3WXJ

Crystal structure of trypanosoma brucei gambiense glycerol kinase in complex with glycerol 3-phosphate

External Resource: Annotation

Domain Annotation: SCOP/SCOPe Classification
Domain Annotation: ECOD Classification
Domain Annotation: CATH
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification

Domain Annotation: SCOP/SCOPe Classification SCOP-e Database Homepage

Chains	Domain Info	Class	Fold	Superfamily	Family	Domain	Species	Provenance Source (Version)
D	d3wxjd1	Alpha and beta proteins (a/b)	Ribonuclease H-like motif	Actin-like ATPase domain	automated matches	automated matches	(Trypanosoma brucei gambiense ) [TaxId: 31285 ],	SCOPe (2.08)
D	d3wxjd3	Artifacts	Tags	Tags	Tags	N-terminal Tags	(Trypanosoma brucei gambiense ) [TaxId: 31285 ],	SCOPe (2.08)
A	d3wxja1	Alpha and beta proteins (a/b)	Ribonuclease H-like motif	Actin-like ATPase domain	automated matches	automated matches	(Trypanosoma brucei gambiense ) [TaxId: 31285 ],	SCOPe (2.08)
A	d3wxja3	Artifacts	Tags	Tags	Tags	N-terminal Tags	(Trypanosoma brucei gambiense ) [TaxId: 31285 ],	SCOPe (2.08)
B	d3wxjb1	Alpha and beta proteins (a/b)	Ribonuclease H-like motif	Actin-like ATPase domain	automated matches	automated matches	(Trypanosoma brucei gambiense ) [TaxId: 31285 ],	SCOPe (2.08)
B	d3wxjb3	Artifacts	Tags	Tags	Tags	N-terminal Tags	(Trypanosoma brucei gambiense ) [TaxId: 31285 ],	SCOPe (2.08)
C	d3wxjc1	Alpha and beta proteins (a/b)	Ribonuclease H-like motif	Actin-like ATPase domain	automated matches	automated matches	(Trypanosoma brucei gambiense ) [TaxId: 31285 ],	SCOPe (2.08)
C	d3wxjc3	Artifacts	Tags	Tags	Tags	N-terminal Tags	(Trypanosoma brucei gambiense ) [TaxId: 31285 ],	SCOPe (2.08)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
D	FGGY_C	e3wxjD2	A: mixed a+b and a/b	X: Ribonuclease H-like	H: Ribonuclease H-like (From Topology)	T: Ribonuclease H-like	F: FGGY_C	ECOD (1.6)
D	FGGY_N	e3wxjD1	A: mixed a+b and a/b	X: Ribonuclease H-like	H: Ribonuclease H-like (From Topology)	T: Ribonuclease H-like	F: FGGY_N	ECOD (1.6)
A	FGGY_C	e3wxjA2	A: mixed a+b and a/b	X: Ribonuclease H-like	H: Ribonuclease H-like (From Topology)	T: Ribonuclease H-like	F: FGGY_C	ECOD (1.6)
A	FGGY_N	e3wxjA1	A: mixed a+b and a/b	X: Ribonuclease H-like	H: Ribonuclease H-like (From Topology)	T: Ribonuclease H-like	F: FGGY_N	ECOD (1.6)
B	FGGY_C	e3wxjB1	A: mixed a+b and a/b	X: Ribonuclease H-like	H: Ribonuclease H-like (From Topology)	T: Ribonuclease H-like	F: FGGY_C	ECOD (1.6)
B	FGGY_N	e3wxjB2	A: mixed a+b and a/b	X: Ribonuclease H-like	H: Ribonuclease H-like (From Topology)	T: Ribonuclease H-like	F: FGGY_N	ECOD (1.6)
C	FGGY_C	e3wxjC1	A: mixed a+b and a/b	X: Ribonuclease H-like	H: Ribonuclease H-like (From Topology)	T: Ribonuclease H-like	F: FGGY_C	ECOD (1.6)
C	FGGY_N	e3wxjC2	A: mixed a+b and a/b	X: Ribonuclease H-like	H: Ribonuclease H-like (From Topology)	T: Ribonuclease H-like	F: FGGY_N	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
D	3.30.420.40	Alpha Beta	2-Layer Sandwich	Nucleotidyltransferase	domain 5	CATH (4.3.0)
A	3.30.420.40	Alpha Beta	2-Layer Sandwich	Nucleotidyltransferase	domain 5	CATH (4.3.0)
B	3.30.420.40	Alpha Beta	2-Layer Sandwich	Nucleotidyltransferase	domain 5	CATH (4.3.0)
C	3.30.420.40	Alpha Beta	2-Layer Sandwich	Nucleotidyltransferase	domain 5	CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A, B, C, D	PF00370	FGGY family of carbohydrate kinases, N-terminal domain (FGGY_N)	FGGY family of carbohydrate kinases, N-terminal domain	This domain adopts a ribonuclease H-like fold and is structurally related to the C-terminal domain.	Domain
