2G47

Crystal structure of human insulin-degrading enzyme in complex with amyloid-beta (1-40)

External Resource: Annotation

Domain Annotation: ECOD Classification
Domain Annotation: CATH
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification
Pharos: Disease Associations

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
B	Peptidase_M16_M_C	e2g47B11	A: a+b two layers	X: LuxS, MPP, ThrRS/AlaRS common domain	H: LuxS, MPP, ThrRS/AlaRS common domain	T: LuxS/MPP-like metallohydrolase	F: Peptidase_M16_M_C	ECOD (1.6)
B	Peptidase_M16_M_N	e2g47B12	A: a+b two layers	X: LuxS, MPP, ThrRS/AlaRS common domain	H: LuxS, MPP, ThrRS/AlaRS common domain	T: LuxS/MPP-like metallohydrolase	F: Peptidase_M16_M_N	ECOD (1.6)
B	Peptidase_M16_C_2	e2g47B13	A: a+b two layers	X: LuxS, MPP, ThrRS/AlaRS common domain	H: LuxS, MPP, ThrRS/AlaRS common domain	T: LuxS/MPP-like metallohydrolase	F: Peptidase_M16_C_2	ECOD (1.6)
B	Peptidase_M16	e2g47B4	A: a+b two layers	X: LuxS, MPP, ThrRS/AlaRS common domain	H: LuxS, MPP, ThrRS/AlaRS common domain	T: LuxS/MPP-like metallohydrolase	F: Peptidase_M16	ECOD (1.6)
A	Peptidase_M16_M_C	e2g47A11	A: a+b two layers	X: LuxS, MPP, ThrRS/AlaRS common domain	H: LuxS, MPP, ThrRS/AlaRS common domain	T: LuxS/MPP-like metallohydrolase	F: Peptidase_M16_M_C	ECOD (1.6)
A	Peptidase_M16_M_N	e2g47A12	A: a+b two layers	X: LuxS, MPP, ThrRS/AlaRS common domain	H: LuxS, MPP, ThrRS/AlaRS common domain	T: LuxS/MPP-like metallohydrolase	F: Peptidase_M16_M_N	ECOD (1.6)
A	Peptidase_M16_C_2	e2g47A13	A: a+b two layers	X: LuxS, MPP, ThrRS/AlaRS common domain	H: LuxS, MPP, ThrRS/AlaRS common domain	T: LuxS/MPP-like metallohydrolase	F: Peptidase_M16_C_2	ECOD (1.6)
A	Peptidase_M16	e2g47A2	A: a+b two layers	X: LuxS, MPP, ThrRS/AlaRS common domain	H: LuxS, MPP, ThrRS/AlaRS common domain	T: LuxS/MPP-like metallohydrolase	F: Peptidase_M16	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
B	3.30.830.10	Alpha Beta	2-Layer Sandwich	Cytochrome Bc1 Complex	Chain A, domain 1	CATH (4.3.0)
A	3.30.830.10	Alpha Beta	2-Layer Sandwich	Cytochrome Bc1 Complex	Chain A, domain 1	CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A, B	PF05193	Peptidase M16 inactive domain (Peptidase_M16_C)	Peptidase M16 inactive domain	Peptidase M16 consists of two structurally related domains. One is the active peptidase, whereas the other is inactive. The two domains hold the substrate like a clamp [1].	Domain
A, B	PF16187	Middle or third domain of peptidase_M16 (Peptidase_M16_M)	Middle or third domain of peptidase_M16	-	Family
A, B	PF00675	Insulinase (Peptidase family M16) (Peptidase_M16)	Insulinase (Peptidase family M16)	-	Family

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A, B	Insulin-degrading enzyme	protein binding binding virus receptor activity exogenous protein binding amide binding peptide hormone binding hormone binding insulin binding peptidase activity catalytic activity, acting on a protein metalloendopeptidase activity hydrolase activity metallopeptidase activity catalytic activity protein binding binding virus receptor activity exogenous protein binding amide binding peptide hormone binding hormone binding insulin binding peptidase activity catalytic activity, acting on a protein metalloendopeptidase activity hydrolase activity metallopeptidase activity catalytic activity endopeptidase activity adenyl ribonucleotide binding nucleotide binding purine ribonucleotide binding purine ribonucleoside triphosphate binding nucleoside phosphate binding ion binding purine nucleotide binding organic cyclic compound binding anion binding adenyl nucleotide binding ATP binding heterocyclic compound binding carbohydrate derivative binding ribonucleotide binding small molecule binding identical protein binding protein homodimerization activity protein dimerization activity peptide binding cation binding transition metal ion binding zinc ion binding metal ion binding	amyloid-beta metabolic process metabolic process cellular process amide metabolic process cellular catabolic process catabolic process peptide metabolic process peptide catabolic process multicellular organismal process amyloid-beta clearance by cellular catabolic process amyloid-beta clearance primary metabolic process protein metabolic process macromolecule metabolic process amyloid-beta metabolic process metabolic process cellular process amide metabolic process cellular catabolic process catabolic process peptide metabolic process peptide catabolic process multicellular organismal process amyloid-beta clearance by cellular catabolic process amyloid-beta clearance primary metabolic process protein metabolic process macromolecule metabolic process insulin metabolic process protein catabolic process macromolecule catabolic process proteolysis involved in protein catabolic process proteolysis regulation of cellular process positive regulation of protein metabolic process positive regulation of biological process regulation of