4L7K

Crystal Structure of Ketosteroid Isomerase D38E from Pseudomonas Testosteroni (tKSI)

External Resource: Annotation

Domain Annotation: SCOP/SCOPe Classification
Domain Annotation: SCOP2 Classification
Domain Annotation: ECOD Classification
Domain Annotation: CATH
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification

Domain Annotation: SCOP/SCOPe Classification SCOP-e Database Homepage

Chains	Domain Info	Class	Fold	Superfamily	Family	Domain	Species	Provenance Source (Version)
B	d4l7kb_	Alpha and beta proteins (a+b)	Cystatin-like	NTF2-like	Ketosteroid isomerase-like	Delta-5-3-ketosteroid isomerase, steroid delta-isomerase, KSI	(Comamonas testosteroni ) [TaxId: 285 ],	SCOPe (2.08)
C	d4l7kc_	Alpha and beta proteins (a+b)	Cystatin-like	NTF2-like	Ketosteroid isomerase-like	Delta-5-3-ketosteroid isomerase, steroid delta-isomerase, KSI	(Comamonas testosteroni ) [TaxId: 285 ],	SCOPe (2.08)
D	d4l7kd_	Alpha and beta proteins (a+b)	Cystatin-like	NTF2-like	Ketosteroid isomerase-like	Delta-5-3-ketosteroid isomerase, steroid delta-isomerase, KSI	(Comamonas testosteroni ) [TaxId: 285 ],	SCOPe (2.08)
E	d4l7ke_	Alpha and beta proteins (a+b)	Cystatin-like	NTF2-like	Ketosteroid isomerase-like	Delta-5-3-ketosteroid isomerase, steroid delta-isomerase, KSI	(Comamonas testosteroni ) [TaxId: 285 ],	SCOPe (2.08)
F	d4l7kf_	Alpha and beta proteins (a+b)	Cystatin-like	NTF2-like	Ketosteroid isomerase-like	Delta-5-3-ketosteroid isomerase, steroid delta-isomerase, KSI	(Comamonas testosteroni ) [TaxId: 285 ],	SCOPe (2.08)
G	d4l7kg_	Alpha and beta proteins (a+b)	Cystatin-like	NTF2-like	Ketosteroid isomerase-like	Delta-5-3-ketosteroid isomerase, steroid delta-isomerase, KSI	(Comamonas testosteroni ) [TaxId: 285 ],	SCOPe (2.08)
J	d4l7kj_	Alpha and beta proteins (a+b)	Cystatin-like	NTF2-like	Ketosteroid isomerase-like	Delta-5-3-ketosteroid isomerase, steroid delta-isomerase, KSI	(Comamonas testosteroni ) [TaxId: 285 ],	SCOPe (2.08)
K	d4l7kk_	Alpha and beta proteins (a+b)	Cystatin-like	NTF2-like	Ketosteroid isomerase-like	Delta-5-3-ketosteroid isomerase, steroid delta-isomerase, KSI	(Comamonas testosteroni ) [TaxId: 285 ],	SCOPe (2.08)
A	d4l7ka_	Alpha and beta proteins (a+b)	Cystatin-like	NTF2-like	Ketosteroid isomerase-like	Delta-5-3-ketosteroid isomerase, steroid delta-isomerase, KSI	(Comamonas testosteroni ) [TaxId: 285 ],	SCOPe (2.08)
H	d4l7kh_	Alpha and beta proteins (a+b)	Cystatin-like	NTF2-like	Ketosteroid isomerase-like	Delta-5-3-ketosteroid isomerase, steroid delta-isomerase, KSI	(Comamonas testosteroni ) [TaxId: 285 ],	SCOPe (2.08)
I	d4l7ki_	Alpha and beta proteins (a+b)	Cystatin-like	NTF2-like	Ketosteroid isomerase-like	Delta-5-3-ketosteroid isomerase, steroid delta-isomerase, KSI	(Comamonas testosteroni ) [TaxId: 285 ],	SCOPe (2.08)
L [auth O]	d4l7ko_	Alpha and beta proteins (a+b)	Cystatin-like	NTF2-like	Ketosteroid isomerase-like	Delta-5-3-ketosteroid isomerase, steroid delta-isomerase, KSI	(Comamonas testosteroni ) [TaxId: 285 ],	SCOPe (2.08)

