Annotations: 6QLY

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A	PF09379	FERM N-terminal domain (FERM_N)	FERM N-terminal domain	This domain is the N-terminal ubiquitin-like structural domain of the FERM domain.	Domain
A	PF09380	FERM C-terminal PH-like domain (FERM_C)	FERM C-terminal PH-like domain	-	Domain
A	PF00373	FERM central domain (FERM_M)	FERM central domain	This domain is the central structural domain of the FERM domain.	Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A	E3 ubiquitin-protein ligase MYLIP	cytoskeletal protein binding protein binding binding aminoacyltransferase activity ubiquitin-like protein transferase activity catalytic activity, acting on a protein acyltransferase activity ubiquitin-like protein ligase activity ubiquitin protein ligase activity transferase activity catalytic activity ubiquitin-protein transferase activity cation binding ion binding cytoskeletal protein binding protein binding binding aminoacyltransferase activity ubiquitin-like protein transferase activity catalytic activity, acting on a protein acyltransferase activity ubiquitin-like protein ligase activity ubiquitin protein ligase activity transferase activity catalytic activity ubiquitin-protein transferase activity cation binding ion binding metal ion binding small molecule binding	protein destabilization regulation of protein stability biological regulation regulation of biological quality regulation of cellular process catabolic process positive regulation of protein metabolic process positive regulation of biological process macromolecule catabolic process regulation of primary metabolic process positive regulation of metabolic process positive regulation of macromolecule metabolic process protein metabolic process positive regulation of cellular process protein destabilization regulation of protein stability biological regulation regulation of biological quality regulation of cellular process catabolic process positive regulation of protein metabolic process positive regulation of biological process macromolecule catabolic process regulation of primary metabolic process positive regulation of metabolic process positive regulation of macromolecule metabolic process protein metabolic process positive regulation of cellular process regulation of biological process regulation of protein metabolic process primary metabolic process regulation of macromolecule metabolic process protein catabolic process regulation of catabolic process positive regulation of protein catabolic process positive regulation of catabolic process metabolic process cellular process macromolecule metabolic process regulation of metabolic process regulation of protein catabolic process sterol homeostasis chemical homeostasis homeostatic process cholesterol homeostasis lipid homeostasis protein ubiquitination macromolecule modification post-translational protein modification protein modification process protein modification by small protein conjugation protein modification by small protein conjugation or removal regulation of neuron projection development multicellular organismal process regulation of cellular component organization cellular developmental process cell projection organization negative regulation of biological process cell development neuron projection development cellular component organization neurogenesis multicellular organism development neuron differentiation cell differentiation anatomical structure development negative regulation of cellular process cellular component organization or biogenesis negative regulation of cell projection organization system development developmental process plasma membrane bounded cell projection organization negative regulation of cellular component organization regulation of cell projection organization nervous system development negative regulation of neuron projection development generation of neurons neuron development regulation of plasma membrane bounded cell projection organization proteolysis involved in protein catabolic process modification-dependent macromolecule catabolic process modification-dependent protein catabolic process proteolysis ubiquitin-dependent protein catabolic process regulation of plasma lipoprotein particle levels regulation of low-density lipoprotein particle clearance negative regulation of low-density lipoprotein particle clearance plasma lipoprotein particle clearance negative regulation of lipoprotein particle clearance regulation of lipoprotein particle clearance regulation of multicellular organismal process low-density lipoprotein particle clearance negative regulation of multicellular organismal process receptor catabolic process cellular catabolic process receptor metabolic process regulation of low-density lipoprotein particle receptor catabolic process low-density lipoprotein particle receptor catabolic process low-density lipoprotein receptor particle metabolic process regulation of receptor catabolic process	cellular anatomical structure intracellular anatomical structure cytoplasm cytosol cell periphery plasma membrane membrane intracellular organelle cytoskeleton organelle membraneless organelle intracellular membraneless organelle

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A	IPR000299	FERM domain	Domain
A	IPR014352	FERM/acyl-CoA-binding protein superfamily	Homologous Superfamily
A	IPR019748	FERM central domain	Domain
A	IPR018980	FERM, C-terminal PH-like domain	Domain
A	IPR000798	Ezrin/radixin/moesin-like	Family
A	IPR011993	PH-like domain superfamily	Homologous Superfamily
A	IPR019749	Band 4.1 domain	Domain
A	IPR035963	FERM superfamily, second domain	Homologous Superfamily
A	IPR013083	Zinc finger, RING/FYVE/PHD-type	Homologous Superfamily
A	IPR041790	MYLIP, FERM domain C-lobe	Domain
A	IPR018979	FERM, N-terminal	Domain
A	IPR029071	Ubiquitin-like domain superfamily	Homologous Superfamily
A	IPR001841	Zinc finger, RING-type	Domain

Pharos: Disease Associations Pharos Homepage Annotation

Chains	Drug Target	Associated Disease
A	Pharos: Q8WY64	endometriosis acute myeloid leukemia Endometrioma malignant glioma medulloblastoma tuberculosis adrenal cortex carcinoma large cell medulloblastoma malignant mesothelioma osteosarcoma ulcerative colitis atypical teratoid rhabdoid tumor exocrine pancreatic carcinoma lung adenocarcinoma malignant pancreatic neoplasm endometriosis acute myeloid leukemia Endometrioma malignant glioma medulloblastoma tuberculosis adrenal cortex carcinoma large cell medulloblastoma malignant mesothelioma osteosarcoma ulcerative colitis atypical teratoid rhabdoid tumor exocrine pancreatic carcinoma lung adenocarcinoma malignant pancreatic neoplasm ovarian cancer

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM157729.