primary metabolic process positive regulation of metabolic process positive regulation of macromolecule metabolic process positive regulation of cellular process regulation of biological process regulation of protein metabolic process biological regulation regulation of macromolecule metabolic process regulation of catabolic process positive regulation of protein catabolic process positive regulation of catabolic process regulation of metabolic process regulation of protein catabolic process cellular homeostasis homeostatic process ubiquitin recycling cellular response to nitrogen compound cellular response to stimulus response to stimulus signaling response to peptide hormone insulin receptor signaling pathway cell surface receptor protein tyrosine kinase signaling pathway cell communication cellular response to endogenous stimulus response to hormone signal transduction enzyme-linked receptor protein signaling pathway cellular response to hormone stimulus cell surface receptor signaling pathway response to endogenous stimulus response to oxygen-containing compound cellular response to peptide hormone stimulus response to nitrogen compound cellular response to oxygen-containing compound cellular response to chemical stimulus response to chemical response to insulin cellular response to insulin stimulus antigen processing and presentation immune system process antigen processing and presentation of endogenous peptide antigen antigen processing and presentation of peptide antigen via MHC class I antigen processing and presentation of peptide antigen antigen processing and presentation of endogenous antigen antigen processing and presentation of endogenous peptide antigen via MHC class I regulation of hormone levels regulation of biological quality hormone metabolic process hormone catabolic process bradykinin catabolic process aerobic respiration cellular respiration energy derivation by oxidation of organic compounds regulation of generation of precursor metabolites and energy generation of precursor metabolites and energy regulation of cellular respiration regulation of aerobic respiration regulation of protein binding positive regulation of molecular function regulation of molecular function positive regulation of protein binding regulation of binding positive regulation of binding insulin catabolic process	membrane-bounded organelle intracellular organelle cellular anatomical structure intracellular anatomical structure mitochondrion organelle cytoplasm intracellular membrane-bounded organelle cell periphery cell surface membrane plasma membrane external side of plasma membrane side of membrane membrane-bounded organelle intracellular organelle cellular anatomical structure intracellular anatomical structure mitochondrion organelle cytoplasm intracellular membrane-bounded organelle cell periphery cell surface membrane plasma membrane external side of plasma membrane side of membrane extracellular exosome extracellular vesicle extracellular organelle extracellular region extracellular space vesicle extracellular membrane-bounded organelle cytosol basal part of cell basal plasma membrane plasma membrane region basolateral plasma membrane peroxisome microbody peroxisomal matrix membrane-enclosed lumen intracellular organelle lumen organelle lumen microbody lumen nucleus
C, D	amyloid protein beta A4	DNA binding binding organic cyclic compound binding nucleic acid binding protein binding signaling receptor binding cation binding transition metal ion binding ion binding metal ion binding small molecule binding PTB domain binding protein domain specific binding identical protein binding DNA binding binding organic cyclic compound binding nucleic acid binding protein binding signaling receptor binding cation binding transition metal ion binding ion binding metal ion binding small molecule binding PTB domain binding protein domain specific binding identical protein binding molecular function activator activity molecular function regulator activity signaling receptor regulator activity receptor ligand activity signaling receptor activator activity sequence-specific DNA binding double-stranded DNA binding RNA polymerase II transcription regulatory region sequence-specific DNA binding cis-regulatory region sequence-specific DNA binding sequence-specific double-stranded DNA binding transcription cis-regulatory region binding transcription regulatory region nucleic acid binding RNA polymerase II cis-regulatory region sequence-specific DNA binding enzyme regulator activity molecular function inhibitor activity peptidase regulator activity serine-type endopeptidase inhibitor activity enzyme inhibitor activity peptidase inhibitor activity endopeptidase regulator activity endopeptidase inhibitor activity protein serine/threonine kinase binding kinase binding enzyme binding protein kinase binding heparin binding glycosaminoglycan binding carbohydrate derivative binding