2W2C

STRUCTURE OF THE TETRADECAMERIC OLIGOMERISATION DOMAIN OF CALCIUM- CALMODULIN DEPENDENT PROTEIN KINASE II DELTA

External Resource: Annotation

Domain Annotation: SCOP/SCOPe Classification
Domain Annotation: SCOP2 Classification
Domain Annotation: ECOD Classification
Domain Annotation: CATH
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification
Pharos: Disease Associations

Domain Annotation: SCOP/SCOPe Classification SCOP-e Database Homepage

Chains	Domain Info	Class	Fold	Superfamily	Family	Domain	Species	Provenance Source (Version)
A	d2w2ca_	Alpha and beta proteins (a+b)	Cystatin-like	NTF2-like	Association domain of calcium/calmodulin-dependent protein kinase type II alpha subunit, CAMK2A	automated matches	HUMAN (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)
B	d2w2cb_	Alpha and beta proteins (a+b)	Cystatin-like	NTF2-like	Association domain of calcium/calmodulin-dependent protein kinase type II alpha subunit, CAMK2A	automated matches	HUMAN (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)
C	d2w2cc_	Alpha and beta proteins (a+b)	Cystatin-like	NTF2-like	Association domain of calcium/calmodulin-dependent protein kinase type II alpha subunit, CAMK2A	automated matches	HUMAN (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)
D	d2w2cd_	Alpha and beta proteins (a+b)	Cystatin-like	NTF2-like	Association domain of calcium/calmodulin-dependent protein kinase type II alpha subunit, CAMK2A	automated matches	HUMAN (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)
F	d2w2cf_	Alpha and beta proteins (a+b)	Cystatin-like	NTF2-like	Association domain of calcium/calmodulin-dependent protein kinase type II alpha subunit, CAMK2A	automated matches	HUMAN (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)
H	d2w2ch_	Alpha and beta proteins (a+b)	Cystatin-like	NTF2-like	Association domain of calcium/calmodulin-dependent protein kinase type II alpha subunit, CAMK2A	automated matches	HUMAN (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)
I	d2w2ci_	Alpha and beta proteins (a+b)	Cystatin-like	NTF2-like	Association domain of calcium/calmodulin-dependent protein kinase type II alpha subunit, CAMK2A	automated matches	HUMAN (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)
J	d2w2cj_	Alpha and beta proteins (a+b)	Cystatin-like	NTF2-like	Association domain of calcium/calmodulin-dependent protein kinase type II alpha subunit, CAMK2A	automated matches	HUMAN (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)
K	d2w2ck_	Alpha and beta proteins (a+b)	Cystatin-like	NTF2-like	Association domain of calcium/calmodulin-dependent protein kinase type II alpha subunit, CAMK2A	automated matches	HUMAN (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)
N	d2w2cn_	Alpha and beta proteins (a+b)	Cystatin-like	NTF2-like	Association domain of calcium/calmodulin-dependent protein kinase type II alpha subunit, CAMK2A	automated matches	HUMAN (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)
E	d2w2ce_	Alpha and beta proteins (a+b)	Cystatin-like	NTF2-like	Association domain of calcium/calmodulin-dependent protein kinase type II alpha subunit, CAMK2A	automated matches	HUMAN (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)
G	d2w2cg_	Alpha and beta proteins (a+b)	Cystatin-like	NTF2-like	Association domain of calcium/calmodulin-dependent protein kinase type II alpha subunit, CAMK2A	automated matches	HUMAN (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)
L	d2w2cl_	Alpha and beta proteins (a+b)	Cystatin-like	NTF2-like	Association domain of calcium/calmodulin-dependent protein kinase type II alpha subunit, CAMK2A	automated matches	HUMAN (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)
M	d2w2cm_	Alpha and beta proteins (a+b)	Cystatin-like	NTF2-like	Association domain of calcium/calmodulin-dependent protein kinase type II alpha subunit, CAMK2A	automated matches	HUMAN (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
A	SCOP2B Superfamily	NTF2-like	8066421	3000472	SCOP2B (2022-06-29)
B	SCOP2B Superfamily	NTF2-like	8066421	3000472	SCOP2B (2022-06-29)
C	SCOP2B Superfamily	NTF2-like	8066421	3000472	SCOP2B (2022-06-29)
D	SCOP2B Superfamily	NTF2-like	8066421	3000472	SCOP2B (2022-06-29)
F	SCOP2B Superfamily	NTF2-like	8066421	3000472	SCOP2B (2022-06-29)
H	SCOP2B Superfamily	NTF2-like	8066421	3000472	SCOP2B (2022-06-29)
I	SCOP2B Superfamily	NTF2-like	8066421	3000472	SCOP2B (2022-06-29)
J	SCOP2B Superfamily	NTF2-like	8066421	3000472	SCOP2B (2022-06-29)
K	SCOP2B Superfamily	NTF2-like	8066421	3000472	SCOP2B (2022-06-29)
N	SCOP2B Superfamily	NTF2-like	8066421	3000472	SCOP2B (2022-06-29)
E	SCOP2B Superfamily	NTF2-like	8066421	3000472	SCOP2B (2022-06-29)
G	SCOP2B Superfamily	NTF2-like	8066421	3000472	SCOP2B (2022-06-29)
L	SCOP2B Superfamily	NTF2-like	8066421	3000472	SCOP2B (2022-06-29)
M	SCOP2 Family	Association domain of calcium/calmodulin-dependent protein kinase type II alpha subunit, CAMK2A	8066420	4000593	SCOP2 (2022-06-29)
M	SCOP2 Superfamily	NTF2-like	8066421	3000472	SCOP2 (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	DUF4440	e2w2cA1	A: a+b two layers	X: Cystatin-like	H: NTF2-like (From Topology)	T: NTF2-like	F: DUF4440	ECOD (1.6)
