1DTP

THE STRUCTURE OF THE ISOLATED CATALYTIC DOMAIN OF DIPHTHERIA TOXIN

External Resource: Annotation

Domain Annotation: SCOP/SCOPe Classification
Domain Annotation: SCOP2 Classification
Domain Annotation: ECOD Classification
Domain Annotation: CATH
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification

Domain Annotation: SCOP/SCOPe Classification SCOP-e Database Homepage

Chains	Domain Info	Class	Fold	Superfamily	Family	Domain	Species	Provenance Source (Version)
A	d1dtpa_	Alpha and beta proteins (a+b)	ADP-ribosylation	ADP-ribosylation	ADP-ribosylating toxins	Diphtheria toxin, N-terminal domain	(Corynephage beta ) [TaxId: 10703 ],	SCOPe (2.08)

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
A	SCOP2B Superfamily	ADP-ribosylation	8036997	3001208	SCOP2B (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	Diphtheria_C	e1dtpA1	A: a+b complex topology	X: ADP-ribosylation (From Topology)	H: ADP-ribosylation (From Topology)	T: ADP-ribosylation	F: Diphtheria_C	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
A	3.90.175.10	Alpha Beta	Alpha-Beta Complex	Diphtheria Toxin	domain 1	CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A	PF02763	Diphtheria toxin, C domain (Diphtheria_C)	Diphtheria toxin, C domain	N-terminal catalytic (C) domain - blocks protein synthesis by transfer of ADP-ribose from NAD to a diphthamide residue of EF-2.	Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A	DIPHTHERIA TOXIN	macromolecule transmembrane transporter activity protein transporter activity protein transmembrane transporter activity transporter activity transmembrane transporter activity pentosyltransferase activity glycosyltransferase activity NAD+-diphthamide ADP-ribosyltransferase activity transferase activity catalytic activity toxin activity nucleotidyltransferase activity transferase activity, transferring phosphorus-containing groups identical protein binding macromolecule transmembrane transporter activity protein transporter activity protein transmembrane transporter activity transporter activity transmembrane transporter activity pentosyltransferase activity glycosyltransferase activity NAD+-diphthamide ADP-ribosyltransferase activity transferase activity catalytic activity toxin activity nucleotidyltransferase activity transferase activity, transferring phosphorus-containing groups identical protein binding protein binding binding	-	cellular anatomical structure extracellular region cell periphery plasma membrane membrane extracellular space

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A	IPR036799	Diphtheria toxin, receptor-binding domain superfamily	Homologous Superfamily
A	IPR000512	Diphtheria toxin (NAD+-dipthamide ADP-ribosyltransferase)	Family
A	IPR022404	Diphtheria toxin, receptor-binding domain	Domain
A	IPR036801	Diphtheria toxin, translocation domain superfamily	Homologous Superfamily
A	IPR022406	Diphtheria toxin, catalytic domain	Domain

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM157729.