sulfur compound binding	negative regulation of long-term synaptic potentiation positive regulation of cell communication regulation of cellular process modulation of chemical synaptic transmission signaling positive regulation of biological process negative regulation of biological process cell communication long-term synaptic potentiation synaptic signaling regulation of biological quality positive regulation of cellular process regulation of synaptic plasticity trans-synaptic signaling negative regulation of long-term synaptic potentiation positive regulation of cell communication regulation of cellular process modulation of chemical synaptic transmission signaling positive regulation of biological process negative regulation of biological process cell communication long-term synaptic potentiation synaptic signaling regulation of biological quality positive regulation of cellular process regulation of synaptic plasticity trans-synaptic signaling regulation of biological process regulation of signaling biological regulation cell-cell signaling positive regulation of synaptic transmission chemical synaptic transmission regulation of trans-synaptic signaling anterograde trans-synaptic signaling regulation of long-term synaptic potentiation regulation of cell communication cellular process positive regulation of signaling regulation of synapse structure or activity cellular response to stimulus multicellular organismal process regulation of postsynaptic membrane potential system process response to stimulus regulation of system process regulation of signal transduction chemical synaptic transmission, postsynaptic modulation of excitatory postsynaptic potential regulation of multicellular organismal process signal transduction cell surface receptor signaling pathway nervous system process regulation of nervous system process regulation of response to stimulus excitatory postsynaptic potential regulation of membrane potential positive regulation of signal transduction intracellular signal transduction positive regulation of response to stimulus regulation of intracellular signal transduction intracellular signaling cassette regulation of calcium-mediated signaling positive regulation of calcium-mediated signaling positive regulation of intracellular signal transduction calcium-mediated signaling cellular component organization extracellular matrix organization cellular component organization or biogenesis extracellular structure organization external encapsulating structure organization positive regulation of phosphorylation regulation of protein modification process regulation of protein phosphorylation positive regulation of protein metabolic process regulation of peptidyl-serine phosphorylation positive regulation of phosphate metabolic process peptidyl-serine modification regulation of primary metabolic process positive regulation of metabolic process positive regulation of protein modification process peptidyl-serine phosphorylation regulation of phosphate metabolic process phosphate-containing compound metabolic process peptidyl-amino acid modification positive regulation of macromolecule metabolic process protein metabolic process positive regulation of protein phosphorylation phosphorus metabolic process protein modification process protein phosphorylation positive regulation of phosphorus metabolic process phosphorylation regulation of protein metabolic process primary metabolic process regulation of macromolecule metabolic process positive regulation of peptidyl-serine phosphorylation macromolecule modification regulation of phosphorus metabolic process metabolic process regulation of phosphorylation macromolecule metabolic process regulation of metabolic process regulation of multicellular organism growth developmental process regulation of growth regulation of developmental growth regulation of developmental process developmental growth growth multicellular organism growth axonogenesis cellular developmental process cell projection organization plasma membrane bounded cell projection morphogenesis cell development neuron projection development cell morphogenesis neurogenesis multicellular organism development cell projection morphogenesis neuron differentiation neuron projection morphogenesis cell differentiation anatomical structure development system development plasma membrane bounded cell projection organization nervous system development axon development cell morphogenesis involved in neuron differentiation generation of neurons anatomical structure morphogenesis neuron development cell growth collateral sprouting in absence of injury collateral sprouting developmental cell growth developmental growth involved in morphogenesis positive regulation of macromolecule biosynthetic process positive regulation of biosynthetic process regulation of cytokine production cytokine production regulation of biosynthetic process gene expression macromolecule