3H52

Crystal structure of the antagonist form of human glucocorticoid receptor

External Resource: Annotation

Domain Annotation: SCOP/SCOPe Classification
Domain Annotation: SCOP2 Classification
Domain Annotation: ECOD Classification
Domain Annotation: CATH
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification
Pharos: Disease Associations

Domain Annotation: SCOP/SCOPe Classification SCOP-e Database Homepage

Chains	Domain Info	Class	Fold	Superfamily	Family	Domain	Species	Provenance Source (Version)
D	d3h52d_	All alpha proteins	Nuclear receptor ligand-binding domain	Nuclear receptor ligand-binding domain	Nuclear receptor ligand-binding domain	automated matches	Human (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)
A	d3h52a1	All alpha proteins	Nuclear receptor ligand-binding domain	Nuclear receptor ligand-binding domain	Nuclear receptor ligand-binding domain	automated matches	Human (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)
A	d3h52a2	Artifacts	Tags	Tags	Tags	N-terminal Tags	Human (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)
B	d3h52b_	All alpha proteins	Nuclear receptor ligand-binding domain	Nuclear receptor ligand-binding domain	Nuclear receptor ligand-binding domain	automated matches	Human (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)
C	d3h52c1	All alpha proteins	Nuclear receptor ligand-binding domain	Nuclear receptor ligand-binding domain	Nuclear receptor ligand-binding domain	automated matches	Human (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)
C	d3h52c2	Artifacts	Tags	Tags	Tags	N-terminal Tags	Human (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
D	SCOP2B Superfamily	Nuclear receptor ligand-binding domain	8033332	3001442	SCOP2B (2022-06-29)
A	SCOP2B Superfamily	Nuclear receptor ligand-binding domain	8033332	3001442	SCOP2B (2022-06-29)
B	SCOP2B Superfamily	Nuclear receptor ligand-binding domain	8033332	3001442	SCOP2B (2022-06-29)
C	SCOP2B Superfamily	Nuclear receptor ligand-binding domain	8033332	3001442	SCOP2B (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
D	Hormone_recep	e3h52D1	A: alpha arrays	X: Nuclear receptor ligand-binding domain (From Topology)	H: Nuclear receptor ligand-binding domain (From Topology)	T: Nuclear receptor ligand-binding domain	F: Hormone_recep	ECOD (1.6)
A	Hormone_recep	e3h52A1	A: alpha arrays	X: Nuclear receptor ligand-binding domain (From Topology)	H: Nuclear receptor ligand-binding domain (From Topology)	T: Nuclear receptor ligand-binding domain	F: Hormone_recep	ECOD (1.6)
B	Hormone_recep	e3h52B1	A: alpha arrays	X: Nuclear receptor ligand-binding domain (From Topology)	H: Nuclear receptor ligand-binding domain (From Topology)	T: Nuclear receptor ligand-binding domain	F: Hormone_recep	ECOD (1.6)
C	Hormone_recep	e3h52C1	A: alpha arrays	X: Nuclear receptor ligand-binding domain (From Topology)	H: Nuclear receptor ligand-binding domain (From Topology)	T: Nuclear receptor ligand-binding domain	F: Hormone_recep	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
D	1.10.565.10	Mainly Alpha	Orthogonal Bundle	Retinoid X Receptor	Retinoid X Receptor	CATH (4.3.0)
A	6.10.250.340	Special	Helix non-globular	Single alpha-helices involved in coiled-coils or other helix-helix interfaces		CATH (4.3.0)
A	1.10.565.10	Mainly Alpha	Orthogonal Bundle	Retinoid X Receptor	Retinoid X Receptor	CATH (4.3.0)
B	1.10.565.10	Mainly Alpha	Orthogonal Bundle	Retinoid X Receptor	Retinoid X Receptor	CATH (4.3.0)
C	1.10.565.10	Mainly Alpha	Orthogonal Bundle	Retinoid X Receptor	Retinoid X Receptor	CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A, B, C, D	PF00104	Ligand-binding domain of nuclear hormone receptor (Hormone_recep)	Ligand-binding domain of nuclear hormone receptor	This all helical domain is involved in binding the hormone in these receptors.	Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
E [auth N], F [auth M]	Nuclear receptor corepressor 1	DNA binding sequence-specific DNA binding sequence-specific double-stranded DNA binding transcription cis-regulatory region binding binding double-stranded DNA binding organic cyclic compound binding nucleic acid binding transcription regulatory region nucleic acid binding histone deacetylase binding protein binding enzyme binding transcription factor binding RNA polymerase II-specific DNA-binding transcription factor binding DNA binding sequence-specific DNA binding sequence-specific double-stranded DNA binding transcription cis-regulatory region binding binding double-stranded DNA binding organic cyclic compound binding nucleic acid binding transcription regulatory region nucleic acid binding histone deacetylase binding protein binding enzyme binding transcription factor binding RNA polymerase II-specific DNA-binding transcription factor binding nuclear receptor binding nuclear thyroid hormone receptor binding