B	DUF4440	e2w2cB1	A: a+b two layers	X: Cystatin-like	H: NTF2-like (From Topology)	T: NTF2-like	F: DUF4440	ECOD (1.6)
C	DUF4440	e2w2cC1	A: a+b two layers	X: Cystatin-like	H: NTF2-like (From Topology)	T: NTF2-like	F: DUF4440	ECOD (1.6)
D	DUF4440	e2w2cD1	A: a+b two layers	X: Cystatin-like	H: NTF2-like (From Topology)	T: NTF2-like	F: DUF4440	ECOD (1.6)
F	DUF4440	e2w2cF1	A: a+b two layers	X: Cystatin-like	H: NTF2-like (From Topology)	T: NTF2-like	F: DUF4440	ECOD (1.6)
H	DUF4440	e2w2cH1	A: a+b two layers	X: Cystatin-like	H: NTF2-like (From Topology)	T: NTF2-like	F: DUF4440	ECOD (1.6)
I	DUF4440	e2w2cI1	A: a+b two layers	X: Cystatin-like	H: NTF2-like (From Topology)	T: NTF2-like	F: DUF4440	ECOD (1.6)
J	DUF4440	e2w2cJ1	A: a+b two layers	X: Cystatin-like	H: NTF2-like (From Topology)	T: NTF2-like	F: DUF4440	ECOD (1.6)
K	DUF4440	e2w2cK1	A: a+b two layers	X: Cystatin-like	H: NTF2-like (From Topology)	T: NTF2-like	F: DUF4440	ECOD (1.6)
N	DUF4440	e2w2cN1	A: a+b two layers	X: Cystatin-like	H: NTF2-like (From Topology)	T: NTF2-like	F: DUF4440	ECOD (1.6)
E	DUF4440	e2w2cE1	A: a+b two layers	X: Cystatin-like	H: NTF2-like (From Topology)	T: NTF2-like	F: DUF4440	ECOD (1.6)
G	DUF4440	e2w2cG1	A: a+b two layers	X: Cystatin-like	H: NTF2-like (From Topology)	T: NTF2-like	F: DUF4440	ECOD (1.6)
L	DUF4440	e2w2cL1	A: a+b two layers	X: Cystatin-like	H: NTF2-like (From Topology)	T: NTF2-like	F: DUF4440	ECOD (1.6)
M	DUF4440	e2w2cM1	A: a+b two layers	X: Cystatin-like	H: NTF2-like (From Topology)	T: NTF2-like	F: DUF4440	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
A	3.10.450.50	Alpha Beta	Roll	Nuclear Transport Factor 2	Chain: A,	CATH (4.3.0)
B	3.10.450.50	Alpha Beta	Roll	Nuclear Transport Factor 2	Chain: A,	CATH (4.3.0)
C	3.10.450.50	Alpha Beta	Roll	Nuclear Transport Factor 2	Chain: A,	CATH (4.3.0)
D	3.10.450.50	Alpha Beta	Roll	Nuclear Transport Factor 2	Chain: A,	CATH (4.3.0)
F	3.10.450.50	Alpha Beta	Roll	Nuclear Transport Factor 2	Chain: A,	CATH (4.3.0)
H	3.10.450.50	Alpha Beta	Roll	Nuclear Transport Factor 2	Chain: A,	CATH (4.3.0)
I	3.10.450.50	Alpha Beta	Roll	Nuclear Transport Factor 2	Chain: A,	CATH (4.3.0)
J	3.10.450.50	Alpha Beta	Roll	Nuclear Transport Factor 2	Chain: A,	CATH (4.3.0)
K	3.10.450.50	Alpha Beta	Roll	Nuclear Transport Factor 2	Chain: A,	CATH (4.3.0)
N	3.10.450.50	Alpha Beta	Roll	Nuclear Transport Factor 2	Chain: A,	CATH (4.3.0)
E	3.10.450.50	Alpha Beta	Roll	Nuclear Transport Factor 2	Chain: A,	CATH (4.3.0)
G	3.10.450.50	Alpha Beta	Roll	Nuclear Transport Factor 2	Chain: A,	CATH (4.3.0)
L	3.10.450.50	Alpha Beta	Roll	Nuclear Transport Factor 2	Chain: A,	CATH (4.3.0)
M	3.10.450.50	Alpha Beta	Roll	Nuclear Transport Factor 2	Chain: A,	CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A, B, C, D, E A, B, C, D, E, F, G, H, I, J, K, L, M, N	PF08332	Calcium/calmodulin dependent protein kinase II association domain (CaMKII_AD)	Calcium/calmodulin dependent protein kinase II association domain	This domain is found at the C-terminus of the Calcium/calmodulin dependent protein kinases II (CaMKII). These proteins also have a Ser/Thr protein kinase domain (Pfam:PF00069) at their N-terminus [1]. The function of the CaMKII association domain i ...	This domain is found at the C-terminus of the Calcium/calmodulin dependent protein kinases II (CaMKII). These proteins also have a Ser/Thr protein kinase domain (Pfam:PF00069) at their N-terminus [1]. The function of the CaMKII association domain is the assembly of the single proteins into large (8 to 14 subunits) multimers [2].	Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A, B, C, D, E A, B, C, D, E, F, G, H, I, J, K, L, M, N	CALCIUM/CALMODULIN-DEPENDENT PROTEIN KINASE TYPE II DELTA CHAIN	molecular function inhibitor activity sodium channel inhibitor activity channel regulator activity transporter inhibitor activity ion channel regulator activity ion channel inhibitor activity molecular function regulator activity sodium channel regulator activity transporter regulator activity channel inhibitor activity cytoskeletal protein binding titin binding protein binding binding molecular function inhibitor activity sodium channel inhibitor activity channel regulator activity transporter inhibitor activity ion channel regulator activity ion channel inhibitor activity molecular function regulator activity sodium channel regulator activity transporter regulator activity channel inhibitor activity cytoskeletal protein binding titin binding protein binding binding protein serine/threonine kinase activity catalytic activity, acting on a protein kinase activity protein kinase activity calcium/calmodulin-dependent protein kinase activity transferase activity catalytic activity phosphotransferase activity, alcohol group as acceptor transferase activity, transferring phosphorus-containing groups adenyl ribonucleotide binding nucleotide binding purine ribonucleotide binding purine ribonucleoside triphosphate binding nucleoside phosphate