biosynthetic process regulation of chemokine production regulation of gene expression biosynthetic process positive regulation of gene expression chemokine production positive regulation of chemokine production positive regulation of multicellular organismal process regulation of macromolecule biosynthetic process positive regulation of cytokine production behavior suckling behavior feeding behavior astrocyte differentiation astrocyte activation glial cell development astrocyte development gliogenesis response to stress defense response cell activation central nervous system development glial cell differentiation glial cell activation inflammatory response neuroinflammatory response Notch signaling pathway cell cycle G2/M phase transition mitotic cell cycle process G2/M transition of mitotic cell cycle cell cycle phase transition cell cycle mitotic cell cycle cell cycle process mitotic cell cycle phase transition myeloid leukocyte activation leukocyte activation macrophage activation immune system process leukocyte activation involved in inflammatory response microglial cell activation cellular homeostasis neuron cellular homeostasis homeostatic process neuron recognition axon choice point recognition cell recognition axon midline choice point recognition axon guidance neuron projection guidance ribonucleotide catabolic process pyridine nucleotide catabolic process oxoacid metabolic process carbohydrate catabolic process carbohydrate derivative metabolic process organophosphate catabolic process regulation of generation of precursor metabolites and energy nucleoside phosphate catabolic process organic acid metabolic process regulation of ATP metabolic process nucleobase-containing compound metabolic process regulation of purine nucleotide catabolic process positive regulation of nucleotide catabolic process regulation of small molecule metabolic process glycolytic process regulation of nucleotide metabolic process pyridine-containing compound metabolic process small molecule metabolic process regulation of nucleobase-containing compound metabolic process purine ribonucleotide catabolic process pyridine nucleotide metabolic process nucleoside phosphate metabolic process nicotinamide nucleotide metabolic process pyruvate metabolic process regulation of carbohydrate catabolic process positive regulation of nucleobase-containing compound metabolic process purine nucleoside diphosphate metabolic process purine-containing compound catabolic process nucleotide metabolic process regulation of purine nucleotide metabolic process nucleobase-containing compound catabolic process positive regulation of ATP metabolic process nucleoside diphosphate metabolic process purine nucleoside diphosphate catabolic process nucleoside diphosphate catabolic process regulation of nucleotide catabolic process nucleoside triphosphate metabolic process positive regulation of carbohydrate metabolic process monocarboxylic acid metabolic process purine ribonucleotide metabolic process pyridine-containing compound catabolic process ribose phosphate metabolic process ATP metabolic process catabolic process positive regulation of nucleotide metabolic process positive regulation of purine nucleotide catabolic process purine nucleotide metabolic process ribonucleotide metabolic process nucleobase-containing small molecule metabolic process purine ribonucleoside triphosphate metabolic process ribonucleoside diphosphate metabolic process ribonucleoside diphosphate catabolic process regulation of carbohydrate metabolic process ribonucleoside triphosphate metabolic process nucleotide catabolic process purine nucleoside triphosphate metabolic process carbohydrate metabolic process purine nucleotide catabolic process carbohydrate derivative catabolic process positive regulation of glycolytic process ADP catabolic process carboxylic acid metabolic process generation of precursor metabolites and energy regulation of catabolic process regulation of glycolytic process purine-containing compound metabolic process positive regulation of purine nucleotide metabolic process positive regulation of catabolic process ADP metabolic process organophosphate metabolic process purine ribonucleoside diphosphate metabolic process positive regulation of small molecule metabolic process purine ribonucleoside diphosphate catabolic process myeloid leukocyte differentiation mononuclear cell differentiation microglia differentiation hemopoiesis macrophage differentiation microglia development myeloid cell differentiation myeloid cell development leukocyte differentiation regulation of cellular component organization positive regulation of cellular component organization positive regulation of amyloid fibril formation regulation of amyloid fibril formation amyloid fibril formation positive regulation of supramolecular fiber organization regulation of supramolecular fiber organization supramolecular fiber organization positive