1N4R

Protein Geranylgeranyltransferase type-I Complexed with a Geranylgeranylated KKKSKTKCVIL Peptide Product


Domain Annotation: SCOP/SCOPe Classification SCOP-e Database Homepage

ChainsDomain InfoClassFoldSuperfamilyFamilyDomainSpeciesProvenance Source (Version)
Ad1n4ra_ All alpha proteins alpha-alpha superhelix Protein prenylyltransferase Protein prenylyltransferase Protein farnesyltransferase alpha-subunit Rat (Rattus norvegicus ) [TaxId: 10116 ], SCOPe (2.08)
Ed1n4re_ All alpha proteins alpha-alpha superhelix Protein prenylyltransferase Protein prenylyltransferase Protein farnesyltransferase alpha-subunit Rat (Rattus norvegicus ) [TaxId: 10116 ], SCOPe (2.08)
Id1n4ri_ All alpha proteins alpha-alpha superhelix Protein prenylyltransferase Protein prenylyltransferase Protein farnesyltransferase alpha-subunit Rat (Rattus norvegicus ) [TaxId: 10116 ], SCOPe (2.08)
Kd1n4rk_ All alpha proteins alpha-alpha superhelix Protein prenylyltransferase Protein prenylyltransferase Protein farnesyltransferase alpha-subunit Rat (Rattus norvegicus ) [TaxId: 10116 ], SCOPe (2.08)
Cd1n4rc_ All alpha proteins alpha-alpha superhelix Protein prenylyltransferase Protein prenylyltransferase Protein farnesyltransferase alpha-subunit Rat (Rattus norvegicus ) [TaxId: 10116 ], SCOPe (2.08)
Gd1n4rg_ All alpha proteins alpha-alpha superhelix Protein prenylyltransferase Protein prenylyltransferase Protein farnesyltransferase alpha-subunit Rat (Rattus norvegicus ) [TaxId: 10116 ], SCOPe (2.08)
Bd1n4rb_ All alpha proteins alpha/alpha toroid Terpenoid cyclases/Protein prenyltransferases Protein prenyltransferases Protein farnesyltransferase, beta-subunit Rat (Rattus norvegicus ) [TaxId: 10116 ], SCOPe (2.08)
Dd1n4rd_ All alpha proteins alpha/alpha toroid Terpenoid cyclases/Protein prenyltransferases Protein prenyltransferases Protein farnesyltransferase, beta-subunit Rat (Rattus norvegicus ) [TaxId: 10116 ], SCOPe (2.08)
Hd1n4rh_ All alpha proteins alpha/alpha toroid Terpenoid cyclases/Protein prenyltransferases Protein prenyltransferases Protein farnesyltransferase, beta-subunit Rat (Rattus norvegicus ) [TaxId: 10116 ], SCOPe (2.08)
Ld1n4rl_ All alpha proteins alpha/alpha toroid Terpenoid cyclases/Protein prenyltransferases Protein prenyltransferases Protein farnesyltransferase, beta-subunit Rat (Rattus norvegicus ) [TaxId: 10116 ], SCOPe (2.08)
Fd1n4rf_ All alpha proteins alpha/alpha toroid Terpenoid cyclases/Protein prenyltransferases Protein prenyltransferases Protein farnesyltransferase, beta-subunit Rat (Rattus norvegicus ) [TaxId: 10116 ], SCOPe (2.08)
Jd1n4rj_ All alpha proteins alpha/alpha toroid Terpenoid cyclases/Protein prenyltransferases Protein prenyltransferases Protein farnesyltransferase, beta-subunit Rat (Rattus norvegicus ) [TaxId: 10116 ], SCOPe (2.08)

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

ChainsTypeFamily Name Domain Identifier Family IdentifierProvenance Source (Version)
ASCOP2B SuperfamilyProtein prenylyltransferase 8038634 3001312 SCOP2B (2022-06-29)
ESCOP2B SuperfamilyProtein prenylyltransferase 8038634 3001312 SCOP2B (2022-06-29)
ISCOP2B SuperfamilyProtein prenylyltransferase 8038634 3001312 SCOP2B (2022-06-29)
KSCOP2B SuperfamilyProtein prenylyltransferase 8038634 3001312 SCOP2B (2022-06-29)
CSCOP2B SuperfamilyProtein prenylyltransferase 8038634 3001312 SCOP2B (2022-06-29)
GSCOP2B SuperfamilyProtein prenylyltransferase 8038634 3001312 SCOP2B (2022-06-29)
BSCOP2B SuperfamilyTerpenoid cyclases/Protein prenyltransferases 8084558 3001024 SCOP2B (2022-06-29)
DSCOP2B SuperfamilyTerpenoid cyclases/Protein prenyltransferases 8084558 3001024 SCOP2B (2022-06-29)
HSCOP2B SuperfamilyTerpenoid cyclases/Protein prenyltransferases 8084558 3001024 SCOP2B (2022-06-29)
LSCOP2B SuperfamilyTerpenoid cyclases/Protein prenyltransferases 8084558 3001024 SCOP2B (2022-06-29)
FSCOP2B SuperfamilyTerpenoid cyclases/Protein prenyltransferases 8084558 3001024 SCOP2B (2022-06-29)
JSCOP2B SuperfamilyTerpenoid cyclases/Protein prenyltransferases 8084558 3001024 SCOP2B (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

