2Y05

Crystal structure of human leukotriene B4 12-hydroxydehydrogenase in complex with NADP and raloxifene

External Resource: Annotation

Domain Annotation: ECOD Classification
Domain Annotation: CATH
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification
Pharos: Disease Associations

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
C	ADH_N_2	e2y05C1	A: beta barrels	X: GroES-like	H: GroES-related	T: Alcohol dehydrogenase-like, N-terminal domain	F: ADH_N_2	ECOD (1.6)
C	ADH_zinc_N	e2y05C2	A: a/b three-layered sandwiches	X: Rossmann-like	H: Rossmann-related	T: NAD(P)-binding Rossmann-fold domains	F: ADH_zinc_N	ECOD (1.6)
A	ADH_N_2	e2y05A1	A: beta barrels	X: GroES-like	H: GroES-related	T: Alcohol dehydrogenase-like, N-terminal domain	F: ADH_N_2	ECOD (1.6)
A	ADH_zinc_N	e2y05A2	A: a/b three-layered sandwiches	X: Rossmann-like	H: Rossmann-related	T: NAD(P)-binding Rossmann-fold domains	F: ADH_zinc_N	ECOD (1.6)
B	ADH_N_2	e2y05B1	A: beta barrels	X: GroES-like	H: GroES-related	T: Alcohol dehydrogenase-like, N-terminal domain	F: ADH_N_2	ECOD (1.6)
B	ADH_zinc_N	e2y05B2	A: a/b three-layered sandwiches	X: Rossmann-like	H: Rossmann-related	T: NAD(P)-binding Rossmann-fold domains	F: ADH_zinc_N	ECOD (1.6)
D	ADH_N_2	e2y05D1	A: beta barrels	X: GroES-like	H: GroES-related	T: Alcohol dehydrogenase-like, N-terminal domain	F: ADH_N_2	ECOD (1.6)
D	ADH_zinc_N	e2y05D2	A: a/b three-layered sandwiches	X: Rossmann-like	H: Rossmann-related	T: NAD(P)-binding Rossmann-fold domains	F: ADH_zinc_N	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
C	3.90.180.10	Alpha Beta	Alpha-Beta Complex	Quinone Oxidoreductase	Chain A, domain 1	CATH (4.3.0)
C	3.40.50.720	Alpha Beta	3-Layer(aba) Sandwich	Rossmann fold	NAD(P)-binding Rossmann-like Domain	CATH (4.3.0)
A	3.90.180.10	Alpha Beta	Alpha-Beta Complex	Quinone Oxidoreductase	Chain A, domain 1	CATH (4.3.0)
A	3.40.50.720	Alpha Beta	3-Layer(aba) Sandwich	Rossmann fold	NAD(P)-binding Rossmann-like Domain	CATH (4.3.0)
B	3.90.180.10	Alpha Beta	Alpha-Beta Complex	Quinone Oxidoreductase	Chain A, domain 1	CATH (4.3.0)
B	3.40.50.720	Alpha Beta	3-Layer(aba) Sandwich	Rossmann fold	NAD(P)-binding Rossmann-like Domain	CATH (4.3.0)
D	3.90.180.10	Alpha Beta	Alpha-Beta Complex	Quinone Oxidoreductase	Chain A, domain 1	CATH (4.3.0)
D	3.40.50.720	Alpha Beta	3-Layer(aba) Sandwich	Rossmann fold	NAD(P)-binding Rossmann-like Domain	CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A, B, C, D	PF00107	Zinc-binding dehydrogenase (ADH_zinc_N)	Zinc-binding dehydrogenase	-	Domain
A, B, C, D	PF16884	N-terminal domain of oxidoreductase (ADH_N_2)	N-terminal domain of oxidoreductase	-	Family

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A, B, C, D	PROSTAGLANDIN REDUCTASE 1	leukotriene B4 12-hydroxy dehydrogenase activity oxidoreductase activity oxidoreductase activity, acting on CH-OH group of donors catalytic activity 2-alkenal reductase (NADPH) activity oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor 2-alkenal reductase [NAD(P)+] activity oxidoreductase activity, acting on the CH-CH group of donors 15-oxoprostaglandin 13-oxidase [NAD(P)+] activity oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor 13-lipoxin reductase activity	fatty acid metabolic process long-chain fatty acid metabolic process unsaturated fatty acid metabolic process oxoacid metabolic process lipoxin metabolic process organic hydroxy compound metabolic process carboxylic acid metabolic process primary metabolic process organic acid metabolic process fatty acid derivative metabolic process metabolic process cellular process small molecule metabolic process monocarboxylic acid metabolic process fatty acid metabolic process long-chain fatty acid metabolic process unsaturated fatty acid metabolic process oxoacid metabolic process lipoxin metabolic process organic hydroxy compound metabolic process carboxylic acid metabolic process primary metabolic process organic acid metabolic process fatty acid derivative metabolic process metabolic process cellular process small molecule metabolic process monocarboxylic acid metabolic process lipoxin A4 metabolic process lipid metabolic process prostaglandin metabolic process icosanoid metabolic process prostanoid metabolic process leukotriene metabolic process leukotriene B4 metabolic process	extracellular exosome membrane-bounded organelle extracellular vesicle cellular anatomical structure extracellular organelle extracellular region organelle extracellular space vesicle extracellular membrane-bounded organelle intracellular anatomical structure cytoplasm

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A, B, C, D	IPR045010	Medium-chain dehydrogenase/reductase	Family
A, B, C, D	IPR014190	Leukotriene B4 12-hydroxydehydrogenase/15-oxo-prostaglandin 13-reductase	Family
A, B, C, D	IPR011032	GroES-like superfamily	Homologous Superfamily
A, B, C, D	IPR041694	Oxidoreductase, N-terminal domain	Domain
A, B, C, D	IPR020843	Polyketide synthase, enoylreductase domain	Domain
A, B, C, D	IPR036291	NAD(P)-binding domain superfamily	Homologous Superfamily
A, B, C, D	IPR013149	Alcohol dehydrogenase-like, C-terminal	Domain

Pharos: Disease Associations Pharos Homepage Annotation

Chains	Drug Target	Associated Disease
A, B, C, D	Pharos: Q14914	adenoma interstitial cystitis nasopharyngeal carcinoma ovarian cancer pancreatic intraductal papillary-mucinous neoplasm with low grade dysplasia progressive supranuclear palsy ulcerative colitis astrocytic tumor invasive ductal breast carcinoma non-small cell lung carcinoma pancreatic ductal adenocarcinoma Pick disease psoriasis heart disease malignant ependymoma adenoma interstitial cystitis nasopharyngeal carcinoma ovarian cancer pancreatic intraductal papillary-mucinous neoplasm with low grade dysplasia progressive supranuclear palsy ulcerative colitis astrocytic tumor invasive ductal breast carcinoma non-small cell lung carcinoma pancreatic ductal adenocarcinoma Pick disease psoriasis heart disease malignant ependymoma osteosarcoma pancreatic intraductal papillary-mucinous neoplasm primitive neuroectodermal tumor transitional cell carcinoma

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM157729.