2QB0

Structure of the 2TEL crystallization module fused to T4 lysozyme with an Ala-Gly-Pro linker.

External Resource: Annotation

Domain Annotation: SCOP/SCOPe Classification
Domain Annotation: SCOP2 Classification
Domain Annotation: ECOD Classification
Domain Annotation: CATH
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification
Pharos: Disease Associations

Domain Annotation: SCOP/SCOPe Classification SCOP-e Database Homepage

Chains	Domain Info	Class	Fold	Superfamily	Family	Domain	Species	Provenance Source (Version)
A	d2qb0a_	All alpha proteins	SAM domain-like	SAM/Pointed domain	Pointed domain	Etv6 transcription factor pointed domain (Tel SAM)	(Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)
C	d2qb0c_	All alpha proteins	SAM domain-like	SAM/Pointed domain	Pointed domain	Etv6 transcription factor pointed domain (Tel SAM)	(Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
A	SCOP2B Superfamily	SAM/Pointed domain	8039910	3000479	SCOP2B (2022-06-29)
C	SCOP2B Superfamily	SAM/Pointed domain	8039910	3000479	SCOP2B (2022-06-29)
B	SCOP2B Superfamily	Lysozyme-like	8033861	3001879	SCOP2B (2022-06-29)
D	SCOP2B Superfamily	Lysozyme-like	8033861	3001879	SCOP2B (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	SAM_PNT	e2qb0A1	A: alpha arrays	X: HhH/H2TH	H: SAM/DNA-glycosylase	T: SAM domain-like	F: SAM_PNT	ECOD (1.6)
C	SAM_PNT	e2qb0C1	A: alpha arrays	X: HhH/H2TH	H: SAM/DNA-glycosylase	T: SAM domain-like	F: SAM_PNT	ECOD (1.6)
B	SAM_PNT	e2qb0B2	A: alpha arrays	X: HhH/H2TH	H: SAM/DNA-glycosylase	T: SAM domain-like	F: SAM_PNT	ECOD (1.6)
B	Phage_lysozyme_2	e2qb0B1	A: a+b complex topology	X: Lysozyme-like (From Homology)	H: Lysozyme-like	T: Lysozyme-like	F: Phage_lysozyme_2	ECOD (1.6)
D	SAM_PNT	e2qb0D2	A: alpha arrays	X: HhH/H2TH	H: SAM/DNA-glycosylase	T: SAM domain-like	F: SAM_PNT	ECOD (1.6)
D	Phage_lysozyme_2	e2qb0D1	A: a+b complex topology	X: Lysozyme-like (From Homology)	H: Lysozyme-like	T: Lysozyme-like	F: Phage_lysozyme_2	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
A	1.10.150.50	Mainly Alpha	Orthogonal Bundle	DNA polymerase	domain 1	CATH (4.3.0)
C	1.10.150.50	Mainly Alpha	Orthogonal Bundle	DNA polymerase	domain 1	CATH (4.3.0)
B	1.10.150.50	Mainly Alpha	Orthogonal Bundle	DNA polymerase	domain 1	CATH (4.3.0)
B	1.10.530.40	Mainly Alpha	Orthogonal Bundle	Lysozyme		CATH (4.3.0)
D	1.10.150.50	Mainly Alpha	Orthogonal Bundle	DNA polymerase	domain 1	CATH (4.3.0)
D	1.10.530.40	Mainly Alpha	Orthogonal Bundle	Lysozyme		CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A, C	PF02198	Sterile alpha motif (SAM)/Pointed domain (SAM_PNT)	Sterile alpha motif (SAM)/Pointed domain	-	Domain
B, D	PF00959	Phage lysozyme (Phage_lysozyme)	Phage lysozyme	This family includes lambda phage lysozyme and E. coli endolysin.	Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A, C	Transcription factor ETV6	DNA-binding transcription factor activity, RNA polymerase II-specific transcription regulator activity DNA-binding transcription factor activity protein binding binding protein domain specific binding DNA-binding transcription repressor activity, RNA polymerase II-specific DNA-binding transcription repressor activity DNA binding sequence-specific DNA binding double-stranded DNA binding nucleic acid binding RNA polymerase II transcription regulatory region sequence-specific DNA binding cis-regulatory region sequence-specific DNA binding DNA-binding transcription factor activity, RNA polymerase II-specific transcription regulator activity DNA-binding transcription factor activity protein binding binding protein domain specific binding DNA-binding transcription repressor activity, RNA polymerase II-specific DNA-binding transcription repressor activity DNA binding sequence-specific DNA binding double-stranded DNA binding nucleic acid binding RNA polymerase II transcription regulatory region sequence-specific DNA binding cis-regulatory region sequence-specific DNA binding sequence-specific double-stranded DNA binding transcription cis-regulatory region binding organic cyclic compound binding transcription regulatory region nucleic acid binding RNA polymerase II cis-regulatory region sequence-specific DNA binding DNA-binding transcription activator activity, RNA polymerase II-specific DNA-binding transcription activator activity	developmental process stem cell proliferation cell population proliferation cellular developmental process hemopoiesis cell differentiation anatomical structure development hematopoietic stem cell proliferation cell development cellular process neurogenesis multicellular organism development multicellular organismal process nervous system development developmental process stem cell proliferation cell population proliferation cellular developmental process hemopoiesis cell differentiation anatomical structure development hematopoietic stem cell proliferation cell development cellular process neurogenesis multicellular organism development