binding ion binding purine nucleotide binding organic cyclic compound binding anion binding adenyl nucleotide binding ATP binding heterocyclic compound binding carbohydrate derivative binding ribonucleotide binding small molecule binding calmodulin binding identical protein binding protein serine kinase activity transmembrane transporter binding protein homodimerization activity protein dimerization activity	heart process multicellular organismal process system process regulation of biological process regulation of heart contraction regulation of system process biological regulation circulatory system process regulation of blood circulation regulation of multicellular organismal process heart contraction blood circulation inorganic ion homeostasis intracellular calcium ion homeostasis heart process multicellular organismal process system process regulation of biological process regulation of heart contraction regulation of system process biological regulation circulatory system process regulation of blood circulation regulation of multicellular organismal process heart contraction blood circulation inorganic ion homeostasis intracellular calcium ion homeostasis homeostatic process calcium ion homeostasis endoplasmic reticulum calcium ion homeostasis cellular homeostasis chemical homeostasis intracellular monoatomic cation homeostasis monoatomic ion homeostasis intracellular chemical homeostasis monoatomic cation homeostasis intracellular monoatomic ion homeostasis relaxation of cardiac muscle regulation of relaxation of cardiac muscle regulation of muscle system process muscle system process relaxation of muscle regulation of relaxation of muscle regulation of calcium ion transport regulation of localization regulation of cellular process negative regulation of biological process sarcoplasmic reticulum calcium ion transport release of sequestered calcium ion into cytosol by sarcoplasmic reticulum calcium ion transport localization monoatomic cation transport release of sequestered calcium ion into cytosol by endoplasmic reticulum regulation of release of sequestered calcium ion into cytosol regulation of monoatomic ion transport inorganic ion transmembrane transport establishment of localization inorganic cation transmembrane transport maintenance of location transmembrane transport release of sequestered calcium ion into cytosol regulation of transmembrane transport cellular localization transport monoatomic ion transmembrane transport regulation of monoatomic ion transmembrane transport negative regulation of sequestering of calcium ion metal ion transport maintenance of location in cell regulation of calcium ion transmembrane transport monoatomic cation transmembrane transport negative regulation of cellular process monoatomic ion transport regulation of metal ion transport regulation of sequestering of calcium ion calcium ion transmembrane import into cytosol regulation of transport sequestering of calcium ion cellular process regulation of monoatomic cation transmembrane transport calcium ion transmembrane transport regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum regulation of calcium ion transmembrane transporter activity regulation of cation channel activity regulation of molecular function regulation of transmembrane transporter activity regulation of transporter activity regulation of monoatomic ion transmembrane transporter activity regulation of ryanodine-sensitive calcium-release channel activity regulation of growth regulation of cellular component organization growth regulation of cell growth cell growth cellular component organization cellular component organization or biogenesis protein phosphorylation phosphorylation primary metabolic process macromolecule modification peptidyl-amino acid modification phosphate-containing compound metabolic process metabolic process peptidyl-threonine modification protein metabolic process macromolecule metabolic process protein modification process phosphorus metabolic process peptidyl-threonine phosphorylation protein autophosphorylation cellular response to stimulus cellular response to metal ion cellular response to chemical stimulus response to stimulus response to metal ion response to chemical cellular response to calcium ion response to calcium ion regulation of actin filament-based process cardiac muscle contraction striated muscle contraction regulation of cardiac muscle cell action potential actin filament-based process regulation of biological quality cardiac muscle cell contraction regulation of action potential regulation of cardiac muscle contraction action potential actin filament-based movement muscle contraction regulation of cardiac muscle cell action potential involved in regulation of contraction regulation of striated muscle contraction regulation of actin filament-based movement regulation of muscle contraction regulation of cardiac muscle cell contraction actin-mediated cell contraction cardiac muscle cell action potential regulation of membrane potential muscle hypertrophy