ChainsFamily NameDomain Identifier ArchitecturePossible HomologyHomologyTopologyFamilyProvenance Source (Version)
APPTAe1n4rA1 A: alpha superhelicesX: Repetitive alpha hairpinsH: ARM repeat (From Topology)T: ARM repeatF: PPTAECOD (1.6)
EPPTAe1n4rE1 A: alpha superhelicesX: Repetitive alpha hairpinsH: ARM repeat (From Topology)T: ARM repeatF: PPTAECOD (1.6)
IPPTAe1n4rI1 A: alpha superhelicesX: Repetitive alpha hairpinsH: ARM repeat (From Topology)T: ARM repeatF: PPTAECOD (1.6)
KPPTAe1n4rK1 A: alpha superhelicesX: Repetitive alpha hairpinsH: ARM repeat (From Topology)T: ARM repeatF: PPTAECOD (1.6)
CPPTAe1n4rC1 A: alpha superhelicesX: Repetitive alpha hairpinsH: ARM repeat (From Topology)T: ARM repeatF: PPTAECOD (1.6)
GPPTAe1n4rG1 A: alpha superhelicesX: Repetitive alpha hairpinsH: ARM repeat (From Topology)T: ARM repeatF: PPTAECOD (1.6)
BSQHop_cyclase_Ce1n4rB1 A: alpha superhelicesX: Repetitive alpha hairpinsH: alpha/alpha toroid (From Topology)T: alpha/alpha toroidF: SQHop_cyclase_CECOD (1.6)
DSQHop_cyclase_Ce1n4rD1 A: alpha superhelicesX: Repetitive alpha hairpinsH: alpha/alpha toroid (From Topology)T: alpha/alpha toroidF: SQHop_cyclase_CECOD (1.6)
HSQHop_cyclase_Ce1n4rH1 A: alpha superhelicesX: Repetitive alpha hairpinsH: alpha/alpha toroid (From Topology)T: alpha/alpha toroidF: SQHop_cyclase_CECOD (1.6)
LSQHop_cyclase_Ce1n4rL1 A: alpha superhelicesX: Repetitive alpha hairpinsH: alpha/alpha toroid (From Topology)T: alpha/alpha toroidF: SQHop_cyclase_CECOD (1.6)
FSQHop_cyclase_Ce1n4rF1 A: alpha superhelicesX: Repetitive alpha hairpinsH: alpha/alpha toroid (From Topology)T: alpha/alpha toroidF: SQHop_cyclase_CECOD (1.6)
JSQHop_cyclase_Ce1n4rJ1 A: alpha superhelicesX: Repetitive alpha hairpinsH: alpha/alpha toroid (From Topology)T: alpha/alpha toroidF: SQHop_cyclase_CECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Protein Family Annotation Pfam Database Homepage

ChainsAccessionNameDescriptionCommentsSource
A, C, E, G, I
PF01239Protein prenyltransferase alpha subunit repeat (PPTA)Protein prenyltransferase alpha subunit repeat- Repeat
B, D, F, H, J
PF00432Prenyltransferase alpha-alpha toroid domain (Prenyltrans)Prenyltransferase and squalene oxidase repeat- Repeat

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

ChainsPolymerMolecular FunctionBiological ProcessCellular Component
A, C, E, G, I
Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha
B, D, F, H, J
Geranylgeranyl transferase type-1 subunit beta
M, N, O, P, Q
Fusion protein consisting of transforming protein p21b and Ras related protein Rap-2b

InterPro: Protein Family Classification InterPro Database Homepage

Pharos: Disease Associations Pharos Homepage Annotation

ChainsDrug Target  Associated Disease
M, N, O, P, Q
PharosP01116