DNA-binding transcription factor binding transcription corepressor activity transcription regulator activity transcription coregulator activity protein-macromolecule adaptor activity molecular adaptor activity	regulation of cellular process negative regulation of biological process RNA metabolic process regulation of primary metabolic process negative regulation of RNA biosynthetic process RNA biosynthetic process nucleobase-containing compound metabolic process DNA-templated transcription nucleic acid biosynthetic process regulation of RNA metabolic process negative regulation of cellular process negative regulation of nucleobase-containing compound metabolic process regulation of nucleobase-containing compound metabolic process regulation of RNA biosynthetic process regulation of cellular process negative regulation of biological process RNA metabolic process regulation of primary metabolic process negative regulation of RNA biosynthetic process RNA biosynthetic process nucleobase-containing compound metabolic process DNA-templated transcription nucleic acid biosynthetic process regulation of RNA metabolic process negative regulation of cellular process negative regulation of nucleobase-containing compound metabolic process regulation of nucleobase-containing compound metabolic process regulation of RNA biosynthetic process negative regulation of macromolecule metabolic process regulation of biosynthetic process negative regulation of DNA-templated transcription regulation of biological process negative regulation of metabolic process biological regulation primary metabolic process regulation of macromolecule metabolic process nucleobase-containing compound biosynthetic process gene expression macromolecule biosynthetic process nucleic acid metabolic process regulation of gene expression biosynthetic process negative regulation of biosynthetic process negative regulation of macromolecule biosynthetic process metabolic process cellular process regulation of macromolecule biosynthetic process macromolecule metabolic process regulation of DNA-templated transcription regulation of metabolic process negative regulation of RNA metabolic process negative regulation of small molecule metabolic process oxoacid metabolic process ketone metabolic process regulation of lipid metabolic process organic acid metabolic process regulation of small molecule metabolic process small molecule metabolic process fatty acid metabolic process negative regulation of fatty acid metabolic process carboxylic acid metabolic process regulation of ketone metabolic process regulation of fatty acid metabolic process monocarboxylic acid metabolic process negative regulation of lipid metabolic process lipid metabolic process ribonucleotide catabolic process pyridine nucleotide catabolic process negative regulation of glycolytic process carbohydrate catabolic process organophosphate catabolic process carbohydrate derivative metabolic process regulation of generation of precursor metabolites and energy nucleoside phosphate catabolic process negative regulation of ATP metabolic process regulation of ATP metabolic process regulation of purine nucleotide catabolic process negative regulation of nucleotide metabolic process glycolytic process regulation of nucleotide metabolic process regulation of phosphate metabolic process phosphate-containing compound metabolic process pyridine-containing compound metabolic process purine ribonucleotide catabolic process phosphorus metabolic process pyridine nucleotide metabolic process negative regulation of carbohydrate metabolic process nucleoside phosphate metabolic process nicotinamide nucleotide metabolic process pyruvate metabolic process regulation of carbohydrate catabolic process negative regulation of purine nucleotide catabolic process purine nucleoside diphosphate metabolic process purine-containing compound catabolic process nucleotide metabolic process regulation of purine nucleotide metabolic process nucleobase-containing compound catabolic process nucleoside diphosphate metabolic process purine nucleoside diphosphate catabolic process nucleoside diphosphate catabolic process regulation of nucleotide catabolic process regulation of phosphorus metabolic process nucleoside triphosphate metabolic process purine ribonucleotide metabolic process pyridine-containing compound catabolic process ribose phosphate metabolic process catabolic process ATP metabolic process negative regulation of purine nucleotide metabolic process negative regulation of phosphate metabolic process purine nucleotide metabolic process ribonucleotide metabolic process nucleobase-containing small molecule metabolic process purine ribonucleoside triphosphate metabolic process ribonucleoside diphosphate metabolic process ribonucleoside diphosphate catabolic process