Annotations: 6W8C

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
B	Ion_trans_2_1	e6w8cB2	A: alpha complex topology	X: Voltage-gated ion channels (From Topology)	H: Voltage-gated ion channels (From Topology)	T: Voltage-gated ion channels	F: Ion_trans_2_1	ECOD (1.6)
B	Ion_trans_2	e6w8cB1	A: alpha complex topology	X: Voltage-gated ion channels (From Topology)	H: Voltage-gated ion channels (From Topology)	T: Voltage-gated ion channels	F: Ion_trans_2	ECOD (1.6)
A	Ion_trans_2_1	e6w8cA1	A: alpha complex topology	X: Voltage-gated ion channels (From Topology)	H: Voltage-gated ion channels (From Topology)	T: Voltage-gated ion channels	F: Ion_trans_2_1	ECOD (1.6)
A	Ion_trans_2	e6w8cA2	A: alpha complex topology	X: Voltage-gated ion channels (From Topology)	H: Voltage-gated ion channels (From Topology)	T: Voltage-gated ion channels	F: Ion_trans_2	ECOD (1.6)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A, B	PF07885	Ion channel (Ion_trans_2)	Ion channel	-	Family

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A, B	Potassium channel subfamily K member 2	protein heterodimerization activity protein binding binding protein dimerization activity monoatomic cation transmembrane transporter activity gated channel activity monoatomic ion channel activity potassium ion transmembrane transporter activity voltage-gated channel activity voltage-gated monoatomic ion channel activity potassium channel activity voltage-gated monoatomic cation channel activity monoatomic cation channel activity passive transmembrane transporter activity protein heterodimerization activity protein binding binding protein dimerization activity monoatomic cation transmembrane transporter activity gated channel activity monoatomic ion channel activity potassium ion transmembrane transporter activity voltage-gated channel activity voltage-gated monoatomic ion channel activity potassium channel activity voltage-gated monoatomic cation channel activity monoatomic cation channel activity passive transmembrane transporter activity voltage-gated potassium channel activity inorganic molecular entity transmembrane transporter activity channel activity inorganic cation transmembrane transporter activity monoatomic ion transmembrane transporter activity transporter activity metal ion transmembrane transporter activity transmembrane transporter activity potassium ion leak channel activity narrow pore channel activity leak channel activity mechanosensitive monoatomic cation channel activity mechanosensitive potassium channel activity mechanosensitive monoatomic ion channel activity ligand-gated channel activity cation binding ion binding metal ion binding small molecule binding identical protein binding outward rectifier potassium channel activity	developmental process ear development sensory organ development inner ear development cochlea development animal organ development anatomical structure development response to stimulus response to stress response to wounding response to axon injury trans-synaptic signaling regulation of biological process regulation of signaling developmental process ear development sensory organ development inner ear development cochlea development animal organ development anatomical structure development response to stimulus response to stress response to wounding response to axon injury trans-synaptic signaling regulation of biological process regulation of signaling regulation of cellular process synaptic transmission, GABAergic modulation of chemical synaptic transmission signaling biological regulation cell-cell signaling chemical synaptic transmission cell communication synaptic signaling regulation of trans-synaptic signaling anterograde trans-synaptic signaling regulation of cell communication cellular process regulation of synaptic transmission, GABAergic organic anion transport nitrogen compound transport carboxylic acid transport transport secretion export from cell establishment of localization organic acid transport amino acid transport localization acidic amino acid transport secretion by cell dicarboxylic acid transport glutamate secretion monoatomic ion transmembrane transport inorganic ion transmembrane transport inorganic anion transmembrane transport chloride transport transmembrane transport chloride transmembrane transport monoatomic anion transport monoatomic anion transmembrane transport monoatomic ion transport inorganic anion transport negative regulation of biological process regulation of DNA biosynthetic process regulation of primary metabolic process nucleobase-containing compound metabolic process nucleic acid biosynthetic process negative regulation of cellular process negative regulation of nucleobase-containing compound metabolic process regulation of nucleobase-containing compound metabolic process negative regulation of macromolecule metabolic process regulation of biosynthetic process negative regulation of metabolic process primary metabolic process regulation of macromolecule metabolic process DNA metabolic process nucleobase-containing compound biosynthetic process macromolecule biosynthetic process nucleic acid metabolic process biosynthetic process negative regulation of biosynthetic process negative regulation of macromolecule biosynthetic process negative regulation of DNA metabolic process metabolic process regulation of macromolecule biosynthetic process macromolecule metabolic process regulation of metabolic