1HM8

CRYSTAL STRUCTURE OF S.PNEUMONIAE N-ACETYLGLUCOSAMINE-1-PHOSPHATE URIDYLTRANSFERASE, GLMU, BOUND TO ACETYL COENZYME A

External Resource: Annotation

Domain Annotation: SCOP/SCOPe Classification
Domain Annotation: SCOP2 Classification
Domain Annotation: ECOD Classification
Domain Annotation: CATH
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification

Domain Annotation: SCOP/SCOPe Classification SCOP-e Database Homepage

Chains	Domain Info	Class	Fold	Superfamily	Family	Domain	Species	Provenance Source (Version)
B	d1hm8b1	All beta proteins	Single-stranded left-handed beta-helix	Trimeric LpxA-like enzymes	GlmU C-terminal domain-like	N-acetylglucosamine 1-phosphate uridyltransferase GlmU, C-terminal domain	(Streptococcus pneumoniae ) [TaxId: 1313 ],	SCOPe (2.08)
B	d1hm8b2	Alpha and beta proteins (a/b)	Nucleotide-diphospho-sugar transferases	Nucleotide-diphospho-sugar transferases	UDP-glucose pyrophosphorylase	N-acetylglucosamine 1-phosphate uridyltransferase GlmU, N-terminal domain	(Streptococcus pneumoniae ) [TaxId: 1313 ],	SCOPe (2.08)
A	d1hm8a1	All beta proteins	Single-stranded left-handed beta-helix	Trimeric LpxA-like enzymes	GlmU C-terminal domain-like	N-acetylglucosamine 1-phosphate uridyltransferase GlmU, C-terminal domain	(Streptococcus pneumoniae ) [TaxId: 1313 ],	SCOPe (2.08)
A	d1hm8a2	Alpha and beta proteins (a/b)	Nucleotide-diphospho-sugar transferases	Nucleotide-diphospho-sugar transferases	UDP-glucose pyrophosphorylase	N-acetylglucosamine 1-phosphate uridyltransferase GlmU, N-terminal domain	(Streptococcus pneumoniae ) [TaxId: 1313 ],	SCOPe (2.08)

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
B	SCOP2B Superfamily	Trimeric LpxA-like enzymes	8032705	3001804	SCOP2B (2022-06-29)
B	SCOP2B Superfamily	Nucleotide-diphospho-sugar transferases	8032706	3000077	SCOP2B (2022-06-29)
A	SCOP2B Superfamily	Nucleotide-diphospho-sugar transferases	8032706	3000077	SCOP2B (2022-06-29)
A	SCOP2B Superfamily	Trimeric LpxA-like enzymes	8032705	3001804	SCOP2B (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
B	Hexapep_2_1	e1hm8B1	A: beta duplicates or obligate multimers	X: Single-stranded left-handed beta-helix	H: Trimeric LpxA-like enzymes (From Topology)	T: Trimeric LpxA-like enzymes	F: Hexapep_2_1	ECOD (1.6)
B	NTP_transferase_1	e1hm8B2	A: a/b three-layered sandwiches	X: Nucleotide-diphospho-sugar transferases (From Topology)	H: Nucleotide-diphospho-sugar transferases (From Topology)	T: Nucleotide-diphospho-sugar transferases	F: NTP_transferase_1	ECOD (1.6)
A	Hexapep_2_1	e1hm8A1	A: beta duplicates or obligate multimers	X: Single-stranded left-handed beta-helix	H: Trimeric LpxA-like enzymes (From Topology)	T: Trimeric LpxA-like enzymes	F: Hexapep_2_1	ECOD (1.6)
A	NTP_transferase_1	e1hm8A2	A: a/b three-layered sandwiches	X: Nucleotide-diphospho-sugar transferases (From Topology)	H: Nucleotide-diphospho-sugar transferases (From Topology)	T: Nucleotide-diphospho-sugar transferases	F: NTP_transferase_1	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
B	3.90.550.10	Alpha Beta	Alpha-Beta Complex	Spore Coat Polysaccharide Biosynthesis Protein SpsA	Chain A	CATH (4.3.0)
B	2.160.10.10	Mainly Beta	3 Solenoid	UDP N-Acetylglucosamine Acyltransferase	domain 1	CATH (4.3.0)
A	3.90.550.10	Alpha Beta	Alpha-Beta Complex	Spore Coat Polysaccharide Biosynthesis Protein SpsA	Chain A	CATH (4.3.0)
A	2.160.10.10	Mainly Beta	3 Solenoid	UDP N-Acetylglucosamine Acyltransferase	domain 1	CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A, B	PF00483	Nucleotidyl transferase (NTP_transferase)	Nucleotidyl transferase	-	Family
A, B	PF00132	Bacterial transferase hexapeptide (six repeats) (Hexapep)	Bacterial transferase hexapeptide (six repeats)	-	Repeat