regulation of carbohydrate metabolic process nucleotide catabolic process ribonucleoside triphosphate metabolic process negative regulation of nucleotide catabolic process negative regulation of catabolic process purine nucleoside triphosphate metabolic process purine nucleotide catabolic process carbohydrate metabolic process carbohydrate derivative catabolic process ADP catabolic process regulation of catabolic process generation of precursor metabolites and energy regulation of glycolytic process purine-containing compound metabolic process ADP metabolic process organophosphate metabolic process negative regulation of phosphorus metabolic process purine ribonucleoside diphosphate metabolic process purine ribonucleoside diphosphate catabolic process cellular response to stimulus response to stimulus signaling negative regulation of signaling negative regulation of intracellular signal transduction regulation of signal transduction intracellular signal transduction negative regulation of cell communication cell communication negative regulation of JNK cascade regulation of intracellular signal transduction JNK cascade intracellular signaling cassette signal transduction regulation of signaling negative regulation of response to stimulus regulation of JNK cascade regulation of MAPK cascade negative regulation of signal transduction regulation of response to stimulus MAPK cascade regulation of cell communication negative regulation of MAPK cascade organelle assembly microtubule cytoskeleton organization membraneless organelle assembly spindle assembly cellular component organization cellular component biogenesis organelle organization cellular component assembly microtubule-based process cell cycle cellular component organization or biogenesis cytoskeleton organization chromosome segregation spindle organization cell cycle process negative regulation of miRNA transcription miRNA transcription regulation of miRNA metabolic process miRNA metabolic process negative regulation of miRNA metabolic process regulation of miRNA transcription behavior rhythmic process multicellular organismal process circadian behavior locomotory behavior rhythmic behavior circadian rhythm locomotor rhythm intracellular receptor signaling pathway response to lipid hormone-mediated signaling pathway negative regulation of intracellular steroid hormone receptor signaling pathway cellular response to endogenous stimulus response to hormone response to steroid hormone regulation of intracellular steroid hormone receptor signaling pathway androgen receptor signaling pathway nuclear receptor-mediated steroid hormone signaling pathway cellular response to steroid hormone stimulus response to organic cyclic compound steroid hormone receptor signaling pathway cellular response to hormone stimulus response to endogenous stimulus cellular response to organic cyclic compound regulation of androgen receptor signaling pathway cellular response to chemical stimulus response to chemical cellular response to lipid negative regulation of androgen receptor signaling pathway nuclear receptor-mediated signaling pathway transcription by RNA polymerase II regulation of transcription by RNA polymerase II negative regulation of transcription by RNA polymerase II chromatin organization	cellular anatomical structure membrane intracellular anatomical structure cytoplasm cytosol intracellular organelle mitotic spindle cytoskeleton spindle organelle membraneless organelle intracellular membraneless organelle microtubule cytoskeleton membrane-bounded organelle cellular anatomical structure membrane intracellular anatomical structure cytoplasm cytosol intracellular organelle mitotic spindle cytoskeleton spindle organelle membraneless organelle intracellular membraneless organelle microtubule cytoskeleton membrane-bounded organelle nucleus membrane-enclosed lumen intracellular membrane-bounded organelle intracellular organelle lumen nucleoplasm organelle lumen nuclear lumen chromatin chromosome protein-containing complex catalytic complex nuclear protein-containing complex histone deacetylase complex transcription regulator complex transcription repressor complex
