2Q4K

Ensemble refinement of the protein crystal structure of gene product from Homo sapiens Hs.433573

External Resource: Annotation

Domain Annotation: SCOP/SCOPe Classification
Domain Annotation: SCOP2 Classification
Domain Annotation: ECOD Classification
Domain Annotation: CATH
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification
Pharos: Disease Associations

Domain Annotation: SCOP/SCOPe Classification SCOP-e Database Homepage

Chains	Domain Info	Class	Fold	Superfamily	Family	Domain	Species	Provenance Source (Version)
B	d2q4kb_	Alpha and beta proteins (a+b)	eIF4e-like	eIF4e-like	BLES03-like	Basophilic leukemia expressed protein BLES03	human (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)
C	d2q4kc_	Alpha and beta proteins (a+b)	eIF4e-like	eIF4e-like	BLES03-like	Basophilic leukemia expressed protein BLES03	human (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)
A	d2q4ka_	Alpha and beta proteins (a+b)	eIF4e-like	eIF4e-like	BLES03-like	Basophilic leukemia expressed protein BLES03	human (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
B	SCOP2B Superfamily	eIF4e-like	8036257	3001871	SCOP2B (2022-06-29)
C	SCOP2B Superfamily	eIF4e-like	8036257	3001871	SCOP2B (2022-06-29)
A	SCOP2B Superfamily	eIF4e-like	8036257	3001871	SCOP2B (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
B	DUF1917	e2q4kB1	A: a+b two layers	X: Translation initiation factor eIF4e and phosphothreonine lyase (From Topology)	H: Translation initiation factor eIF4e and phosphothreonine lyase (From Topology)	T: Translation initiation factor eIF4e and phosphothreonine lyase	F: DUF1917	ECOD (1.6)
C	DUF1917	e2q4kC1	A: a+b two layers	X: Translation initiation factor eIF4e and phosphothreonine lyase (From Topology)	H: Translation initiation factor eIF4e and phosphothreonine lyase (From Topology)	T: Translation initiation factor eIF4e and phosphothreonine lyase	F: DUF1917	ECOD (1.6)
A	DUF1917	e2q4kA1	A: a+b two layers	X: Translation initiation factor eIF4e and phosphothreonine lyase (From Topology)	H: Translation initiation factor eIF4e and phosphothreonine lyase (From Topology)	T: Translation initiation factor eIF4e and phosphothreonine lyase	F: DUF1917	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
B	3.30.760.10	Alpha Beta	2-Layer Sandwich	RNA Cap, Translation Initiation Factor Eif4e	RNA Cap, Translation Initiation Factor Eif4e	CATH (4.3.0)
C	3.30.760.10	Alpha Beta	2-Layer Sandwich	RNA Cap, Translation Initiation Factor Eif4e	RNA Cap, Translation Initiation Factor Eif4e	CATH (4.3.0)
A	3.30.760.10	Alpha Beta	2-Layer Sandwich	RNA Cap, Translation Initiation Factor Eif4e	RNA Cap, Translation Initiation Factor Eif4e	CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A, B, C	PF08939	Basophilic leukemia-expressed protein Bles03 (Bles03)	Basophilic leukemia-expressed protein Bles03	This domain is found in Basophilic leukemia-expressed protein Bles03 from humans (also known as UPF0696 protein C11orf68, Swiss:Q9H3H3) and various proteins from eukaryotes, bacteria and archaea. Bles03 has been suggested to have phosphothreonine lya ...	This domain is found in Basophilic leukemia-expressed protein Bles03 from humans (also known as UPF0696 protein C11orf68, Swiss:Q9H3H3) and various proteins from eukaryotes, bacteria and archaea. Bles03 has been suggested to have phosphothreonine lyase activity and to play a role in the biosynthesis of dehydro amino acids [1]. It shows a two-layer sandwich architecture with a a nine-stranded beta-sheet and three alpha-helices on each side [2].	Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A, B, C	Uncharacterized protein C11orf68	RNA binding binding organic cyclic compound binding nucleic acid binding	-	-

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A, B, C	IPR023398	Translation Initiation factor eIF- 4e-like	Homologous Superfamily
A, B, C	IPR015034	Basophilic leukemia-expressed protein Bles03-like	Family

Pharos: Disease Associations Pharos Homepage Annotation

Chains	Drug Target	Associated Disease
A, B, C	Pharos: Q9H3H3	melanoma Crohn disease cutaneous melanoma ovarian cancer inflammatory bowel disease skin basal cell carcinoma

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM157729.