4NC2
Crystal structure of TcdB-B1 bound to B39 VHH
Domain Annotation: SCOP/SCOPe Classification SCOP-e Database Homepage
Chains | Domain Info | Class | Fold | Superfamily | Family | Domain | Species | Provenance Source (Version) |
---|---|---|---|---|---|---|---|---|
B | d4nc2b_ | All beta proteins | Immunoglobulin-like beta-sandwich | Immunoglobulin | automated matches | automated matches | (Lama glama ) [TaxId: 9844 ], | SCOPe (2.08) |
Domain Annotation: ECOD Classification ECOD Database Homepage
Chains | Family Name | Domain Identifier | Architecture | Possible Homology | Homology | Topology | Family | Provenance Source (Version) |
---|---|---|---|---|---|---|---|---|
A | CW_binding_1 | e4nc2A1 | A: beta duplicates or obligate multimers | X: beta-hairpin stack (From Topology) | H: beta-hairpin stack (From Topology) | T: beta-hairpin stack | F: CW_binding_1 | ECOD (1.6) |
B | V-set_8 | e4nc2B1 | A: beta sandwiches | X: Immunoglobulin-like beta-sandwich | H: Immunoglobulin-related | T: Immunoglobulin/Fibronectin type III/E set domains/PapD-like | F: V-set_8 | ECOD (1.6) |
Domain Annotation: CATH CATH Database Homepage
Chain | Domain | Class | Architecture | Topology | Homology | Provenance Source (Version) |
---|---|---|---|---|---|---|
A | 2.10.270.10 | Mainly Beta | Ribbon | left handed beta-beta-3-solenoid | Cholin Binding | CATH (4.3.0) |
B | 2.60.40.10 | Mainly Beta | Sandwich | Immunoglobulin-like | Immunoglobulins | CATH (4.3.0) |
IMGT Antibody Annotation IMGT Database Homepage
Chain | Protein Name | Description | Organism Name | Gene Allele Name(s) | Domain Name(s) | Receptor Type | Receptor Description | Provenance Source |
---|---|---|---|---|---|---|---|---|
B39 VHH | VH | Lama glama (llama) | IGHV3S3*01, IGHJ4*01 | V-DOMAIN VH | IG | (VH) | IMGT (202448-0) |
SAbDab Antibody Annotation SAbDab Database Homepage
Chain | Chain Class | Chain Subclass | Chain Type | Antigen Name(s) | Provenance Source |
---|---|---|---|---|---|
Heavy Chain | IGHV1 | - | toxin b | SAbDab (2024-12-06) |
Protein Family Annotation Pfam Database Homepage
Chains | Accession | Name | Description | Comments | Source |
---|---|---|---|---|---|
PF01473 | Putative cell wall binding repeat (Choline_bind_1) | Putative cell wall binding repeat | - | Repeat | |
Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage
InterPro: Protein Family Classification InterPro Database Homepage
Chains | Accession | Name | Type |
---|---|---|---|
IPR038383 | CGT/MARTX, cysteine protease (CPD) domain superfamily | Homologous Superfamily | |
IPR024772 | TcdA/TcdB toxin, N-terminal helical domain | Domain | |
IPR020974 | CGT/MARTX, cysteine protease (CPD) domain | Domain | |
IPR024769 | TcdA/TcdB toxin, pore forming domain | Domain | |
IPR029044 | Nucleotide-diphospho-sugar transferases | Homologous Superfamily | |
IPR024770 | TcdA/TcdB toxin, catalytic glycosyltransferase domain | Domain | |
IPR018337 | Cell wall/choline-binding repeat | Repeat |