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
B	SCOP2B Superfamily	NTF2-like	8034686	3000472	SCOP2B (2022-06-29)
C	SCOP2B Superfamily	NTF2-like	8034686	3000472	SCOP2B (2022-06-29)
D	SCOP2B Superfamily	NTF2-like	8034686	3000472	SCOP2B (2022-06-29)
E	SCOP2B Superfamily	NTF2-like	8034686	3000472	SCOP2B (2022-06-29)
F	SCOP2B Superfamily	NTF2-like	8034686	3000472	SCOP2B (2022-06-29)
G	SCOP2B Superfamily	NTF2-like	8034686	3000472	SCOP2B (2022-06-29)
J	SCOP2B Superfamily	NTF2-like	8034686	3000472	SCOP2B (2022-06-29)
K	SCOP2B Superfamily	NTF2-like	8034686	3000472	SCOP2B (2022-06-29)
A	SCOP2B Superfamily	NTF2-like	8034686	3000472	SCOP2B (2022-06-29)
H	SCOP2B Superfamily	NTF2-like	8034686	3000472	SCOP2B (2022-06-29)
I	SCOP2B Superfamily	NTF2-like	8034686	3000472	SCOP2B (2022-06-29)
L [auth O]	SCOP2B Superfamily	NTF2-like	8034686	3000472	SCOP2B (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
B	SnoaL_1	e4l7kB1	A: a+b two layers	X: Cystatin-like	H: NTF2-like (From Topology)	T: NTF2-like	F: SnoaL_1	ECOD (1.6)
C	SnoaL_1	e4l7kC1	A: a+b two layers	X: Cystatin-like	H: NTF2-like (From Topology)	T: NTF2-like	F: SnoaL_1	ECOD (1.6)
D	SnoaL_1	e4l7kD1	A: a+b two layers	X: Cystatin-like	H: NTF2-like (From Topology)	T: NTF2-like	F: SnoaL_1	ECOD (1.6)
E	SnoaL_1	e4l7kE1	A: a+b two layers	X: Cystatin-like	H: NTF2-like (From Topology)	T: NTF2-like	F: SnoaL_1	ECOD (1.6)
F	SnoaL_1	e4l7kF1	A: a+b two layers	X: Cystatin-like	H: NTF2-like (From Topology)	T: NTF2-like	F: SnoaL_1	ECOD (1.6)
G	SnoaL_1	e4l7kG1	A: a+b two layers	X: Cystatin-like	H: NTF2-like (From Topology)	T: NTF2-like	F: SnoaL_1	ECOD (1.6)
J	SnoaL_1	e4l7kJ1	A: a+b two layers	X: Cystatin-like	H: NTF2-like (From Topology)	T: NTF2-like	F: SnoaL_1	ECOD (1.6)
K	SnoaL_1	e4l7kK1	A: a+b two layers	X: Cystatin-like	H: NTF2-like (From Topology)	T: NTF2-like	F: SnoaL_1	ECOD (1.6)
A	SnoaL_1	e4l7kA1	A: a+b two layers	X: Cystatin-like	H: NTF2-like (From Topology)	T: NTF2-like	F: SnoaL_1	ECOD (1.6)
H	SnoaL_1	e4l7kH1	A: a+b two layers	X: Cystatin-like	H: NTF2-like (From Topology)	T: NTF2-like	F: SnoaL_1	ECOD (1.6)
I	SnoaL_1	e4l7kI1	A: a+b two layers	X: Cystatin-like	H: NTF2-like (From Topology)	T: NTF2-like	F: SnoaL_1	ECOD (1.6)
L [auth O]	SnoaL_1	e4l7kO1	A: a+b two layers	X: Cystatin-like	H: NTF2-like (From Topology)	T: NTF2-like	F: SnoaL_1	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
B	3.10.450.50	Alpha Beta	Roll	Nuclear Transport Factor 2	Chain: A,	CATH (4.3.0)
C	3.10.450.50	Alpha Beta	Roll	Nuclear Transport Factor 2	Chain: A,	CATH (4.3.0)
D	3.10.450.50	Alpha Beta	Roll	Nuclear Transport Factor 2	Chain: A,	CATH (4.3.0)
E	3.10.450.50	Alpha Beta	Roll	Nuclear Transport Factor 2	Chain: A,	CATH (4.3.0)
F	3.10.450.50	Alpha Beta	Roll	Nuclear Transport Factor 2	Chain: A,	CATH (4.3.0)
G	3.10.450.50	Alpha Beta	Roll	Nuclear Transport Factor 2	Chain: A,	CATH (4.3.0)
J	3.10.450.50	Alpha Beta	Roll	Nuclear Transport Factor 2	Chain: A,	CATH (4.3.0)
K	3.10.450.50	Alpha Beta	Roll	Nuclear Transport Factor 2	Chain: A,	CATH (4.3.0)
A	3.10.450.50	Alpha Beta	Roll	Nuclear Transport Factor 2	Chain: A,	CATH (4.3.0)
H	3.10.450.50	Alpha Beta	Roll	Nuclear Transport Factor 2	Chain: A,	CATH (4.3.0)
I	3.10.450.50	Alpha Beta	Roll	Nuclear Transport Factor 2	Chain: A,	CATH (4.3.0)
L [auth O]	3.10.450.50	Alpha Beta	Roll	Nuclear Transport Factor 2	Chain: A,	CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A, B, C, D, E, A, B, C, D, E, F, G, H, I, J, K, L [auth O]	PF12680	SnoaL-like domain (SnoaL_2)	SnoaL-like domain	This family contains a large number of proteins that share the SnoaL fold.	Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A, B, C, D, E, A, B, C, D, E, F, G, H, I, J, K, L [auth O]	Steroid Delta-isomerase	isomerase activity intramolecular oxidoreductase activity, transposing C=C bonds steroid delta-isomerase activity intramolecular oxidoreductase activity catalytic activity	steroid metabolic process primary metabolic process metabolic process cellular process lipid metabolic process	-

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A, B, C, D, E, A, B, C, D, E, F, G, H, I, J, K, L [auth O]	IPR032710	NTF2-like domain superfamily	Homologous Superfamily
A, B, C, D, E, A, B, C, D, E, F, G, H, I, J, K, L [auth O]	IPR039256	Ketosteroid isomerase	Family
A, B, C, D, E, A, B, C, D, E, F, G, H, I, J, K, L [auth O]	IPR037401	SnoaL-like domain	Domain
A, B, C, D, E, A, B, C, D, E, F, G, H, I, J, K, L [auth O]	IPR011944	Steroid delta5-4-isomerase	Family

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM157729.