process DNA biosynthetic process negative regulation of DNA biosynthetic process regulation of DNA metabolic process response to decreased oxygen levels cellular response to stimulus cellular response to oxygen levels cellular response to hypoxia cellular response to decreased oxygen levels cellular response to chemical stimulus cellular response to stress response to hypoxia response to chemical response to oxygen levels response to abiotic stimulus regulation of cellular response to hypoxia positive regulation of biological process regulation of cellular response to stress positive regulation of response to stimulus regulation of response to stress positive regulation of cellular response to hypoxia positive regulation of cellular process regulation of response to stimulus behavior multicellular organismal process system process learning or memory nervous system process cognition memory regulation of growth regulation of cardiac muscle tissue growth regulation of developmental process developmental growth cardiac muscle cell proliferation negative regulation of cardiac muscle tissue growth organ growth striated muscle tissue development negative regulation of organ growth multicellular organism development negative regulation of growth regulation of organ growth regulation of heart growth regulation of cardiac muscle cell proliferation muscle cell proliferation regulation of multicellular organismal process cardiac muscle tissue growth muscle tissue development system development striated muscle cell proliferation heart development negative regulation of cell population proliferation heart growth regulation of multicellular organismal development cell population proliferation regulation of developmental growth negative regulation of heart growth cardiac muscle tissue development negative regulation of developmental process growth tissue development circulatory system development negative regulation of developmental growth regulation of cell population proliferation negative regulation of multicellular organismal process negative regulation of cardiac muscle cell proliferation cell surface receptor signaling pathway chemical synaptic transmission, postsynaptic signal transduction cardiac chamber development cardiac ventricle development potassium ion transport monoatomic cation transport metal ion transport action potential transmission of nerve impulse neuronal action potential regulation of biological quality regulation of membrane potential detection of external stimulus response to mechanical stimulus detection of mechanical stimulus involved in sensory perception of touch response to external stimulus sensory perception of touch detection of mechanical stimulus involved in sensory perception sensory perception of mechanical stimulus detection of abiotic stimulus detection of stimulus sensory perception detection of mechanical stimulus detection of stimulus involved in sensory perception response to lipid response to fatty acid response to oxygen-containing compound cellular response to arachidonate cellular response to oxygen-containing compound cellular response to fatty acid cellular response to lipid response to arachidonate stabilization of membrane potential G protein-coupled receptor signaling pathway	postsynaptic specialization membrane postsynaptic specialization synapse membrane plasma membrane postsynaptic density membrane synaptic membrane cell periphery postsynaptic density postsynapse cellular anatomical structure neuron to neuron synapse organelle cell junction postsynaptic specialization membrane postsynaptic specialization synapse membrane plasma membrane postsynaptic density membrane synaptic membrane cell periphery postsynaptic density postsynapse cellular anatomical structure neuron to neuron synapse organelle cell junction postsynaptic membrane asymmetric synapse plasma membrane region apical part of cell apical plasma membrane axon cell projection main axon neuron projection node of Ranvier plasma membrane bounded cell projection glial cell projection astrocyte projection cell surface sarcolemma somatodendritic compartment dendrite dendritic tree voltage-gated potassium channel complex protein-containing complex plasma membrane protein complex potassium channel complex membrane protein complex cation channel complex transporter complex transmembrane transporter complex monoatomic ion channel complex axon terminus presynapse distal axon calyx of Held neuron projection terminus Schaffer collateral - CA1 synapse cell body neuronal cell body

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A, B	IPR013099	Potassium channel domain	Domain
A, B	IPR003976	Two pore domain potassium channel, TREK	Family
A, B	IPR003280	Two pore domain potassium channel	Family

Membrane Protein Annotation: OPM OPM Database Homepage

Chains	External Link	Type	Class	Superfamily	Family
A, B	OPM	Transmembrane	Alpha-helical polytopic	Ion channel (VIC) superfamily	Two pore Na+ channels

Membrane Protein Annotation: PDBTM PDBTM Database Homepage

Chains	External Link	Comment
A, B	PDBTM	Annotated as membrane protein by PDBTM

Membrane Protein Annotation: mpstruc mpstruc Database Homepage

Chains	Resource Link	Group	Subgroup	Protein
A, B	mpstruc	TRANSMEMBRANE PROTEINS: ALPHA-HELICAL	Channels: Potassium, Sodium, & Proton Ion-Selective	Two-Pore Domain Potassium Channel K_2P2.1 (TREK-1), 0 mM K⁺

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM157729.