2ZMH

Crystal Structure of Rat Vitamin D Receptor Bound to Adamantyl Vitamin D Analogs: Structural Basis for Vitamin D Receptor Antagonism and/or Partial Agonism

External Resource: Annotation

Domain Annotation: SCOP/SCOPe Classification
Domain Annotation: SCOP2 Classification
Domain Annotation: ECOD Classification
Domain Annotation: CATH
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification

Domain Annotation: SCOP/SCOPe Classification SCOP-e Database Homepage

Chains	Domain Info	Class	Fold	Superfamily	Family	Domain	Species	Provenance Source (Version)
A	d2zmha_	All alpha proteins	Nuclear receptor ligand-binding domain	Nuclear receptor ligand-binding domain	Nuclear receptor ligand-binding domain	Vitamin D nuclear receptor	Rat (Rattus norvegicus ) [TaxId: 10116 ],	SCOPe (2.08)

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
A	SCOP2B Superfamily	Nuclear receptor ligand-binding domain	8038686	3001442	SCOP2B (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	Hormone_recep	e2zmhA1	A: alpha arrays	X: Nuclear receptor ligand-binding domain (From Topology)	H: Nuclear receptor ligand-binding domain (From Topology)	T: Nuclear receptor ligand-binding domain	F: Hormone_recep	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
A	1.10.565.10	Mainly Alpha	Orthogonal Bundle	Retinoid X Receptor	Retinoid X Receptor	CATH (4.3.0)