A, B, C, D	PF02782	FGGY family of carbohydrate kinases, C-terminal domain (FGGY_C)	FGGY family of carbohydrate kinases, C-terminal domain	This domain adopts a ribonuclease H-like fold and is structurally related to the N-terminal domain.	Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A, B, C, D	Glycerol kinase	binding adenyl ribonucleotide binding nucleotide binding purine ribonucleotide binding purine ribonucleoside triphosphate binding nucleoside phosphate binding ion binding purine nucleotide binding organic cyclic compound binding anion binding adenyl nucleotide binding ATP binding heterocyclic compound binding carbohydrate derivative binding binding adenyl ribonucleotide binding nucleotide binding purine ribonucleotide binding purine ribonucleoside triphosphate binding nucleoside phosphate binding ion binding purine nucleotide binding organic cyclic compound binding anion binding adenyl nucleotide binding ATP binding heterocyclic compound binding carbohydrate derivative binding ribonucleotide binding small molecule binding kinase activity glycerol kinase activity transferase activity catalytic activity phosphotransferase activity, alcohol group as acceptor transferase activity, transferring phosphorus-containing groups	carbohydrate metabolic process polyol metabolic process alcohol catabolic process catabolic process organic hydroxy compound metabolic process polyol catabolic process carbohydrate catabolic process primary metabolic process alcohol metabolic process alditol catabolic process glycerol metabolic process alditol metabolic process organic hydroxy compound catabolic process glycerol catabolic process carbohydrate metabolic process polyol metabolic process alcohol catabolic process catabolic process organic hydroxy compound metabolic process polyol catabolic process carbohydrate catabolic process primary metabolic process alcohol metabolic process alditol catabolic process glycerol metabolic process alditol metabolic process organic hydroxy compound catabolic process glycerol catabolic process metabolic process cellular process small molecule metabolic process small molecule catabolic process neutral lipid metabolic process triglyceride metabolic process glycerolipid metabolic process acylglycerol metabolic process lipid metabolic process phosphorylation phosphate-containing compound metabolic process phosphorus metabolic process carbohydrate derivative biosynthetic process glycerol-3-phosphate biosynthetic process carbohydrate derivative metabolic process biosynthetic process glycerol-3-phosphate metabolic process organophosphate metabolic process organophosphate biosynthetic process alditol phosphate metabolic process	membrane-bounded organelle intracellular organelle cellular anatomical structure intracellular anatomical structure mitochondrion organelle cytoplasm intracellular membrane-bounded organelle

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A, B, C, D	IPR018483	Carbohydrate kinase, FGGY, conserved site	Conserved Site
A, B, C, D	IPR043129	ATPase, nucleotide binding domain	Homologous Superfamily
A, B, C, D	IPR018485	Carbohydrate kinase FGGY, C-terminal	Domain
A, B, C, D	IPR005999	Glycerol kinase	Family
A, B, C, D	IPR000577	Carbohydrate kinase, FGGY	Family
A, B, C, D	IPR018484	Carbohydrate kinase FGGY, N-terminal	Domain

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM157729.