regulation of muscle adaptation positive regulation of cardiac muscle hypertrophy positive regulation of biological process striated muscle hypertrophy regulation of cardiac muscle hypertrophy regulation of muscle hypertrophy muscle adaptation regulation of response to stimulus positive regulation of muscle hypertrophy cardiac muscle hypertrophy positive regulation of multicellular organismal process intracellular signal transduction cell communication intracellular signaling cassette signal transduction calcium-mediated signaling signaling regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion regulation of cardiac muscle contraction by calcium ion signaling negative regulation of ion transmembrane transporter activity negative regulation of monoatomic ion transport sodium ion transmembrane transport negative regulation of transport regulation of sodium ion transport negative regulation of sodium ion transmembrane transporter activity regulation of sodium ion transmembrane transport negative regulation of transmembrane transport regulation of sodium ion transmembrane transporter activity negative regulation of monoatomic ion transmembrane transport negative regulation of cation transmembrane transport negative regulation of transporter activity negative regulation of molecular function negative regulation of sodium ion transmembrane transport negative regulation of sodium ion transport sodium ion transport peptidyl-serine modification peptidyl-serine phosphorylation regulation of calcium ion transmembrane transport via high voltage-gated calcium channel calcium ion transmembrane transport via high voltage-gated calcium channel cardiac conduction regulation of heart rate by cardiac conduction regulation of heart rate regulation of cell communication regulation of cell communication by electrical coupling cell communication by electrical coupling regulation of the force of heart contraction regulation of cellular localization regulation of membrane depolarization membrane depolarization positive regulation of cardiac muscle cell apoptotic process positive regulation of programmed cell death muscle cell apoptotic process positive regulation of striated muscle cell apoptotic process regulation of apoptotic process regulation of cardiac muscle cell apoptotic process regulation of muscle cell apoptotic process regulation of programmed cell death cell death positive regulation of apoptotic process cardiac muscle cell apoptotic process positive regulation of muscle cell apoptotic process regulation of striated muscle cell apoptotic process striated muscle cell apoptotic process apoptotic process programmed cell death positive regulation of cellular process cell communication by electrical coupling involved in cardiac conduction regulation of cell communication by electrical coupling involved in cardiac conduction cell communication involved in cardiac conduction RNA metabolic process regulation of primary metabolic process RNA biosynthetic process nucleobase-containing compound metabolic process DNA-templated transcription nucleic acid biosynthetic process regulation of RNA metabolic process transcription by RNA polymerase II regulation of nucleobase-containing compound metabolic process regulation of RNA biosynthetic process regulation of transcription by RNA polymerase II regulation of biosynthetic process regulation of macromolecule metabolic process nucleobase-containing compound biosynthetic process gene expression macromolecule biosynthetic process nucleic acid metabolic process regulation of gene expression biosynthetic process regulation of macromolecule biosynthetic process regulation of DNA-templated transcription regulation of metabolic process	cellular anatomical structure membrane intracellular anatomical structure cytoplasm cytosol cell periphery sarcolemma plasma membrane cell projection neuron projection plasma membrane bounded cell projection protein-containing complex catalytic complex calcium- and calmodulin-dependent protein kinase complex cellular anatomical structure membrane intracellular anatomical structure cytoplasm cytosol cell periphery sarcolemma plasma membrane cell projection neuron projection plasma membrane bounded cell projection protein-containing complex catalytic complex calcium- and calmodulin-dependent protein kinase complex intracellular protein-containing complex membrane-bounded organelle intracellular vesicle intracellular membrane-bounded organelle intracellular organelle cytoplasmic vesicle membrane bounding membrane of organelle cytoplasmic vesicle vesicle membrane organelle endocytic vesicle membrane vesicle organelle membrane endocytic vesicle organelle subcompartment endomembrane system sarcoplasm endoplasmic reticulum subcompartment nuclear outer membrane-endoplasmic reticulum membrane network endoplasmic reticulum sarcoplasmic reticulum sarcoplasmic reticulum membrane endoplasmic reticulum membrane nucleus membrane-enclosed lumen intracellular organelle lumen nucleoplasm organelle lumen nuclear lumen