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
B [auth C]	Mediator of RNA polymerase II transcription subunit 1	transcription regulator activity transcription coregulator activity protein-macromolecule adaptor activity molecular adaptor activity	regulation of cellular process positive regulation of DNA-templated transcription positive regulation of biological process RNA metabolic process positive regulation of macromolecule biosynthetic process regulation of primary metabolic process nucleobase-containing compound metabolic process RNA biosynthetic process nucleic acid biosynthetic process positive regulation of metabolic process DNA-templated transcription regulation of RNA metabolic process transcription by RNA polymerase II positive regulation of biosynthetic process regulation of cellular process positive regulation of DNA-templated transcription positive regulation of biological process RNA metabolic process positive regulation of macromolecule biosynthetic process regulation of primary metabolic process nucleobase-containing compound metabolic process RNA biosynthetic process nucleic acid biosynthetic process positive regulation of metabolic process DNA-templated transcription regulation of RNA metabolic process transcription by RNA polymerase II positive regulation of biosynthetic process positive regulation of macromolecule metabolic process regulation of nucleobase-containing compound metabolic process positive regulation of cellular process regulation of RNA biosynthetic process regulation of biosynthetic process regulation of transcription by RNA polymerase II regulation of biological process positive regulation of nucleobase-containing compound metabolic process biological regulation primary metabolic process regulation of macromolecule metabolic process positive regulation of transcription by RNA polymerase II nucleobase-containing compound biosynthetic process gene expression macromolecule biosynthetic process nucleic acid metabolic process positive regulation of RNA metabolic process regulation of gene expression biosynthetic process positive regulation of RNA biosynthetic process metabolic process cellular process regulation of macromolecule biosynthetic process macromolecule metabolic process regulation of DNA-templated transcription regulation of metabolic process	membrane-bounded organelle intracellular organelle protein-containing complex cellular anatomical structure intracellular anatomical structure organelle nucleus nuclear protein-containing complex intracellular membrane-bounded organelle mediator complex
A	Vitamin D3 receptor	vitamin binding binding organic cyclic compound binding vitamin D binding steroid binding lipid binding small molecule binding calcitriol binding D3 vitamins binding sequence-specific DNA binding DNA binding nucleic acid binding lithocholic acid binding organic acid binding vitamin binding binding organic cyclic compound binding vitamin D binding steroid binding lipid binding small molecule binding calcitriol binding D3 vitamins binding sequence-specific DNA binding DNA binding nucleic acid binding lithocholic acid binding organic acid binding bile acid binding ion binding anion binding carboxylic acid binding monocarboxylic acid binding nuclear receptor activity DNA-binding transcription factor activity, RNA polymerase II-specific molecular transducer activity transcription regulator activity ligand-activated transcription factor activity DNA-binding transcription factor activity signaling receptor activity double-stranded DNA binding RNA polymerase II transcription regulatory region sequence-specific DNA binding cis-regulatory region sequence-specific DNA binding sequence-specific double-stranded DNA binding transcription cis-regulatory region binding transcription regulatory region nucleic acid binding RNA polymerase II cis-regulatory region sequence-specific DNA binding transcription factor binding nuclear retinoic acid receptor binding RNA polymerase II-specific DNA-binding transcription factor binding nuclear receptor binding protein binding nuclear retinoid X receptor binding DNA-binding transcription factor binding cation binding transition metal ion binding zinc ion binding metal ion binding bile acid nuclear receptor activity	developmental process heart development multicellular organism development multicellular organismal process anatomical structure development animal organ development circulatory system development system development regulation of calcium ion transport regulation of localization regulation of biological process transport regulation of transport regulation of monoatomic ion transport developmental process heart development multicellular organism development multicellular organismal process anatomical structure development animal organ development circulatory system development system development regulation of calcium ion transport regulation of localization regulation of biological process transport regulation of transport regulation of monoatomic ion transport biological regulation establishment of localization metal ion transport calcium ion transport localization monoatomic ion transport regulation of metal ion transport monoatomic cation transport response to stimulus response to metal ion response to chemical response to calcium ion skeletal system development regulation of biosynthetic process regulation of cellular process positive regulation of biological process regulation of macromolecule metabolic process gene expression macromolecule biosynthetic process positive regulation of macromolecule biosynthetic process regulation of gene expression positive regulation of metabolic process biosynthetic process positive regulation of gene expression positive regulation of biosynthetic process regulation of macromolecule biosynthetic process metabolic process cellular process positive regulation of macromolecule metabolic process macromolecule metabolic process regulation of metabolic process positive regulation of cellular process system process digestion intestinal absorption digestive system process inorganic ion homeostasis intracellular calcium ion homeostasis homeostatic process calcium ion homeostasis cellular homeostasis chemical homeostasis intracellular monoatomic cation homeostasis monoatomic ion homeostasis intracellular chemical homeostasis monoatomic cation homeostasis intracellular monoatomic ion homeostasis RNA metabolic process regulation of primary metabolic process nucleobase-containing compound metabolic process RNA biosynthetic process nucleic acid biosynthetic process DNA-templated transcription regulation of RNA metabolic process regulation of nucleobase-containing compound metabolic process regulation of RNA biosynthetic process primary metabolic process nucleobase-containing compound biosynthetic process nucleic acid metabolic process regulation of DNA-templated transcription response to bile acid response to lipid response to oxygen-containing compound response to organic cyclic compound anatomical structure morphogenesis cell morphogenesis mRNA transcription by RNA polymerase II mRNA transcription mRNA metabolic process transcription by RNA polymerase II regulation of body fluid levels secretion mammary gland development gland development body fluid secretion lactation regulation of biological quality negative regulation of cell population proliferation cell population proliferation regulation of keratinocyte proliferation negative regulation of biological process negative regulation of keratinocyte proliferation regulation of cell population proliferation negative regulation of cellular process regulation of epithelial cell proliferation epithelial cell proliferation negative regulation of epithelial cell proliferation keratinocyte proliferation response to aldosterone response to