2AQ5 | pdb_00002aq5

Crystal Structure of Murine Coronin-1

External Resource: Annotation

Domain Annotation: SCOP2 Classification
Domain Annotation: ECOD Classification
Domain Annotation: CATH
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification
Protein Modification Annotation

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
A	SCOP2 Family	Coronin-1A-like	8045298	4004396	SCOP2 (2022-06-29)
A	SCOP2 Superfamily	WD40 repeat-like	8055775	3001694	SCOP2 (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	DUF1899	e2aq5A1	A: beta duplicates or obligate multimers	X: beta-propeller-like	H: beta-propeller	T: 7-bladed	F: DUF1899	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
A	2.130.10.10	Mainly Beta	7 Propeller	Methylamine Dehydrogenase	Chain H	CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A	PF16300	Type of WD40 repeat (WD40_4)	Type of WD40 repeat	-	Repeat
A	PF00400	WD domain, G-beta repeat (WD40)	WD domain, G-beta repeat	-	Repeat

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A	Coronin-1A	cytoskeletal protein binding actin binding protein-containing complex binding protein binding binding actin filament binding phosphatidylinositol 3-kinase binding myosin heavy chain binding myosin binding identical protein binding actin monomer binding protein homodimerization activity protein dimerization activity	multicellular organismal process multicellular organismal-level homeostasis homeostatic process homeostasis of number of cells within a tissue anatomical structure homeostasis tissue homeostasis homeostasis of number of cells response to interleukin-4 response to peptide response to stimulus response to chemical response to cytokine cellular response to cytokine stimulus cellular response to interleukin-4 multicellular organismal process multicellular organismal-level homeostasis homeostatic process homeostasis of number of cells within a tissue anatomical structure homeostasis tissue homeostasis homeostasis of number of cells response to interleukin-4 response to peptide response to stimulus response to chemical response to cytokine cellular response to cytokine stimulus cellular response to interleukin-4 leukocyte migration immune system process mononuclear cell migration lymphocyte migration cell migration cellular process T cell migration cell motility import into cell vacuole organization organelle assembly lytic vacuole organization transport phagosome maturation establishment of localization vesicle-mediated transport cellular component organization cellular component biogenesis vesicle organization lysosome organization localization organelle organization cellular component assembly phagolysosome assembly phagocytosis cellular component organization or biogenesis endocytosis positive chemotaxis chemotaxis taxis response to external stimulus locomotion lymphocyte mediated immunity regulated exocytosis cellular localization biological process involved in interspecies interaction between organisms lymphocyte activation cell activation involved in immune response leukocyte degranulation response to biotic stimulus leukocyte activation secretion by cell response to stress natural killer cell activation involved in immune response leukocyte activation involved in immune response establishment of localization in cell innate immune response leukocyte mediated immunity response to external biotic stimulus natural killer cell mediated immunity lymphocyte activation involved in immune response immune response response to other organism defense response secretion cell activation export from cell defense response to symbiont natural killer cell activation leukocyte mediated cytotoxicity immune effector process exocytosis defense response to other organism natural killer cell degranulation natural killer cell mediated cytotoxicity cell killing regulation of cytoskeleton organization regulation of cellular component organization regulation of cellular process regulation of actin filament-based process regulation of cellular component size actin filament-based process regulation of biological quality actin polymerization or depolymerization regulation of biological process regulation of actin filament organization actin cytoskeleton organization regulation of actin polymerization or depolymerization biological regulation actin filament organization regulation of organelle organization regulation of actin filament length regulation of actin cytoskeleton organization regulation of supramolecular fiber organization supramolecular fiber organization cytoskeleton organization regulation of anatomical structure size cell population proliferation leukocyte proliferation mononuclear cell proliferation T cell activation lymphocyte proliferation T cell proliferation positive regulation of locomotion regulation of cell motility positive regulation of biological process regulation of lymphocyte migration positive regulation of cell migration positive regulation of cell motility regulation of cell migration positive regulation of mononuclear cell migration regulation of immune system process regulation of mononuclear cell migration positive regulation of immune system process positive regulation of cellular process positive regulation of lymphocyte migration regulation of leukocyte migration positive regulation of T cell migration positive regulation of leukocyte migration regulation of locomotion regulation of T cell migration thymocyte migration cell chemotaxis cellular response to stimulus cellular response to chemical stimulus leukocyte chemotaxis regulation of calcium ion transport regulation of localization intracellular calcium ion homeostasis negative regulation of biological process calcium ion transport monoatomic cation homeostasis monoatomic cation transport intracellular monoatomic ion homeostasis regulation of release of sequestered calcium ion into cytosol regulation of monoatomic ion transport inorganic ion transmembrane transport inorganic cation transmembrane transport maintenance of location transmembrane transport release of sequestered calcium ion into cytosol regulation of transmembrane transport chemical homeostasis inorganic ion homeostasis monoatomic ion transmembrane