Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

ChainsTypeFamily Name Domain Identifier Family IdentifierProvenance Source (Version)
CSCOP2B SuperfamilyNuclear receptor ligand-binding domain 8033332 3001442 SCOP2B (2022-06-29)
GSCOP2B SuperfamilyNuclear receptor ligand-binding domain 8033332 3001442 SCOP2B (2022-06-29)
ISCOP2B SuperfamilyNuclear receptor ligand-binding domain 8033332 3001442 SCOP2B (2022-06-29)
ASCOP2B SuperfamilyNuclear receptor ligand-binding domain 8033332 3001442 SCOP2B (2022-06-29)
ESCOP2B SuperfamilyNuclear receptor ligand-binding domain 8033332 3001442 SCOP2B (2022-06-29)
KSCOP2B SuperfamilyNuclear receptor ligand-binding domain 8033332 3001442 SCOP2B (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

ChainsFamily NameDomain Identifier ArchitecturePossible HomologyHomologyTopologyFamilyProvenance Source (Version)
CHormone_recepe4p6xC1 A: alpha arraysX: Nuclear receptor ligand-binding domain (From Topology)H: Nuclear receptor ligand-binding domain (From Topology)T: Nuclear receptor ligand-binding domainF: Hormone_recepECOD (1.6)
GHormone_recepe4p6xG1 A: alpha arraysX: Nuclear receptor ligand-binding domain (From Topology)H: Nuclear receptor ligand-binding domain (From Topology)T: Nuclear receptor ligand-binding domainF: Hormone_recepECOD (1.6)
IHormone_recepe4p6xI1 A: alpha arraysX: Nuclear receptor ligand-binding domain (From Topology)H: Nuclear receptor ligand-binding domain (From Topology)T: Nuclear receptor ligand-binding domainF: Hormone_recepECOD (1.6)
AHormone_recepe4p6xA1 A: alpha arraysX: Nuclear receptor ligand-binding domain (From Topology)H: Nuclear receptor ligand-binding domain (From Topology)T: Nuclear receptor ligand-binding domainF: Hormone_recepECOD (1.6)
EHormone_recepe4p6xE1 A: alpha arraysX: Nuclear receptor ligand-binding domain (From Topology)H: Nuclear receptor ligand-binding domain (From Topology)T: Nuclear receptor ligand-binding domainF: Hormone_recepECOD (1.6)
KHormone_recepe4p6xK1 A: alpha arraysX: Nuclear receptor ligand-binding domain (From Topology)H: Nuclear receptor ligand-binding domain (From Topology)T: Nuclear receptor ligand-binding domainF: Hormone_recepECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Protein Family Annotation Pfam Database Homepage

ChainsAccessionNameDescriptionCommentsSource
A, C, E, G, I
PF00104Ligand-binding domain of nuclear hormone receptor (Hormone_recep)Ligand-binding domain of nuclear hormone receptorThis all helical domain is involved in binding the hormone in these receptors.Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

ChainsPolymerMolecular FunctionBiological ProcessCellular Component
A, C, E, G, I
Glucocorticoid receptor
B, D, F, H, J
Nuclear receptor coactivator 2

InterPro: Protein Family Classification InterPro Database Homepage

ChainsAccessionNameType
A, C, E, G, I
IPR001628Zinc finger, nuclear hormone receptor-typeDomain
A, C, E, G, I
IPR050200Nuclear hormone receptor family NR3 subfamilyFamily
A, C, E, G, I
IPR013088Zinc finger, NHR/GATA-typeHomologous Superfamily
A, C, E, G, I
IPR001409Glucocorticoid receptorFamily
A, C, E, G, I
IPR001723Nuclear hormone receptorFamily
A, C, E, G, I
IPR000536Nuclear hormone receptor, ligand-binding domainDomain
A, C, E, G, I
IPR035500Nuclear hormone receptor-like domain superfamilyHomologous Superfamily
B, D, F, H, J
IPR010011Nuclear receptor coactivator, DUF1518Domain
B, D, F, H, J
IPR009110Nuclear receptor coactivator, interlockingHomologous Superfamily
B, D, F, H, J
IPR037077Nuclear receptor coactivator, Ncoa-type, interlocking domain superfamilyHomologous Superfamily
B, D, F, H, J
IPR017426Nuclear receptor coactivatorFamily
B, D, F, H, J
IPR014935Nuclear receptor coactivator, receptor-binding domainDomain
B, D, F, H, J
IPR013767PAS foldDomain
B, D, F, H, J
IPR000014PAS domainDomain
B, D, F, H, J
IPR011598Myc-type, basic helix-loop-helix (bHLH) domainDomain
B, D, F, H, J
IPR014920Nuclear receptor coactivator, Ncoa-type, interlockingDomain
B, D, F, H, J
IPR035965PAS domain superfamilyHomologous Superfamily
B, D, F, H, J
IPR028822Nuclear receptor coactivator 2, basic helix-loop-helixDomain
B, D, F, H, J
IPR032565Nuclear receptor coactivator 2/3, DUF4927Domain
B, D, F, H, J
IPR036638Helix-loop-helix DNA-binding domain superfamilyHomologous Superfamily

Pharos: Disease Associations Pharos Homepage Annotation

ChainsDrug Target  Associated Disease
A, C, E, G, I
PharosP04150
B, D, F, H, J
PharosQ15596