3F7U

Crystal Structure of soluble domain of CA4 in complex with small molecule.

External Resource: Annotation

Domain Annotation: SCOP/SCOPe Classification
Domain Annotation: SCOP2 Classification
Domain Annotation: ECOD Classification
Domain Annotation: CATH
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification
Pharos: Disease Associations

Domain Annotation: SCOP/SCOPe Classification SCOP-e Database Homepage

Chains	Domain Info	Class	Fold	Superfamily	Family	Domain	Species	Provenance Source (Version)
A	d3f7ua_	All beta proteins	Carbonic anhydrase	Carbonic anhydrase	Carbonic anhydrase	Carbonic anhydrase	Human (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)
C	d3f7uc_	All beta proteins	Carbonic anhydrase	Carbonic anhydrase	Carbonic anhydrase	Carbonic anhydrase	Human (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)
D	d3f7ud_	All beta proteins	Carbonic anhydrase	Carbonic anhydrase	Carbonic anhydrase	Carbonic anhydrase	Human (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)
B	d3f7ub_	All beta proteins	Carbonic anhydrase	Carbonic anhydrase	Carbonic anhydrase	Carbonic anhydrase	Human (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
A	SCOP2B Superfamily	Carbonic anhydrase	8042989	3001672	SCOP2B (2022-06-29)
C	SCOP2B Superfamily	Carbonic anhydrase	8042989	3001672	SCOP2B (2022-06-29)
D	SCOP2B Superfamily	Carbonic anhydrase	8042989	3001672	SCOP2B (2022-06-29)
B	SCOP2B Superfamily	Carbonic anhydrase	8042989	3001672	SCOP2B (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	Carb_anhydrase	e3f7uA1	A: beta meanders	X: Carbonic anhydrase (From Topology)	H: Carbonic anhydrase (From Topology)	T: Carbonic anhydrase	F: Carb_anhydrase	ECOD (1.6)
C	Carb_anhydrase	e3f7uC1	A: beta meanders	X: Carbonic anhydrase (From Topology)	H: Carbonic anhydrase (From Topology)	T: Carbonic anhydrase	F: Carb_anhydrase	ECOD (1.6)
D	Carb_anhydrase	e3f7uD1	A: beta meanders	X: Carbonic anhydrase (From Topology)	H: Carbonic anhydrase (From Topology)	T: Carbonic anhydrase	F: Carb_anhydrase	ECOD (1.6)
B	Carb_anhydrase	e3f7uB1	A: beta meanders	X: Carbonic anhydrase (From Topology)	H: Carbonic anhydrase (From Topology)	T: Carbonic anhydrase	F: Carb_anhydrase	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
A	3.10.200.10	Alpha Beta	Roll	Carbonic Anhydrase II	Alpha carbonic anhydrase	CATH (4.3.0)
C	3.10.200.10	Alpha Beta	Roll	Carbonic Anhydrase II	Alpha carbonic anhydrase	CATH (4.3.0)
D	3.10.200.10	Alpha Beta	Roll	Carbonic Anhydrase II	Alpha carbonic anhydrase	CATH (4.3.0)
B	3.10.200.10	Alpha Beta	Roll	Carbonic Anhydrase II	Alpha carbonic anhydrase	CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A, B, C, D	PF00194	Eukaryotic-type carbonic anhydrase (Carb_anhydrase)	Eukaryotic-type carbonic anhydrase	-	Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A, B, C, D	Carbonic anhydrase 4	cation binding transition metal ion binding zinc ion binding ion binding binding metal ion binding small molecule binding carbonate dehydratase activity hydro-lyase activity lyase activity catalytic activity carbon-oxygen lyase activity	small molecule metabolic process metabolic process cellular process one-carbon metabolic process localization bicarbonate transport organic anion transport transport establishment of localization	cell periphery cellular anatomical structure cell surface membrane plasma membrane external side of plasma membrane side of membrane membrane-bounded organelle intracellular anatomical structure intracellular vesicle intracellular membrane-bounded organelle endomembrane system intracellular organelle cytoplasmic vesicle membrane cell periphery cellular anatomical structure cell surface membrane plasma membrane external side of plasma membrane side of membrane membrane-bounded organelle intracellular anatomical structure intracellular vesicle intracellular membrane-bounded organelle endomembrane system intracellular organelle cytoplasmic vesicle membrane bounding membrane of organelle vesicle membrane cytoplasmic vesicle organelle secretory granule secretory vesicle cytoplasm vesicle organelle membrane secretory granule membrane Golgi apparatus subcompartment Golgi apparatus organelle subcompartment trans-Golgi network apical part of cell plasma membrane region apical plasma membrane extracellular exosome extracellular vesicle extracellular organelle extracellular region extracellular space extracellular membrane-bounded organelle perinuclear region of cytoplasm brush border membrane cluster of actin-based cell projections plasma membrane bounded cell projection brush border cell projection cell projection membrane endoplasmic reticulum-Golgi intermediate compartment transport vesicle transport vesicle membrane rough endoplasmic reticulum endoplasmic reticulum

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A, B, C, D	IPR018338	Carbonic anhydrase, alpha-class, conserved site	Conserved Site
A, B, C, D	IPR041874	Carbonic anhydrase, CA4/CA15	Family
A, B, C, D	IPR001148	Alpha carbonic anhydrase domain	Domain
A, B, C, D	IPR036398	Alpha carbonic anhydrase domain superfamily	Homologous Superfamily
A, B, C, D	IPR023561	Carbonic anhydrase, alpha-class	Family

Pharos: Disease Associations Pharos Homepage Annotation

Chains	Drug Target	Associated Disease
A, B, C, D	Pharos: P22748	retinitis pigmentosa retinitis pigmentosa 17 malignant glioma Migraine Prevention osteosarcoma pancreatic intraductal papillary-mucinous neoplasm with low grade dysplasia angle-closure glaucoma pilocytic astrocytoma childhood absence epilepsy psoriasis spina bifida gastric carcinoma invasive ductal breast carcinoma lung adenocarcinoma malignant colon neoplasm retinitis pigmentosa retinitis pigmentosa 17 malignant glioma Migraine Prevention osteosarcoma pancreatic intraductal papillary-mucinous neoplasm with low grade dysplasia angle-closure glaucoma pilocytic astrocytoma childhood absence epilepsy psoriasis spina bifida gastric carcinoma invasive ductal breast carcinoma lung adenocarcinoma malignant colon neoplasm malignant pancreatic neoplasm non-small cell lung carcinoma pancreatic intraductal papillary-mucinous carcinoma pituitary cancer cone-rod dystrophy retinal degeneration subependymal giant cell astrocytoma glioblastoma large cell medulloblastoma lung cancer medulloblastoma open-angle glaucoma pancreatic intraductal papillary-mucinous neoplasm astrocytic tumor primitive neuroectodermal tumor ductal breast carcinoma in situ epilepsy with generalized tonic-clonic seizures ulcerative colitis interstitial cystitis Lennox-Gastaut syndrome lung carcinoma

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM157729.