regulation of ERK1 and ERK2 cascade positive regulation of MAPK cascade regulation of MAPK cascade MAPK cascade ERK1 and ERK2 cascade regulation of ERK1 and ERK2 cascade positive regulation of long-term synaptic potentiation regulation of peptidyl-threonine phosphorylation peptidyl-threonine modification positive regulation of peptidyl-threonine phosphorylation peptidyl-threonine phosphorylation cellular localization transport intracellular transport establishment of localization localization axo-dendritic transport establishment of localization in cell microtubule-based transport transport along microtubule cytoskeleton-dependent intracellular transport microtubule-based movement microtubule-based process neuromuscular process neuromuscular process controlling balance organic hydroxy compound metabolic process sterol metabolic process steroid metabolic process cholesterol metabolic process alcohol metabolic process secondary alcohol metabolic process lipid metabolic process cell junction organization synapse organization head development forebrain development animal organ development brain development regulation of Wnt signaling pathway Wnt signaling pathway neuron apoptotic process apoptotic process cell death programmed cell death ligand-gated ion channel signaling pathway ionotropic glutamate receptor signaling pathway glutamate receptor signaling pathway regulation of non-canonical NF-kappaB signal transduction non-canonical NF-kappaB signal transduction positive regulation of non-canonical NF-kappaB signal transduction regulation of presynapse assembly cellular component biogenesis regulation of nervous system development regulation of presynapse organization cellular component assembly negative regulation of cell junction assembly cell junction assembly negative regulation of cellular process negative regulation of nervous system development regulation of synapse assembly regulation of multicellular organismal development negative regulation of cellular component organization negative regulation of developmental process presynapse organization negative regulation of synapse organization regulation of cellular component biogenesis regulation of cell junction assembly regulation of synapse organization negative regulation of presynapse assembly synapse assembly negative regulation of multicellular organismal process negative regulation of synapse assembly presynapse assembly cell activation involved in immune response astrocyte activation involved in immune response immune response immune effector process negative regulation of metabolic process negative regulation of gene expression negative regulation of biosynthetic process negative regulation of macromolecule biosynthetic process negative regulation of macromolecule metabolic process positive regulation of cell cycle regulation of mitotic cell cycle positive regulation of mitotic cell cycle regulation of cell cycle regulation of tumor necrosis factor production positive regulation of tumor necrosis factor superfamily cytokine production tumor necrosis factor superfamily cytokine production positive regulation of tumor necrosis factor production tumor necrosis factor production regulation of tumor necrosis factor superfamily cytokine production response to oxidative stress neuron projection maintenance neuron projection organization cellular response to nitrogen compound response to oxygen-containing compound response to nitrogen compound cellular response to amyloid-beta cellular response to oxygen-containing compound cellular response to chemical stimulus response to chemical response to amyloid-beta regulation of cell cycle phase transition positive regulation of mitotic cell cycle phase transition positive regulation of cell cycle process positive regulation of G2/M transition of mitotic cell cycle regulation of G2/M transition of mitotic cell cycle regulation of cell cycle process regulation of cell cycle G2/M phase transition positive regulation of cell cycle G2/M phase transition regulation of mitotic cell cycle phase transition positive regulation of cell cycle phase transition regulation of cell differentiation negative regulation of cell differentiation negative regulation of neuron differentiation regulation of neuron differentiation learning learning or memory cognition regulation of defense response regulation of response to external stimulus response to external stimulus regulation of inflammatory response positive regulation of response to external stimulus positive regulation of inflammatory response regulation of response to stress positive regulation of defense response inorganic ion homeostasis intracellular copper ion homeostasis copper ion homeostasis chemical homeostasis intracellular monoatomic cation homeostasis monoatomic ion homeostasis intracellular chemical homeostasis monoatomic cation homeostasis intracellular monoatomic ion homeostasis developmental maturation