (From Topology)	T: Lipocalins	F: Lipocalin_7	ECOD (1.6)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A, B	PF14651	Lipocalin / cytosolic fatty-acid binding protein family (Lipocalin_7)	Lipocalin / cytosolic fatty-acid binding protein family	Lipocalins are transporters for small hydrophobic molecules, such as lipids, steroid hormones, bilins, and retinoids. The family also encompasses the enzyme prostaglandin D synthase (EC:5.3.99.2).	Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A, B	Fatty acid-binding protein, liver	antioxidant activity bile acid binding organic acid binding binding ion binding anion binding carboxylic acid binding monocarboxylic acid binding small molecule binding fatty acid binding lipid binding chromatin binding long-chain fatty acid transmembrane transporter activity lipid transporter activity antioxidant activity bile acid binding organic acid binding binding ion binding anion binding carboxylic acid binding monocarboxylic acid binding small molecule binding fatty acid binding lipid binding chromatin binding long-chain fatty acid transmembrane transporter activity lipid transporter activity lipid transmembrane transporter activity fatty acid transmembrane transporter activity transporter activity monocarboxylic acid transmembrane transporter activity carboxylic acid transmembrane transporter activity organic acid transmembrane transporter activity transmembrane transporter activity organic anion transmembrane transporter activity phospholipid binding long-chain fatty acid binding oleic acid binding heterocyclic compound binding	catabolic process regulation of cellular process oxoacid metabolic process ketone metabolic process regulation of lipid metabolic process positive regulation of biological process organic acid catabolic process organic acid metabolic process regulation of primary metabolic process cellular catabolic process regulation of fatty acid oxidation positive regulation of metabolic process positive regulation of fatty acid beta-oxidation monocarboxylic acid catabolic process fatty acid oxidation catabolic process regulation of cellular process oxoacid metabolic process ketone metabolic process regulation of lipid metabolic process positive regulation of biological process organic acid catabolic process organic acid metabolic process regulation of primary metabolic process cellular catabolic process regulation of fatty acid oxidation positive regulation of metabolic process positive regulation of fatty acid beta-oxidation monocarboxylic acid catabolic process fatty acid oxidation positive regulation of lipid catabolic process regulation of small molecule metabolic process carboxylic acid catabolic process fatty acid beta-oxidation positive regulation of lipid metabolic process small molecule metabolic process lipid oxidation positive regulation of cellular process positive regulation of fatty acid metabolic process fatty acid metabolic process regulation of biological process lipid catabolic process regulation of fatty acid beta-oxidation biological regulation carboxylic acid metabolic process primary metabolic process lipid modification regulation of catabolic process regulation of lipid catabolic process regulation of ketone metabolic process fatty acid catabolic process positive regulation of catabolic process positive regulation of fatty acid oxidation regulation of fatty acid metabolic process metabolic process cellular process monocarboxylic acid metabolic process small molecule catabolic process positive regulation of small molecule metabolic process regulation of metabolic process lipid metabolic process negative regulation of programmed cell death regulation of apoptotic process negative regulation of biological process regulation of programmed cell death cell death negative regulation of apoptotic process negative regulation of cellular process apoptotic process programmed cell death response to decreased oxygen levels cellular response to stimulus response to stimulus cellular response to oxygen levels cellular response to hypoxia cellular response to decreased oxygen levels cellular response to chemical stimulus cellular response to stress response to hypoxia response to stress response to chemical response to oxygen levels response to abiotic stimulus multicellular organismal process system process digestion intestinal absorption digestive system process response to nutrient levels response to nutrient response to vitamin B3 response to vitamin cellular response to oxidative stress response to oxygen-containing compound cellular response to chemical stress cellular response to oxygen-containing compound cellular response to hydrogen peroxide response to reactive oxygen species response to hydrogen peroxide response to oxidative stress cellular response to reactive oxygen species organic anion transport carboxylic acid transport transport lipid localization lipid transport establishment of localization organic acid transport localization monocarboxylic acid transport fatty acid transport macromolecule localization	extracellular exosome membrane-bounded organelle extracellular vesicle cellular anatomical structure extracellular organelle extracellular region organelle extracellular space vesicle extracellular membrane-bounded organelle intracellular anatomical structure cytoplasm cytosol nucleus extracellular exosome membrane-bounded organelle extracellular vesicle cellular anatomical structure extracellular organelle extracellular region organelle extracellular space vesicle extracellular membrane-bounded organelle intracellular anatomical structure cytoplasm cytosol nucleus membrane-enclosed lumen intracellular membrane-bounded organelle intracellular organelle lumen intracellular organelle nucleoplasm organelle lumen nuclear lumen protein-containing complex peroxisomal matrix peroxisome microbody lumen microbody cell periphery cell cortex apical part of cell cell cortex region cytoplasmic region apical cortex

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A, B	IPR012674	Calycin	Homologous Superfamily
A, B	IPR000463	Cytosolic fatty-acid binding	Domain
A, B	IPR031259	Intracellular lipid binding protein	Family

Pharos: Disease Associations Pharos Homepage Annotation

Chains	Drug Target	Associated Disease
A, B	Pharos: P07148	acute kidney tubular necrosis chronic kidney disease Lipoidosis nephrosclerosis ulcerative colitis lysosomal lipid storage disorder pancreatic ductal adenocarcinoma Crohn disease malignant colon neoplasm psoriasis

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM157729.