transport calcium ion homeostasis regulation of monoatomic ion transmembrane transport negative regulation of sequestering of calcium ion metal ion transport maintenance of location in cell regulation of calcium ion transmembrane transport monoatomic cation transmembrane transport intracellular monoatomic cation homeostasis monoatomic ion homeostasis negative regulation of cellular process monoatomic ion transport intracellular chemical homeostasis regulation of metal ion transport regulation of sequestering of calcium ion calcium ion transmembrane import into cytosol regulation of transport sequestering of calcium ion cellular homeostasis regulation of monoatomic cation transmembrane transport calcium ion transmembrane transport intracellular transport endosomal transport vesicle-mediated transport between endosomal compartments early endosome to recycling endosome transport positive regulation of cell population proliferation regulation of leukocyte activation regulation of cell activation positive regulation of cell activation positive regulation of leukocyte activation regulation of leukocyte proliferation positive regulation of T cell activation positive regulation of lymphocyte proliferation positive regulation of T cell proliferation regulation of cell population proliferation regulation of leukocyte cell-cell adhesion positive regulation of leukocyte proliferation positive regulation of multicellular organismal process positive regulation of leukocyte cell-cell adhesion leukocyte cell-cell adhesion positive regulation of cell-cell adhesion positive regulation of lymphocyte activation cell adhesion cell-cell adhesion positive regulation of mononuclear cell proliferation regulation of multicellular organismal process regulation of cell-cell adhesion regulation of lymphocyte proliferation positive regulation of cell adhesion regulation of cell adhesion regulation of T cell activation regulation of T cell proliferation regulation of mononuclear cell proliferation regulation of lymphocyte activation regulation of protein-containing complex assembly protein-containing complex assembly regulation of actin filament polymerization protein polymerization actin filament polymerization protein-containing complex organization regulation of cellular component biogenesis regulation of protein polymerization cellular response to growth factor stimulus cell surface receptor signaling pathway signaling response to endogenous stimulus cellular response to nerve growth factor stimulus cell communication cellular response to endogenous stimulus nerve growth factor signaling pathway neurotrophin signaling pathway response to nerve growth factor response to growth factor signal transduction epithelium migration tissue migration ameboidal-type cell migration epithelial cell migration membrane organization membrane fusion organelle membrane fusion organelle fusion vesicle fusion leukocyte homeostasis T cell homeostasis lymphocyte homeostasis regulation of vesicle fusion negative regulation of vesicle fusion negative regulation of transport negative regulation of cellular component organization regulation of vesicle-mediated transport negative regulation of organelle organization regulation of actin nucleation negative regulation of supramolecular fiber organization negative regulation of actin nucleation negative regulation of cytoskeleton organization actin nucleation neuron apoptotic process negative regulation of neuron apoptotic process negative regulation of programmed cell death regulation of apoptotic process regulation of programmed cell death cell death negative regulation of apoptotic process apoptotic process programmed cell death regulation of neuron apoptotic process developmental process regulation of developmental process regulation of cell shape cell morphogenesis regulation of cell morphogenesis anatomical structure morphogenesis anatomical structure development regulation of anatomical structure morphogenesis plasma membrane bounded cell projection organization cell projection organization uropod organization cell-substrate adhesion	cell projection cellular anatomical structure cell leading edge plasma membrane bounded cell projection lamellipodium cell-cell junction anchoring junction cell junction stereocilium actin-based cell projection organelle stereocilium tip stereocilium bundle neuron projection cell projection cellular anatomical structure cell leading edge plasma membrane bounded cell projection lamellipodium cell-cell junction anchoring junction cell junction stereocilium actin-based cell projection organelle stereocilium tip stereocilium bundle neuron projection cluster of actin-based cell projections intracellular organelle intracellular anatomical structure cytoskeleton membraneless organelle intracellular membraneless organelle actin cytoskeleton synapse glutamatergic synapse membrane-bounded organelle membrane intracellular vesicle phagocytic vesicle intracellular membrane-bounded organelle phagocytic vesicle membrane cytoplasmic vesicle membrane bounding membrane of organelle cytoplasmic vesicle vesicle membrane endocytic vesicle membrane cytoplasm vesicle organelle membrane endocytic vesicle polymeric cytoskeletal fiber actin filament supramolecular fiber supramolecular polymer supramolecular complex axon phagocytic cup cell periphery plasma membrane protein-containing complex early endosome endosome endomembrane system immunological synapse cell cortex cortical cytoskeleton cortical actin cytoskeleton

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A	IPR019775	WD40 repeat, conserved site	Conserved Site
A	IPR015048	Domain of unknown function DUF1899	Domain
A	IPR036322	WD40-repeat-containing domain superfamily	Homologous Superfamily
A	IPR015505	Coronin	Family
A	IPR015943	WD40/YVTN repeat-like-containing domain superfamily	Homologous Superfamily
A	IPR015049	Trimerisation motif	Domain
A	IPR001680	WD40 repeat	Repeat

Protein Modification Annotation

Modified Residue(s)
Chain	Residue(s)	Description
A	CME	Parent Component: CYS
A	CSO	Parent Component: CYS RESID: AA0205 PSI-MOD : L-cysteine sulfenic acid MOD:00210

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM157729.