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A, B	UDP-N-ACETYLGLUCOSAMINE-1-PHOSPHATE URIDYLTRANSFERASE	cation binding magnesium ion binding ion binding binding metal ion binding small molecule binding acetyltransferase activity glucosamine-1-phosphate N-acetyltransferase activity N-acetyltransferase activity acyltransferase activity acyltransferase activity, transferring groups other than amino-acyl groups transferase activity catalytic activity N-acyltransferase activity cation binding magnesium ion binding ion binding binding metal ion binding small molecule binding acetyltransferase activity glucosamine-1-phosphate N-acetyltransferase activity N-acetyltransferase activity acyltransferase activity acyltransferase activity, transferring groups other than amino-acyl groups transferase activity catalytic activity N-acyltransferase activity uridylyltransferase activity UDP-N-acetylglucosamine diphosphorylase activity nucleotidyltransferase activity transferase activity, transferring phosphorus-containing groups	developmental process regulation of biological process regulation of developmental process biological regulation regulation of cell shape cell morphogenesis regulation of cell morphogenesis anatomical structure morphogenesis anatomical structure development regulation of biological quality regulation of anatomical structure morphogenesis glycolipid metabolic process lipid A biosynthetic process carbohydrate derivative metabolic process developmental process regulation of biological process regulation of developmental process biological regulation regulation of cell shape cell morphogenesis regulation of cell morphogenesis anatomical structure morphogenesis anatomical structure development regulation of biological quality regulation of anatomical structure morphogenesis glycolipid metabolic process lipid A biosynthetic process carbohydrate derivative metabolic process lipid biosynthetic process phospholipid metabolic process phosphate-containing compound metabolic process lipooligosaccharide biosynthetic process phosphorus metabolic process carbohydrate derivative biosynthetic process membrane lipid metabolic process lipooligosaccharide metabolic process liposaccharide metabolic process primary metabolic process glycolipid biosynthetic process phospholipid biosynthetic process lipid A metabolic process biosynthetic process organophosphate metabolic process organophosphate biosynthetic process metabolic process cellular process membrane lipid biosynthetic process lipid metabolic process cellular component organization cell wall organization or biogenesis cell wall organization cellular component organization or biogenesis external encapsulating structure organization nucleoside phosphate metabolic process amino sugar biosynthetic process nucleotide-sugar metabolic process nucleobase-containing compound biosynthetic process UDP-N-acetylglucosamine biosynthetic process nucleobase-containing compound metabolic process nucleobase-containing small molecule metabolic process nucleoside phosphate biosynthetic process amino sugar metabolic process small molecule metabolic process nucleotide-sugar biosynthetic process UDP-N-acetylglucosamine metabolic process peptidoglycan-based cell wall biogenesis glycosaminoglycan metabolic process macromolecule biosynthetic process cellular component biogenesis peptidoglycan biosynthetic process cell wall biogenesis cell wall macromolecule biosynthetic process aminoglycan metabolic process peptidoglycan metabolic process aminoglycan biosynthetic process glycosaminoglycan biosynthetic process macromolecule metabolic process	cellular anatomical structure intracellular anatomical structure cytoplasm

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A, B	IPR050065	Bifunctional protein GlmU-like	Family
A, B	IPR038009	GlmU, C-terminal LbH domain	Domain
A, B	IPR005882	Bifunctional protein GlmU	Family
A, B	IPR001451	Hexapeptide repeat	Repeat
A, B	IPR011004	Trimeric LpxA-like superfamily	Homologous Superfamily
A, B	IPR005835	Nucleotidyl transferase domain	Domain
A, B	IPR029044	Nucleotide-diphospho-sugar transferases	Homologous Superfamily
A, B	IPR018357	Hexapeptide transferase, conserved site	Conserved Site

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM157729.