3O2H

E. coli ClpS in complex with a Leu N-end rule peptide

External Resource: Annotation

Domain Annotation: SCOP/SCOPe Classification
Domain Annotation: SCOP2 Classification
Domain Annotation: ECOD Classification
Domain Annotation: CATH
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification

Domain Annotation: SCOP/SCOPe Classification SCOP-e Database Homepage

Chains	Domain Info	Class	Fold	Superfamily	Family	Domain	Species	Provenance Source (Version)
A	d3o2ha_	Alpha and beta proteins (a+b)	ClpS-like	ClpS-like	Adaptor protein ClpS (YljA)	Adaptor protein ClpS (YljA)	(Escherichia coli K-12 ) [TaxId: 83333 ],	SCOPe (2.08)

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
A	SCOP2B Superfamily	ClpS-like	8032304	3000936	SCOP2B (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	ClpS	e3o2hA1	A: a+b two layers	X: ClpS-like	H: ClpS-related (From Topology)	T: ClpS-related	F: ClpS	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
A	3.30.1390.10	Alpha Beta	2-Layer Sandwich	Ribosomal Protein L30	Chain: A,	CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A	PF02617	ATP-dependent Clp protease adaptor protein ClpS (ClpS)	ATP-dependent Clp protease adaptor protein ClpS	-	Family

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A	ATP-dependent Clp protease adaptor protein ClpS	protein binding binding protein-folding chaperone binding molecular function inhibitor activity molecular function regulator activity	catabolic process metabolic process cellular process primary metabolic process protein catabolic process protein metabolic process macromolecule metabolic process macromolecule catabolic process proteolysis response to stimulus response to stress response to heat response to abiotic stimulus response to temperature stimulus	-
B	DNA protection during starvation protein	DNA binding binding organic cyclic compound binding nucleic acid binding oxidoreductase activity, acting on metal ions oxidoreductase activity catalytic activity cation binding ferric iron binding transition metal ion binding iron ion binding ion binding metal ion binding small molecule binding DNA binding binding organic cyclic compound binding nucleic acid binding oxidoreductase activity, acting on metal ions oxidoreductase activity catalytic activity cation binding ferric iron binding transition metal ion binding iron ion binding ion binding metal ion binding small molecule binding identical protein binding protein binding	intracellular iron ion homeostasis inorganic ion homeostasis cellular homeostasis chemical homeostasis homeostatic process intracellular monoatomic cation homeostasis monoatomic ion homeostasis intracellular chemical homeostasis monoatomic cation homeostasis intracellular monoatomic ion homeostasis regulation of DNA-templated DNA replication initiation regulation of cellular process negative regulation of biological process negative regulation of DNA-templated DNA replication initiation intracellular iron ion homeostasis inorganic ion homeostasis cellular homeostasis chemical homeostasis homeostatic process intracellular monoatomic cation homeostasis monoatomic ion homeostasis intracellular chemical homeostasis monoatomic cation homeostasis intracellular monoatomic ion homeostasis regulation of DNA-templated DNA replication initiation regulation of cellular process negative regulation of biological process negative regulation of DNA-templated DNA replication initiation regulation of primary metabolic process nucleobase-containing compound metabolic process negative regulation of DNA-templated DNA replication negative regulation of cellular process negative regulation of nucleobase-containing compound metabolic process regulation of nucleobase-containing compound metabolic process negative regulation of macromolecule metabolic process DNA-templated DNA replication regulation of biological process negative regulation of DNA replication DNA replication initiation negative regulation of metabolic process biological regulation primary metabolic process DNA metabolic process regulation of macromolecule metabolic process nucleic acid metabolic process DNA replication regulation of DNA-templated DNA replication metabolic process cellular process negative regulation of DNA metabolic process macromolecule metabolic process regulation of metabolic process regulation of DNA replication regulation of DNA metabolic process cellular component organization organelle organization chromosome condensation chromosome organization cellular component organization or biogenesis response to stimulus response to stress response to nutrient levels response to starvation	cellular anatomical structure membrane protein-containing complex intracellular anatomical structure DnaA-Dps complex protein-DNA complex intracellular membraneless organelle chromosome replication inhibiting complex intracellular organelle organelle membraneless organelle replication fork replisome cellular anatomical structure membrane protein-containing complex intracellular anatomical structure DnaA-Dps complex protein-DNA complex intracellular membraneless organelle chromosome replication inhibiting complex intracellular organelle organelle membraneless organelle replication fork replisome nucleoid cytoplasm

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A	IPR003769	Adaptor protein ClpS, core	Domain
A	IPR014719	Ribosomal protein bL12, C-terminal/adaptor protein ClpS-like	Homologous Superfamily
A	IPR022935	ATP-dependent Clp protease adaptor protein ClpS	Family
B	IPR002177	DNA-binding protein Dps	Family
B	IPR012347	Ferritin-like	Homologous Superfamily
B	IPR009078	Ferritin-like superfamily	Homologous Superfamily
B	IPR023067	DNA protection during starvation protein, gammaproteobacteria	Family
B	IPR023188	DNA-binding protein Dps, conserved site	Conserved Site
B	IPR008331	Ferritin/DPS protein domain	Domain

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM157729.