A, B, C, D	Glucocorticoid receptor	DNA binding sequence-specific DNA binding sequence-specific double-stranded DNA binding transcription cis-regulatory region binding binding double-stranded DNA binding organic cyclic compound binding core promoter sequence-specific DNA binding nucleic acid binding transcription regulatory region nucleic acid binding steroid hormone binding steroid binding lipid binding hormone binding DNA binding sequence-specific DNA binding sequence-specific double-stranded DNA binding transcription cis-regulatory region binding binding double-stranded DNA binding organic cyclic compound binding core promoter sequence-specific DNA binding nucleic acid binding transcription regulatory region nucleic acid binding steroid hormone binding steroid binding lipid binding hormone binding DNA-binding transcription factor activity, RNA polymerase II-specific transcription regulator activity DNA-binding transcription factor activity RNA polymerase II transcription regulatory region sequence-specific DNA binding cis-regulatory region sequence-specific DNA binding estrogen response element binding RNA polymerase II cis-regulatory region sequence-specific DNA binding transcription factor binding protein binding TBP-class protein binding general transcription initiation factor binding nuclear receptor activity molecular transducer activity ligand-activated transcription factor activity signaling receptor activity nuclear steroid receptor activity nuclear glucocorticoid receptor activity DNA-binding transcription activator activity, RNA polymerase II-specific DNA-binding transcription activator activity identical protein binding DNA-binding transcription repressor activity, RNA polymerase II-specific DNA-binding transcription repressor activity Hsp90 protein binding heat shock protein binding RNA binding kinase binding enzyme binding protein kinase binding cation binding transition metal ion binding zinc ion binding ion binding metal ion binding small molecule binding	cellular process cell division cell cycle chromosome segregation cell cycle process apoptotic process cell death programmed cell death regulation of biological process neuron apoptotic process positive regulation of programmed cell death regulation of cellular process regulation of apoptotic process biological regulation cellular process cell division cell cycle chromosome segregation cell cycle process apoptotic process cell death programmed cell death regulation of biological process neuron apoptotic process positive regulation of programmed cell death regulation of cellular process regulation of apoptotic process biological regulation positive regulation of biological process regulation of programmed cell death positive regulation of apoptotic process positive regulation of neuron apoptotic process positive regulation of cellular process regulation of neuron apoptotic process cellular response to stimulus response to lipid response to stimulus response to endogenous stimulus cellular response to organic cyclic compound cellular response to endogenous stimulus cellular response to chemical stimulus response to hormone response to chemical response to steroid hormone cellular response to lipid cellular response to steroid hormone stimulus response to organic cyclic compound cellular response to hormone stimulus developmental process multicellular organismal process epithelium development tube development mammary gland morphogenesis mammary gland development gland development animal organ development morphogenesis of an epithelium tissue development mammary gland duct morphogenesis tissue morphogenesis anatomical structure morphogenesis multicellular organism development tube morphogenesis gland morphogenesis mammary gland epithelium development anatomical structure development animal organ morphogenesis epithelial tube morphogenesis response to ketone cellular response to ketone cellular response to dexamethasone stimulus response to glucocorticoid cellular response to glucocorticoid stimulus response to oxygen-containing compound cellular response to oxygen-containing compound cellular response to corticosteroid stimulus response to corticosteroid response to dexamethasone positive regulation of DNA-templated transcription RNA metabolic process positive regulation of miRNA transcription positive regulation of miRNA metabolic process positive regulation of macromolecule biosynthetic process regulation of primary metabolic process nucleobase-containing compound metabolic process RNA biosynthetic process DNA-templated transcription nucleic acid biosynthetic process positive regulation of metabolic process regulation of RNA metabolic process miRNA transcription positive regulation of biosynthetic process regulation of miRNA metabolic process positive regulation of macromolecule metabolic process regulation of nucleobase-containing compound metabolic process miRNA metabolic process regulation of RNA biosynthetic process regulation of biosynthetic process positive regulation of nucleobase-containing compound metabolic process primary metabolic process regulation of macromolecule metabolic process nucleobase-containing compound biosynthetic process gene expression macromolecule biosynthetic process nucleic acid metabolic process positive regulation of RNA metabolic process regulation of gene expression biosynthetic process positive regulation of RNA biosynthetic process metabolic process regulation of macromolecule