neuron remodeling anatomical structure maturation neuron maturation cell maturation reproductive process multicellular organismal reproductive process reproductive behavior mating behavior peptidyl-tyrosine modification regulation of peptidyl-tyrosine phosphorylation peptidyl-tyrosine phosphorylation translation post-transcriptional regulation of gene expression regulation of translation interleukin-1 production regulation of interleukin-1 beta production positive regulation of interleukin-1 beta production positive regulation of interleukin-1 production regulation of interleukin-1 production interleukin-1 beta production regulation of neuronal synaptic plasticity regulation of long-term neuronal synaptic plasticity positive regulation of JNK cascade JNK cascade regulation of JNK cascade positive regulation of locomotion regulation of cell motility regulation of lymphocyte migration positive regulation of cell migration positive regulation of cell motility regulation of cell migration positive regulation of mononuclear cell migration cell migration regulation of immune system process cell motility regulation of mononuclear cell migration positive regulation of immune system process locomotion positive regulation of lymphocyte migration regulation of leukocyte migration positive regulation of T cell migration lymphocyte migration positive regulation of leukocyte migration leukocyte migration regulation of locomotion regulation of T cell migration mononuclear cell migration T cell migration cell adhesion NMDA selective glutamate receptor signaling pathway positive regulation of DNA-templated transcription RNA metabolic process RNA biosynthetic process nucleic acid biosynthetic process DNA-templated transcription regulation of RNA metabolic process transcription by RNA polymerase II regulation of RNA biosynthetic process regulation of transcription by RNA polymerase II positive regulation of transcription by RNA polymerase II nucleobase-containing compound biosynthetic process nucleic acid metabolic process positive regulation of RNA metabolic process positive regulation of RNA biosynthetic process regulation of DNA-templated transcription locomotory behavior adult locomotory behavior adult behavior cytosolic mRNA polyadenylation mRNA metabolic process interleukin-6 production positive regulation of interleukin-6 production regulation of interleukin-6 production import into cell endocytosis vesicle-mediated transport spontaneous synaptic transmission regulation of spontaneous synaptic transmission response to peptide response to cytokine response to interleukin-1 neuromuscular junction development synaptic assembly at neuromuscular junction response to light stimulus visual learning visual behavior associative learning response to radiation response to abiotic stimulus dendrite development negative regulation of cell population proliferation cell population proliferation regulation of cell population proliferation intracellular calcium ion homeostasis smooth endoplasmic reticulum calcium ion homeostasis calcium ion homeostasis endoplasmic reticulum calcium ion homeostasis negative regulation of hydrolase activity negative regulation of proteolysis regulation of catalytic activity negative regulation of catalytic activity negative regulation of peptidase activity regulation of proteolysis proteolysis negative regulation of protein metabolic process negative regulation of molecular function regulation of peptidase activity regulation of molecular function regulation of hydrolase activity	somatodendritic compartment cell body cellular anatomical structure perikaryon neuronal cell body presynapse synapse cell junction presynaptic active zone cell-cell junction anchoring junction intracellular anatomical structure cytoplasm cytosol somatodendritic compartment cell body cellular anatomical structure perikaryon neuronal cell body presynapse synapse cell junction presynaptic active zone cell-cell junction anchoring junction intracellular anatomical structure cytoplasm cytosol membrane-bounded organelle intracellular organelle organelle endoplasmic reticulum smooth endoplasmic reticulum intracellular membrane-bounded organelle endomembrane system protein-containing complex receptor complex neuromuscular junction membrane-enclosed lumen intracellular organelle lumen endoplasmic reticulum lumen organelle lumen endosome intracellular vesicle recycling endosome cytoplasmic vesicle vesicle neuron spine neuron projection dendritic spine plasma membrane bounded cell projection cell projection postsynapse dendrite dendritic tree ciliary rootlet intracellular membraneless organelle cilium cytoskeleton membraneless organelle extracellular region extracellular space transport vesicle synaptic vesicle secretory vesicle exocytic vesicle mitochondrial membrane organelle inner membrane mitochondrion membrane mitochondrial inner membrane organelle envelope mitochondrial envelope