ketone response to endogenous stimulus response to alcohol response to mineralocorticoid response to corticosteroid response to hormone response to steroid hormone negative regulation of RNA biosynthetic process negative regulation of nucleobase-containing compound metabolic process negative regulation of macromolecule metabolic process regulation of transcription by RNA polymerase II negative regulation of DNA-templated transcription negative regulation of transcription by RNA polymerase II negative regulation of metabolic process negative regulation of biosynthetic process negative regulation of macromolecule biosynthetic process negative regulation of RNA metabolic process positive regulation of DNA-templated transcription positive regulation of nucleobase-containing compound metabolic process positive regulation of transcription by RNA polymerase II positive regulation of RNA metabolic process positive regulation of RNA biosynthetic process transmembrane transport phosphate ion transmembrane transport phosphate ion transport inorganic ion transmembrane transport inorganic anion transmembrane transport inorganic anion transport apoptotic process involved in morphogenesis mammary gland morphogenesis apoptotic process involved in mammary gland involution cell death apoptotic process involved in development gland morphogenesis tissue remodeling mammary gland involution animal organ morphogenesis apoptotic process programmed cell death cellular developmental process cell differentiation regulation of developmental process negative regulation of developmental process bone trabecula formation bone trabecula morphogenesis anatomical structure formation involved in morphogenesis regulation of bone trabecula formation skeletal system morphogenesis negative regulation of bone trabecula formation trabecula formation trabecula morphogenesis cellular response to stimulus response to nutrient levels intracellular receptor signaling pathway signaling response to vitamin hormone-mediated signaling pathway intracellular signal transduction cell communication cellular response to vitamin D cellular response to endogenous stimulus response to vitamin D signal transduction cellular response to hormone stimulus response to nutrient cellular response to organic cyclic compound cellular response to oxygen-containing compound vitamin D receptor signaling pathway cellular response to nutrient levels cellular response to chemical stimulus cellular response to vitamin cellular response to lipid cellular response to nutrient nuclear receptor-mediated signaling pathway branching involved in mammary gland duct morphogenesis multi-multicellular organism process reproductive process maternal process involved in female pregnancy branching morphogenesis of an epithelial tube developmental process involved in reproduction tube morphogenesis mammary gland branching involved in pregnancy epithelial tube morphogenesis female pregnancy epithelium development tube development multicellular organismal reproductive process morphogenesis of an epithelium tissue development mammary gland duct morphogenesis tissue morphogenesis mammary gland epithelium development morphogenesis of a branching structure multi-organism reproductive process morphogenesis of a branching epithelium positive regulation of cell communication regulation of parathyroid hormone secretion regulation of hormone secretion regulation of system process positive regulation of secretion by cell hormone secretion positive regulation of parathyroid hormone secretion regulation of secretion by cell secretion by cell positive regulation of hormone secretion positive regulation of secretion signal release regulation of multicellular organismal process regulation of signaling regulation of hormone levels export from cell cell-cell signaling parathyroid hormone secretion regulation of secretion endocrine process endocrine hormone secretion positive regulation of transport regulation of cell communication hormone transport positive regulation of multicellular organismal process regulation of endocrine process positive regulation of signaling regulation of response to nutrient levels positive regulation of signal transduction regulation of signal transduction positive regulation of intracellular signal transduction regulation of response to stimulus regulation of vitamin D receptor signaling pathway positive regulation of response to stimulus regulation of intracellular signal transduction positive regulation of vitamin D receptor signaling pathway placenta development maternal placenta development decidualization apoptotic signaling pathway positive regulation of keratinocyte differentiation regulation of epidermal cell differentiation epidermis development regulation of cell differentiation epithelial cell differentiation regulation of epithelial cell differentiation positive regulation of developmental process positive regulation of cell differentiation regulation of multicellular organismal development epidermal cell differentiation positive regulation of epidermis development positive regulation of epithelial cell differentiation skin development keratinocyte differentiation regulation of epidermis development regulation of keratinocyte differentiation positive regulation of epidermal cell differentiation ossification negative regulation of multicellular organismal process regulation of ossification negative regulation of ossification cellular response to nitrogen compound response to nitrogen compound cellular response to amyloid-beta response to amyloid-beta regulation of programmed cell death positive regulation of apoptotic process involved in mammary gland involution positive regulation of apoptotic process involved in morphogenesis positive regulation of programmed cell death positive regulation of apoptotic process involved in development regulation of apoptotic process regulation of apoptotic process involved in development positive regulation of apoptotic process regulation of apoptotic process involved in morphogenesis response to estradiol	cell periphery cellular anatomical structure sarcolemma plasma membrane membrane T-tubule protein-containing complex receptor complex intracellular organelle intracellular anatomical structure organelle membraneless organelle intracellular membraneless organelle chromatin cell periphery cellular anatomical structure sarcolemma plasma membrane membrane T-tubule protein-containing complex receptor complex intracellular organelle intracellular anatomical structure organelle membraneless organelle intracellular membraneless organelle chromatin chromosome heterochromatin perinuclear region of cytoplasm cytoplasm membrane-bounded organelle nucleus membrane-enclosed lumen intracellular membrane-bounded organelle intracellular organelle lumen organelle lumen nuclear periphery nuclear lumen nuclear matrix RNA polymerase II transcription regulator complex nuclear protein-containing complex transcription regulator complex membrane microdomain membrane raft plasma membrane raft plasma membrane region caveola nucleolus dense fibrillar component euchromatin

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
B [auth C]	IPR019680	Mediator complex, subunit Med1	Domain
B [auth C]	IPR051999	Mediator complex subunit 1	Family
A	IPR001628	Zinc finger, nuclear hormone receptor-type	Domain
A	IPR013088	Zinc finger, NHR/GATA-type	Homologous Superfamily
A	IPR042153	VDR, DNA-binding domain	Domain
A	IPR050234	Nuclear hormone receptor family NR1 subfamily	Family
A	IPR001723	Nuclear hormone receptor	Family
A	IPR000324	Vitamin D receptor	Family
A	IPR000536	Nuclear hormone receptor, ligand-binding domain	Domain
A	IPR035500	Nuclear hormone receptor-like domain superfamily	Homologous Superfamily

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM157729.