biosynthetic process macromolecule metabolic process regulation of DNA-templated transcription regulation of metabolic process regulation of miRNA transcription negative regulation of biological process negative regulation of RNA biosynthetic process transcription by RNA polymerase II negative regulation of cellular process negative regulation of nucleobase-containing compound metabolic process negative regulation of macromolecule metabolic process regulation of transcription by RNA polymerase II negative regulation of DNA-templated transcription negative regulation of transcription by RNA polymerase II negative regulation of metabolic process negative regulation of biosynthetic process negative regulation of macromolecule biosynthetic process negative regulation of RNA metabolic process positive regulation of transcription by RNA polymerase II cellular component organization chromatin organization cellular component organization or biogenesis monosaccharide metabolic process gluconeogenesis regulation of small molecule metabolic process small molecule metabolic process regulation of carbohydrate metabolic process regulation of glucose metabolic process carbohydrate metabolic process small molecule biosynthetic process carbohydrate biosynthetic process hexose metabolic process monosaccharide biosynthetic process hexose biosynthetic process regulation of gluconeogenesis regulation of carbohydrate biosynthetic process glucose metabolic process glucocorticoid metabolic process steroid metabolic process lipid metabolic process cellular response to growth factor stimulus response to transforming growth factor beta cellular response to transforming growth factor beta stimulus response to growth factor defense response response to stress inflammatory response neuroinflammatory response maternal behavior behavior parental behavior reproductive process multicellular organismal reproductive process reproductive behavior intracellular receptor signaling pathway signaling hormone-mediated signaling pathway intracellular signal transduction cell communication signal transduction nuclear receptor-mediated steroid hormone signaling pathway steroid hormone receptor signaling pathway nuclear receptor-mediated signaling pathway myeloid leukocyte differentiation cellular developmental process hemopoiesis macrophage differentiation cell development mononuclear cell differentiation nervous system development neurogenesis central nervous system development gliogenesis glial cell differentiation myeloid cell differentiation cell differentiation microglia differentiation system development leukocyte differentiation astrocyte differentiation adrenal gland development endocrine system development motor behavior regulation of steroid biosynthetic process regulation of hormone biosynthetic process regulation of hormone metabolic process regulation of lipid metabolic process lipid biosynthetic process regulation of glucocorticoid metabolic process regulation of biological quality regulation of glucocorticoid biosynthetic process steroid biosynthetic process hormone biosynthetic process steroid hormone biosynthetic process regulation of steroid hormone biosynthetic process regulation of hormone levels regulation of steroid metabolic process hormone metabolic process glucocorticoid biosynthetic process regulation of lipid biosynthetic process trans-synaptic signaling synaptic transmission, glutamatergic cell-cell signaling chemical synaptic transmission synaptic signaling anterograde trans-synaptic signaling	cellular anatomical structure membrane membrane-bounded organelle intracellular anatomical structure nucleus membrane-enclosed lumen intracellular membrane-bounded organelle intracellular organelle lumen nuclear speck nuclear body intracellular organelle nucleoplasm organelle lumen organelle cellular anatomical structure membrane membrane-bounded organelle intracellular anatomical structure nucleus membrane-enclosed lumen intracellular membrane-bounded organelle intracellular organelle lumen nuclear speck nuclear body intracellular organelle nucleoplasm organelle lumen organelle nuclear lumen cytoplasm cytosol membraneless organelle intracellular membraneless organelle chromatin chromosome cytoskeleton spindle microtubule cytoskeleton centrosome microtubule organizing center protein-containing complex synapse cell junction mitochondrion mitochondrial matrix

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
E [auth N], F [auth M]	IPR017930	Myb domain	Domain
E [auth N], F [auth M]	IPR051571	Nuclear receptor corepressor	Family
E [auth N], F [auth M]	IPR009057	Homedomain-like superfamily	Homologous Superfamily
E [auth N], F [auth M]	IPR031557	N-CoR, GPS2-interacting domain	Domain
E [auth N], F [auth M]	IPR017884	SANT domain	Domain
E [auth N], F [auth M]	IPR001005	SANT/Myb domain	Domain