multicellular organismal process nervous system development system development cellular component organization sexual reproduction reproductive process multicellular organismal reproductive process cytoplasm organization cellular component organization or biogenesis female gamete generation vitellogenesis gamete generation regulation of cellular process RNA metabolic process regulation of primary metabolic process RNA biosynthetic process nucleobase-containing compound metabolic process DNA-templated transcription nucleic acid biosynthetic process regulation of RNA metabolic process transcription by RNA polymerase II regulation of nucleobase-containing compound metabolic process regulation of RNA biosynthetic process regulation of transcription by RNA polymerase II regulation of biosynthetic process regulation of biological process biological regulation primary metabolic process regulation of macromolecule metabolic process nucleobase-containing compound biosynthetic process gene expression macromolecule biosynthetic process nucleic acid metabolic process regulation of gene expression biosynthetic process metabolic process regulation of macromolecule biosynthetic process macromolecule metabolic process regulation of DNA-templated transcription regulation of metabolic process mesenchymal cell apoptotic process apoptotic process cell death programmed cell death negative regulation of biological process negative regulation of RNA biosynthetic process negative regulation of cellular process negative regulation of nucleobase-containing compound metabolic process negative regulation of macromolecule metabolic process negative regulation of DNA-templated transcription negative regulation of transcription by RNA polymerase II negative regulation of metabolic process negative regulation of biosynthetic process negative regulation of macromolecule biosynthetic process negative regulation of RNA metabolic process	membrane-bounded organelle intracellular anatomical structure nucleus membrane-enclosed lumen intracellular membraneless organelle intracellular membrane-bounded organelle nucleolus intracellular organelle lumen intracellular organelle cellular anatomical structure organelle lumen organelle membraneless organelle nuclear lumen membrane-bounded organelle intracellular anatomical structure nucleus membrane-enclosed lumen intracellular membraneless organelle intracellular membrane-bounded organelle nucleolus intracellular organelle lumen intracellular organelle cellular anatomical structure organelle lumen organelle membraneless organelle nuclear lumen cytoplasm cytosol cell periphery plasma membrane membrane chromatin chromosome
B, D	Transcription factor ETV6,Endolysin	hydrolase activity, acting on glycosyl bonds peptidoglycan muralytic activity hydrolase activity, hydrolyzing O-glycosyl compounds lysozyme activity hydrolase activity catalytic activity	biological process involved in interspecies interaction between organisms response to stimulus response to other organism defense response response to external stimulus response to biotic stimulus defense response to bacterium defense response to other organism response to stress response to bacterium response to external biotic stimulus carbohydrate derivative catabolic process catabolic process peptidoglycan catabolic process biological process involved in interspecies interaction between organisms response to stimulus response to other organism defense response response to external stimulus response to biotic stimulus defense response to bacterium defense response to other organism response to stress response to bacterium response to external biotic stimulus carbohydrate derivative catabolic process catabolic process peptidoglycan catabolic process glycosaminoglycan metabolic process carbohydrate derivative metabolic process aminoglycan catabolic process macromolecule catabolic process glycosaminoglycan catabolic process aminoglycan metabolic process peptidoglycan metabolic process metabolic process cellular process macromolecule metabolic process symbiont-mediated cytolysis of host cell viral life cycle disruption of cell in another organism cytolysis biological process involved in interaction with host biological process involved in symbiotic interaction viral release from host cell by cytolysis disruption of cellular anatomical structure in another organism exit from host cell viral process cytolysis in another organism viral release from host cell disruption of anatomical structure in another organism symbiont-mediated killing of host cell killing of cells of another organism cell killing disruption of plasma membrane integrity in another organism cell wall organization or biogenesis cell wall macromolecule catabolic process cell wall macromolecule metabolic process	host cellular component host intracellular part cellular anatomical structure host cell cytoplasm host cell part host intracellular region

