2JOA | pdb_00002joa

HtrA1 bound to an optimized peptide: NMR assignment of PDZ domain and ligand resonances

External Resource: Annotation

Domain Annotation: ECOD Classification
Domain Annotation: CATH
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification
Pharos: Disease Associations

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	PDZ_2	e2joaA1	A: beta barrels	X: PDZ domain (From Topology)	H: PDZ domain (From Topology)	T: PDZ domain	F: PDZ_2	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
A	2.30.42.10	Mainly Beta	Roll	Pdz3 Domain	PDZ domain	CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A	PF17820	PDZ domain (PDZ_6)	PDZ domain	This entry represents the PDZ domain from a wide variety of proteins.	Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A	Serine protease HTRA1	peptidase activity catalytic activity, acting on a protein serine hydrolase activity serine-type peptidase activity hydrolase activity serine-type endopeptidase activity catalytic activity endopeptidase activity protein binding binding growth factor binding molecular function activator activity molecular function regulator activity identical protein binding	developmental process placenta development animal organ development anatomical structure development extraembryonic membrane development chorion development cellular developmental process cell differentiation chorionic trophoblast cell differentiation cellular process regulation of biological process positive regulation of programmed cell death regulation of cellular process regulation of apoptotic process developmental process placenta development animal organ development anatomical structure development extraembryonic membrane development chorion development cellular developmental process cell differentiation chorionic trophoblast cell differentiation cellular process regulation of biological process positive regulation of programmed cell death regulation of cellular process regulation of apoptotic process biological regulation positive regulation of biological process regulation of programmed cell death cell death positive regulation of apoptotic process apoptotic process programmed cell death positive regulation of cellular process cellular response to stimulus cell surface receptor protein serine/threonine kinase signaling pathway cellular response to growth factor stimulus response to stimulus signaling negative regulation of signaling regulation of transmembrane receptor protein serine/threonine kinase signaling pathway negative regulation of biological process regulation of signal transduction negative regulation of cellular response to growth factor stimulus negative regulation of BMP signaling pathway negative regulation of cell communication cell communication cellular response to endogenous stimulus negative regulation of cellular process signal transduction BMP signaling pathway enzyme-linked receptor protein signaling pathway cellular response to BMP stimulus regulation of signaling cell surface receptor signaling pathway regulation of BMP signaling pathway negative regulation of response to stimulus response to endogenous stimulus regulation of cellular response to growth factor stimulus negative regulation of signal transduction response to BMP regulation of response to stimulus regulation of cell communication transforming growth factor beta receptor superfamily signaling pathway response to growth factor negative regulation of transmembrane receptor protein serine/threonine kinase signaling pathway negative regulation of transforming growth factor beta receptor signaling pathway cellular response to transforming growth factor beta stimulus regulation of transforming growth factor beta receptor signaling pathway regulation of cellular response to transforming growth factor beta stimulus response to transforming growth factor beta transforming growth factor beta receptor signaling pathway proteolysis metabolic process primary metabolic process protein metabolic process macromolecule metabolic process	extracellular exosome membrane-bounded organelle extracellular vesicle cellular anatomical structure extracellular organelle extracellular region organelle extracellular space vesicle extracellular membrane-bounded organelle cell periphery extracellular matrix external encapsulating structure collagen-containing extracellular matrix extracellular exosome membrane-bounded organelle extracellular vesicle cellular anatomical structure extracellular organelle extracellular region organelle extracellular space vesicle extracellular membrane-bounded organelle cell periphery extracellular matrix external encapsulating structure collagen-containing extracellular matrix intracellular anatomical structure cytoplasm cytosol plasma membrane membrane
B	Peptide H1-C1	-	-	-

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A	IPR036058	Kazal domain superfamily	Homologous Superfamily
A	IPR002350	Kazal domain	Domain
A	IPR000867	Insulin-like growth factor-binding protein, IGFBP	Domain
A	IPR009003	Peptidase S1, PA clan	Homologous Superfamily
A	IPR041489	PDZ domain 6	Domain
A	IPR001940	Peptidase S1C	Family
A	IPR036034	PDZ superfamily	Homologous Superfamily
A	IPR009030	Growth factor receptor cysteine-rich domain superfamily	Homologous Superfamily
A	IPR001478	PDZ domain	Domain

Pharos: Disease Associations Pharos Homepage Annotation

Chains	Drug Target	Associated Disease
A	Pharos: Q92743	CARASIL syndrome age related macular degeneration 7 age-related macular degeneration cerebral arteriopathy, autosomal dominant, with subcortical infarcts and leukoencephalopathy, type 2 limb-girdle muscular dystrophy macular degeneration malignant pancreatic neoplasm myopathy pancreatic ductal adenocarcinoma breast cancer Pick disease cerebral arteriopathy, autosomal dominant, with subcortical infarcts and leukoencephalopathy, type 1 ulcerative colitis cystic fibrosis exocrine pancreatic carcinoma CARASIL syndrome age related macular degeneration 7 age-related macular degeneration cerebral arteriopathy, autosomal dominant, with subcortical infarcts and leukoencephalopathy, type 2 limb-girdle muscular dystrophy macular degeneration malignant pancreatic neoplasm myopathy pancreatic ductal adenocarcinoma breast cancer Pick disease cerebral arteriopathy, autosomal dominant, with subcortical infarcts and leukoencephalopathy, type 1 ulcerative colitis cystic fibrosis exocrine pancreatic carcinoma heart disease large cell medulloblastoma lung benign neoplasm malignant mesothelioma malignant peripheral nerve sheath tumor neurofibrosarcoma pancreatic intraductal papillary-mucinous carcinoma CADASILM primitive neuroectodermal tumor wet macular degeneration Duchenne muscular dystrophy gastric carcinoma hypertensive disorder leukodystrophy medulloblastoma ovarian cancer atypical teratoid rhabdoid tumor pancreatic intraductal papillary-mucinous neoplasm with low grade dysplasia retinal degeneration cerebrovascular disorder Emery-Dreifuss muscular dystrophy Hashimoto thyroiditis invasive ductal breast carcinoma

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM157729.