A, B, C, D	IPR001628	Zinc finger, nuclear hormone receptor-type	Domain
A, B, C, D	IPR050200	Nuclear hormone receptor family NR3 subfamily	Family
A, B, C, D	IPR013088	Zinc finger, NHR/GATA-type	Homologous Superfamily
A, B, C, D	IPR001409	Glucocorticoid receptor	Family
A, B, C, D	IPR001723	Nuclear hormone receptor	Family
A, B, C, D	IPR000536	Nuclear hormone receptor, ligand-binding domain	Domain
A, B, C, D	IPR035500	Nuclear hormone receptor-like domain superfamily	Homologous Superfamily

Pharos: Disease Associations Pharos Homepage Annotation

Chains	Drug Target	Associated Disease
E [auth N], F [auth M]	Pharos: O75376	glioblastoma transitional cell carcinoma urinary bladder cancer breast cancer liver cancer prostate cancer breast carcinoma endometriosis Hyperbilirubinemia, Neonatal giant cell glioblastoma ovarian cancer pancreatic intraductal papillary-mucinous neoplasm with low grade dysplasia primary cutaneous T-cell lymphoma psoriasis acute myeloid leukemia glioblastoma transitional cell carcinoma urinary bladder cancer breast cancer liver cancer prostate cancer breast carcinoma endometriosis Hyperbilirubinemia, Neonatal giant cell glioblastoma ovarian cancer pancreatic intraductal papillary-mucinous neoplasm with low grade dysplasia primary cutaneous T-cell lymphoma psoriasis acute myeloid leukemia malignant mesothelioma oligodendroglioma pancreatic ductal adenocarcinoma Pick disease subependymal giant cell astrocytoma astrocytic tumor urinary bladder neoplasm liver neoplasm mature T-cell and NK-cell non-Hodgkin lymphoma osteosarcoma pancreatic intraductal papillary-mucinous carcinoma pituitary cancer breast adenocarcinoma malignant ependymoma
A, B, C, D	Pharos: P04150	glucocorticoid resistance endometriosis potassium deficiency disease psoriasis ocular hypertension atrial fibrillation 46,XX disorder of sex development melancholia schizophrenia ulcerative colitis hypokalemia cocaine abuse plasma cell myeloma endogenous depression cocaine dependence glucocorticoid resistance endometriosis potassium deficiency disease psoriasis ocular hypertension atrial fibrillation 46,XX disorder of sex development melancholia schizophrenia ulcerative colitis hypokalemia cocaine abuse plasma cell myeloma endogenous depression cocaine dependence obstructive lung disease bipolar disorder schizoaffective disorder hypertensive disorder prostate cancer sympathetic ophthalmia keratitis otitis externa exanthem autoimmune hemolytic anemia pulmonary fibrosis Crohn disease temporal arteritis ovarian cancer eye disease bacterial conjunctivitis thyroiditis perennial allergic rhinitis granuloma annulare blepharoconjunctivitis rhinitis breast cancer scalp dermatosis dermatitis herpetiformis trichinosis acute lymphoblastic leukemia polymyalgia rheumatica Diamond-Blackfan anemia seasonal allergic rhinitis multiple sclerosis vasomotor rhinitis alopecia areata proctitis inherited aplastic anemia skin disease neurotic disorder anterior uveitis pseudohermaphroditism iridocyclitis epicondylitis aspiration pneumonitis atopic conjunctivitis psoriatic arthritis juvenile idiopathic arthritis congenital adrenal hyperplasia synovitis atypical teratoid rhabdoid tumor pulmonary emphysema large cell medulloblastoma autoimmune thrombocytopenic purpura punctate epithelial keratoconjunctivitis lung cancer tendinitis pancreatic intraductal papillary-mucinous carcinoma rheumatic heart disease dacryocystitis tinea corporis hemorrhoid rosacea medulloblastoma depressive disorder breast carcinoma dermatophytosis of groin and perianal area tuberculosis Addison disease hyperaldosteronism Burkitt lymphoma schizophreniform disorder mood disorder allergic asthma idiopathic acute eosinophilic pneumonia seborrheic dermatitis musculoskeletal system disease ductal breast carcinoma in situ allergic rhinitis primary cutaneous T-cell lymphoma inflammatory bowel disease choroiditis angioedema intrinsic asthma chronic obstructive pulmonary disease eosinophilic esophagitis anxiety disorder iritis erythema multiforme asthma atopic eczema contact dermatitis osteosarcoma autoimmune disease pulmonary eosinophilia lichen planus corneal ulcer systemic lupus erythematosus extrinsic allergic alveolitis B-cell chronic lymphocytic leukemia major depressive disorder tenosynovitis pemphigus rheumatoid arthritis tinea pedis gout sarcoidosis acquired thrombocytopenia pneumocystosis Hodgkins lymphoma bronchitis miliary tuberculosis adrenocortical insufficiency bursitis uveitis allergic bronchopulmonary aspergillosis mycosis fungoides primitive neuroectodermal tumor chronic beryllium disease Sjogren syndrome nephrotic syndrome ankylosing spondylitis invasive ductal breast carcinoma Stevens-Johnson syndrome eosinophilic pneumonia aphthous stomatitis

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM157729.