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A, C	IPR013761	Sterile alpha motif/pointed domain superfamily	Homologous Superfamily
A, C	IPR036388	Winged helix-like DNA-binding domain superfamily	Homologous Superfamily
A, C	IPR000418	Ets domain	Domain
A, C	IPR036390	Winged helix DNA-binding domain superfamily	Homologous Superfamily
A, C	IPR046328	ETS family	Family
A, C	IPR003118	Pointed domain	Domain
B, D	IPR052619	Bacteriophage lysozyme-like	Family
B, D	IPR001165	T4-type lysozyme	Family
B, D	IPR034690	Endolysin T4 type	Family
B, D	IPR002196	Glycoside hydrolase, family 24	Family
B, D	IPR023347	Lysozyme domain superfamily	Homologous Superfamily
B, D	IPR023346	Lysozyme-like domain superfamily	Homologous Superfamily

Pharos: Disease Associations Pharos Homepage Annotation

Chains	Drug Target	Associated Disease
A, C	Pharos: P41212	acute myeloid leukemia thrombocytopenia 5 chronic myelomonocytic leukemia fibrosarcoma thrombocytopenia congenital mesoblastic nephroma myeloproliferative disorder, chronic, with eosinophilia cancer Precursor B-Cell Lymphoblastic Leukemia-Lymphoma hematopoietic and lymphoid system neoplasm juvenile idiopathic arthritis macrocytosis, familial leukemia, acute lymphocytic, susceptibility to, 1 malignant ependymoma acute lymphoblastic leukemia acute myeloid leukemia thrombocytopenia 5 chronic myelomonocytic leukemia fibrosarcoma thrombocytopenia congenital mesoblastic nephroma myeloproliferative disorder, chronic, with eosinophilia cancer Precursor B-Cell Lymphoblastic Leukemia-Lymphoma hematopoietic and lymphoid system neoplasm juvenile idiopathic arthritis macrocytosis, familial leukemia, acute lymphocytic, susceptibility to, 1 malignant ependymoma acute lymphoblastic leukemia ovarian cancer Burkitt lymphoma subependymal giant cell astrocytoma substance dependence hematologic disease thyroid gland papillary carcinoma malignant glioma pancreatic intraductal papillary-mucinous neoplasm colorectal cancer drug dependence substance abuse tuberculosis large cell medulloblastoma medulloblastoma osteosarcoma breast cancer pilocytic astrocytoma childhood acute lymphoblastic leukemia psoriasis glioblastoma substance-related disorder hereditary thrombocytopenia and hematologic cancer predisposition syndrome

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM157729.