organelle membrane cell surface cell periphery plasma membrane membrane microdomain membrane raft Golgi apparatus subcompartment Golgi apparatus organelle subcompartment trans-Golgi network membrane trans-Golgi network clathrin-coated pit apical part of cell spindle spindle midzone microtubule cytoskeleton extracellular exosome extracellular vesicle extracellular organelle extracellular membrane-bounded organelle COPII-coated ER to Golgi transport vesicle coated vesicle nucleus organelle envelope lumen nuclear envelope lumen nuclear envelope dendritic shaft perinuclear region of cytoplasm vesicle lumen cytoplasmic vesicle lumen secretory granule lumen secretory granule platelet alpha granule platelet alpha granule lumen axon Golgi-associated vesicle growth cone distal axon site of polarized growth early endosome Golgi lumen endosome lumen

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A, B	IPR011249	Metalloenzyme, LuxS/M16 peptidase-like	Homologous Superfamily
A, B	IPR050626	Peptidase M16	Family
A, B	IPR032632	Peptidase M16, middle/third domain	Domain
A, B	IPR001431	Peptidase M16, zinc-binding site	Binding Site
A, B	IPR007863	Peptidase M16, C-terminal	Domain
A, B	IPR054734	Coenzyme PQQ synthesis protein F-like, C-terminal lobe, domain 4	Domain
A, B	IPR011765	Peptidase M16, N-terminal	Domain
C, D	IPR013803	Amyloidogenic glycoprotein, amyloid-beta peptide	Domain
C, D	IPR008154	Amyloidogenic glycoprotein, extracellular	Domain
C, D	IPR036176	E2 domain superfamily	Homologous Superfamily
C, D	IPR024329	Amyloidogenic glycoprotein, E2 domain	Domain
C, D	IPR036669	Amyloidogenic glycoprotein, copper-binding domain superfamily	Homologous Superfamily
C, D	IPR019745	Amyloidogenic glycoprotein, intracellular domain, conserved site	Conserved Site
C, D	IPR011178	Amyloidogenic glycoprotein, copper-binding	Domain
C, D	IPR037071	Amyloidogenic glycoprotein, amyloid-beta peptide superfamily	Homologous Superfamily
C, D	IPR020901	Proteinase inhibitor I2, Kunitz, conserved site	Conserved Site
C, D	IPR019744	Amyloidogenic glycoprotein, copper-binding domain conserved site	Conserved Site
C, D	IPR002223	Pancreatic trypsin inhibitor Kunitz domain	Domain
C, D	IPR015849	Amyloidogenic glycoprotein, heparin-binding	Domain
C, D	IPR036454	Amyloidogenic glycoprotein, heparin-binding domain superfamily	Homologous Superfamily
C, D	IPR011993	PH-like domain superfamily	Homologous Superfamily
C, D	IPR019543	Beta-amyloid precursor protein C-terminal	Domain
C, D	IPR036880	Pancreatic trypsin inhibitor Kunitz domain superfamily	Homologous Superfamily
C, D	IPR008155	Amyloidogenic glycoprotein	Family

Pharos: Disease Associations Pharos Homepage Annotation

Chains	Drug Target	Associated Disease
A, B	Pharos: P14735	Alzheimer disease Presenile dementia atopic eczema large cell medulloblastoma malignant ependymoma osteosarcoma psoriasis atypical teratoid rhabdoid tumor glioblastoma lung cancer non-alcoholic fatty liver disease ovarian cancer schizophrenia amyotrophic lateral sclerosis dementia Alzheimer disease Presenile dementia atopic eczema large cell medulloblastoma malignant ependymoma osteosarcoma psoriasis atypical teratoid rhabdoid tumor glioblastoma lung cancer non-alcoholic fatty liver disease ovarian cancer schizophrenia amyotrophic lateral sclerosis dementia invasive ductal breast carcinoma lymphoplasmacytic lymphoma non-small cell lung carcinoma
C, D	Pharos: P05067	Alzheimer disease amyloidosis cerebral amyloid angiopathy dementia cerebral amyloid angiopathy, APP-related fragile X syndrome Down syndrome neurodegenerative disease Necrosis brain disease premature aging syndrome Alzheimer disease type 1 spinal cord disease dissociative amnesia amnestic disorder Alzheimer disease amyloidosis cerebral amyloid angiopathy dementia cerebral amyloid angiopathy, APP-related fragile X syndrome Down syndrome neurodegenerative disease Necrosis brain disease premature aging syndrome Alzheimer disease type 1 spinal cord disease dissociative amnesia amnestic disorder endogenous depression Gerstmann-Straussler-Scheinker syndrome osteosarcoma Huntington disease astrocytic tumor juvenile dermatomyositis ABeta amyloidosis, Arctic type Pick disease learning disability ABeta amyloidosis, Italian type Lewy body dementia prion disease cerebrovascular disorder malignant ependymoma amyotrophic lateral sclerosis ovarian cancer Parkinson disease atypical teratoid rhabdoid tumor large cell medulloblastoma ABeta amyloidosis, dutch type breast cancer ABetaL34V amyloidosis ACys amyloidosis psoriasis chronic obstructive pulmonary disease medulloblastoma depressive disorder Emery-Dreifuss muscular dystrophy FRAXE intellectual disability oligodendroglioma anxiety disorder head and neck cancer palsy periodic fever syndrome bipolar disorder ABeta amyloidosis, Iowa type polycystic ovary syndrome cardiomyopathy acquired metabolic disease lung carcinoma ADan amyloidosis rheumatoid arthritis dermatomyositis toxic encephalopathy