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A, B, C, D, E A, B, C, D, E, F, G, H, I, J, K, L, M, N	IPR000719	Protein kinase domain	Domain
A, B, C, D, E A, B, C, D, E, F, G, H, I, J, K, L, M, N	IPR032710	NTF2-like domain superfamily	Homologous Superfamily
A, B, C, D, E A, B, C, D, E, F, G, H, I, J, K, L, M, N	IPR017441	Protein kinase, ATP binding site	Binding Site
A, B, C, D, E A, B, C, D, E, F, G, H, I, J, K, L, M, N	IPR013543	Calcium/calmodulin-dependent protein kinase II, association-domain	Domain
A, B, C, D, E A, B, C, D, E, F, G, H, I, J, K, L, M, N	IPR011009	Protein kinase-like domain superfamily	Homologous Superfamily
A, B, C, D, E A, B, C, D, E, F, G, H, I, J, K, L, M, N	IPR008271	Serine/threonine-protein kinase, active site	Active Site

Pharos: Disease Associations Pharos Homepage Annotation

Chains	Drug Target	Associated Disease
A, B, C, D, E A, B, C, D, E, F, G, H, I, J, K, L, M, N	Pharos: Q13557	polycystic ovary syndrome atrial fibrillation B-cell chronic lymphocytic leukemia Liver Cirrhosis, Experimental osteosarcoma pancreatic intraductal papillary-mucinous carcinoma Pick disease amyotrophic lateral sclerosis tuberculosis breast cancer coronary artery disease glioblastoma juvenile dermatomyositis malignant ependymoma medulloblastoma polycystic ovary syndrome atrial fibrillation B-cell chronic lymphocytic leukemia Liver Cirrhosis, Experimental osteosarcoma pancreatic intraductal papillary-mucinous carcinoma Pick disease amyotrophic lateral sclerosis tuberculosis breast cancer coronary artery disease glioblastoma juvenile dermatomyositis malignant ependymoma medulloblastoma ovarian cancer pancreatic intraductal papillary-mucinous neoplasm pilocytic astrocytoma sinusitis ulcerative colitis bronchitis cystic fibrosis large cell medulloblastoma malignant glioma myocardial ischemia pancreatic ductal adenocarcinoma pancreatic intraductal papillary-mucinous neoplasm with low grade dysplasia Sjogren syndrome cerebrovascular disorder diabetes mellitus malignant pancreatic neoplasm

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM157729.